Dr Martin Lewis

Biography/ Background

1992 Department of Haematology, Flinders Medical Centre

1993 - 1999 Department of Genetic Medicine, Women's & Children's Hospital

2000 - 2004 School of Pharmacy, University of South Australia

2005 - 2008 University of Adelaide, Discipline of Genetics & The Centre for the Molecular Genetics of Development

2009 - 2010 University of Adelaide, Discipline of Genetics & The Stroke (cerebral ischaemia) Research Program

Qualifications

BSc - Flinders University, School of Biological Sciences

BSc (Hons) - Flinders University, School of Medicine, Department of Biochemistry

PhD - University of Adelaide, School of Paediatrics, Department of Genetic Medicine

Research Interests

Stem Cell biology

Cerebral ischaemic (stroke), brain injury and repair

bHLH / PAS transcription factors

Publications

Tran HB, Lewis MD, Tan LW, Lester SE, Baker LM, Ng J, Hamilton-Bruce MA, Hill CL, Koblar SA, Rischmueller M, Ruffin R, Wormald PJ, Zalewski PD and Lang CJ. Immunolocalization of NLRP3 Inflammasome in Normal Murine Airway Epithelium and Changes Following Induction of Ovalbumin-Induced Airway Inflammation. Journal of Allergy. 2012  (accepted)

Holliday E, Maguire J, Biros E, Golledge J, Lewis MD, Koblar SA, Jannes J, Hankey G, Baker R, Parsons M, Sturm J, Lincz L, Moscato P, Scott R, Attia J and Levi C. Genome-wide association studies of ischaemic stroke and large artery atherosclerosis. International Journal of Stroke 2011 6 SUPPL. 1 (53)

Leong WK, Klaric TS, Lewis MD and Koblar SA.  Upregulation of Npas4 expression is early and transient following focal cerebral ischemia in adult rodent brain.  International Journal of Stroke 2011 6 SUPPL. 1 (47)

Maguire J, Holliday E, Sturm J, Golledge J, Lewis MD, Koblar SA, Jannes J, Hankey G, Lincz L, Moscato P, Baker R, Parsons M, Scott R, Attia J and Levi C.   Australian stroke genetics collaborative: Genetic associations with ischaemic stroke functional outcome.  International Journal of Stroke 2011 6 SUPPL. 1 (44)

Djukic M, Lewis MD, Leung E, Jannes J, Hamilton-Bruce MA, Chataway TK and Koblar SA. Human plasma biomarker investigation of transient ischaemic attack (TIA) by 2D-differential in-gel electrophoresis (DIGE) and mass spectrometry: A pilot study. International Journal of Stroke 2011 6 SUPPL. 1 (42)

Leong WK, Henshall TL, Arthur A, Kremer KL, Lewis MD, Helps SC, Field J, Hamilton-Bruce A, Warming S, Manavis J, Vink R, Gronthos S and Koblar SA.  Human adult stem cells as a treatment for focal cerebral ischaemia.  International Journal of Stroke 2011 6 SUPPL. 1 (33).

Tran H, Rischmueller M, Lester S, Tan LW, Lewis MD, Koblar SA, Lang C and Zalewski P. Inflammasome activation is implicated in disease pathogenesis in asthma and primary Sjogren's syndrome. Internal Medicine Journal 2011 41 SUPPL. 1 (9)

Manning JA, Lewis MD, Koblar SA, Kumar S. An essential function for the centrosomal protein NEDD1 in zebrafish development. Cell Death Differ. 2010 Aug;17(8):1302-14. Epub 2010 Feb 12. PubMed PMID: 20150915 (IF 7.548).

Roberts RR, Ellis M, Gwynne RM, Bergner AJ, Lewis MD, Beckett EA, Bornstein JC, Young HM. The first intestinal motility patterns in fetal mice are not mediated by neurons or interstitial cells of Cajal. J Physiol. 2010 Apr 1;588(Pt 7):1153-69. Epub 2010 Feb 8. PubMed PMID: 20142273; PubMed Central PMCID: PMC2853002 (IF 4.469).

Djukic M, Lewis MD, Leung E, Hamilton-Bruce MA, Chataway TK and Koblar SA.  Proteomic analysis of plasma following transient ischaemic attack (TIA). International Journal of Stroke. 2010 6 SUPPL. 1 (38)

Lewis MD, Roberts BJ. Role of CYP2E1 activity in endoplasmic reticulum ubiquitination, proteasome association, and the unfolded protein response. Arch Biochem Biophys. 2005 Apr 15;436(2):237-45. PubMed PMID: 15797236 (IF 3.152).

Lewis MD, Roberts BJ. Role of the C-terminal alpha-helical domain of the von Hippel-Lindau protein in its E3 ubiquitin ligase activity. Oncogene. 2004 Mar 25;23(13):2315-23. PubMed PMID: 14691445 (IF 6.872).

Lewis MD, Roberts BJ. Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein. Oncogene. 2003 Jun 26;22(26):3992-7. PubMed PMID: 12821933 (IF 6.872).

Chataway TK, Whittle AM, Lewis MD, Bindloss CA, Davey RC, Moritz RL, Simpson RJ, Hopwood JJ, Meikle PJ. Two-dimensional mapping and microsequencing of lysosomal proteins from human placenta. Placenta. 1998 Nov;19(8):643-54. PubMed PMID: 9859869 (IF 2.969).

Chataway TK, Whittle AM, Lewis MD, Bindloss CA, Moritz RL, Simpson RJ, Hopwood JJ, Meikle PJ. Development of a two-dimensional gel electrophoresis database of human lysosomal proteins. Electrophoresis. 1998 May;19(5):834-6. PubMed PMID: 9629923 (IF 4.101).

Human lysosomal sulphate transport / Martin David Lewis. [Thesis] 2001

Hughes BP, Both K, Harland L, Hunt J, Hurst KM, Lewis MD, Barritt GJ. Identification of an mRNA species which encodes a voltage-operated Ca2+ channel in rat liver mRNA. Biochem Mol Biol Int. 1993 Sep;31(1):193-200. PubMed PMID: 7505152 (IF 2.857).

Professional Associations

Memberships

Society for Neuroscience (USA)
Australian Neuroscience Society Inc
Computational Neuroscience Research Cluster (CNRC)

Stroke Society of Australasia

Stroke Research Program

 

Committee member of:

Genetics Society of Australasia (GSA)
Research Career Development Network (RCDN)

Entry last updated: Thursday, 9 Feb 2012