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Professor Bill Hague

Position Professor
Email bill.hague@adelaide.edu.au
Fax +61 8 8161 7652
Mobile +61 4 1111 4575
Building WCH - Norwich Centre
Campus Womens & Childrens Hospital
Org Unit Paediatrics and Reproductive Health

To link to this page, please use the following URL:
http://www.adelaide.edu.au/directory/bill.hague

Biography/ Background

 

Made in China, produced in Hong Kong and brought up in the UK, Bill Hague has been working since 1990 in Obstetric Medicine at the Women’s and Children’s Hospital (W&CH) in Adelaide, South Australia.  After undergraduate training at Trinity College, Cambridge and St Thomas' Hospital, London, he did postgraduate training in Cambridge, Sheffield and London, in particular with Professor Michael de Swiet at Queen Charlotte's Hospital, London, and with Professor Howard Jacobs at the Middlesex Hospital, London, with specialist qualifications in both Internal Medicine and Obstetrics and Gynaecology, and a Cambridge MD in Familial Aspects of Polycystic Ovaries.  The service he has helped to build up at the W&CH is recognised around Australia and overseas for its quality and commitment.  His clinical service work, teaching and research achievements were recognised by The University of Adelaide with a promotion to full Professor in November 2011.  His contributions include the first robust demonstration of the efficacy and safety of metformin in women with gestational diabetes (the MiG Study) in collaboration with Dr Janet Rowan from Auckland, published in the NEJM in 2008.  He founded the Obstetric Medicine Group of Australasia (OMGA), and in 2009 became the first Honorary Member of the Society of Obstetric Medicine of Australia and New Zealand (SOMANZ), following the amalgamation of OMGA and the Australasian Society for the Study of Hypertension in Pregnancy (ASSHP), of which he is a former President.  He is also involved in the Australasian Maternity Outcomes Surveillance System (AMOSS).

He is currently Senior Consultant Physician in Obstetric Medicine, Women & Children's Hospital,  Adelaide, having previously been a member of the Visiting Staff at Women & Children's Hospital, The Queen Elizabeth Hospital and Flinders Medical Centre.

 

Other Appointments
  • Chair of the South Australian Maternal Mortality Committee
  • Previous Member of the Australian National Advisory Committee on Maternal Mortality and Serious Morbidity
  • South Australian Coordinator, Australasian Maternity Outcomes Surveillance System (AMOSS)
  • Regional Secretary Oceania Region, International Christian Medical and Dental Association
  • Oceania Desk-holder, Partners in International Medical Education
  • Past National Chairman of the Christian Medical and Dental Fellowship of Australia
  • Past Member of Advisory Council for South Australian Stillbirth and Neonatal Death Support Group

Qualifications

  • 2001 FRCP (London) 
  • 1993 FRCOG
  • 1988 MD (Cantab)
  • 1987 Certificate of Accreditation (JCHMT), Endocrinology and Obstetric Medicine
  • 1983 MRCOG
  • 1978 MRCP(UK)
  • 1975 MA (Cantab)
  • 1975 MB, BChir (Cantab)
  • 1972 BA (Cantab)

 

Research Interests

  • The comparison of pregnancy and health economic outcomes in women diagnosed as gestational diabetes (GDM) using ADIPS-1998 criteria compared with those diagnosed using IADPSG criteria
  • The comparison of pregnancy and health economic outcomes in women diagnosed as GDM randomised to "tight" and "very tight" glucose control
  • The prevalence of MODY genotypes in South Australian women with GDM
  • Follow-up of offspring of women with GDM treated with metformin or insulin
  • Metformin as an alternative to insulin in the management of women with GDM
  • Metformin in the prevention of recurrent GDM
  • Metformin effects on insulin resistance in women with GDM
  • Metformin effects on vitamin B12 metabolism in women with GDM
  • Pharmacokinetics of metformin in women with GDM
  • Metformin for women who are obese during pregnancy for improving maternal and infant outcomes
  • Postpartum SMS reminders to women who have had GDM to test for type 2 diabetes: a randomised controlled trial: The DIAMIND study
  • The place of low molecular weight heparin in the prevention of recurrent utero-placental thrombosis and associated diseases in women with thrombophilia
  • The role of genetic and acquired thrombophilia, including polymorphisms of methylenetetrahydrofolate reductase, activated protein C resistance, prothrombin gene mutation, protein S deficiency, hyperhomocysteinaemia and antiphospholipid antibodies in the aetiology of pre-eclampsia, placental abruption, intra-uterine growth restriction and recurrent miscarriage
  • The role of genetic thrombophilia, including polymorphisms of methylenetetrahydrofolate reductase, activated protein C resistance and the prothrombin gene mutation in the aetiology of cerebral palsy
  • The relationship of pre-eclampsia to the subsequent development of vascular disease and its link to hyperhomocysteinaemia
  • The effect of folate supplementation on the prevention of pre-eclampsia: the Folic Acid Clinical Trial (FACT)
  • Investigations in the Folic Acid Clinical Trial - the INFACT study
  • The effect of folate supplementation on the prevention of recurrent pre-eclampsia in women with hyperhomocysteinaemia
  • Longitudinal study of genome stability in the mother, fetus, neonate and child in relation to folate and B12 status
  • The role of common polymorphisms in the methylenetetrahydrofolate reductase, methionine synthase and thymidylate synthase genes as determinants of genome stability in mothers, fetuses, neonates and children
  • Treatment of obstetric cholestasis: the PITCH study
  • Genetic Mechanisms of bile transporters
  • The aetiology of microvesicular hepatic steatosis and its relationship to clinical outcomes in women and sheep
  • The control of hypertension in pregnancy: the CHIPS study
  • Follow-up of the offspring of the CHIPS study: the CHIPS-CHILD study
  • The Australasian Maternity Outcomes Surveillance System (AMOSS)

 

Publications

Publications since 2010

  • Interventions for treating cholestasis in pregnancy. Gurung V, Middleton P, Milan S J, Hague W M, Thornton J G. Cochrane Database of Systematic Reviews, 2013.  doi: 10.1002/14651858.CD000493.pub2.
  • Metformin for women who are obese during pregnancy for improving maternal and infant outcomes. Eames A J, Grivell R M, Deussen A R, Hague W M, Dodd J M. Cochrane Database of Systematic Reviews, 2013.  doi: 10.1002/14651858.CD010564.
  • The DIAMIND Study: Postpartum SMS reminders to women who have had gestational diabetes mellitus to test for type 2 diabetes: a randomised controlled trial - study protocol. Heatley E M, Middleton P, Hague W M, Crowther C A. BMC pregnancy and childbirth 2013 13: 92
  • Vitamin B12 and homocysteine status during pregnancy in the Metformin in Gestational diabetes (MiG) trial: responses to maternal metformin compared with insulin treatment. Gatford K L, Houda C M, Lu Z, Coat S, Baghurst P, Owens J, Sikaris K, Rowan J A, Hague W M. Diabetes, obesity & metabolism 2013 doi: 10.1111/dom.12080
  • Determinants of maternal triglycerides in women with gestational diabetes mellitus in the Metformin in Gestational diabetes (MiG) study. Barrett H L, Nitert M D, Jones L, O'Rourke P, Lust K, Gatford K L, De Blasio M J, Coat S, Owens J A, Hague W M, McIntyre H D, Callaway L, Rowan J. Diabetes Care 2013 doi 10.2337/dc12-2132
  • Maternal and Neonatal Circulating Markers of Metabolic and Cardiovascular Risk in the Metformin in Gestational Diabetes (MiG) Trial: Responses to maternal metformin versus insulin treatment. Barrett H L, Gatford K L, Houda C M, De Blasio M J, McIntyre H D, Callaway L, Nitert M D, Coat S, Owens J A, Hague W M, Rowan J. Diabetes Care 36 (3), (2013): 529-536
  • A case of postpartum Group B streptococcal meningitis. Gayford K, McCarthy A, Hague W M. Obstetric Medicine 5(1), (2012): 25-26.
  • Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT. de Vries J I, van Pampus M G, Hague W M, Bezemer P D, Joosten J H, FRUIT Investigators. Journal of Thrombosis and Haemostasis 10(1), (2012): 64-72.
  • Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT: a reply to a rebuttal. de Vries J I, Hague W M, van Pampus M G, For the FRUIT investigators. Journal of Thrombosis and Haemostasis 10(6), (2012): 1196.
  • The IDEAL study: investigation of dietary advice and lifestyle for women with borderline gestational diabetes: a randomised controlled trial - study protocol. Crowther C A, Hague W M, Middleton P F, Baghurst P A, McPhee A J, Tran T S, Yelland L N, Ashwood P, Han S, Dodd J M, Robinson J S, IDEAL Study Group. BMC pregnancy and childbirth 12 (2012): 106
  • Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. Rowan J A, Rush E C, Obolonkin V, Battin M, Wouldes T, Hague W M. Diabetes Care 34(10), (2011): 2279-84.
  • A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart. Miragoli M, Kadir S H, Sheppard M N, Salvarani N, Virta M, Wells S, Lab M J, Nikolaev V O, Moshkov A, Hague W M, Rohr S, Williamson C, Gorelik J. Hepatology 54(4), (2011): 1282-92.
  • Folate, Vitamin B12, Vitamin B6 and homocysteine: impact on pregnancy outcome. Furness D, Fenech M, Dekker G, Khong T Y, Roberts C, Hague W. Maternal and Child Nutrition. 2011. Epub 2011/10/26. doi 10.1111/j.1740-8709.2011.00364.x
  • Fractionated heparin in pregnant women with a history of Utero-placental Insufficiency and Thrombophilia, a randomised trial (the FRUIT study). de Vries J I, van Pampus M G, Hague W M, Bezemer P D, Joosten J H, FRUIT trial collaborators. Reproductive Sciences 18(3 suppl), (2011): 352A
  • Anti-diabetic agents for women with pre-existing diabetes mellitus/impaired glucose tolerance or previous gestational diabetes mellitus. Tieu J, Coat S, Hague W, Middleton P. Cochrane Database of Systematic Reviews 2010, Issue 10. Art. No.: CD007724. DOI: 10.1002/14651858.CD007724.pub2
  • Increased lymphocyte micronucleus frequency in early pregnancy is associated prospectively with pre-eclampsia and/or intrauterine growth restriction. Furness D L, Dekker G A, Hague W M, Khong T Y, Fenech M F. Mutagenesis 25(5), (2010): 489-98.
  • Glycemia and its relationship to outcomes in the MiG trial. Rowan J A, Gao W, Hague W M, McIntyre H D. Diabetes Care 33, (2010): 9-16
  • Long-term follow-up of women with gestational diabetes mellitus: the South Australian Gestational Diabetes Mellitus Recall Register. Chittleborough C, Baldock K, Taylor A, Hague W, Willson T, Martin W, Wood J, Phillips P. Aust N Z J Obstet Gynaecol, (2010): 10.1111/j.1479-828X.2010.01140.x

 

Professional Associations

  • Past President of the Australasian Society for the Study of Hypertension in Pregnancy
  • Founder Member and Convenor of the Obstetric Medicine Group of Australasia
  • First Honorary Member of the Society of Obstetric Medicine of Australia and New Zealand
  • Council Member and Meetings Organiser of the International Society of Obstetric Medicine
  • Member of the International Society for the Study of Hypertension in Pregnancy 
  • Member of the Australasian Diabetes in Pregnancy Society
  • Fellow of the Royal Society of Medicine: Member of the Endocrinology and Obstetrics/Gynaecology sections.
  • Member of the Endocrine Society of Australia
  • Member of the Australian Menopause Society
  • Member of the Adelaide Clinical Endocrine Society
  • Member of the Adelaide Liver Research Group
  • Fellow of the Institute for the Study of Christianity in an Age of Science and Technology

 

Entry last updated: Wednesday, 8 Feb 2017

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