Associate Professor Christine Feinle-Bisset
Biography/ Background
Degrees
1985 - 1991 Degree in Nutritional Sciences (equivalent to BSc (Hon))
University of Hohenheim, Stuttgart, Germany
1991 - 1992 MMedSci (Human Nutrition), Centre for Human Nutrition, University of Sheffield, UK
1992 - 1995 PhD, Institute of Zoophysiology, University of Hohenheim, Germany, and
Centre for Human Nutrition, The University of Sheffield, UK
Previous appointments
1989 - 1991 Research Assistant, Institute of Zoophysiology, Division of Gastrointestinal
Physiology, University of Hohenheim, Germany
1995 - 1999 Postdoctoral Research Fellow, Department of Internal Medicine,
Division of Gastroenterology, University Hospital Zürich, Switzerland
2000 FTT Fricker Research Fellow, Department of Medicine, University of Adelaide
2001 - 2003 Florey Research Fellow, Department of Medicine, Royal Adelaide Hospital
2001 - 2003 Affiliate Senior Lecturer (Level C), Department of Medicine, Royal Adelaide Hospital
2004 - 2007 Senior Lecturer (Level C), University of Adelaide
Current appointments
2004 - NHMRC Research Fellow (Clinical Career Development Award)
2001 - Clinical Research Scientist, Endocrine & Metabolic Unit, Royal Adelaide Hospital
2008 - Associate Professor, University of Adelaide, Discipline of Medicine
Awards & Achievements
A/Prof Christine Feinle-Bisset has recently received a prestigious international research award. At an award ceremony, taking place at the Annual Meeting of the American Gastroenterological Association in Chicago, USA, in early June 2009, A/Prof Feinle-Bisset received a Masters Award in Gastroenterology to honour her outstanding contributions to clinical digestive sciences. The award, which is one of the most prestigious awards in the field of gastroenterology, recognises her work on the gastrointestinal regulation of appetite in humans. A/Prof Feinle-Bisset is recognised internationally for her innovative research characterising interactions of dietary nutrients with gastrointestinal motor and hormonal functions to regulate appetite and energy intake in healthy humans, changes that occur in obesity, as well as mechanisms underlying the generation of digestive symptoms in functional dyspepsia.
2004 NHMRC Career Development Award
2002 Hanson Institute New Investigator Award, Royal Adelaide Hospital
2001 Florey Research Fellowship, Royal Adelaide Hospital
2000 FTT Fricker Research Fellowship, University of Adelaide
1998 Young Investigator Award, International Society of Gastrointestinal Motility
1998 Young Investigator Award, European Society of Gastrointestinal Motility
Research Funding
Current research funding
2009 - 2011 NHMRC Project Grant No 565311 ($714,000)
“Effects of the fatty acid, lauric acid, on energy intake and gut motor and hormonal
function in health and obesity“
(Feinle-Bisset C, Horowitz M, Clifton PM, Rades T, Jones KL, Rayner CK)
2009 - 2011 NHMRC Project Grant No 565312 ($714,000)
“Gastrointestinal function and appetite in obesity – acute and longer-term effects of
changes in energy intake“
(Feinle-Bisset C, Clifton PM, Horowitz M, Jones KL, Wittert GA)
2009 - 2011 Swiss National Science Foundation Project Grant (CHF523,000)
“The effects of dietary intervention on gastrointestinal motility,
hormonal feedback,
visceral perception and satiety in patients with
anorexia nervosa and obesity“
(Fried M, Fox M, Boesiger P, Goetze O, Milos G, Berneis K, Schwizer W, Feinle-
Bisset C, Wooster T)
2007 - 2011 NHMRC Centre of Clinical Research Excellence Grant No 453557 ($2,000,000)
“Centre of Clinical Research Excellence in nutritional physiology, interventions and
outcomes“
(Horowitz M, Clifton PM, Wittert GA, Chapman I, Fraser RJ, Rayner CK, Feinle-
Bisset C, Jones KL)
2007 - 2009 NHMRC Project Grant No 453650 ($450,800)
“Pathophysiology of postprandial hypotension in the elderly - role of "gastric" and
"small intestinal" mechanisms“
(Jones KL, Horowitz M, Chapman I, Feinle-Bisset C, Rayner CK)
2007 - 2009 NHMRC Project Grant No 453647 ($522,000)
“Upper gastroduodenal motility and glycaemic control in diabetes mellitus“
(Horowitz M, Jones KL, Rayner CK, Feinle-Bisset C, Smout A, Samsom M)
Publications
Publications since 2005
1. Kunz P, Feinle-Bisset C, Faas H, Boesiger P, Fried M, Steingoetter A, Schwizer W. Effect of ingestion order of the fat component of a solid meal on intragastric fat distribution as assessed by MRI. J Magn Reson Imaging 2005; 21: 383-390.
2. Chapman IM, Parker B, Doran S, Feinle-Bisset C, Wishart JM, Strobel W, Lush C, Weyer C, Horowitz M. Effect of pramlintide on satiety and food intake in obese subjects and subjects with type 2 diabetes. Diabetologia 2005; 48: 838-848.
3. Brennan IM, Feltrin KL, Horowitz M, Wishart J, Smout AJPM, Meyer JH, Feinle-Bisset C. Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake and antropyloroduodenal motility in healthy men. Am J Physiol Regul Integr Comp Physiol 2005; 288: R1477-R1485.
4. O’Donovan D, Feinle-Bisset C, Chong C, Cameron A, Tonkin A, Wishart J, Horowitz M, Jones KL. Intraduodenal guar attenuates the fall in blood pressure induced by glucose in healthy older subjects. J Gerontol A: Biol Sci Med Sci 2005; 60: 940-946.
5. Chaikomin R, Doran S, Jones KL, Feinle-Bisset C, O’Donovan DG, Rayner C, Horowitz M. Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP and GLP-1, but does not improve overall glycemia in healthy subjects. Am J Physiol Endocrinol Metab 2005; 289: E504-E507.
6. Little TJ, Feltrin KL, Horowitz M, Smout AJPM, Rades T, Meyer JH, Wishart JM, Feinle-Bisset C. Dose-related effects of lauric acid on antropyloroduodenal motility, appetite, energy intake and gastrointestinal hormone release in healthy men. Am J Physiol Regul Integr Comp Physiol 2005; 289: R1090-R1098.
7. Little TJ, Horowitz M, Feinle-Bisset C. Role of CCK in appetite control and body weight regulation. Obesity Reviews 2005; 6: 297 - 306. (invited review)
8. Feinle-Bisset C, Patterson M, Ghatei MA, Bloom SR, Horowitz M. Fat digestion is required for the lipid-induced modulation of ghrelin, PYY and PP secretion. Am J Physiol Endocrinol Metab 2005; 289: E948-E953.
9. Pilichiewicz AN, Little TJ, Brennan IM, Meyer JH, Wishart JM, Otto B, Horowitz M, Feinle-Bisset C. Effects of load, and duration, of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. Am J Physiol Regul Integr Comp Physiol 2006; 290: R668-R677.
10. Little TJ, Pilichiewicz AN, Russo A, Phillips L, Jones KL, Nauck MA, Wishart J, Horowitz M, Feinle-Bisset C. Effects of intravenous GLP-1 on gastric emptying and intragastric distribution in healthy subjects: Relationships with postprandial glycemic and insulinemic responses. J Clin Endocrinol Metab 2006; 91: 1916-1923.
11. Gentilcore D, Chaikomin R, Jones KL, Russo A, Feinle-Bisset C, Wishart JM, Rayner CK, Horowitz M. Effects of fat on gastric emptying of, and the glycemic, insulin and incretin responses to, a carbohydrate meal in type 2 diabetes. J Clin Endocrinol Metab 2006; 91: 2062-2067.
12. Feinle-Bisset C, Horowitz M. Dietary factors in functional dyspepsia. Neurogastroenterol Motil 2006; 18: 608 - 618. (invited review)
13. Feltrin KL, Patterson M, Ghatei MA, Bloom SR, Meyer JH, Horowitz M, Feinle-Bisset C. Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men. Peptides 2006; 27: 1638-1643.
14. Nguyen, NQ, Fraser RJ, Chapman M, Bryant L, Holloway RH, Vozzo R, Feinle-Bisset C. Proximal gastric response to small intestinal nutrients is abnormal in mechanically ventilated critically ill patients. World J Gastroenterol 2006; 12: 4383-4388.
15. Little TJ, Doran S, Meyer JH, Smout AJPM, Jones KL, Wishart JM, Rayner C, Horowitz M, Feinle-Bisset C. The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed. Am J Physiol Endocrinol Metab 2006; 91: E647-E655.
16. Chaikomin R, Russo A, Rayner C, Feinle-Bisset C, O’Donovan DG, Horowitz M, Jones KL. Effects of lipase inhibition on gastric emptying and alcohol absorption in healthy subjects. Br J Nutr 2006; 96: 883-887.
17. Nguyen NQ, Fraser RJ, Chapman M, Bryant L, Holloway RH, Vozzo R, Wishart J, Feinle-Bisset C, Horowitz M. Feed intolerance of critical illness is associated with increased basal and nutrient-stimulated plasma cholecystokinin concentrations. Crit Care Med 2007; 35: 82 - 88.
18. Brennan IM, Otto B, Feltrin KL, Meyer JH, Horowitz M, Feinle-Bisset C. Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY in healthy young men. Peptides 2007; 28: 607 - 611.
19. Little TJ, Horowitz M, Feinle-Bisset C. Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity. Am J Clin Nutr 2007; 86: 531 - 541. (invited review)
20. Chapman IM, Parker B, Doran S, Feinle-Bisset C, Wishart J, Lush CW, LaCerte C, Weyer C, Horowitz M. Low-dose pramlintide reduced food intake and meal duration in healthy, normal-weight subjects. Obesity 2007; 15: 1179 - 1186.
21. Pilichiewicz AN, Horowitz M, Russo A, Maddox A, Jones KL, Schemann M, Holtmann G, Feinle-Bisset C. Effects of Iberogast® on proximal gastric volume, antropyloroduodenal motility and gastric emptying in humans. Am J Gastroenterol 2007; 102: 1276 - 1283.
22. Feltrin KL, Little TJ, Meyer JH, Horowitz M, Rades T, Wishart J, Feinle-Bisset C. Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY and energy intake are load, but not concentration, dependent in humans. J Physiol 2007; 581: 767 - 777.
23. Little TJ, Russo A, Meyer JH, Horowitz M, Smyth D, Bellon M, Wishart JM, Jones KL, Feinle-Bisset C. Free fatty acids have more potent effects on gastric emptying, gut hormones and appetite than triacylglycerides. Gastroenterology 2007; 133: 1124 - 1131.
24. Pilichiewicz AN, Chaikomin R, Brennan IM, Jones KL, Rayner CK, Horowitz M, Smout AJPM, Feinle-Bisset C. Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men. Am J Physiol Endocrinol Metab 2007; 293: E743 - E753.
25. Gentilcore D, Little TJ, Feinle-Bisset C, Samsom M, Smout AJPM, Horowitz M, Jones KL. Role of 5-hydroxytryptamine mechanisms in mediating the effects of small intestinal glucose on blood pressure and antropyloroduodenal motility in older subjects. Am J Physiol Gastrointest Liver Physiol 2007; 293: G692 - G698.
26. Pilichiewicz AN, Papadopoulos P, Brennan IM, Little TJ, Meyer JH, Wishart JM, Horowitz M, Feinle-Bisset C. Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. Am J Physiol Regul Integr Comp Physiol 2007; 293: R2170 - R2178.
27. Little TJ, Feltrin KL, Horowitz M, Wishart JM, Meyer JH, Chapman IM, Feinle-Bisset C. A high-fat diet raises fasting plasma CCK, but does not affect upper gut motility, PYY and ghrelin, or energy intake during CCK-8 infusion in lean men. Am J Physiol Regul Integr Comp Physiol 2008; 294: R45 - R51.
28. Kuo P, Chaikomin R, Pilichiewicz A, O’Donovan D, Wishart JM, Meyer JH, Jones KL, Feinle-Bisset C, Horowitz M, Rayner CK. Transient, early release of glucagon-like peptide-1 during low rates of intraduodenal glucose delivery. Regul Pept 2008; 146: 1 - 3.
29. Van Orshoven NP, Van Schelven LJ, Akkermans LMA, Jansen PAF, Horowitz M, Feinle-Bisset C, Van Huffelen AC, Oey PL. The effect of intraduodenal glucose on muscle sympathetic nerve activity in healthy young and older subjects. Clin Auton Res 2008; 18: 28 - 35.
30. Feltrin KL, Little TJ, Meyer JH, Horowitz M, Rades T, Wishart J, Feinle-Bisset C. Comparative effects of intraduodenal administration of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite and energy intake in healthy males. Am J Clin Nutr 2008; 87: 1181 - 1187.
31. Cukier K, Pilichiewicz AN, Chaikomin R, Brennan IM, Wishart JM, Rayner CK, Jones KL, Horowitz M, Feinle-Bisset C. Effect of small intestinal glucose load on plasma ghrelin in healthy men. Am J Physiol Regulatory Integr Comp Physiol 2008; 295: R459 - R462.
32. Chaikomin R, Wu KL, Doran S, Meyer JH, Jones KL, Feinle-Bisset C, Horowitz M, Rayner CK. Effects of mid-jejunal compared to duodenal glucose infusion on peptide hormone release and appetite in healthy men. Regul Pept 2008; 150: 38 - 42.
33. Pilichiewicz AN, Feltrin KL, Horowitz M, Holtmann G, Wishart JM, Jones KL, Talley NJ, Feinle-Bisset C. Functional dyspepsia is associated with a greater symptomatic response to fat but not carbohydrate, increased fasting and postprandial CCK, and diminished PYY. Am J Gastroenterol 2008; 103: 2613 - 2623.
34. Brennan IM, Little TJ, Feltrin KL, Smout AJPM, Wishart JM, Horowitz M, Feinle-Bisset C. Dose-dependent effects of cholecystokinin-8 on antropyloroduodenal motility, gastrointestinal hormones, appetite and energy intake in healthy men. Am J Physiol Endocrinol Metab 2008; 295: E1487 - E1494.
35. Pilichiewicz AN, Horowitz M, Holtmann GJ, Talley NJ, Feinle-Bisset C. Relationship between symptoms and dietary patterns in patients with functional dyspepsia. Clin Gastroenterol Hepatol 2009; 7: 317 - 322.
36. Chaikomin R, Jones KL, Feinle-Bisset C, Meyer JH, Horowitz M, Rayner CK. Effects of intraluminal local anaesthetic on upper gastrointestinal motor, sensory and peptide hormone responses to intraduodenal glucose. Eur J Gastroenterol Hepatol 2009; 21: 258 - 265.
37. Seimon RV, Feltrin KL, Meyer JH, Brennan IM, Wishart JM, Horowitz M, Feinle-Bisset C. Effects of varying combinations of intraduodenal lipid and carbohydrate on antropyloroduodenal motility, hormone release and appetite in healthy males. Am J Physiol Regul Integr Comp Physiol 2009; 296; R912 - R920.
38. Nair NS, Brennan IM, Little TJ, Gentilcore D, Hausken T, Jones KL, Wishart JM, Horowitz M, Feinle-Bisset C. Reproducibility of energy intake, gastric emptying, blood glucose, plasma insulin and cholecystokinin responses in healthy young males. Br J Nutr 2009; 101: 1094 - 1102.
39. Wright TH, Yazbeck R, Lymn KA, Whitford EJ, Cheah KY, Butler RN, Feinle-Bisset C, Pilichiewicz AN, Mashtoub S, Howarth GS. The herbal extract, Iberogast®, improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis. Cancer Biol Ther 2009; 8: 923 - 929.
40. Seimon RV, Wooster T, Otto B, Golding M, Day L, Little TJ, Horowitz M, Clifton PM, Feinle-Bisset C. The droplet size of intraduodenal fat emulsions influences antropyloroduodenal motility, hormone release and appetite in healthy males. Am J Clin Nutr 2009; 89: 1729 - 1736.
41. Brennan IM, Feltrin KL, Nair NS, Hausken T, Little TJ, Gentilcore D, Wishart JM, Jones KL, Horowitz M, Feinle-Bisset C. Effects of the phases of the menstrual cycle on gastric emptying of glucose, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. Am J Physiol Gastrointestinal (accepted for publication June 18, 2009).
Entry last updated: Wednesday, 1 Jul 2009
