A/Prof Christopher Rayner MBBS PhD FRACP
Current Appointments | Biography | Relevant Publications
Current Appointments
| Gwendolyn Michell Associate Professor, Discipline of Medicine, University of Adelaide |
| Consultant Gastroenterologist, Royal Adelaide Hospital |
Biography
Chris Rayner is a gastroenterologist, whose research concerns the function of the upper gastrointestinal tract in health and disease. A particular focus is the interaction between nutrients and the gut, including the release of small intestinal peptides that regulate appetite, blood glucose, and gastrointestinal motility.
Current research projects are investigating:
• The determinants of release of "incretin" peptides from the small intestine
• Characterisation of small intestinal flow patterns and their relationship to glucose absorption
• Glucose sensing in the small intestine
• The mechanisms of disordered stomach function in diabetes
• Dietary strategies to optimise postprandial blood glucose in people with diabetes
Key techniques include:
• Gastrointestinal manometry
• Intraluminal impedance monitoring to measure flow events in the small intestine
• 3D gastric ultrasound
• Scintigraphy
• Breath tests for gastric emptying
• Assays for gut peptides (GLP-1, GIP, CCK, PYY, ghrelin)
Relevant Publications
Kuo P, Wishart JM, Bellon M, Smout AJ, Holloway RH, Fraser RJ, Horowitz M, Jones KL, Rayner CK. Effects of Physiological Hyperglycemia on Duodenal Motility and Flow Events, Glucose Absorption, and Incretin Secretion in Healthy Humans. J Clin Endocrinol Metab. (in press)
Ma J, Stevens JE, Cukier K, Maddox AF, Wishart JM, Jones KL, Clifton PM, Horowitz M, Rayner CK. Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes. Diabetes Care. 2009;32:1600-2.
Kuo P, Gentilcore D, Nair N, Stevens JE, Wishart JM, Lange K, Gilja OH, Hausken T, Horowitz M, Jones KL, Rayner CK. The nitric oxide synthase inhibitor, Ng-nitro-L-arginine-methyl-ester, attenuates the delay in gastric emptying induced by hyperglycaemia in healthy humans. Neurogastroenterol Motil. 2009; 21:1175-e103.
Young RL, Sutherland K, Pezos N, Brierley SM, Horowitz M, Rayner CK, Blackshaw LA. Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut. 2009; 58:337-46.
Rayner CK, Horowitz M. Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited? J Clin Invest. 2006;116:299-302. R
