Our research in autoimmune diseases

Our research in autoimmune diseases investigates disorders in which the immune system attacks itself by mistake. The focus of our work is on regulatory T cells (Treg), which are the policemen of the immune system. T cells attack viruses or bacteria in the body while leaving food proteins and body tissues unharmed. As such, the breakdown of Treg cells can result in autoimmune disorders such as cancer, multiple sclerosis and organ rejection. By manipulating Treg numbers and function, we are trying to find new ways of treating autoimmunity in all of its forms.

Inspired by pioneers such as Sir Peter Medawar, whose discoveries in skin grafting and organ transplantation led the way in immunological tolerance, our laboratory uses cellular and molecular approaches to identify genes involved in the function of T cells. By comparing clinical samples of healthy tissue with tissue affected by autoimmune disease, we hope to identify new proteins on the surface of regulatory T cells which may be useful in diagnosing and treating autoimmune diseases. The Children's Research Centre is unique in bringing together basic scientific technologies with clinical expertise, and in this way aims to contribute significantly to the advancement of immunological therapies.