Australian Research Centre for Health of Women and Babies

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ARCH
Discipline of Obstetrics and Gynaecology
The University of Adelaide

Women's and Children's Hospital
King William Road
North Adelaide SA 5006
AUSTRALIA
Email

Phone: +61 8 8161 7619
Facsimile: +61 8 8161 7652

PROGRESS: PROGesterone after previous preterm birth for prevention of neonatal RESpiratory distress Syndrome

This trial is currently recruiting. The trial is open for other centres to join the study.

Neonatal respiratory disease, due to immature lung development, is a significant consequence of preterm birth and the major cause of early neonatal mortality and morbidity. The incidence of preterm birth (birth less than 37 weeks gestation) is approximately 7.0%, with 2.6% of all births occurring before 34 weeks gestation. The exact mechanism of the onset of labour in humans is complex. Progesterone is essential for maintaining pregnancy, having an important role in uterine relaxation. Although recent reports of progesterone supplementation for women at risk of preterm birth show promise, there is currently insufficient data to recommend the use of progesterone to prevent preterm birth. This trial will involve women who have a history of spontaneous preterm birth at less than 34 weeks in the preceding pregnancy and will compare vaginal progesterone pessaries with placebo pessaries.

Chief Investigators:	Prof Caroline Crowther, Dr Jodie Dodd, Dr Andrew McPhee, Ms Vicki Flenady, Prof Jeffrey Robinson
Clinical Trial Coordinator:	Ms Pat Ashwood
Email:	progress@adelaide.edu.au
Phone: Fax:	61 8 8161 7767 61 8 8161 7652
Address:	ARCH Discipline of Obstetrics and Gynaecology The University of Adelaide Women's and Children's Hospital King William Road North Adelaide South Australia 5006
Collaborating Centres:	Christchurch Women’s Hospital, New Zealand Dunedin Hospital, New Zealand Hervey Bay Hospital, Queensland Ipswich Hospital, Queensland John Hunter Hospital, New South Wales Launceston General Hospital, Tasmania Lyell McEwin Hospital, South Australia Mackay Base Hospital, Queensland Mater Mothers’ Hospital, Queensland Mercy Hospital for Women, Victoria Modbury Hospital, South Australia Monash Medical Centre, Victoria National Women’s Hospital, New Zealand Nepean Hospital, New South Wales Palmerston North Hospital, New Zealand Redcliffe-Caboolture Hospital, Queensland Royal Hospital for Women, Sydney, New South Wales Royal North Shore Hospital, New South Wales Royal Prince Alfred Hospital Women’s & Babies Hospital, New South Wales Royal Brisbane & Women’s Hospital, Queensland Royal Women’s Hospital, Victoria St George Hospital, New South Wales Sydney Adventist Hospital, New South Wales The Canberra Hospital, Australian Capital Territory Toowoomba Base Hospital, Queensland Townsville Hospital, Queensland Wellington Women’s Hospital, New Zealand Westmead Hospital, New South Wales Women's and Children's Hospital, South Australia

References

Dodd J, Ashwood P, Flenady V, Jenkins-Manning S, Cincotta R, Crowther CA. A Survey of clinicians and patients towards the use of progesterone for women at risk of preterm birth. Aust N Z J Obstet Gynaecol 2007;47:106-109. (IF 0.835)

Dodd JM, Flenady V, Cincotta R, Crowther CA. Prenatal administration of progesterone for preventing preterm birth. Cochrane Database of Systematic Reviews 2006, Issue 1.

Dodd JM, Crowther CA, Cincotta R, Flenady V & Robinson JS. Progesterone supplementation for prevention of preterm birth: a systematic review and meta-analysis. Acta Obstetrica et Gynecologica Scandinavica 2005 84, 1-8. (IF: 1.327).

Dodd JM, Flenady VJ, Cincotta R, Crowther CA.Progesterone for the prevention of preterm birth: a systematic review. Obstet Gynecol. 2008 Jul;112(1):127-34.