Mucosal Research
Members
- Professor Dorothy Keefe
- Associate Professor Richard Logan
- Dr Rachel Gibson
- Dr Joanne Bowen
- Dr Andrea Stringer
- Dr Ann Yeoh
- Ms Noor Al-Dasooqi
- Ms Jocelyn Darby
- Ms Rachel Jennings
- Ms Erin Plews
Research Goals
The goal of the research being undertaken by the mucositis research group is to understand the pathobiology of chemotherapy- and radiotherapy-induced mucositis, from the nanotechnology aspect through to animal models, and translation into clinical research.
Current Projects
Cancer Australia / Cure Cancer
- Faecal microflora and circulating pro-inflammatory cytokines: key elements to chemotherapy-induced diarrhoea.
The Cancer Council South Australia
- Intestinal stem cells
Glaxo-Smith Kline
- Tyrosine kinase inhibitor-induced mucosal injury and diarrhoea
Nestlé Nutrition
- The role of dietary supplements in ameliorating chemotherapy-induced mucosal damage
Helsinn
- The role of 5-HT3 receptor inhibitors in ameliorating chemotherapy-induced diarrhoea.
School of Dentistry, University of Adelaide
- The expression of NF-κB and TNF in the oral mucosa of the tongue following the administration of mucotoxic chemotherapeutic drugs
- Pre-treatment identification of biomarkers for severe mucositis in oesophageal cancer patients
ARI, University of Adelaide
- Development of the Wistar Rat model for mucositis
Recent Publications
Al-Dasooqi N, Gibson R, Bowen J, Keefe D (2009). HER2 Targeted Therapies for Cancer and the Gastrointestinal Tract. Current Drug Targets 10(6):537-42
Lalla RV, Pilbeam CC, Walsh SJ, Sonis ST, Keefe DM, Peterson DE. Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study. Support Care Cancer. 2009 Apr 29. [Epub ahead of print]
Al-Dasooqi N, Gibson RJ, Bowen JM, Keefe DM. Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis? Cancer Chemother Pharmacol. 2009 Jun;64(1):1-9.
Stringer AM, Gibson RJ, Logan RM, Bowen JM, Yeoh ASJ and Keefe DMK (2009). Gastrointestinal microflora and mucins play a role in the development of 5-Fluorouracil-induced gastrointestinal mucositis in rats. Experimental Biology and Medicine 2009 Apr;234(4):430-41.
Stringer AM, Gibson RJ, Logan RM, Bowen JM, Laurence J and Keefe DM (2009). Irinotecan-induced mucositis is associated with changes in intestinal mucins. Cancer Chemotherapy and Pharmacology Jun;64(1):123-32.
Stringer AM, Gibson RJ, Bowen JM and Keefe DMK (2009). Chemotherapy-induced changes to microflora: Evidence and implications of change. Current Drug Metabolisms 10(1):79-83.
Logan RM, Stringer AM, Bowen JM, Gibson RJ, Sonis ST and Keefe DM (2009). Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered? Cancer Chemotherapy Pharmacology 63(2):239-51 IF 2.568.
Elting LS, Keefe DM, Sonis ST, Garden AS, Spijkervet FK, Barasch A, Tishler RB, Canty TP, Kudrimoti MK, Vera-Llonch M; Burden of Illness Head and Neck Writing Committee. Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life. Cancer. 2008 Nov 15;113(10):2704-13.
Stringer AM, Gibson RJ, Logan RM, Bowen JM, Yeoh ASJ and Keefe DMK (2008). Faecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhoea model in rats. Cancer Biology Therapy 7(12):1919-25
Logan RM, Stringer AM, Bowen JM, Gibson RJ, Sonis ST and Keefe DMK (2008). Serum levels of Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biology Therapy 2008 7(7):1139-45.Keefe DM, Sonis ST, Bowen JM. Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22. Review.
Gibson RJ, Bowen JM, Keefe DM. Technological advances in mucositis research: new insights and new issues. Cancer Treat Rev. 2008 Aug;34(5):476-82.
