Professor David Kennaway
|Org Unit||Paediatrics and Reproductive Health|
|Telephone||+61 8 8313 4090|
Adelaide Health and Medical Sciences Building
Senior Research Fellow
FacilityDirector, The Adelaide Research Assay Facility
- Research Program Leader of Circadian Physiology group
Circadian Physiology Group Members
|Professor David Kennaway||Senior Research Fellow|
|Dr Tamara Varcoe||Research Fellow|
|Mr Mark Salkeld||Research Assistant|
|Mr Hong Liu
1978 PhD, Discipline of Obstetrics and Gynaecology, University of Adelaide (Dr RF Seamark, supervisor).
1973 Hons (First class), Disciplines of Physiology and Obstetrics and Gynaecology, University of Adelaide.
1972 BSc, University of Adelaide.
2006 Most Outstanding Contribution to the Discipline (Discipline of Obstetrics and Gynaecology)
2006 Most Outstanding Research Training and Mentorship Award (Discipline of Obstetrics and Gynaecology)
1980 Australian JC "Five Outstanding Young Australians" Award
- 1977 Organon Award - Endocrine Society of Australia (best presentation at the annual scientific meeting)
Foundation Chair Australasian Chronobiology Society
European Biological Rhythms Society
Society for Research on Biological Rhythms
International Neuroendocrinology Federation
Society for Reproductive Biology
Endocrine Society of Australia
Australasian Society for the Study of Obesity
Australasian Chronobiology Society
Australian Neuroendocrinology Group
Australian Society for Medical Research
More than 1.4 million Australians work outside normal working hours. Shift work and increased light exposure at night has been associated with poor sleep and fatigue, resulting in workplace accidents and incidents. But there is now emerging evidence that shift work is a significant public health issue, with the workers being at significantly higher risk of developing or exacerbating chronic diseases. Since 2009 there have been more than 50 workplace-based studies reporting increased risk of Metabolic Syndrome, in particular vascular events, diabetes/impaired glucose tolerance, elevated BMI/obesity, as well as adverse impacts on fertility/pregnancy and increased risk of breast, ovary and prostate cancers.
We do not yet know why night-time activity and daytime sleep increase the risk of developing or exacerbating chronic diseases; but one strong possibility is that this lifestyle disrupts fundamental cellular circadian rhythms that are essential for normal physiological functions.
In 2012 the American Medical Association adopted a policy statement on night-time lighting and human health. They concluded that among the diseases exacerbated by circadian disruption are: “obesity, diabetes, depression and mood disorders, and reproductive problems. ... Due to the nearly ubiquitous exposure to light at inappropriate times relative to endogenous circadian rhythms, [we need] further multidisciplinary research on occupational and environmental exposure to light-at-night, the risk of cancer and effects on various chronic diseases.”
I have made major contributions to our understanding of circadian physiology and through unique and significant cutting-edge research, have revealed how disrupted circadian and cell rhythms affect major physiological systems. My group, for example, was the first to show that circadian rhythm disruption during pregnancy pre-disposes the offspring to metabolic disorders later in life.
I am now working towards understanding the consequences of shift work on the metabolic health of men and women, the fertility of women and the health of their children. While animal models cannot replicate actual human shift work, a key innovation in the project will be our approach of simulating the circadian rhythm disruption of human shift work, such as altered light/dark cycles, timed food access, and diet quality, all of which also will be tested in humans. The outcome will be a significantly deeper understanding of the physiological effects of shift work; this is likely to increase the health of shift workers and their families by driving changes in such factors as roster design, illumination of workplaces and exercise and dietary advice.
My research program will pursue two themes:
(1) The impact of circadian rhythm disruption on metabolic control;
(2) The impact of circadian rhythm disruption on fertility, pregnancy outcomes and long-term health of offspring.
Publications up to end 2014:
Go to my Researcher Profile above (http://researchers.adelaide.edu.au/profile/david.kennaway) for my most recent publications.
1. KENNAWAY, D. J. Are the proposed benefits of melatonin-rich foods too hard to swallow? Critical Reviews in Food Science and Nutrition (2014) Accepted for publication.
2. Swinbourne, A. M., Kelly, J. M., Kind, K. L., KENNAWAY, D. J. and van Wettere, W. H. E. J. The effects of season and moderate nutritional restriction on ovarian function and oocyte nuclear maturation in cycling gilts. Theriogenology (2014) Accepted for publication.
3. KENNAWAY, D. J., Varcoe, T. J., Voultsios, A., Salkeld, M. D., Rattanatray, L., Boden, M. J. Acute inhibition of casein kinase 1δ/ε rapidly delays peripheral clock gene rhythms. Molecular and Cellular Biochemistry. (2014) Sep 23. [Epub ahead of print] PMID: 25245819
4. Akison, L. K., Boden, M. J., KENNAWAY, D. J., Russell, D. L., Robker, R. L. Progesterone receptor (PGR) dependent regulation of genes in the oviducts of female mice Physiological Genomics (2014): 46(16):583-92 PMID: 24916968: RGMS ID P01869552
5. Varcoe, T. J., Gatford, K. L., Voultsios, A., Salkeld, M. D., Boden, M. J., Rattanatray, L., KENNAWAY, D. J. Rapidly alternating photoperiods disrupt central and peripheral rhythmicity and decrease plasma glucose, but do not affect glucose tolerance or insulin secretion in sheep Experimental Physiology (2014) 99:1214-28: PMID: 24951500: RGMS ID P01869550
6. KENNAWAY, D. J. Light at night, melatonin and breast cancer. Chronobiology International (2014) 31, 297-98: PMID: 24328783: RGMS ID P01619217
7. Lovato, N., Lack, L., Wright, H., KENNAWAY, D. J. Evaluation of a brief treatment program of cognitive behavior therapy for insomnia in older adults. Sleep (2014) 37, 117-26: PMID: 24470701: RGMS ID P01572419
8. Abu Shamsi, N., Salkeld, M. D., Rattanatray, L., Voultsios, A., Varcoe, T. J., Boden, M. J., KENNAWAY, D. J. Metabolic consequences of timed feeding in mice. Physiology & Behavior (2014) 128, 188-201: PMID: 24534172: RGMS ID P01703888
9. van Wettere, W. H. E. J., Kaisler-Smith, C., Terry, R., Weaver, A., Herde, P., KENNAWAY, D. J., Hughes, P.E., Kind, K. Boar contact, but not PG600, is an effective stimulant of ovulation during early lactation. Livestock Science (2013) 155, 454-58: RGMS ID P01619242
10. Varcoe, T. J.; Boden, M. J.; Voultsios, A.; Salkeld, M. D.; Rattanatray, L.; KENNAWAY, D. J. Characterisation of the maternal response to chronic phase shifts during gestation in the rat: implications for fetal metabolic programming. PLoS One (2013) 8, e53800 -: PMID: 23342007: RGMS ID P01326628
11. Kentish, S. J., Frisby, C. L., KENNAWAY, D. J., Wittert, G. A., Page, A. J. Circadian variation in gastric vagal afferent mechanosensitivity. Journal of Neuroscience (2013) 33, 19238-42: PMID: 24305819: RGMS ID P01619211
12. Athorn, R. Z.; Stott, P.; Bouwman, E. G.; Chen, T. Y.; KENNAWAY, D. J.; Langendijk, P. Effect of feeding level on progesterone concentration in the vena cava during early pregnancy in gilts. Reproduction Fertility and Development (2013) 25, 531-8: PMID: 23464500: RGMS ID P01326614
13. KENNAWAY, D. J.; Varcoe, T. J.; Voultsios A.; Boden, M. J. Global loss of Bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism. PLoS One (2013) 8, e65255 -: PMID: 23750248: RGMS ID P01417682
14. Weaver, A. C.; Kelly, J. M.; Kind, K. L.; Gatford, K. L.; KENNAWAY, D. J.; Herde, P. J.; van Wettere, W. H. E. J. Oocyte maturation and embryo survival in nulliparous female pigs (gilts) is improved by feeding a lupin-based high fibre diet. Reproduction Fertility and Development (2013) 25, 1216-23: PMID: 23257568: RGMS ID P01326622
15. Lovato, N., Lack, L., Wright, H., & KENNAWAY, D. J. Predictors of improvement in subjective sleep quality reported by older adults following group-based Cognitive-Behavior Therapy for sleep maintenance and early morning awakening insomnia. Journal of Sleep Medicine (2013) 14, 888-93: PMID: 23871260: RGMS ID P01572417
16. Terry, R., Kind, K. L., Hughes, P. E., KENNAWAY, D.J., Herde, P. J., van Wettere, W. H. Split weaning increases the incidence of lactation oestrus in boar-exposed sows. Animal Reproduction Science (2013) 142, 48-55: PMID: 24051168: RGMS ID P01619229
17. KENNAWAY, D. J.; Owens, J. A.; Voultsios, A.; Wight, N. Adipokines and adipocyte function in Clock mutant mice that retain melatonin rhythmicity. Obesity (2012) 20, 295-305: PMID: 21918578: RGMS ID P01067044
18. Boden, M. J.; Varcoe, T. J.; KENNAWAY, D. J. Circadian regulation of reproduction: from gamete to offspring. Progress in Biophysics and Molecular Biology (2013) 113, 387-97: PMID: 23380455: RGMS ID P01326625
19. Ogeil, R. P.; KENNAWAY, D. J.; Salkeld, M. D.; Rajaratnam, S. M. W.; Broadbear, J. H. MDMA induces Per1, Per2 and c-fos gene expression in rat suprachiasmatic nuclei. Psychopharmacology (2012) 220, 835-843: PMID: 22038537: RGMS ID P01067047
20. Zhou, X.; Ferguson, S. A.; Matthews, R.W.; Sargent, C.; Darwent, D.; KENNAWAY, D. J.; Roach G. D. Mismatch between subjective alertness and objective performance under sleep restriction is greatest during the biological night. Journal of Sleep Research (2012) 21, 40-49: PMID: 21564364: RGMS ID P01033107
21. KENNAWAY, D. J.; Boden, M. J.; Varcoe, T. J. Circadian rhythms and fertility. Molecular and Cellular Endocrinology (2012) 349, 56-61: PMID: 21872642: RGMS ID P01067045
22. Pitcher, J. B.; Riley, A. M.; Doeltgen, S. H.; Kurylowicz, L.; Rothwell, J. C.; McAllister, S. M.; Smith, A. E.; Clow, A.; KENNAWAY, D. J.; Ridding, M. C. Physiological evidence consistent with reduced neuroplasticity in human adolescents born preterm. Journal of Neuroscience (2012) 32, 16410-16416: PMID: 23152623: RGMS ID P01326607
23. Matthews, R. W.; Ferguson, S. A.; Zhou, X.; Kosmadopoulos, A.; KENNAWAY, D. J.; Roach, G. D. Simulated driving under the influence of extended wake, time of day and sleep restriction. Accident Analysis and Prevention (2012) 45S, 55-61: PMID: 22239933: RGMS ID P01067049
24. Ferguson, S. A.; Baker, A.; KENNAWAY, D. J.; Lamond, N.; Dawson, D. Sleep and circadian rhythms in mining operators: limited evidence of adaptation to night shifts. Applied Ergonomics (2012) 43, 695-701: PMID: 22133975: RGMS ID P01067046
25. Sargent, C.; Darwent. D.; Ferguson, S. A.; KENNAWAY, D. J.; Roach, G. D. Sleep restriction masks the influence of the circadian process on sleep propensity. Chronobiology International (2012) 29, 565-71: PMID: 22621352: RGMS ID P01138737
26. Ferguson, S. A.;Paech, G. M.; Sargent, C.; Darwent, D.; KENNAWAY, D. J.; Roach, G. D. The influence of circadian time and sleep dose on subjective fatigue ratings. Accident Analysis and Prevention (2012) 45S, 50-54: PMID: 22239932: RGMS ID P01067048
27. Paech, G. M.; Ferguson, S. A.; Sargent, C.; KENNAWAY, D. J.; Roach, G. D. The relative contributions of the homeostatic and circadian processes to sleep regulation under conditions of severe sleep restriction. Sleep (2012) 35, 941-948: PMID: 22754040: RGMS ID P01326599
28. Matthews, R. W.; Ferguson, S. A.; Zhou, X.; Sargent, C.; Darwent, D.; KENNAWAY, D. J.; Roach, G. D. Time-of-day mediates the influences of extended wake and sleep restriction on simulated driving. Chronobiology International (2012) 29, 572-9: PMID: 22621353: RGMS ID P01225448
29. Varcoe, T. J.; Wight, N.; Voultsios, A.; Salkeld, M. D.; KENNAWAY, D. J. Chronic phase shifts of the photoperiod throughout pregnancy programs glucose intolerance and insulin resistance in the rat. PLoS One (2011) 6, e18504 -: PMID: 21494686: RGMS ID P00925168
30. Zhou X.; Ferguson, S. A.; Matthews, R. W.; Sargent, C.; Darwent, D.; KENNAWAY, D. J.; Roach, G. D. Dynamics of neurobehavioural performance variability under forced desynchrony: evidence of state instability. Sleep (2011) 34, 57-63: PMID: 21203373: RGMS ID P00784302
31. Zhou, X.; Ferguson, S. A.; Matthews, R. W.; Sargent, C.; Darwent, D.; KENNAWAY, D. J.; Roach, G. D. Sleep, wake and phase dependent changes in neurobehavioural function under forced desynchrony. Sleep (2011) 34, 931-41: PMID: 21731143: RGMS ID P00810589
32. KENNAWAY, D. J. Clock genes at the heart of depression. Journal of Psychopharmacology (2010) 24, Suppl 5-14: : RGMS ID P00784307
33. Paech, G. M.; Ferguson, S. A.; Sargent, C.; Darwent, D.; Williams, L.; KENNAWAY, D. J.; Roach, G. D. A 28 hour day, sleep and a single beat period; revisiting forced desynchrony studies? Ergonomia IJE&HF (2010) 32, 125-132: RGMS ID P01067051
34. Darwent, D.; Ferguson, S. A.; Sargent, C.; Paech, G.; Zhou, X.; Matthews, R.; Williams, L.; Dawson, D.; KENNAWAY, D. J.; Roach, G. D. Contribution of core body temperature, prior wake time and sleep stages to cognitive throughput performance during forced desynchrony. Chronobiology International (2010) 27, 898-910: PMID: 20636204: RGMS ID P00101128
35. Zhou, X.; Ferguson, S. A.; Matthews, R. W.; Sargent, C.; Darwent, D.; KENNAWAY, D. J.; Roach G. D. Inter-individual differences in neurobehavioural performance in response to increasing homeostatic sleep pressure Chronobiology International (2010) 27, 922-933: RGMS ID P00101341
36. Roach, G. D.; Sargent, C.; Darwent, D.; KENNAWAY, D. J.; Ferguson, S. A. Lost in transit: The journey of ingestible temperature sensors through the human digestive tract. Ergonomia IJE&HF (2010) 32, 49-61: RGMS ID P01067050
37. KENNAWAY, D. J. Re: "Salivary and gingival crevicular fluid melatonin in periodontal health and disease". Journal of Periodontology (2010) 81, 1102: RGMS ID P00784316
38. Firth, B. T.; Christian, K. A.; Belan, I.; KENNAWAY, D. J. Melatonin rhythms in the Australian freshwater crocodile (Crocodylus johnstoni): a reptile lacking a pineal complex? Journal of Comparative Physiology B (2010) 180, 67-72: RGMS ID P_5113641
39. Boden, M. J.; Varcoe, T. J.; Voultsios, A.; KENNAWAY, D. J. Reproductive biology of female Bmal1 null mice. Reproduction (2010) 139, 1077-1090: RGMS ID P00044696
40. Ferguson, S. A.; Baker, A.; Lamond, N.; KENNAWAY, D. J.; Dawson, D. Sleep in a live-in mining operation: the influence of start times and restricted non-work activities. Applied Ergonomics (2010) 42, 71-75: PMID: 20615493: RGMS ID P00559839
41. Zhou X.; Ferguson, S. A.; Matthews, R. W.; Sargent, C.; Darwent, D.; KENNAWAY, D. J.; Roach, G. D. Sleep, wake and phase dependent changes in subjective alertness. Living in a 24/7 world: The impact of circadian disruption on sleep, work and health. Sargent C, Darwent D, Roach GD (Eds). Proceedings Australasian Chronobiology Society. (2010): 19-23: RGMS ID P00784289
42. Heath, G.; Sargent, C.; Darwent, D.; Ferguson, S. A.; KENNAWAY, D. J.; Hampton, L. K.; Matthews, R. W.; Roach, G. D. Subjective mood is influenced by sleep-related and circadian processes in a forced desynchrony protocol with severe sleep restriction. Living in a 24/7 world: The impact of circadian disruption on sleep, work and health. Sargent C, Darwent D, Roach GD (Eds). Proceedings Australasian Chronobiology Society. (2010): 7-11: RGMS ID P00784278
43. Sargent, C.; Ferguson, S. A.; Darwent, D.; KENNAWAY, D. J.; Roach, G. D. The influence of circadian phase and prior wake on neuromuscular function. Chronobiology International (2010) 27, 911-921 RGMS ID P00784311
44. Hampton, L. K.; Darwent, D.; Matthews, R. W.; Heath, G.; Ferguson, S. A.; Sargent, C.; KENNAWAY, D. J.; Roach, G. D. The influence of circadian phase and prior wake on positive and negative mood during a sleep-restricted forced desynchrony protocol Living in a 24/7 world: The impact of circadian disruption on sleep, work and health. Sargent C, Darwent D, Roach GD (Eds). Proceedings Australasian Chronobiology Society. (2010): 13-14: RGMS ID P00784283
45. Matthews, R. W.; Ferguson, S. A.; Zhou, X.; Darwent, D.; Sargent, C.; KENNAWAY, D. J.; Roach, G. D. The interactive influence of the internal body clock and prior wake on task vigilance. Ergonomia IJE&HF (2010) 32, 37-48: RGMS ID P01067052
46. McFarlane, A. C.; Barton, C. A.; Briggs, N.; KENNAWAY, D. J. The relationship between urinary melatonin metabolite excretion and posttraumatic symptoms following traumatic injury. Journal of Affective Disorders (2010) 127, 365-369: RGMS ID P00101347
47. Fagan, A. B.; KENNAWAY, D. J.; Oakley, A. P. Pinealectomy in the chicken: a good model of scoliosis? European Spine Journal (2009) 18, 1154-1159: RGMS ID P_5113663
- Publications - RGMS_Publications_08-07-2014.pdf [593.6K] (application/pdf)
To link to this page, please use the following URL: http://www.adelaide.edu.au/directory/david.kennaway