Professor Mark Bartold

Qualifications

I received my Bachelor of Dental Surgery from the University of Adelaide in 1979. In 1980 I received my Bachelor of Science in Dentistry with First Class Honours and in 1983 graduated Doctor of Philosophy. I qualified for Fellowship of the Royal Australasian College of Dental Surgeons in the Special Stream of Periodontics in 1991. In 1996 I qualified for the degree of Doctor of Dental Science on the basis of a collection of published research papers. I am a Fellow of the Academy of Dentistry, the International College of Dentists and the Pierre Fauchard Academy.  In 2004 I became a Member of the Order of Austrlia for my contributions to periodontla research and teaching.    

 

Teaching Interests

I am the current supervisor of the Doctor of Clinical Dentistry (Periodontics) postgraduate training program.  A copy of the programme can be found below.

Research Interests

I am principally interested in the biology of the periodontal connective tissues  in health, disease and regeneration.  Research activities also focus on the relationship between periodontal disease and its effect on systemic health.

Current active areas of research include:

 

1. Tissue engineering of Periodontal Tissues using cell seeding into bioresorbable matrices. This includes specific studies on the role of matrix components in the regeneration of periodontal structures.
2. Charaacterization and utilization of periodontal mesenchymal stem cells and induced pluripotent stem cells of periodontal origin
3. The relationship between periodontitis and rheumatoid arthritis.
4. Development of novel drugs to modulate pathologic bone loss in periodontitis
5. The use of fish oil as an adjunct to periodontal treatment
   

 

Publications

Some Recent Publications:

1.          Bartold PM. Periodontal tissues in health and disease. Periodontology 2000 40: 7-10; 2006

 

2.          PM Bartold, AS Narayanan Molecular and Cell Biology of Healthy and Diseased Periodontal Tissues Periodontology 2000 40: 29-49, 2006

 

3.       PM Bartold, S Shi, S Gronthos Stem Cells and Periodontal Regeneration Periodontology 2000 40: 164-172; 2006

 

4.          Kong LX, Peng Z, Li S-D, Bartold. Nanotechnology and its role in the management of periodontal diseases. Periodontology 2000 40: 184-196; 2006

 

5.          Slavkin HC, Bartold PM. Challenges and potential in tissue engineering. Periodontolgy 2000 41: 9-15; 2006

 

6.          Bartold, PM, Xiao Y, Lyngstaadas SP, Paine ML, Snead ML. Principles and applications of cell delivery systems for periodontal regeneration. Periodontology 2000 41: 123-135, 2006

 

7.          Kinane DF, Bartold PM Clinical relevance of the host responses of periodontitis. Periodontology 2000 43: 278-293; 2007.

 

8.          Rincon JC, Young WG, Bartold PM. The epithelial cell rests of Malassez – a role in periodontal regeneration? Journal of Periodontal Research 41: 245-252; 2006

 

9.          Ivanovski S, Gronthos S, Shi S, Bartold PM. Stem cells in the periodontal ligament. Oral Diseases 12: 358-363; 2006

 

10.       Liu Q, Marino V, Bartold PM. Development of novel cell delivery carrier for periodontal regeneration in vitro (In Chinese). Hua Xi Kou Qiang Yi Xue Za Zhi 35: 15-17; 2006

 

11.       Bartold PM. Dentinal hypersensitivity: a review. Australian Dental Journal 51: 212-218; 2006. Reproduced in New Zealand Dental Association News (February 2007). Translated into Polish and republished in Magazine of Esthetical Dentistry which is the  Polish version of Aesthetische Zahnmedizin

 

12.       Chen, S, Marino V, Gronthos S, Bartold PM. Location of putative stem cells in human periodontal ligament. Journal of Periodontal Research 41: 547-553; 2006

 

13.       Gronthos S, Mrozik K, Shi S, Bartold PM. Ovine periodontal ligament stem cells: Isolation, characterization and differentiation potential. Calcified Tissue International 79: 310-317; 2006

 

14.       Lao M, Marino V, Bartold PM. Immunohistochemical study of bone sialoprotein and osteopontin in healthy and diseased root surfaces. Journal of Periodontology 77: 1665-1673; 2006

 

15.       Stokowski A, Shi S, Sun T, Bartold PM, Koblar SA, Gronthos S. EphB/ephrin-B interactioni mediates adult stem cell attachment, spreading and migration: implications for dental tissue repair. Stem Cells. 2007; 25: 156-164.

 

16.       Manakil JF, Seymour GJ, Bartold PM. Effect of cytokine and antigen stimulation on peripheral blood lymphocyte syndecan-1 expression. Oral Microbiology and Immunology  22:272-276; 2007

 

17.       Chang T, Liu Q, Marino V, Bartold PM. Attachment of periodontal fibroblasts to barrier membranes coated with platelet-rich plasma. Australian Dental Journal  52: 227-233; 2007

 

18.       Bartold PM.  Advances in periodontics - how have they changed practice?.  Australian Dental Practice  18:  58-60; 2007

 

19.       Lin N-H, Menicanin D, Mrozik K, Gronthos S, Bartold PM.  Putative stem cells in regenerating human periodontium.  Journal of Periodontal Research 43: 514-523; 2008

 

20.       Menicanin D, Bartold PM, Gronthos.  Stem cells in dental structure regeneration.  Journal of Stomatological Investigation 1: 3-13; 2007

 

21.       Lin N-H, Gronthos PM, Bartold PM  Stem cells and periodontal regeneration.  Australian Dental Journal 53: 108-121; 2008.

 

22.       Liu Y, Zheng Y, Ding F, Fang D, Zhang C, Bartold PM, Gronthos S, Shi S, Wang S.  Periodontal ligament stem cell mediated treatment for periodontitis in miniature swine.  Stem Cells 26:1065-73; 2008.

 

23.       Xu Y, Jiang Y, Lin X, Bartold PM, V M. Human osteoblasts attachment to guided tissue regeneration membranes which were coated either with platelet-rich plasma or platelet-poor plasma.  Zhonghua Kou Qiang Yi Xue Za Zhi. 42:496-500; 2007 . Chinese.

 

24.       Lin N-H, Gronthos S, Bartold PM Stem Cells and Periodontal Regeneration Oral Health 98: 78-101; 2008

 

25.       Bendyk A, Marino V, Zilm PS, Howe P, Bartold PM  Effect of dietary omega-3 polyunsatturated fatty acids on experimental periodontitis in the mouse.  Journal of Periodontal Research 44: 211-216; 2009

 

26.       Cantley MD, Bartold PM, Marino V,Reid RC, Fairlie DP, Wyszynski RN, Zilm PS, DR Haynes DR.  The Use of Live Animal Micro Computed Tomography to Determine the Effect of a Novel Phospholipase A2 Inhibitor on Alveolar Bone Loss in an In Vivo Mouse Model of Periodontitis. Journal of Periodontal Research 44: 317-322; 2009

 

27.       Fitzsimmons TR, Sanders AE, Slade GD, Bartold PM.  Biomarkers of periodontal inflammation in the Australian adult population.  Australian Dental Journal  54: 115-122; 2009

 

28.       Wada N, Menicanin D,  Shi S, Bartold PM, Gronthos S. Immunomodulatory Properties of Human Periodontal Ligament Stem Cells. J Cell Physiol. 2009;219:667-676.

 

29.       Lin NH, Gronthos S, Bartold PM.  Stem cells and future periodontal regeneration.  Periodontology 2000 51: 239-251; 2009

 

30.       Gronthos S, McCarty R, Mrozik, Krzysztof, Fitter, S, Paton S, Menicanin D, Itescu S, Bartold PM, Cory X, Zannetino A.  Heat shock protein-90 (Hsp90) is expressed at the surface of multipotential mesenchymal precursor cells (MPC): Generation of a novel monoclonal antibody STRO--4, with specificity for MPC from human and ovine tissues. Stem Cells Dev. 18: 1253-1261; 2009

 

31.       Menicanin D, Bartold PM, Zannettino CW, Gronthos S.  Genomic profiling of mesenchymal stem cells. Stem Cell Rev. 5: 36-50; 2009.

 

32.       Sanders AE, Slade GD, Fitzsimmons TR, Bartold PM Physical activity, inflammation and periodontitis risk: a population based case control study.  Journal of Clinical Periodontology 36: 388-395; 2009

 

33.       Tang TH, Fitzsimmons TR, Bartold PM.  Effect of smoking on concentrations of RANKL and OPG in human gingival crevicular fluid.  Journal of Clinical Periodontology 36: 713-718; 2009

 

34.       Blinkhorn AS, Bartold PM, Cullinan MP, Madden TE, Marshall RI, Raphael RI, Raphael SL, Seymour GJ  Is there a role for triclosan/copolymer toothpaste in the management of periodontal disease?  British Dental Journal 207: 117-125; 2009.

 

35.       Mrozik K, Gronthos S, Shi, S, Bartold PM.  A method to isolate, purify and characterize human periodontal ligament stem cells.  Methods in Molecular Biology – Oral Biology 666: 269-284; 2010.

 

36.       Lucas H, Bartold PM, Dharmapatni AASSK, Holding CA, Haynes DR.  Inhibition of apoptosis in periodontal disease.  Journal of Dental Research 89: 29-33, 2010.

 

37.       Goss AN, Bartold PM, Sambrook P, Hawker P.  The nature and frequency of bisphosphonate associated osteonecrosis of the jaws in dental implant patients in South Australia. Journal of Oral and Maxillofacial Surgeons  68: 237-243; 2010.

 

38.       Fitzsimmons TR, Sanders AE, Bartold PM, Slade GD. Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis.  Journal of Clinical Periodontology 37: 30-36; 2010.

 

39.       Bartold PM, Cantley MD, Haynes DR.  Mechanisms and control of pathologic bone loss in periodontitis.  Periodontology 2000 53: 55-69; 2010.

 

40.       Mrozik K, Zilm PS, Bagley CJ, Hack S, Hoffman P, Gronthos S, Bartold PM. Proteomic characterization of mesenchymal stem cell-like populations derived from periodontal ligament, dental pulp and bone marrow: analysis of differentially expressed proteins  Stem Cells and Development 19: 1485-1499; 2010

 

41.       Kataria NG, Bartold PM, Dharmapatni AASK, Atkins GJ, Holding CA, Haynes DR.  Expression of tumor necrosis factor like weak inducer of apoptosis (TWEAK) and its receptor FN14 in healthy and periodontitis tissues.  Journal of Periodontal Research  45: 564-573; 2010

 

42.       Bartold PM, Marino, V, Cantley, M, Haynes, DR. Effect of P. gingivalis-induced inflammation on development of rheumatoid arthritis.  Journal of Clinical Periodontology 37: 405-411; 2010

 

43.       Menicanin D, Bartold PM, Zannettino ACW, Gronthos S.  Identification of a common gene expression signature associated with immature clonal mesenchymal cell populations derived from bone marrow and dental tissues.  Stem Cells & Development 19: 1501-1510; 2010

 

44.       Megson E, Fitzsimmons T, Dharmapatni K, Bartold PM.  C-reactive protein in gingival crevicular fluid is indicative of systemic inflammation.  Journal of Clinical Periodontology 37: 797-804; 2010.

 

45.       Bartold PM, Kuliwaba JS, Lee V, Shah S, Marino V, Fazzalari NL.  Influence of surface roughness and shape on microdamage of the osseous surface adjacent to titanium dental implants.  Clinical Oral Implants Research  22: 613-618; 2011.

 

46.       Megson E, Kapellas K, Bartold PM. Relationship between Periodontal Disease and Osteoporosis. International Journal of Evidence-Based Healthcare 8:129-139; 2010.

 

47.       Gronthos S., Arthur A., Bartold PM., and Shi S., A Method to Isolate and Culture Expand Human Dental Pulp Stem Cells. Mesenchymal Stem Cell Assays and Applications.  In:  Methods in Molecular Biology. Editors: Mohan C. Vemuri, Mahendra S. Rao & Lucas G. Chase.   Humana Press NJ, USA. 698: 107-121; 2011.

 

48.       Zilm PS, Bartold PM. Proteomic identification of proteinase inhibitors in the porcine Enamel Matrix Derivative, EMD^®.  Journal of Periodontal Research 46: 111-117, 2011

 

49.       Wada N, Bartold PM, Gronthos S.  Human Foreskin Fibroblasts Exert Immunomodulatory Properties by a Different Mechanism to Bone Marrow Mesenchymal Stem Cells.  Stem Cells and Devlopment 20:647-659; 2011.

 

50.       Bates CE, Marino V, Fazzalari NL, Bartold PM.  Soft tissue attachment to titanium implants coated with growth factors.  Clinical Implant and Related Dentistry 2011 Mar 22. doi: 10.1111/j.1708-8208.2010.00327.x. [Epub ahead of print]

 

51.       Wada N, Wang B, LinN-H, Laslett AL, Gronthos S, Bartold PM. Induced pluripotent stem cell lines derived from human gingival and periodontal ligament fibroblasts  Journal of Periodontal Research 46: 438-447; 2011

 

52.       Cantley MD, Fairlie DP, Bartold PM, Rainsford KD, Le GT, Lucke AJ, Holding CA, Haynes DR.  Compounds that inhibit histone deacetylases in class I and class II effectively suppress human osteoclasts in vitro.  Journal of Cellular Physiology 2011 Feb 22. doi: 10.1002/jcp.22684. [Epub ahead of print].

 

53.       Cantley MD, Haynes DR, Marino V, Bartold PM.  Pre-existing periodontitis exacerbates rheumatoid arthritis in a mouse model.  Journal of Clinical Periodontology Periodontology 38: 532-541; 2011.

 

54.       Mrozik KM, Gronthos S, Menicanin D, Marino V, Bartold PM.  Effect of coating Straumann Bone Ceramic with Emdogain on mesenchymal stromal cell hard tissue formation.  Clinical Oral Investigations 2011 May 17. [Epub ahead of print]).

 

55.       Bartold PM, Meng H.  An Asian perspective of periodontology.  Periodontology 2000  56: 11-13; 2011.

 

56.       Cantley MD, Bartold PM, Marino V, Fairlie DP, Le GT, Lucke AJ, Haynes^.  DR. Histone deacetylase inhibitors suppress bone loss in experimental periodontitis. Journal of Periodontal research (Accepted for publication May 24, 2011).

 

Professional Associations

Editor of the Australian Dental Journal

 

Associate Editor Journal of Periodontal Research

 

Member of the Editorial Board on the following Journals:

Australian Dental Journal

Clinical Implant Dentistry & Related Research

Clinical Oral Implants Research

Journal of the International Academy of Periodontology

Journal of Periodontal Research

Periodoontology 2000

 

 

I am a member of the following organisations:

International Association for Dental Research, Matrix Biology Society of Australia and New Zealand, Australian Dental Association, Australian Society for Periodontology, Periodontal Research Group of IADR, Australia and New Zealand Academy of Periodontists, Federation Dentaire Internationale, Royal Australasian College of Dental Surgeons, Asian Pacific Society of Periodontology, Academy of Dentistry International, Australian Periodontology Research Foundation, New York Academy of Sciences, International Academy of Periodontology, International College of Dentists

Files

• DClinDent Periodontics Candidate Information - periobooklet.pdf [78.9K] (application/pdf)

Expertise for Media Contact

Categories	Dentistry
Expertise	Connective tissue research; tissue engineering; implants
Notes	Alt phone: (08) 8303 3437

Entry last updated: Sunday, 5 Feb 2012