Associate Professor Mounir Ghabriel

Biography/ Background

Biography/ Background

Media Expertise

Associate Professor Mounir Ghabriel

 

Telephone         (08) 8313 5481

Position         Associate Professor of Anatomy

Email mounir.ghabriel@adelaide.edu.au

Fax         (08) 8313 5481

Building Medical School North

Floor/Room       125

Campus         North Terrace

Org Unit Medical Sciences

 

To link to this page, please use the following URL:

http://www.adelaide.edu.au/directory/mounir.ghabriel

 

Biography/ Background

 

Associate Professor Mounir Ghabriel

 

MB, BCh, PhD, DBMSc (Anatomy)

 

Teaching

Mounir has a strong interest and experience in teaching human anatomy to undergraduate and postgraduate students. He taught anatomy at universities in Europe, Australia, Africa and America. Following 15 years of teaching at the University of London as lecturer and senior lecture Mounir moved to Adelaide in 1994. He was awarded the Faculty of Health Sciences Executive Dean’s award for excellence in teaching in 2006, the Richard Pellew Prize in 2009 and 2010 in Recognition of Outstanding Teaching and Service to Medical Students in Years 1-3, and an Australia Learning and Teaching Council Citation in 2011. Mounir was awarded several teaching development grants. Current teaching responsibilities to undergraduate and postgraduate students include: lectures, practical demonstrations in the dissecting laboratory and small group tutorials in gross anatomy, neuroanatomy and embryology to medical, dental, health science and science students. Mounir coordinates the gross anatomy course for second year medical students, the elective of applied anatomy of the cranial nerves, the postgraduate “Applied anatomy course for surgical trainees” (http://health.adelaide.edu.au/school_medsci/research/aandp/) and “Applied anatomy course for neurosurgical registrars”.

 "Applied Anatomy for Surgical Trainees"

A part-time evening course in Anatomy taught over 29 weeks (March - November). The course includes practical demonstrations and Lectures. Topics include head and neck, CNS, thorax, abdomen, pelvis, back and spine, upper limb and lower limb. The course is recognised by the Australian Orthopaedics Association.

For further information contact <mounir.ghabriel@adelaide.edu.au>.

If you would like information on other similar courses please contact <mounir.ghabriel@adelaide.edu.au>.

 

Please Note: Application for this course closes on the 1st February each year. For further information contact: mounir.ghabriel@adelaide.edu.au

 

 

Research

Name of Research Group: The Blood-Brain Barrier (BBB) Group 

Contact name: Associate Professor Mounir Ghabriel

Email: mounir.ghabriel@adelaide.edu.au

Phone: +618-83135481

Research Interests

 My research group is based in the Discipline of Anatomy and Pathology. The group is interested in the structure and function of the blood-brain, blood-CSF and blood-nerve barriers. The research aims at elucidating the factors leading to breakdown of the blood-CNS barrier in pathological conditions. Current research includes the study of barrier vessels in brain trauma, brain tumours and the role of neuroprotective agents. The methodology includes the use of light and electron microscopy, freeze-fracture, immunocytochemistry, electron microscopy, application of tracers, western-blotting and functional studies. The group has strong collaboration with the Centre for neurological diseases at the IMVS, Adelaide.

Current Research projects

Protective role of certain drugs on the BBB in traumatic brain injury.

Role of neurogenic inflammation in the BBB in Traumatic brain injury.

Brain oedema in traumatic brain injury.

The blood-CSF barrier and markers expression following traumatic brain injury.

Role of the blood-brain barrier and neuroprotective agents in tumour invasion and development in the brain.

 

Research Staff: A/Prof. Mounir Ghabriel, Prof. Robert Vink; Dr Stephen Helps, Dr Rami Tadros, Dr Jianjun Lu, Ms Irena Zdziarski, Mr Chris Leigh, Mrs Gail Hermanis, Mr Hany Saad, Dr Philip Makar

Collaborators: Prof. Peter Blumbergs; Prof. Peter Reilly; Prof. Phil Thompson, Professor Brian Setchell

 

Research Students: Ms Kate Lewis; Ms Elizabeth Harford-Wright, Mr Alex Horner, Mr Joshua Burton

  

Publications

Ghabriel MN and Makar PH (2011) Anatomical variations in the ulnar nerve and hypothenar muscles. International Journal of Anatomical Variations, 4: 131-133.

 

Brisch R, Bernstein HG, Dobrowolny H, Krell D, Stauch R, Trübner K, Steiner J, Ghabriel MN, Bielau H, Wolf R, Winter J, Kropf S, Gos T, Bogerts B (2011) A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder. European Archives of Psychiatry and Clinical Neuroscience, 261: 47-58.

 

Khoury J, Mihailidis S, Ghabriel M and Townsend G (2011) Applied anatomy of the pterygomandibular space: improving the success of inferior alveolar nerve blocks. The Australian Dental Journal, 56: 112-121.

 

Khoury J, Mihailidis S, Ghabriel M and Townsend G (2010) Anatomical relationships within the human pterygomandibular space: relevance to local anaesthesia. Clinical Anatomy, 23: 936–944.

 

Ghabriel MN, Zdziarski IM, Leigh C, Vink R (2009) Changes in the blood-CSF barrier in experimental traumatic brain injury. Acta Neurochir suppl, 106: 239-245. Ch.45 In Zbigniew Czernicki, Alexander Baethmann, Umeo Ito, Yoichi Katayama, Toshihiko Kuroiwa and David Mendelow, Eds., Brain Oedema XIV.

 

Kleinig TJ, Helps SC, Ghabriel MN, Manavis J, Leigh C, Blumbergs PC, Vink R (2009) Hemoglobin crystals: a pro-inflammatory potential confounder of rat experimental intracerebral hemorrhage. Brain Research, 1287: 164-172.

 

Cai Z, Finnie JW, Blumbergs PC, Manavis J, Ghabriel MN, Thompson PD (2006) Early paranodal myelin swellings (tomacula) in an avian riboflavin deficiency model of demyelinating neuropathy. Experimental Neurology, 198: 65-71.

 

Ghabriel MN, Thomas A, Vink R (2006) Magnesium restores altered aquaporin–4 immunoreactivity following traumatic brain injury to a preinjury state. Acta Neurochirurgica Suppl., 96: 402-406.

 

Cai Z, Blumbergs PC, Cash K, Rice PJ, Manavis J, Swift J, Ghabriel MN, Thompson PD (2005) Paranodal pathology in Tangier disease with remitting-relapsing multifocal neuropathy. Journal of Clinical Neuroscience, 13: 492-497.

 

Yang L, Jones NR, Blumbergs PC, Van Der Heuvel C, Moore EJ, Manavis J, Sarvestani GT and Ghabriel MN (2005) Severity-dependent expression of proinflammatory cytokines in traumatic spinal cord injury in the rat. Journal of Clinical Neuroscience, 12: 276-284.

 

Bhatia K, Ghabriel MN, Henneberg M (2005) Anatomical variations in the branches of the human aortic arch: a recent study of a South Australian population. Folia Morphologica, 64: 217-223.

 

Ghabriel M, Zhu C, Imran A, Blumbergs P and Reilly P (2004) Blood-brain barrier ultrastructural changes in impact acceleration head trauma. Proceedings of the 7th international Neurotrauma Symposium, Adelaide, Australia, pp 89-92, Medimond International Proceedings, Bologna, Italy. ISBN 88-7587-082-9.

 

Peppi M, Ghabriel MN (2004) Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands. Journal of Anatomy, 205: 257-266.

 

Cai Z, Blumbergs PC, Koblar SA, Cash K, Manavis J, Ghabriel MN, Thompson PD (2004) Peripheral nervous system and central nervous system pathology in rapidly progressive lower motor neurone syndrome with immunoglobulin M anti-GM1 ganglioside antibody. Journal of the peripheral nervous system, 9: 79-91.

 

Ghabriel MN, Lu J, Tadros R and Hermanis G (2004) A narrow time-window for access to the brain by exogenous protein after immunological targeting of a blood-brain barrier antigen. Journal of Comparative Pathology, 131: 52-60.

 

Yang L, Blumbergs PC, Jones NR, Manavis J, Sarvestani GT, Ghabriel MN (2004) Early expression and cellular localization of proinflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor-α in human traumatic spinal cord injury. Spine, 29: 966-971.

 

Ghabriel MN, Zhu C, Leigh C (2002) Electron microscope study of blood-brain barrier opening induced by immunological targeting of the endothelial barrier antigen. Brain Research, 934: 140-151.

 

Ghabriel MN, Lu JJ, Hermanis G, Zhu C and Setchell BP (2002) Expression of a blood-brain barrier-specific antigen in the rat male reproductive tract. Reproduction, 123: 389-397.

 

Zhu C, Ghabriel MN, Blumbergs PC, Reilly PL, Manavis J, Youssef J, Hatami S, Finnie JW (2001) Clostridium perfringens prototoxin-induced alteration of endothelial barrier antigen (EBA) immunoreactivity at the blood-brain barrier (BBB). Experimental Neurology, 169: 72-82.

 

Ghabriel MN, Zhu C, Reilly PL, Blumbergs PC, Manavis J, Finnie JW (2000) Toxin-induced vasogenic cerebral oedema in a rat model. Acta Neurochirorgica Suppl., 76: 231-236.

 

Ghabriel MN, Zhu C, Hermanis G, Allt G (2000) Immunological targeting of the endothelial barrier antigen (EBA) in vivo leads to opening of the blood-brain barrier. Brain Research, 878: 127-135.

 

 

Qualifications

MBBCh, PhD, DBMSc (Anatomy)

Teaching Interests

See above

Publications

 See Above

Google Scholar link

http://scholar.google.com.au/citations?user=LFmpqLUAAAAJ&hl=en

Expertise for Media Contact

Categories	Education, Medicine and medical research
Expertise	Multimedia in teaching the anatomy of the human body; blood vessels of the brain in health and disease; Blood-brain barrier, Head trauma Cereral oedema in brain trauma research
Notes	American Association of Clinical Anatomists Australian and New Zealand Association of Clinical Anatomists Australian Neuroscience Society

Entry last updated: Friday, 2 Nov 2012