Further Enquiries

School of Dentistry
THE UNIVERSITY OF ADELAIDE
SA 5005
AUSTRALIA
Email

Telephone: +61 8 8303 3436
Facsimile: +61 8 8303 6429

Periodontal Pathology

Members

Professor Mark Bartold
Associate Professor Stan Gronthos
Dr T Fitzsimmons
Dr S Ge
Dr D Haynes
Dr K Hynes
Dr N Gully
Dr N Lin
Dr J Xiong
Dr P Zilm
Mr V Marino
Mr K Mrozik
Ms D Menicanin
Ms M Cantley
Ms C Marchant

Research Goals

The goal of the research being undertaken by the periodontolal pathology group is to understand the pathobiology of periodontal diseases, their consequences, and their interactions with other significant health challenges, including such diverse areas as chronic inflammatory diseases, cardiovascular disease and pre-term low birth weight babies.

Current Projects

National Health & Medical Research Council

Relationship between periodontal disease and rheumatoid arthritis.
Risk indicators for periodontal disease in an urban Aboriginal and Torres Strait Islander population.
Generation of induced pluripotent stem cells (iPS) and their potential use in periodontal regeneration.
Novel treatments of pathological bone loss.

Australian Dental Research Foundation

The use of human gingival fibroblasts as the feeder layer for iPS cells.
Investigation of periodontal ligament stem cell self-renewal, survival and tissue regeneration in vivo.
Expression of rheumatoid factor, citrullinated proteins, and anti-citrullinated protein antibodies in normal and inflamed gingival tissues.
Influence of Rheumatoid arthritis (RA) on the expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) in gingival crevicular fluid of patients with and without chronic periodontitis.

Australian Stem Cell Centre

Characterization and utilization of iPS cells for dental regeneration.

Recent Publications

Bartold PM, Cantley MD, Haynes DR. Mechanisms and control of pathologic bone loss in periodontitis. Periodontology 2000 2010;53:55-69.

Bartold PM, Kuliwaba JS, Lee V, Shah S, Marino V, Fazzalari NL. Influence of surface roughness and shape on microdamage of the osseous surface adjacent to titanium dental implants. Clinical Oral Implants Research 2010 Nov 11 [Epub ahead of print]

Bartold PM, Marino V, Cantley M, Haynes DR. Effect of P. gingivalis-induced inflammation on development of rheumatoid arthritis. Journal of Clinical Periodontology 2010;37:405-411.

Bartold PM, Meng H. An Asian perspective of periodontology. Periodontology 2000 2011;56:11-13.

Bates CE, Marino V, Fazzalari NL, Bartold PM. Soft tissue attachment to titanium implants coated with growth factors. Clinical Implant and Related Dentistry 2011;22:613-618.

Cantley MD, Bartold PM, Marino V, Fairlie DP, Le GT, Lucke AJ, Haynes. DR. Histone deacetylase inhibitors suppress bone loss in experimental periodontitis. Journal of Periodontal Research (In Press)

Cantley MD, Haynes DR, Marino V, Bartold PM. Pre-existing periodontitis exacerbates rheumatoid arthritis in a mouse model. Journal of Clinical Periodontology 2011;38:532-541.

Fitzsimmons TR, Sanders AE, Bartold PM, Slade GD. Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis. Journal of Clinical Periodontology 2010;7:30-36.

Goss AN, Bartold PM, Sambrook P, Hawker P. The nature and frequency of bisphosphonate associate osteonecrosis of the jaws in dental implants patients in South Australia. Journal of Oral & Maxillofacial Surgery 2010;68:237-243.

Gronthos S, Arthur A, Bartold PM, Shi S. A method to isolate and culture expand human dental pulp stem cells. Methods Mol Biol 2011;698:107-121.

Kataria NG, Bartold PM, Dharmapatni AASK, Atkins GJ, Holding CA, Haynes DR. Expression of tumor necrosis factor like weak inducer of apoptosis (TWEAK) and its receptor FN14 in healthy and periodontitis tissues. Journal of Periodontal Research 2010;45:564-573.

Lucas H, Bartold PM, Dharmapatni AASSK, Holding CA, Haynes DR. Inhibition of apoptosis in periodontal disease. Journal of Dental Research 2010;89:29-33.

Megson E, Fitzsimmons T, Dharmapatni K, Bartold PM. C-reactive protein in gingival crevicular fluid is indicative of systemic inflammation. Journal of Clinical Periodontology 2010;37:797-804.

Megson E, Kapellas K, Bartold PM. Relationship between periodontal disease and osteoporosis. International Journal of Evidence-Based Healthcare 2010;8:129-139.

Menicanin D, Bartold PM, Zannettino ACW, Gronthos S. Identification of a common gene expression signature associated with immature clonal mesenchymal cell populations derived from bone marrow and dental tissues. Stem Cells & Development 2010;19:1501-1510.

Mrozik K, Gronthos S, Shi S, Bartold PM. A method to isolate, purify and characterize human periodontal ligament stem cells. Methods in Molecular Biology 2010;666:269-84.

Mrozik K, Zilm PS, Bagley CJ, Hack S, Hoffman P, Gronthos S, Bartold PM. Proteomic characterization of mesenchymal stem cell-like populations derived from periodontal ligament, dental pulp and bone marrow: analysis of differentially expressed proteins. Stem Cells & Development 2010;19:1485-1499.

Mrozik KM, Gronthos S, Menicanin D, Marino V, Bartold PM. Effect of coating Straumann Bone Ceramic with Emdogain on mesenchymal stromal cell hard tissue formation. Clinical Oral Investigations (In Press)

Wada N, Bartold PM, Gronthos S. Human foreskin fibroblasts exert immunomodulatory properties by a different mechanism to bone marrow mesenchymal stem cells. Stem Cells & Development 2010 [Epub ahead of print]

Wada N, Wang B, Lin N-H, Laslett AL, Gronthos S, Bartold PM. Induced pluripotent stem cell lines derived from human gingival and periodontal ligament fibroblasts. Journal of Periodontal Research 2011 Mar 29. [Epub ahead of print]

Zilm PS, Bartold PM. Proteomic identification of proteinase inhibitors in the porcine Enamel Matrix Derivative, EMD®. Journal of Periodontal Research 2011;46:111-117.

Zilm PS, Mira A, Bagley CJ, Rogers AH. The effect of alkaline growth pH on the expression of cell envelope proteins in Fusobacterium nucleatum. Microbiology 2010;156:1783-94.