Dr Mark Hutchinson

Biography/ Background

Dr Mark Hutchinson completed a BSc majoring in Pharmacology, Microbiology & Immunology at the University of Adelaide (1998). He continued his studies in Pharmacology with honours (1999) & PhD (2004) examining opioid metabolism & opioid immunodulation, respectively. In 2004 he was awarded the FreshScience prize for communication of science in the media.  He moved to Boulder, Colorado in 2005 to undertake Postdoctoral training in the world leading research group of Prof Linda Watkins in the Center for Neuroscience at the University of Colorado at Boulder. Here he pioneered with Prof Watkins the research which has lead to the discovery of novel drugs activity at innate immune receptors. Moreover, his research has lead to the implication of the brain immune cells in the action of drugs of dependence and the negative side effects of pain killers. Dr Hutchinson was awarded an NHMRC CJ Martin Fellowship in 2007. He returned to Adelaide in 2009 to continue his research in the Discipline of Pharmacology, University of Adelaide. In 2011 he was awarded an Australian Research Council Fellowship for research into sex differences in pain and drug response. He has numerous peer reviewed publications, review papers and book chapters, several patents and is frequently asked to speak at national and international conferences and symposia.

Qualifications

BSc (Hons), PhD (Med)

Awards & Achievements

South Australian Tall Poppy Science Awardee (2010)

Denis Wade Johnson & Johnson New Investigators Award (2009)

National Institute for Drug Addiction Young Investigator Award (2007)

Society on Neuroimmune Pharmacology Travel Award (2006)

Front Range Neuroscience Group Oral Presentation Finalist Winner (2005)

Front Range Neuroscience Group Oral Presentation Finalist Winner (2005)

American Australian Association Merck Company Foundation Fellow (2005)

Front Range Neuroscience Group Chapter travel award nomination  (2005)

Front Range Neuroscience Group Chapter oral presentation winner (2005)

Recipient of a British Council Travel Award (2005)

Australian FreshScience Winner (2004)

FreshScience Australia Finalist (2004)

ASCEPT Oral Prize Finalist (2003)

Health Science Faculty Postgraduate Travel Fellowship (2002)

Mutual Community Postgraduate Travel Grant (2002)

ASCEPT travel grant recipient 99, 00, 01, 03 & 04

 

Publications

Peer Reviewed Publications

Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, Falke JJ, Leinwand LA, Maier SF, Yin H, Rice KC, Watkins LR. Evidence that opioids may have toll like receptor 4 and MD-2 effects. Brain, Behavior and Immunity (in press).

Watkins LR, Hutchinson MR, Rice KC, Maier SF. The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia. Trends in Pharmacological Sciences (in press)

Rodgers KM, Hutchinson MR, Northcutt A, Maier SF, Watkins LR, Barth DS. The cortical innate immune response increases local neuronal excitability leading to seizures. Brain (2009) pp. 1-9

Bland ST, Hutchinson MR, Maier SF, Watkins LR, Johnson KW (2009) The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain, Behavior and Immunity. Accepted Feb 11

Slivka PF, Shridhar M, Lee GI, Sammond DW, Hutchinson MR, Martinko AJ, Buchanan MM, Sholar PW, Kearney JJ, Harrison JA, Watkins LR, Yin H (2009) A Peptide Antagonist of the TLR4-MD2 Interaction. Chembiochem. Epub Jan 30.

 

Hutchinson MR, Lewis SS, Coats BD, Skyba DA, Crysdale NY, Berkelhammer DL, Brzeski A, Northcutt A, Vietz CM, Judd CM, Maier SF, Watkins LR, Johnson KW (2008) Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain, Behavior and Immunity, Epub Oct 4.

Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, Patel SJ, Crysdale NY, Harrison JA, Maier SF, Rice KC, Watkins LR (2008) Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). European Journal of Neuroscience 28: 20-29

Hutchinson MR, Northcutt AL, Chao LW, Kearney JJ, Zhang Y, Berkelhammer DL, Loram LC, Rozeske RR, Bland ST, Maier SF, Gleeson TT, Watkins LR (2008) Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain, Behavior and Immunity, Epub Jul 31

 

Hutchinson MR, Coats BD, Lewis SS, Zhang Y, Sprunger DB, Rezvani N, Baker EM, Jekich BM, Wieseler JL, Somogyi AA, Martin D, Poole S, Judd CM, Maier SF, Watkins LR (2008) Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia, Brain, Behavior and Immunity, Epub Jul 1

Hutchinson, M.R., Bland, S.T., Johnson, K.W., Rice, K.C., Maier, S.F., Watkins, L.R., (2007) Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. P 98-111, Vol 7, ScientificWorldJournal

Watkins, L.R., Hutchinson, M.R., Milligan, E.D., and Maier S.F. (2007) “Listening” and “talking” to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids. P 148-69. Vol 56(1), Brain Research Reviews

Ledeboer, A., Hutchinson, M.R., Watkins, L.R., & Johnson, K.W. (2007) Ibudilast (AV-411): a new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. P 935-950. Vol 16(7) Expert Opinion of Investigational Drugs.

Watkins, L.R., Hutchinson, M.R., Ledeboer, A., Wieseler-Frank, J., Milligan, E.D., & Maier, S.F., (2007) Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids. P 131-146. Vol 21(2) Brain, Behavior & Immunity.

Watkins, L.R., Wieseler-Frank, J., Hutchinson, M.R., Ledeboer, A., Spataro, L., Milligan, E.D., Sloane, E., & Maier, S.F., Neuroimmune interactions and pain: the role of immune and glial cells, Psychoneuroimmunology, Ader, R. (Ed.), Academic Press (2006) 393-414.

Der-Avakian, A; Bland, ST; Rozeske, RR; Tamblyn, JP; Hutchinson, MR; Watkins LR and Maier SF (2007) Single exposure to uncontrollable stress potentiates the subsequent conditioned place preference response to oxycodone, but not cocaine or ethanol. P909-917. 191(4) Psychopharmacology

Watkins, LR; Hutchinson, MR; Johnston, I & Maier, SF (2005) Glia: Novel counter-regulators of opioid analgesia. P661-69. vol 28(12) Trends in Neurosciences

Hutchinson, M.R. & Somogyi, A.A. (2005) Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids. P1713-22, vol 5(12) International Immunopharmacology 

Hutchinson, M.R. & Somogyi, A.A. (2004) (S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(-)-methadone. P1525-30, vol 4(12), International Immunopharmacology

Hutchinson, M.R., La Vincente, S.F. & Somogyi, A.A. (2004). In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance. P751-755, vol 110 Pain

Editorial on publication: Brack A & Stein C. (2004) Potential links between leukocytes and antinociception. P1-2, vol 111 Pain

Hutchinson, MR; Somogyi, AA (2004) Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation. P251-262, vol 494(2-3) European Journal of Pharmacology

Hutchinson, MR; Menelaou, A; Foster, DJR; Coller, JK; Somogyi, AA (2004) CYP2D6 and CYP3A4 involvement in hydrocodone primary oxidative metabolism in human liver microsomes. P287-297, vol 57(3) British Journal of Clinical Pharmacology

Menelaou, A; Hutchinson, MR; Quinn, I; Christensen, A; Somogyi, AA (2003) Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection. P81-88, vol 785 Journal of Chromatography B

Hutchinson, MR; Somogyi, AA (2002) Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies. P27-32, vol 453 European Journal of Pharmacology

 

Books

Hutchinson, M.R.; Johnson, K.W.; Watkins, L.R.; Glial dysregulation of pain & opioid actions - past, present & future, Pain 2008 - An updated review", J.M. Castro-Lopes, S. Raja and M. Schmelz (eds), IASP Press, Seattle, 2008

Watkins, LR; Wieseler-Frank, J; Hutchinson, MR; Ledeboer, A; Spataro, L; Milligan, ED; Sloane, E; & Maier, SF; Neuroimmune interactions and pain: the role of immune and glial cells, Psychoneuroimmunology, Ader, R. (Ed.), Elesevier Press (2006) In Press.

Author of the introduction of a book chapter entitled “Pharmacology of opioid agonists and antagonists” in a book called “Pharmacotherapies For The Treatment Of Opioid Dependence: Efficacy, Cost-Effectiveness And Implementation Guidelines”. Edited Mattick, R (in press)

Conference Proceedings

Coats, B.D., Hutchinson, M.R., Lewis, S.S., Sprunger, D.B., Baker, E.M., Maier, S.F., & Watkins, L.R., Opposition of acute intrathecal morphine analgesia by glia: Mechanisms and mediators, Proc Soc. Neurosci., (2007).

 

Hutchinson, M.R., Coats, B.D., Bland, S.T., Zhang, Y., Lewis, S.S., Sprunger, D.B., Baker, E.M., Hughes, T.S., Maier, S.F., Watkins, L.R., Rice, K.C. & Johnson, K.W., Improving the safety and efficacy of opioids by attenuating glial activation: clinical implications & the search for the novel glial activation site, Proc Soc. Neurosci., (2007).

 

Lewis, SS; Hutchinson M.R.; Shridhar, M; Maier, SF and Watkins, LR. Characterization of glial activation in chronic morphine-induced "paradoxical" allodynia.  Proc. Soc. Neurosci., (2007).

 

Loram, L.C., Hutchinson, M.R., Coats, B.D., Zhang, Y., Lewis, S.S., Sprunger, D.B., Maier, S.F., Johnson, K.W., Rice, K.C. & Watkins, L.R., A molecular link between opioid-induced glial activation and neuropathic pain: a novel therapeutic target, Proc Soc. Neurosci., (2007).

 

Watkins, L.R., Hutchinson, M.R., Zhang, Y., Coats, B.D., Sprunger, D.B., Hughes, T.S., Maier, S.F., Johnson, K.W., & Rice, K.C., Identification and characterization of a novel opioid site of action: implications for opioid-induced glial activation, Proc Soc. Neurosci., (2007).

 

AV411, a blood brain barrier permeable glial activation inhibitor, reduces morphine withdrawal behaviors in rats. SS Lewis, MR Hutchinson, BD Coats, AL Brzeski, SF Maier, LR Watkins, KW Johnson (2006) Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, Online

 

Opioid inactive (+)-naloxone potentiates morphine analgesia: Further evidence that opioid analgesia is opposed by opioid induced glial activation. B.D. Coats, M.R. Hutchinson, & L.R. Watkins (2006) Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, Online

 

Spinal pro-inflammatory cytokines oppose acute opioid analgesia following intrathecal & subcutaneous opioid administration. M.R. Hutchinson, B.D. Coats, S.S. Lewis, S.F. Maier, & L.R. Watkins (2006) Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, Online

 

Studies of chronic fractalkine-induced allodynia & hyperalgesia in rats. D.A. Busha, S. Langer, B. Coats, M.R. Hutchinson, S.F. Maier, R.M. Sapolsky, L. Leinwand, L.R. Watkins, J.K. Harrison. (2006) Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, Online

 

Behavioral control over a stressor determines potentiated conditioned place preference to oxycodone, but not cocaine or ethanol. R.R. Rozeske, A. Der-avakian, S.T. Bland, J.T. Tamblyn, M.R. Hutchinson, L.R. Watkins, S.F. Maier (2006) Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, Online

 

Opioid induced elevations of spinal proinflammatory cytokines are mediated via non-classical opioid mechanisms. M.R. Hutchinson, E.D. Milligan, B. Jekich, B. Coats, S. Lewis, S.F. Maier, & L.R. Watkins. (2006) Proceedings of the Society on Neuroimmune Pharmacology, Santa Fe, NM

AV-411, a novel attenuator of neuropathic pain. Shumilla, JA., Ledeboer, A., Liu, T., Hutchinson, MR., Skyba, D., Pater, C., Watkins, LR., and Johnson, KW, (2005) 8th International Conference on the Mechanisms and Treatment of Neuropathic Pain.

Comparison Of Manual Anterior Lateral Cardioversion with Remote, Anteroposterior Cardioversion Of Atrial Fibrillation Using Current Biphasic Defibrillation, Farquharson, A., Magarey, J., Teo, K., Roberts-Thompson, K. and Hutchinson, MR. (2005) Cardiac Society of Australian and New Zealand 53rd Annual Scientific Meeting, Perth, Western Australia

Hutchinson, MR; Milligan, ED; Maier, SF & Watkins, LR (2005) Interleukin-1 receptor antagonist (IL1ra) “unmasks” analgesia following both R- & S-methadone: Evidence for induction of spinal proinflammatory cytokines (PICs) via non-classical opioid receptors. Program No. 49.11. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, Online

Kwiatek, R; Aidinis, S; Somogyi, AA; Hutchinson, MR; Hill, C; Pile, K (2005) Subcutaneous Subanaesthetic Ketamine Infusions in Treatment-Refractory Fibromyalgia (FM), 1039-P281, 11th World Congress on Pain

Hutchinson, MR; Somogyi, AA (2004) Immunomodulation by 4,5-epoxymorphinans: a structure effect relationship, PO391, p A153, vol 31 Clin & Exp Pharm & Physiol 

Nguyen, M; Lopatko, O; White, JM; Somogyi, AA; Farquharson, AL; Hutchinson, MR; Foster, DJR (2004) The physiological, subjective, immunological and biochemical effects of S-, R- and racemic methadone in healthy volunteers. 10, vol 11 Proceedings of the Australasian Society of Clinical & Experimental Pharmacology & Toxicology

Hutchinson, MR; Somogyi, AA (2003) A biological marker of pain tolerance in humans. 126, vol 10 Proceedings of the Australasian Society of Clinical & Experimental Pharmacology & Toxicology

Somogyi, AA; Hutchinson, MR (2003) S-Methadone is more immunosuppressive than the more potent analgesic R-Methadone. 260, vol 10 Proceedings of the Australasian Society of Clinical & Experimental Pharmacology & Toxicology

Hutchinson, MR; La Vincente, SF; Somogyi, AA (2003) Human pain tolerance correlates with in vitro immunological mitogenesis assay. Neuroscience 2003 Proceedings

Hutchinson, MR; Somogyi, AA (2002) Opioid Immunomodulation is not related to mu receptor binding affinity. PS83-84, vol 66 Drug & Alcohol Dependence

Hutchinson, MR; Somogyi, AA (2001) Substantial differences in the immune response to morphine and methadone in a splenocyte mitogenesis assay.  p38 vol 9 Proceedings of the Australasian Society of Clinical & Experimental Pharmacology & Toxicology

Menelaou, A; Hutchinson, MR; Rasmussen, I; Somogyi, AA (2000) Quantification of hydrocodone and oxycodone oxidative metabolites in human liver microsomes using HPLC with UV detection. p105 vol 8 Proceedings of the Australasian Society of Clinical & Experimental Pharmacology & Toxicology

Hutchinson, MR; Somogyi, AA (2000) Development and optimisation of a mouse splenocyte mitogenesis assay to investigate opioid immunological effects. p83 vol 8 Proceedings of the Australasian Society of Clinical & Experimental Pharmacology & Toxicology

Somogyi, AA; Hutchinson, MR (2000) CYP2D6 and CYP3A4 catalyse the O- and N- demethylations respectively of hydrocodone in human liver microsomes. p186 Proceedings of 13th International Symposium on Microsomal Drug Oxidation

Hutchinson, MR; Menelaou, A; Somogyi, AA (1999) Identification of CYP450 isoforms involved in hydrocodone metabolism by human liver microsomes. p132, vol 6 Proceedings of the Australasian Society of Clinical & Experimental Pharmacology & Toxicology

Professional Associations

Member of the Australasian Society of Clinical & Experimental Pharmacology & Toxicology

Member of the Society for Neuroscience

Member of the International Association for the Study of Pain

Member of the Society on Neuroimmunopharmacology

Member of the American Pain Association 

American Australian Association

British Council – Australia

Rocky Mountain Neuroscience Group

Front Range Neuroscience Group

Expertise for Media Contact

Categories	Medicine and medical research, Drugs
Expertise	Neuroscience; Immunology; Pharmacology; Drug Addiction; Microglia; Cytokine; Chemokine; Pain; Reward; Opioid; Opiate; Alcoholism; Immunogenetics; Toll Like Receptor; Astrocyte; Drug Abuse; Glia; Inflammation; Drug Development; Analgesia; Pain killer;
Notes	Awards South Australian Science Young Tall Poppy Awardee (2010) Denis Wade Johnson & Johnson Young Investigator Award (2009) Julius Axelrod Lecture Award (NIDA) (2009) National Institute for Drug Addiction Young Investigator Award (2007)
Mobile	0466304980
After hours	0466304980

Entry last updated: Sunday, 5 Feb 2012