Dr Simon Pyke

Biography/ Background

1980 – 1984           Bachelor of Science (Honours, First Class), The University of Sydney

1985 – 1989           Doctor of Philosophy, The University of Sydney

1989 – 1992           Postdoctoral Research Associate, School of Chemical Sciences, University of East Anglia, UK

1992 – 1997           Lecturer (Level B), Department of Chemistry, University of Adelaide

1998 – 2008           Senior Lecturer (Level C), Department of Chemistry, University of Adelaide

2006                     Associate Dean (Learning & Teaching), Faculty of Sciences, University of Adelaide
[0.2 Full time equivalent]

2007 –                   Associate Dean (Learning & Quality), Faculty of Sciences, University of Adelaide
[1.0 Full time equivalent; seconded to the Faculty of Sciences at Level D]

2009 –                   Associate Professor (Level D), Department of Chemistry, University of Adelaide

Awards & Achievements

1995     Faculty of Science Award for Excellence in Teaching

2001     Stephen Cole the Elder Prize for Excellence in Teaching

2006     Executive Dean of Sciences Prize for Excellence in Teaching

2006     Highly Commended; Stephen Cole the Elder Award for Excellence in Teaching

2007     D. R. Stranks Medal for Excellence in Chemical Education (SA Branch, RACI)

2008     ALTC Citation for Outstanding Contribution to Student Learning

Teaching Interests

Currently Associate Dean (Learning & Quality) in the Faculty of Sciences with interests in:

• Curriculum design, construction and assessment
• Facilitating development of skills (discipline related & generic)
• Classroom practice. 

Currently participating in two ALTC grants:

Developing leaders of change in the teaching of large university chemistry classes
(ALTC Leadership for Excellence Grant)

Advancing Science by Enhancing Learning in the Laboratory (ASELL)
(ALTC Competitive Grant)

Research Interests

• Medicinal chemistry of small bioactive molecules and their interactions with protein targets
• Bio-organic chemistry & molecular toxicology of highly reactive aldehydes
• Application of NMR spectroscopy for the determination of molecular structure, conformation and dynamics of small organic molecules and protein-small molecule complexes
• Natural products chemistry.

Publications

56.     “The synthesis, characterization and structures of some 4-[((E)-1-{2-hydroxy-5-[(E)-2-(aryl)-1-diazenyl]phenyl}methylidene)amino]benzoic acids” Tushar S. Basu Baul , Pradip Das, Asit K. Chandra, Sivprasad Mitra, Simon M. Pyke, Dyes Pigm., 2009, 82, 379-396.

55.     “Sequential and selective Buchwald-Hartwig amination reactions for the controlled functionalization of 6-bromo-2-chloroquinoline: Synthesis of ligands for the Tec Src homology 3 domain” Jessica A. Smith, Rhiannon K. Jones, Grant W. Booker and Simon M. Pyke, J. Org. Chem., 2008, 73, 8880-8892.

54.     “Synthesis and cyclisations to aurones and flavones, of alkoxy-substituted aryl, arylalkynyl-ketones” Penelope J. Kerr, Simon M. Pyke and A. David Ward, Aust. J. Chem., 2008, 61, 350-358.

53.     “Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury” Phillip C. Burcham, Lisa M. Kaminskas, D. Tan, and Simon M. Pyke, Mini Rev. Med. Chem., 2008, 8, 319-330.

52.     “Antimicrobial compounds from Eremophila serrulata” C. P. Ndi, S. J. Semple, H. J. Griesser, S. M. Pyke and M. D. Barton, Phytochemistry, 2007, 68, 2684-2690.

51.     “Antimicrobial compounds from the Australian desert plant Eremophila neglecta” Chi P. Ndi, Susan J. Semple, Hans J. Griesser, Simon M. Pyke and Mary D. Barton. J. Nat. Prod., 2007, 70, 1439-1443.

50.     “Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: Targets for cytoprotective hydrazino drugs”, L. M. Kaminskas, S. M. Pyke & P. C. Burcham, Rapid Commun. Mass Spec., 2007, 21, 1155-1164.

49.     “Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography” B. J. Davies, M. K. Herbert, J. A. Culbert, S. M. Pyke, J.K. Coller, A. A. Somogyi, R. W. Milne & B. C. Sallustio, J. Chromatogr. B, 2006, 832, 114-120.

48.     “Hydralazine inhibits rapid acrolein-induced protein oligomerization: Role of aldehyde-scavenging and adduct-trapping in cross-link blocking and cytoprotection” P. C. Burcham & S. M. Pyke, Mol. Pharmacol., 2006, 69, 1056-1065.

47.     “Synthesis of N-Benzylated-2-aminoquinolines as Ligands for the Tec SH3 Domain” S. R. Inglis, R. K. Jones, G. W. Booker and S. M. Pyke, Bioorg. Med. Chem. Lett., 2006, 16, 387-390.

46.     “Differences in lysine adduction by acrolein and methyl vinyl ketone: Implications for cytotoxicity in cultured hepatocytes” L. M. Kaminskas, S. M. Pyke & P. C. Burcham, Chem. Res. Toxicol., 2005, 18, 1627-1633.

45.     “Cycloaddition Reactions of 7-Benzylidenecycloocta-1,3,5-triene with Ethenetetracarbo-nitrile and 4-Phenyl-1,2,4-triazoline-3,5-dione” P. Clements, G. E. Gream, P. K. Kirkbride and S. M. Pyke, Helv. Chim. Acta, 2005, 88, 2003-2020.

44.     “Synthesis of 5-, 6- and 7-Substituted 2-Aminoquinolines as SH3 Domain Ligands” S. R. Inglis, R. K. Jones, D. Fritz, C. Stojkoski, G. W. Booker and S. M. Pyke, Org. Biomol. Chem., 2005, 3, 2543-2557.

43.     “Identification and Specificity Studies of Small-Molecule Ligands for SH3 Domains” S. R. Inglis, C. Stojkoski, K. M. Branson, J. F. Cawthray, D. Fritz, E. Wiadrowski, S. M. Pyke, and G. W. Booker, J. Med. Chem., 2004, 47, 5405-5417.

42.     “Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde” L. M. Kaminskas, S. M. Pyke and P. C. Burcham, Org. Biomol. Chem., 2004, 2, 2578-2584.

41.     “Strong Protein Adduct-Trapping Accompanies Abolition of Allyl Alcohol Hepatotoxicity by Hydralazine in Mice” L. M. Kaminskas, S. M. Pyke and P. C. Burcham, J. Pharm. Exp. Ther., 2004, 310, 1003-1010.

40.     “Protein adduct-trapping by hydrazinophthalazine drugs: Mechanisms of cytoprotection against acrolein-mediated toxicity” P. C. Burcham, F. R Fontaine, L. M Kaminskas, D. R. Petersen and S. M Pyke, Mol. Pharmacol., 2004, 65, 655-664. 

39.     “Reactivity with tris(hydroxymethyl)aminomethane confounds immunodetection of acrolein-adducted proteins” P. C. Burcham, F. R. Fontaine, D. R. Petersen and S. M. Pyke^, Chem. Res. Tox., 2003, 16, 1196-1201.

38.     “Complexation of Zinc(II) and Cadmium(II) by Hydroxyethyl- and Bis(hydroxyethyl)-1,4,7-triazacyclononane in Water” S. P. Creaser, S. M. Pyke and S. F. Lincoln, Aust. J. Chem., 2003, 56, 61-64.

37.     “Reaction of 5-nitrooctaethylporphyrins with nucleophiles” M. J. Crossley, L. G. King, S. M. Pyke and C. W. Tansey, J. Porphyr. Phthalocyanines, 2002, 6, 685-694.

36.     “Porphyrin building blocks:  Using a modified Barton-Zard approach to construct annulated pyrroles” K. D. Johnstone, W. A. Pearce and S. M. Pyke, J. Porphyr. Phthalocyanines, 2002, 6, 661-672.

35.     “Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products” P. C. Burcham, L. M. Kaminskas, F. R. Fontaine, D. R. Petersen and S. M. Pyke, Toxicology, 2002, 181-182, 229-236.

34.     “Hydralazine is an efficient scavenger of biogenic aldehydes” L. M. Kaminskas, P. C. Burcham, F. Fontaine and S. M. Pyke, Proc. Aust. Soc. Clin. Exp. Pharmacol. Toxicol., 2001, 9, 94.

Professional Associations

Member, Royal Australian Chemical Institute

Member, Royal Society of Chemistry

Member, Australian & New Zealand Society for Magnetic Resonance  

Director, Australian & New Zealand Society for Magnetic Resonance (2004-2009)

Expertise for Media Contact

Categories	Science and technology
Expertise	Chemistry
Notes	Alt phone: wk, (08) 8303 5365

Entry last updated: Sunday, 22 Nov 2009