Dr Richard L Young PhD
Current Appointment | Biography | Staff & Students | Publications
Current Appointment
| Health Sciences Early Career Research Fellow, School of Medicine, Royal Adelaide Hospital |
Biography
Dr Richard Young was recently appointed to the position of Health Sciences Early Career Research Fellow in 2007, having been involved in collaborative industry-funded research in the Nerve-Gut Research Laboratory, Royal Adelaide Hospital since 2000. His research activities have been based along two main lines – identifying novel interventions that modify sensory and motor control of the lower esophageal sphincter in gastroesophageal reflux, and, the control of gastrointestinal motor and sensory function, particularly in the context of identifying novel nutrient sensing mechanisms in the small intestine that modify gastric emptying. In these areas of research Dr Young has established a number of high resolution surgical, anatomical and immunohistochemical protocols within the Nerve Gut Research Laboratory. He was the recipient of a NHMRC Dora Lush Biomedical Scholarship during his PhD studies, has been funded from competitive research grants since 1998, and is a co-author of 10 peer-reviewed papers. Dr Young has presented research findings at international and national scientific meetings and has been the recipient of a number of awards, including the Healthy Aging Research Cluster Grant Application Award (2005) and a Distinguished Oral Abstract Award at the annual meeting of the American Gastroenterological Association (2006). He is a reviewer for a number of leading journals, has experience with undergraduate and postgraduate training and currently supervises 2 PhD students from the Discipline of Physiology, University of Adelaide.
Higher Degree Students
Ms Nektaria Pezos - PhD
Ms Kate Sutherland - PhD
Current Funded Research
2007 Sweet-taste sensor molecules in the small intestine of humans with diabetes mellitus. C Rayner, R Young, L Blackshaw, M Horowitz. Royal Adelaide Hospital Research Committee Clinical Project Grant 2007 Value: $20,000.
2006-2007 Research collaboration for development of therapeutic treatments for gastro-oesophageal reflux disease (AstraZeneca). J Dent, L Blackshaw, A Page, R Young. Value: $666,271.
2004 M Horowitz, R Young, L Blackshaw, R Margolskee University of Adelaide Faculty of Health Sciences Research Grant Project title: Intestinal glucose sensing mechanisms and their disruption in diabetes Value: $20,000
Recent Publications
Original Papers
Partosoedarso E., Young R. L. and Blackshaw L. A. GABAB receptors on vagal afferent pathways: peripheral and central inhibition. American Journal of Physiology 2001 280:G658-G668.
Smid S. D., Young R. L., Cooper N. C. and Blackshaw L. A. GABAB receptors inhibit vagal afferent responses to distension of the ferret proximal stomach: functional and anatomical studies. American Journal of Physiology 2001 281(6):G1494-501.
Slattery J. A., Page A. J., O’Donnell T. A., Cooper N. J., Young R. L. and Blackshaw L. A. Modulation of gastro-oesophageal vagal afferents by galanin in mouse and ferret. Journal of Physiology 2005 563(3):809-819.
Page A.J., Young R.L., Martin C.M., Umaerus M., O’Donnell T.A., Cooper N.J., Coldwell J.C., Hulander M., Mattsson J., Lehmann A. and Blackshaw L.A. Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Gastroenterology 2005 128(2):402-10.
Hughes P.A, Brierley, S.M., Young R.L. and Blackshaw L.A. Localisation and comparative analysis of acid sensing ion channel (ASIC1, 2 and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. Journal of Comparative Neurology 2007 500(5):863-75.
Young R.L., Page, A.J., O’Donnell T.A., Cooper, N.J. and Blackshaw L.A. Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5. American Journal of Physiology 2007 292 (2): G501-11.
Sutherland K*., Young R.L.*, Cooper, N.J., Horowitz M. and Blackshaw L.A. Phenotypic characterization of taste cells of the mouse small intestine. American Journal of Physiology 2007 292(5):G1420-5 (* equal first authorship).
