Professor Karen Jones

Awards & Achievements

1991 Awarded prize for top Nuclear Medicine student, University of South Australia

1991 Awarded prize for top Nuclear Medicine student in SA, ANZSNM (SA Branch)

1999 Recipient of the Australian Nuclear Science and Technology Organisation (ANSTO) Award

1999 Recipient of the Abbott Laboratories/Roche Products GESA Travel Award

2002        Recipient of a Juvenile Diabetes Foundation of Australia Travel Award

2003        Recipient of a NHMRC/Diabetes Australia Career Development Award

2003        Recipient of the Hanson Institute New Investigator Award for Clinical Research

2010        Recipient of a NHMRC Senior Clinical Career Development Award

2010        Recipient of a NHMRC Achievement Award

 

 

Research Funding

Currently held:

2007 - 2011            M Horowitz, PM Clifton, GA Wittert, IM Chapman, Fraser RJ, CK Rayner, C Feinle-Bisset, KL Jones - NHMRC - 453557 - Project title: CCRE in Nutritional Physiology, Interventions and Outcomes ($2,000,000)

2009 - 2011            C Feinle-Bisset, M Horowitz, PM Clifton, KL Jones, CK Rayner - NHMRC - 565311 - Project title: Effects of the fatty acid, lauric acid, on energy intake, and gut motor and hormonal function in health and obesity ($714,000)

2009 - 2011            C Feinle-Bisset, PM Clifton, M Horowitz, KL Jones, GA Wittert - NHMRC - 565312 - Project title: Modifications in energy intake and gastrointestinal regulation of appetite - implications for weight loss in obesity ($714,000)

2010 - 2012            KL Jones, D Gentilcore, R Visvanathan, I Chapman, C Rayner, M Horowitz - NHMRC - 627189 - Project title: Gastric, small intestinal and cardiovascular mechanisms of postprandial hypotension ($676,500)

2010 - 2012            CK Rayner, M Horowitz, KL Jones, C Feinle-Bisset - NHMRC - 627139 - Project title: Upper gastrointestinal function and glycaemic control in diabetes mellitus ($753,500)

2010 - 2014            KL Jones - NHMRC Senior Career Development Award (Level 2) - NHMRC - 627011 - Project title: Gastric, small intestinal and cardiovascular mechanisms of postprandial hypotension in the elderly ($417,000)

2011  M Horowitz, KL Jones, D Gentilcore, CK Rayner - Rebecca L Cooper Medical Research Foundation - Project title: Measurement of superior mesenteric artery (SMA) blood flow in patients with diabetes with and without postprandial hypotension - ($22,000)

2011 KL Jones, D Gentilcore, R Visvanathan, IM Chapman, CK Rayner, A Deane, M Horowitz – Hanson Institute, Royal Adelaide Hospital Equipment Grant - Project title: Assessment of splanchnic blood flow in humans - ($65,000)

 

Publications

Publications last 5 years (from 2006):

Refereed publications:

1. Stevens JE, Russo A, Delaney CA, Collins PJ, Horowitz M, Jones KL.  Acute effects of C-peptide on gastric emptying in longstanding type 1 diabetes.  Clin Auton Res 2006;16:55-57.
2. Gentilcore D, Doran S, Meyer JH, Horowitz M, Jones KL.  Effects of intraduodenal glucose concentration on blood pressure and heart rate in healthy older subjects.  Dig Dis Sci 2006;51:652-656.
3. Little TJ, Pilichiewicz AN, Russo A, Phillips L, Jones KL, Nauck MA, Wishart J, Horowitz M, Feinle-Bisset C.  Effects of intravenous GLP-1 on gastric emptying and intragastric distribution in healthy subjects - relationships with postprandial glycemic and insulinemic responses.  J Clin Endocrinol Metab 2006;91:1916-1923.
4. Gentilcore D, Chaikomin R, Jones KL, Russo A, Feinle-Bisset C, Wishart JM, Rayner CK, Horowitz M.  Effects of fat on gastric emptying of, and the glycemic, insulin and incretin responses to, a carbohydrate meal in type 2 diabetes.  J Clin Endocrinol Metab 2006;91:2062-2067.
5. Horowitz M, Jones KL, Rayner CK, Read NW. ‘Gastric’ hypoglycaemia- an important concept in diabetes management. Neurogastroenterol Motil 2006;18:405-407.
6. Jones KL, O’Donovan DG, Hausken T, Russo A, Lei Y, Horowitz M.  Effects of posture on gastric emptying, transpyloric flow and hunger after a glucose drink in healthy humans.  Dig Dis Sci 2006;51:1331-1338.
7. Wu KL, Chaikomin R, Doran S, Jones KL, Horowitz M, Rayner CK.  Artificially sweetened, compared to regular mixers, increase gastric emptying and alcohol absorption.  Am J Med 2006;119:802-804.
8. Little TJ, Doran S, Meyer J, Smout A, O'Donovan DG, Wu KL, Jones KL, Wishart J, Rayner CK, Feinle-Bisset C.  The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed.  Am J Physiol - Endo and Metab 2006;29:E647-E655.
9. Chaikomin R, Russo A, Rayner CK, Feinle-Bisset C, O’Donovan DG, Horowitz M, Jones KL.  Effects of lipase inhibition on gastric emptying and alcohol absorption in healthy subjects. Br J Nutrit 2006;96:883-887.
10. Gentilcore D, Hausken T, Horowitz M, Jones KL. Measurements of gastric emptying of low- and high-nutrient liquids using 3D ultrasonography and scintigraphy in healthy subjects. Neurogastroenterol Motil 2006;18:1062-1068.
11. Pilichiewicz AN, Horowitz M, Russo A, Maddox A, Jones KL, Schemann M, Holtmann G, Feinle-Bisset C.  Effects of Iberogast® on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy men.  Am J Gastroenterol 2007;102:1276-1283.
12. Chaikomin R, Wu KL, Doran S, Jones KL, Smout AJPM, Renooij W, Holloway RH, Meyer JH, Horowitz M, Rayner CK.  Concurrent duodenal manometric and impedance recording to evaluate the effects of hyoscine on motility and flow events, glucose absorption, and incretin release.  Am J Physiol - Gastrointest Liver Physiol 2007;292:G1099-G1104.
13. Pilichiewicz AN, Chaikomin R, Brennan IM, Wishart JM, Rayner CK, Jones KL, Smout AJPM, Horowitz M, Feinle-Bisset C.  Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility and energy intake in healthy men.  Am J Physiol - Endo and Metab 2007;293:E743-753.
14. Gentilcore D, Little TJ, Feinle-Bisset C, Samsom M, Smout AJ, Horowitz M, Jones KL. Role of 5-hydroxytryptamine mechanisms in mediating the effects of small intestinal glucose on blood pressure and antropyloroduodenal motility in older subjects. Am J Physiol - Gastrointest Liver Physiol 2007;293:G692-698.
15. Little TJ, Russo A, Meyer JH, Horowitz M, Smyth DR, Bellon M, Wishart JM, Jones KL, Feinle-Bisset C. Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides. Gastroenterology. 2007;133:1124-1131.
16. Karamanlis A, Chaikomin R, Doran S, Bellon M, Bartholomeusz FD, Wishart JM, Jones KL, Horowitz M, Rayner CK. Effects of protein on glycemic and incretin responses and gastric emptying after oral glucose in healthy subjects. Am J Clin Nutr. 2007;86:1364-1368.
17. Gentilcore D, Hausken T, Meyer JH, Chapman IM, Horowitz M, Jones KL.  Effects of intraduodenal glucose, fat and protein on blood pressure, heart rate and splanchnic blood flow in healthy older subjects. Am J Clin Nutrit  2008;87:156-161.
18. Kuo P, Chaikomin R, Pilichiewicz A, O’Donovan D, Wishart JM, Meyer JH, Jones KL, Feinle-Bisset C, Horowitz M, Rayner CK.  Transient, early release of glucagon-like peptide-1 during low rates of intraduodenal glucose delivery.  Regul Pept 2008;146:1-3.
19. Stevens JE, Russo A, Maddox AF, Rayner CK, Phillips L, Talley NJ, Giguere M, Horowitz M, Jones KL. Effect of itopride on gastric emptying in longstanding diabetes mellitus.  Neurogastroenterol Motil. 2008;20:456-463.
20. Nair NS, Brennan IM, Little TJ, Gentilcore D, Hausken T, Jones KL, Wishart JM, Horowitz M, Feinle-Bisset C. Reproducibility of energy intake, gastric emptying, blood glucose, plasma insulin and cholecystokinin responses in healthy young males. Br J Nutr  2008;Aug 5:1-9.
21. Pilichiewicz AN, Feltrin KL, Horowitz M, Holtman G, Wishart JM, Jones KL, Talley NJ, Feinle-Bisset C.  Functional dyspepsia is associated with a greater symptomatic response to fat, but not carbohydrate, increased fasting and postprandial CCK and diminished PYY.  Am J Gastroenterol  2008;103:2613-23. 
22. Cukier K, Pilichiewicz A, Chaikomin R, Brennan I, Wishart J, Rayner C, Jones KL, Horowitz M, Feinle-Bisset C. Effect of small intestinal glucose load on plasma ghrelin in healthy men.  Am J Physiol - Regul Integr Comp Physiol 2008;295:R459-62.
23. Gentilcore D, Meyer JH, Rayner CK, Horowitz M, Jones KL.  Gastric distension attenuates the hypotensive effect of intraduodenal glucose in healthy older subjects.  Am J Physiol - Regul Integr Comp Physiol 2008;295:R472-7.
24. Chaikomin R, Wu KL, Doran S, Meyer JH, Jones KL, Feinle-Bisset C, Horowitz M, Rayner CK.  Effects of mid-jejunal compared to duodenal glucose infusion on peptide hormone release and appetite in healthy men.  Regul Pept  2008;150:38-42.
25. Chaikomin R, Rayner CK, Jones KL, Horowitz M, Meyer J, Feinle-Bisset C. Effects of intraluminal local anaesthetic on upper gastrointestinal motor, sensory and peptide hormone responses to intraduodenal glucose. Eur J Gastroenterol Hepatol 2009;21:258-65.
26. Ma J, Bellon M, Wishart JM, Young RL, Blackshaw LA, Jones KL, Horowitz M, Rayner CK. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. Am J Physiol - Gastrointest Liver Physiol 2009;296:G735-9.
27. Ma J, Stevens J, Cukier K, Maddox A, Wishart J, Jones KL, Clifton P, Horowitz M, Rayner CK. Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes. Diabetes Care 2009:32;1600-2.
28. Brennan I, Smith K, Nair N, Hausken T, Little T, Gentilcore D, Wishart JM, Jones KL, Horowitz M, Feinle-Bisset C. Effects of the phases of the menstrual cycle on gastric emptying of glucose, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. Am J Physiol - Gastrointest Liver Physiol 2009:297;602-10.
29. Gentilcore D, Nair N, Vanis L, Rayner CK, Meyer JH, Hausken T, Horowitz M, Jones KL.  Comparative effects of oral and intraduodenal glucose on blood pressure, heart rate and splanchnic blood flow in healthy older subjects. Am J Physiol - Regul Integrative Comp Physiol 2009;297:R716-22.
30. Kuo P, Gentilcore D, Nair N, Stevens JE, Wishart JM, Lange K, Gilja OH, Hausken T, Horowitz M, Jones KL, Rayner CK.  The nitric oxide synthase inhibitor, N(g)-nitro-l-arginine-methyl-ester, attenuates the delay in gastric emptying induced by hyperglycaemia in healthy humans. Neurogastroenterol Motil 2009;21:1175-e103.
31. Deane AM, Nguyen NQ, Stevens JE, Fraser RJ, Holloway RH, Besanko LK, Burgstad C, Jones KL, Chapman MJ, Rayner CK, Horowitz M. Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects attenuating postprandial glycemia. J Clin Endocrinol Metab 2010:95;215-21.
32. Stevens JE, Doran S, Russo A, O’Donovan D, Feinle-Bisset C, Rayner CK, Horowitz M, Jones KL.  Effects of intravenous fructose on gastric emptying and antropyloroduodenal motility in healthy subjects.  Am J Physiol - Gastrointest Liver Physiol 2009:297;G1274-80.
33. Chapman MJ, Fraser RJ, Matthews G, Russo A, Bellon M, Besanko LK, Jones KL, Butler R, Chatterton B, Horowitz M.  Glucose absorption and gastric emptying in critical illness.  Crit Care 2009;13:R140-47.
34. Ma J, Bellon M, Wishart JM, Young RL, Jones KL, Horowitz M, Rayner CK.  Effects of cefaclor on gastric emptying and cholecystokinin release in healthy humans.  Regul Pept 2010:159;156-9.
35. Deane A, Chapman M, Fraser R, Summers M, Zaknic A, Storey J, Jones KL, Rayner CK, Horowitz M.  Effect of exogenous glucagon-like peptide-1 on gastric emptying and glucose absorption in the critically ill – relationship to glycaemia.  Crit Care Med 2010:38;1261-9.
36. Ma J, Chang J, Checklin HL, Young RL, Jones KL, Horowitz M, Rayner CK.  Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects.  Br J Nutr 2010:27;1-4.
37. Kuo P, Wishart JM, Bellon M, Smout A, Holloway RH, Fraser RJ, Horowitz M, Jones KL, Rayner CK.  Effects of physiological hyperglycemia on duodenal motility and flow events, glucose absorption, and incretin secretion in healthy humans. J Clin Endocrinol Metab 2010;95:3893-900.
38. Vanis L, Tippett R, Gentilcore D, Feinle-Bisset C, Rayner CK, Horowitz M, Jones KL. Effects of gastric distension on blood pressure and superior mesenteric artery blood flow responses to intraduodenal glucose in healthy older subjects. Am J Physiol Regul Integr Comp Physiol 2010;299:R960-7.
39. Tai K, Gentilcore D, Jones KL, Banh L, Gilja OH, Hammond AJ, Feinle-Bisset C, Horowitz M, Chapman IM.  Orlistat accentuates the fat-induced fall in blood pressure in older adults. Br J Nutr (accepted for publication August 2010).
40. Kuo P, Bellon M, Wishart JM, Smout A, Holloway RH, Fraser RJ, Horowitz M, Jones KL, Rayner CK.  Effects of metoclopramide on duodenal motility and flow events, glucose absorption, and incretin hormone release, in response to intraduodenal glucose infusion. Am J Physiol Gastrointest Liver Physiol 2010;299:G1326-33.
41. Stevens JE, Gilja OH, Gentilcore D, Hausken T, Horowitz M, Jones KL.Measurement of gastric emptying of a high-nutrient liquid by 3D-ultrasonography in diabetic gastroparesis. Neurogastroenterol Motil (accepted for publication November 2010)
42. Vanis L, Hausken T, Gentilcore D, Rigda R, Rayner CK, Feinle-Bisset C, Horowitz M, Jones KL. Comparative effects of glucose and xylose, on blood pressure, gastric emptying and incretin hormones in healthy older subjects. Br J Nutr (accepted for publication December 2010).

 Reviews/editorials:

1. Gentilcore D, Jones KL, O’Donovan DG, Horowitz M.  Postprandial hypotension -novel insights into pathophysiology and therapeutic implications.  (review) Curr Vasc Pharmacol 2006;4:161-171.
2. Horowitz M, Jones KL, Rayner CK, Read NW.  ‘Gastric’ hypoglycaemia – an important concept in diabetes management.  (review) Neurogastroenterol Motil 2006;18:405-407.
3. Chaikomin R, Rayner CK, Jones KL, Horowitz M. Upper gastrointestinal function and glycemic control in diabetes mellitus.  (review) World J Gastroenterol 2006;12:5611-5621.
4. Phillips LK, Rayner CK, Jones KL, Horowitz M.  An update on autonomic neuropathy affecting the gastrointestinal tract. (review) Curr Diab Rep 2006;6:417-423.
5. Kuo P, Rayner C, Jones KL, Horowitz M.  Pathophysiology and management of diabetes gastropathy. (review) Drugs 2007;67:1671-1687.
6. Rayner CK, Jones KL, Blackshaw LA, Horowitz M.  The diabetic gut – both aching and unfeeling? (editorial) Pain 2007;131:239-240.
7. Ma J, Rayner CK, Jones KL, Horowitz M. Diabetic Gastroparesis: Diagnosis and Management. (review) Drugs 2009;69:971-86.
8. Khoo J, Rayner CK, Jones KL, Horowitz M. Pathophysiology and management of gastroparesis. (review) Expert Rev Gastroenterol Hepatol 2009;3:167-81.
9. Khoo J, Rayner CK, Jones KL, Horowitz M.  Incretin-based therapies: new treatments for type 2 diabetes in the new millennium. (review) Ther Clin Risk Manag 2009;5:683-98.
10. Ma J, Rayner C, Jones KL, Horowitz M. Insulin secretion in healthy subjects and patients with type 2 diabetes – role of the gastrointestinal tract. (review) Best Pract Res Clin Endocrinol Metab 2009:23;413-24.
11. Parkman HP, Camilleri M, Farrugia G, McCallum RW, Bharucha AE, Mayer EA, Tack JF, Spiller R, Horowitz M, Vinik AI, Galligan JJ, Pasricha PJ, Kuo B, Szarka LA, Marciani L, Jones K, Parrish CR, Sandroni P, Abell T, Ordog T, Hasler W, Koch KL, Sanders K, Norton NJ, Hamilton F.  Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting. (review)  Neurogastroenterol Motil.  2010;22:113-33.
12. Chang J, Rayner CK, Jones KL, Horowitz M.  Diabetic gastroparesis and its impact on glycemia. (review) Endocrinol Metab Clin North America 2010;39:745-62.
13. Wu T, Rayner CK, Jones K, Horowitz M. Dietary effects on incretin hormone secretion. Vitam Horm. 2010;84:81-110.
14. Khoo J, Rayner CK, Feinle-Bisset C, Jones KL, Horowitz M.  Gastrointestinal hormonal dysfunction in gastroparesis and functional dyspepsia. (review)  Neurogastroenterol Motil 2010;22:1270-8.
15. Chang J, Rayner CK, Jones KL, Horowitz M.  Diabetic gastroparesis – Backwards and forwards. (review) J Gastroenterol Hepatol 2011;26:S46-S57.

Entry last updated: Wednesday, 8 Jun 2011