ARCH
Discipline of Obstetrics and Gynaecology
The University of Adelaide

Women's and Children's Hospital
King William Road
North Adelaide SA 5006
AUSTRALIA
Email

Phone: +61 8 8161 7619
Facsimile: +61 8 8161 7652

AMICABLE Collaboration (Antenatal Magnesium IPD International Collaboration: Assessing the Benefits for Babies using the Best Level of Evidence)

Magnesium sulphate prior to birth increases the chances of preterm babies surviving or preventing cerebral palsy. The AMICABLE Collaboration (Antenatal Magnesium IPD International Collaboration: assessing the benefits for babies using the best level of evidence) is undertaking an individual patient data (IPD) meta-analysis on the use of magnesium sulphate in women at risk of very preterm birth for neuroprotection of the fetus. This patient level analysis will clarify optimal gestational age, timing prior to preterm birth magnesium sulphate should be given, the best dose and regimen to use and which women are most likely to benefit.

The ‘Magnesium sulphate in women at risk of preterm birth for fetal neuroprotection - an individual patient data (IPD)' was funded by the NHMRC for two years 2010-2011.

This patient level analysis will clarify:

optimal gestational age;
timing prior to preterm birth when magnesium sulphate should be given;
the best dose and regimen to use; and which women are most likely to benefit.

Publications

AMICABLE Study Group: Antenatal magnesium individual participant data international collaboration: assessing the benefits for babies using the best level of evidence (AMICABLE). Syst Rev 2012, 1(1):21 (Protocol).