Mr Paul Drew
Research Interests
DNA Methylation
mircoRNAs
Oesophageal cancer
Barrett's Oesophagus
Gastrointestinal diseases
Research Funding
2007 The Cancer Council SA Research Grant (453588):
Barrett's oesophagus: insights from and into fundoplication and
oesophagectomy. Jamieson GG, Drew PA, Devitt PG, Ruszkiewicz AR, Smith
E, Liu J-F, Kelly JJ. $71,750.
2007 RAH/IMVS Research Committee Project Grant: The expression of miRNAs in oesophageal disease. Jamieson GG, Devitt PG, Drew PA, Smith E, Kelly JJ, Thompson S. $19,720.
2004-2006 NHMRC Project Grant (275504): Barrett's
oesophagus and reflux oesophagitis: efficacy of medical vs surgical
management. Watson DI, Drew PA, Ruszkiewicz A, Jamieson GG,
Bianco-Miotto T, DJ Hussey. $500,250.
2004 RAH/IMVS Research Committee Clinical Project Grant:
Application for the purchase of a tissue microarrayer for the
construction of tissue microarrays for use in studies into colorectal
and oesophageal cancer. Jamieson GG, Ruskiewicz AR, Drew PA, Smith E. $10,000.
2003-2007 US NIH Grant (CA 001833-03): Molecular
epidemiology of Barrett's esophagus and cancer. Whiteman DC, Drew PA,
Gotley D, Green AC, Hayward NK, Jamieson GG, Parsons PG, Pavey SJ,
Purdie DM, Smithers BM, Watson DI, Webb PM. US$265,000 pa.
2003 RAH/IMVS Research Committee Clinical Project Grant:
Discovery of new genes important in Barrett's oesophagus and
adenocarcinoma of the oesophagus by in vitro demethylation of cell and
tissue cultures. Bianco-Miotto T, Jamieson GG, Watson DI, Smith E, Drew
PA. $20,000.
2002-2004 NHMRC Project Grant (207740): Ablative
therapies for Barrett's oesophagus - evaluation of new clinical and
experimental therapies. Watson DI, G.G. Jamieson GG, Tan L-W, Drew PA,
Schoeman M. $300,000.
Publications
Liu J.F., Zhu G.J., Jamieson G.G., Wu T.C., Zhu T.N., Shan B.E. and Drew P.A. NS-398 induces apoptosis in human oesophageal cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2. Cancer Investigation (in press).
Smith E., De Young N.J, Pavey S.J., Hayward N.K., Nancarrow D.J., Whiteman D.C., Smithers B.M., Ruszkiewicz A.R., Gotley D.C., Devitt P.G., Jamieson G.G. and Drew P.A. Aberrant methylation of multiple genes is similar in Barrett’s esophagus and esophageal adenocarcinoma. Molecular Cancer 7:75, 2008.
Nancarrow D.J, Handoko H.Y., Smithers B.M., Gotley D.C., Drew P.A., Watson D.I., Clouston A.D., Hayward N.K. and Whiteman D.C. Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays. Cancer Research 68, 4163 - 72, 2008.
Kendall B.J, Macdonald G.A., Hayward N.K., Prins J.B., Brown I., Walker N., Pandeya N., Green A.C., Webb P.M., Whiteman D.C for the Study of Digestive Health: Smith, KJ; O'Brien, SM; Smithers, MB; Gotley, DC; Webb, PM; Green, AC; Whiteman, DC; Hayward, NK; Parsons, PG; Pavey, SJ; Purdie, DM; Jamieson, GG; Drew, PA; Watson, DI; Clouston, A. Leptin and the risk of Barrett’s oesophagus. Gut 57, 448 - 454, 2008.
Liu J.F., Zhang S.W., Jamieson G.G., Zhu G.J., Wu T.C., Zhu T.N., Shan B.E. and Drew P.A. The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo. International Journal of Cancer 122, 1639 - 1644, 2008.
Smith E., De Young N.J., Tian Z.Q., Caruso M., Ruszkiewicz A.R., Liu J.F., Jamieson G.G. and Drew P.A. Methylation of TIMP3 in esophageal squamous cell carcinoma World Journal of Gastroenterology 14, 203-210, 2008.
Liebregts T., Adam B., Bredack C., Roth A., Heinzel S., Lester S., Downie-Doyle S., Smith E., Drew P., Talley N.J. and Holtmann G. Immune activation in patients with irritable bowel syndrome. Gastroenterology 132, 913-20, 2007.
Liu J-F., Jamieson G.G., Wu T.C., Zhang S.W., Wang Q.Z. and Drew P.A. Cyclooxygenase-2 expression in squamous cell carcinoma of the esophagus. Diseases of the Esophagus 19, 350-354, 2006.
France M., Drew P.A., Ruszkiewicz A., Watson D.I. and Jamieson G.G. Use of ethylene diamine tetra-acetic acid for in vivo stripping of columnar mucosa. Australian and New Zealand Journal of Surgery 76, 392-397, 2006.
Smith K.J., O'Brien S.M., Smithers B.M., Gotley D.C., Webb P.M., Green A.C., Whiteman D.C. for the Study of Digestive Health: Smith, KJ; O'Brien, SM; Smithers, MB; Gotley, DC; Webb, PM; Green, AC; Whiteman, DC; Hayward, NK; Parsons, PG; Pavey, SJ; Purdie, DM; Jamieson, GG; Drew, PA; Watson, DI; Clouston, A. Interactions among smoking, obesity, and symptoms of acid reflux in Barrett's esophagus. Cancer Epidemiology Biomarkers & Prevention 14, 2481-6, 2005
Smith E., Drew P.A., Tian Z-Q., De Young N.J., Liu J-F., Mayne G.C., Ruszkiewicz A.R., Watson D.I. and Jamieson G.G. Metallothionien 3 expression is frequently down-regulated in oesophageal squamous cell carcinoma by DNA methylation. Molecular Cancer 4:42, 2005.
Liu J-F., Jamieson G.G., Drew P.A., Zhu G-J., Zhang S-W., Zhu T-N., Shan B-E. and Wang Q-Z. Aspirin induces apoptosis in oesophageal cancer cells by inhibiting the pathway of NF-KappaB downstream regulation of cyclooxygenase-2. Australian and New Zealand Journal of Surgery 75, 1011 - 1016, 2005.
France, M., Drew, P.A., Dodd, T. and Watson, D.I. Cyclo-oxygenase-2 expression in oesophageal adenocarcinoma as a determinant of clinical outcome following oesophagectomy. Diseases of the Oesophagus 17, 136 - 40, 2004.
Kinugasa, S., Smith E., Drew, P.A., Watson, D.I. and Jamieson, G.G. Aspirin and indomethacin for the prevention of experimental port site metastases. Surgical Endoscopy 18, 834 - 838, 2004.
Tsopelas, C., Smith, E., Drew, P.A., and Bartholomeusz, F.D.L. Preparation and biological evaluation of 99mTc-stannous fluoride colloid-labelled-leucocytes in rats. Journal of Labelled Compounds and Radiopharmaceuticals 46, 751-763, 2003.
Smith, E., De Young, N.J. and Drew, P.A. Decreased phagocytic capacity of autotransplanted splenic tissue. Australian and New Zealand Journal of Surgery 73, 894-6, 2003.
Smith, E., Bianco-Miotto, T., Drew, P.A. and Watson D.I. Method for optimizing methylation-specific PCR. BioTechniques 35, 32-33, 2003.
Entry last updated: Wednesday, 8 Jun 2011
