Associate Professor Ian Chapman , MBBS, PhD, FRACP

Current Appoinments | Biography | Staff & Students | Publications

Current Appointments

Associate Professor (Endocrinology), University of Adelaide

Associate Member, Hanson Research Institute

Senior Consultant Endocrinologist, Royal Adelaide Hospital

Co-chair, University of Adelaide Health Sciences Admission Committee

Biography

A/Prof Ian Chapman has a well-established track record of clinically based research relating to the endocrinology of aging and nutrition.  His major research interest is currently the “anorexia of aging”, with a particular focus on the gastrointestinal control of appetite and energy intake, including the role of gastrointestinal hormones. This work has been supported by two NHMRC Project Grants (currently 2004-2006), a number of University of Adelaide and Royal Adelaide Hospital grants, and commercial funding (Organon, The Netherlands) – the latter to undertake an intervention study - and has been influential in raising the awareness, both nationally and internationally, of the importance of this problem, and the need for nutritional assessment and intervention where appropriate.  A/Prof Chapman’s standing in the field of nutrition in the elderly is attested to by numerous invitations to speak at national and international scientific meetings (in 2005, he gave 4 invited plenary lectures in the United States).  He is a co-author of 77 refereed publications, and 9 book chapters. Subsequent to his appointment to the Royal Adelaide Hospital in 1996, A/Prof Chapman has supervised 5 PhD students (from science, medical, dietetic, and nursing backgrounds), 4 honours science students, 2 overseas research fellows and numerous medical students undertaking research training attachments.  His current PhD student is a specialist geriatrician, and three of his previous students are continuing in clinical research in the area of nutrition. Since 2000, he has been the Postgraduate Coordinator for the University of Adelaide Department of Medicine, with principal responsibility for PhD students undertaking clinical research

Staff

Ms Amelia Pilichiwicz, Research Assistant
Ms Angela Hammond, Research Assistant

Higher Degree Students

Dr Kamilia Tai - PhD

Current Funded Research

2004-7 NHMRC Project Grant-"The anorexia of ageing: gastrointestinal control of appetite and feeding in the elderly.” $188,250

2007-11           NHMRC CCRE Grant 453557: Centre of Clinical Research Excellence in nutritional physiology, interventions and outcomes. M Horowitz, P Clifton, G Wittert, I Chapman, R Fraser, C Rayner, C Feinle-Bisset, K Jones. ($2,000,000)

2007-9 NHMRC Project Grant (453650) “Pathophysiology of postprandial hypotension
in the elderly – role of “gastric” and “small intestinal” mechanisms”. K Jones, M Horowitz, I Chapman, C Feinle-Bisset, C Rayner,         $468,938

Recent Publications

Boyd KA, O’Donovan DG, Doran S, Wishart J, Chapman IM, Horowitz M, Feinle C. High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men. Am J Physiol 2003;284:G188-196.

Visvanathan R, MacIntosh C, Callary M, Penhall R, Horowitz M, Chapman I. The nutritional status of 250 older recipients of domiciliary care services, and its association with outcomes at 12 months. J Am Geriatr Soc. 2003;51:1007-1011.

Vozzo R, Wittert G, Cocchiaro C, Tan W-C, Mudge J, Fraser R, Chapman I. Similar effects of foods high in protein, carbohydrate and fat on subsequent spontaneous food intake in healthy individuals. Appetite 2003;40: 101-107.

Feinle C, O’Donovan D, Doran S, Andrews JM, Wishart J, Chapman I, Horowitz M. Effects of fat digestion on appetite, antropyloroduodenal motility and gut hormones in response to duodenal fat infusion in humans. Am J Physiol 2003;284:G798-807.

Sturm K, MacIntosh CG, Parker BA, Wishart J, Horowitz M, Chapman IM. Appetite, food intake and plasma concentrations of cholecystokinin, ghrelin and other gastrointestinal hormones in under-nourished older women and well-nourished young and older women. J Clin Endocrinol Metab 2003;88:3747-3755.

Wittert G, Chapman IM, Haren MT, Mackintosh S, Coates P, Morley JE. Low dose oreal testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status. J Gerontol 2003;58:M618-M625.

Parker B, Sturm K, MacIntosh C, C Feinle, Horowitz M, Chapman I. Relationship between food intake and visual analogue scale ratings of sensations in healthy older and young subjects. Eur J Clin Nutr. 2004;58:212-8.

Russo A, Botten R, Kong M-F, Chapman IM, Fraser RJL, Horowitz M, Sun W-M. Effects of acute hyperglycaemia on anorectal and sensory function in diabetes mellitus. Diabetic Medicine 2004;21:176-182.

Visvanathan R, Penhall R, Chapman IM. Nutritional screening of older people in sub-acute care facility in Australia and its relation to discharge outcomes. Age and Ageing. 2004;33:1-6.

Sturm K, Parker B, Wishart J, Feinle-Bisset C, Jones KL,  Chapman IM, Horowitz M. Energy intake and appetite are related to antral area in healthy young and older subjects. Am J Clin Nutr. 2004 80:656-667.

Visvanathan R, Chen R, Horowitz M, Chapman I. Blood Pressure Responses in Healthy Older People to 50g Carbohydrate Drinks With Differing Glycemic Effects. British Journal of Nutrition. 2004 92:335-340.

Visvanathan R, Newbury JW, Chapman IM. Malnutrition in older people: screening and management strategies. Australian Family Physician 2004 33:799-806.

Feltrin KL, Little TJ, Meyer JH, Horowitz M, Smout AJPM, Wishart J, Pilichiewicz AN, Rades T, Chapman IM, Feinle-Bisset C. Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length.Am J Physiol Regul Integr Comp Physiol. 2004287:R524-33.

Parker BA, Ludher AK, Loan TK, Horowitz M, Chapman IM. Relationships of ratings of appetite to food intake in healthy older men and women. Appetite. 2004 43: 227-233.
15. Parker BA, Chapman IM. Food intake and ageing – the role of the gut. Mechanisms of Ageing and Development. 2004 125:859-866.

Haren MT, Wittert GA, Chapman IM, Coates P, Morley JE.  The effect of 12-months of oral testosterone supplementation on the cognitive function, mood and quality of life of healthy elderly males with low-normal gonadal status:  A randomised controlled trial.  Maturitas. 2005 50:124-33.
 
Haren M, Wittert G, Chapman I, Coates P, Morley J.  Effect of 12-month oral testosterone on testosterone deficiency symptoms in symptomatic elderly males with low-normal gonadal status.  Age and Ageing. 2005 34:125-30.

Chapman IM. Haemochromatosis and diabetes. Diabetes Management. 2005 10:10. 

Visvanathan R, Chen R, Garcia M, Horowitz M, Chapman I. The Effects of Drinks Made From Simple Sugars on Blood Pressure in Healthy Older People. Brit J Nutrition.  2005 93:575-9.

Parker BA, Doran S, Wishart J, Horowitz M, Chapman IM. Effects of small intestinal and gastric glucose administration on the suppression of plasma ghrelin concentrations in healthy older men and women. Clin Endocrinol 2005 62:539-546.

Chapman I, Parker B, Doran S, Feinle-Bisset C, Wishart J, Strobel S, Wang Y, Burns C, Lush C, Weyer C, Horowitz M. Effect of Pramlintide on Satiety and Food Intake in Obese Subjects and Subjects with Type 2 Diabetes. Diabetalogia. 2005 48:838-848.

Visvanathan R, Chapman I. Prognosis in obesity: older people should not be misinformed about being overweight. BMJ. 2005 331:452.

Visvanathan R, Horowitz M, Chapman I.  The hypotensive response to oral fat is comparable, but slower compared to carbohydrate in healthy older people.  Brit J Nutr 2006 95:340-345.

Chapman IM, Parker B, Doran S, et al. Low-Dose Pramlintide Reduced Food Intake and Meal Duration in Healthy, Normal Weight Subjects. Obesity. 2007 15:1179-1186
 
Book Chapters

Chapman IM Pituitary Gland Disorders. The Merck Manual of Medical Information Second Home Edition 2003 Published by Merck Research Laboratories, New Jersey USA. 940-947.

Chapman IM. Endocrinology of Anorexia of Ageing. In: Best Practice & Research Clinical Endocrinology and Metabolism “Endocrinology of Ageing” Guest editor Prof. MO Thorner (USA). Publishers; Rapid Medical Media East Sussex, UK.2004 18:437-452.

Chapman IM. The Anorexia of Aging. In:  Principles and Practice of Geriatric Medicine. 4th Edited by M.S. John Pathy, Alan J Sinclair and John E Morley, 2006 John Wiley & Sons Ltd.

Chapman IM, Pituitary Disorders. In: The Merck Manual of Diagnosis and Therapy 18th Edition. Published by Merck Research Laboratories, New Jersey USA. 2006.

Wittert G, Chapman I. Physiology of gut hormones – An Overview. In: Current Opinions in Endocrinology and Diabetes. Ed Bloom S. 2006 Accepted for publication.

Chapman IM. Nutritional Disorders in the Elderly.  In: Geriatric Medicine; Medical Clinics of North America 2006, 80:887-907: Editors John E. Morley and Julie K. Gammack.

Chapman IM. Obesity in Old Age. In: Obesity and Metabolism; Frontiers in Hormone Research, for publication 2007: Editor Márta Korbonits.

Chapman IM. The anorexia of aging. In: Clinics in Geriatric Medicine: Gastroenterology Editors: John E Morley and Syed H Tariq, Published by Elsevier Saunders Inc 2007, Accepted for Publication.