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Associate Professor Stuart Brierley
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A/Prof Brierley is an NHMRC R.D Wright Biomedical Fellow and Head of the Visceral Pain Group, Discipline of Medicine, University of Adelaide located in the Centre for Nutrition and Gastrointestinal Diseases at the South Australian Health and Medical Research Institute (SAHMRI).
A/Prof Brierley is an international authority on the different afferent classes innervating the gut, the mechanotransduction channels underlying their function, the interaction of these channels with inflammatory mediators, and how this changes in acute and chronic pain. A/Prof Brierley has a proven track record in coordinating multi-faceted research programs for high-impact publications in journal such as Nature Communications, Nature Reviews Gastroenterology and Hepatology, Gastroenterology, Gut and The Journal of Neuroscience.
His recent collaborations with Industry partners identified the mechanism of pain relief of a new drug, linaclotide, in treating patient with Irritable Bowel Syndrome with Constipation (IBS-C). Linaclotide, a guanylate cyclase-C (GC-C) agonist is effective in relieving abdominal pain associated with IBS-C and is already available and registered for use by IBS-C patients in the USA and Europe.
A/Prof Brierley is the current South Australian State Representative of the Australasian Neuroscience Society, the Treasurer of the Australasian Neurogastroenterology and Motility Association (ANGMA) and a Node leader for the Adelaide Centre For Neuroscience Research. He was also a South Australian Tall Poppy recipient in 2011.
Bachelor of Science, Honours (1st Class), PhD.
Awards & Achievements
2012: NHMRC R.D Wright Biomedical Fellowship.
2011: South Australian 2011 Tall Poppy Science Awards.
2011: Invitation to the NHMRC 75th Anniversary Symposium, Canberra.
2007: NHMRC Australian Biomedical Fellowship.
2006: Hanson Institute New Investigator Award for Basic Research.
2005: GSK Research Young Investigator Award in the Biology of Functional Bowel Disorders.
RESEARCH OPPORTUNITIES ARE CURRENTLY AVAILABLE FOR MOTIVATED, OUTSTANDING APPLICANTS FOR HONOURS, MSC AND PHD POSITIONS:
1) TRP channels: Critical targets for the treatment of chronic visceral pain.
This project will investigate TRP channels in colonic sensory neurons, determine their mechano and chemosensory properties, and how their function changes across acute and chronic pain models. We will determine how TRP expression is altered in tissue from human patients with chronic visceral, thereby linking TRP levels with symptoms. Project funded by NHMRC Australia.
2) Other Projects: Several additional projects are available that we are happy to discuss with potential HDR students. These projects focus on other pain targets and are also funded by NHMRC Australia. Contact: firstname.lastname@example.org for details.
Techniques that students will perform include: electrophysiological afferent fibre recordings, patch clamp recordings, neuronal labeling, laser capture microdissection, QRT-PCR, tissue collection.
MOLECULAR MECHANISMS OF ABDOMINAL PAIN: CAUSES AND CURES.
For most people pain normally serves as an alarm that is activated in response to tissue damage. However, for people who suffer from chronic or long term pain, it does not subside and can in fact worsen over time. Clinically, chronic pain is a major unresolved worldwide problem.
A/Prof Brierley's research focuses on pain arising from the gut with particular emphasis on Irritable Bowel Syndrome (IBS). In Australia IBS effects up to 15% of the population and although chronic pain is debilitating and significantly reduces a patient's quality of life there is no effective treatment. This research determines the mechanisms responsible for detecting painful events in the gut and how they change during acute and chronic conditions. It is clear that certain mechanisms are reprogrammed during chronic pain, which fail to "reset" back to normal. Overall, understanding how these mechanisms are changed is the first step in finding new therapeutic treatments for gut based pain.
Key aspects of gut based pain are discussed in A/Prof Brierley’s talk at the “Research Tuesday” free public seminar series at the University of Adelaide. Please see link below.
2015-2018: NHMRC Project Grant APP#1083480. (AUS$873,233). Chief Investigators. A/Prof Stuart M Brierley, Dr Daniel Poole, Prof Martin Steinhoff. "Is abdominal discomfort a colonic itch?"
2014-2017: NHMRC Project Grant APP#1063803 (AUS$660,558). Chief Investigators: Prof Paul Alewood, Dr Stuart M Brierley. "Stable oxytocin analogues - potential treatment for irritable bowel syndrome"
2013-2015: NHMRC Project Grant #APP1049928. (AUS $665,267.85). Chief Investigators: Prof David Adams, Dr Stuart M Brierley, Prof David Craik. "GABA(B) Receptor Modulation of Gastrointestinal Function in Health and Disease by Alpha-Conotoxins"
2013-2015: NHMRC Project Grant #APP1049682. (AUS $351,173.55). Chief Investigators: Prof Nigel Bunnett, Dr Graeme Cottrell, Dr Stuart M Brierley. "Mechanisms of protease-driven visceral pain"
2012-2014: NHMRC Project Grant #APP1023972. (AUS $603,375). Chief Investigators: A/Prof Amanda Page, Prof L. Ashley Blackshaw, Prof Gary Wittert, Dr Stuart M. Brierley. "The role of adipokines in modulation of gastric vagal afferent satiety signals".
2011-2013: NHMRC Project Grant #APP1008100. (AUS $436,299). Chief Investigators: Dr Stuart M. Brierley, Prof L. Ashley Blackshaw, A/Prof Grigori Y. Rychkov. "Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity"
2010-2012: NHMRC Project Grant #626960. (AUS $548,026). Chief Investigators: Dr Stuart M. Brierley, Prof L. Ashley Blackshaw, Prof Gerald Holtmann. "Viscerosensory neuroimmune interactions".
2008-2010: NHMRC Project Grant #508103. (AUS $641,000). Chief Investigators: Prof L. Ashley Blackshaw, Dr Stuart M. Brierley, Dr Grigori Y. Rychkov, Prof Gerald Holtmann. "Transient receptor potential channels (TRPs) as transducers and targets in primary visceral afferents".
2006-2008: NHMRC Project Grant #399324. (AUS $602,250). Chief Investigators: Prof L. Ashley Blackshaw, Prof Simon Brookes, Dr Stuart M. Brierley, Dr Amanda J Page. "How does inflammation of the gut change its sensory innervation?"
2004-2006: NHMRC Project Grant #298942. (AUS $249,750). Chief Investigators: A/Prof L. Ashley Blackshaw, Dr Amanda J Page, Dr Stuart M. Brierley. "Mechanisms of mechanotransduction in primary visceral afferents".
1). Peer Reviewed journal articles:
1). Malsch P, Andratsch M, Vogl C, Link A, Alzheimer C, Brierley S.M, Hughes PA, and M Kress. (2014) Deletion of Interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechano-nociception and down-regulates TRPA1. Journal of Neuroscience, 2014 Jul 23;34(30):9845-56. (Impact factor 7.12).
2). Dantas de Araujo A, Mehdi Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan JJ, Lewis R.J, King G.F, Brierley S.M* & Alewood P.F*. Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications. (* Equal senior authorship). 2014 Jan 30;5:3165. doi: 10.1038/ncomms4165. (Impact factor 10.015). Received a Nature Reviews Gastroenterology & Hepatology highlights article.
3). Hughes P.A, Moretta M, Lim A, Grasby D.J, Bird D, Brierley S.M, Liebregts T, Adam B, Blackshaw L.A, Holtmann G, Bampton P, Hoffmann P, Andrews J.M, Zola H, Krumbiegel D.(2014). Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients. Brain Behavior and Immunity. 014 Jul 22. pii: S0889-1591(14)00391-2. Doi.
4). Hughes P.A, Castro J, Harrington A.M, Issacs NJ, Moretta M, Hick G.A, Urso D and Brierley S.M. (2014). Increased kappa-opioid receptor expression and function during chronic visceral hypersensitivity. Gut. 2014 Jul;63(7):1199-200. doi:. [Epub ahead of print. (Impact factor 10.73).
5). Castro J, Harrington A.M, Hughes P.A, Martin CM, Ge P, Shea CM, Jin H, Jacobson S, Hannig G, Mann E, Cohen MB, MacDougall JE, Lavins BJ, Kurtz CB, Silos-Santiago I, Johnston JM, Currie MG, Blackshaw LA and Brierley S.M (2013). Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic GMP. Gastroenterology 2013 Dec;145(6):1334-46.e1-11. doi: 10.1053/j.gastro.2013.08.017. Epub 2013 Aug 16. (Impact factor 12.81). Nature Reviews Gastroenterology & Hepatology highlights article.
6). Hughes PA, Harrington AM, Castro J, Liebregts T, Adam B, Grasby DJ, Issacs NJ, Maldeniya L, Martin CM, Persson J, Andrews JM, Holtmann GJ, Blackshaw LA and Brierley S.M. (2013). Sensory neuro-immune interactions differ between IBS subtypes. Gut. 2013 Oct;62(10):1456-65. doi: 10.1136/gutjnl-2011-301856. (Impact factor 10.73). Faculty 1000 Prime recommended manuscript. Nature Reviews Gastroenterology & Hepatology highlights article.
7). Harrington AM, Brierley S.M, Nicole J. Isaacs NJ, Young RL, LA. Blackshaw. (2013). Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology and Motility. 2013 Oct;25(10):e660-8. doi: 10.1111/nmo.12180. Epub 2013 Jul 12. [Epub ahead of print]. (Impact factor 2.94).
8). Kentish SJ, O'Donnell TA, Isaacs NJ, Young RL, Li H, Harrington AM, Brierley SM, Wittert GA, Blackshaw LA, Page AJ. (2013). Gastric vagal afferent modulation by leptin is influenced by food intake status.The Journal of Physiology. 2013 Apr 1;591(Pt 7):1921-34. doi: 10.1113/jphysiol. 2012.247577. (Impact factor 4.38).
9). Boakye PA, Brierley S.M, Pasilis SP, Balemba OB. (2012) Garcina buchanani bark extract is an effective anti-diarrheal remedy for lacotise-induced diarrhea. Journal of Ethnopharmacology. Jul 13;142(2):539-47. (Impact factor 3.32).
10). Harrington AM, Brierley S.M, Isaacs NJ, Hughes PA, Castro J and Blackshaw LA. (2012). Sprouting of colonic afferent central terminals and increased spinal MAP kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology. Jul 1;520(10):2241-55. (Faculty 1000 nominated publication). (Impact factor 3.66).
11). Boakye PA, Stenkamp-Strahm C, Bhattarai Y, Heckman MD, Brierley S.M, Pasilis SP and Balemba OB. (2012). 5-HT3 and 5-HT4 receptors contribute to the anti-motility effects of Garcinia buchananii bark extract in the guinea-pig distal colon. Neurogastroenterology & Motility, Jan;24(1):e27-40, Epub 2011 Nov 10. (Impact factor 2.94).
12). Brierley S.M, Castro J, Harrington AM, Hughes PA, Page AJ, Rychkov GY and Blackshaw LA. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. The Journal of Physiology. 2011 Jul 15;589(Pt 14):3575-93. Epub 2011 May 9. (Impact factor 4.38).
13). Harrington AM, Hughes PA, Martin CM, Yang J, Castro J, Isaacs NJ, Blackshaw LA and Brierley S.M. (2011). A novel role for TRPM8 in visceral afferent function. Pain. 152(7):1459-68. (Impact factor: 5.371). Received an editorial review in Pain.
14). Liebregts T, Adam B, Bredack C, Gururatsakul M, Pilkington KR, Brierley S.M, Blackshaw LA, Gerken G, Talley NJ & G Holtmann. (2011). Small bowel homing T cells are associated with symptoms and delayed gastric emptying in functional dyspepsia. American Journal of Gastroenterology. Jun;106(6) :1089-98. Epub 2011 Jan 18. (Impact factor 6.012).
15). Brierley S.M, Hughes PA, Page, AJ, Kwan K, Martin CM, O’Donnell TA , Cooper NJ, Harrington AM, Adam B, Liebregts T, Holtmann G, Corey DP, Rychkov GY & Blackshaw LA. (2009). TRPA1 mediates mechanotransduction in sensory neurons and is modulated by algesic stimuli. Gastroenterology. Dec;137(6):2084-2095.e3. Epub 2009 Jul 24. Impact factor: 12.1. (Faculty 1000 nominated publication).
16). *Hughes P.A, *Brierley S.M, Martin C.M, Brookes SJH, Linden D.R & Blackshaw L.A. (2009). Post-inflammatory colonic afferent sensitization: different subtypes, different pathways, and different time-courses. Gut. Oct;58(10):1333-41. Epub 2009 Mar 25. (* Equal first authorship). Impact factor: 10.015
17). Young RL, Sutherland K, Pezos N, Brierley SM, Horowitz MK, Rayner CK & Blackshaw LA. (2009). Expression of taste receptor molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut. 2009 Mar;58(3):337-46. Epub 2008 Nov 27. (Impact factor: 10.015).
18). Hughes PA, Brierley SM, Martin CM, Liebregts T, Adam B, Persson J, Holtmann G & LA Blackshaw (2008) TRPV1-expressing sensory fibres and IBS: links with immune function. Gut. Mar;58(3):465-6. Impact factor: 10.015)
19). Brierley SM, Page AJ, Hughes PA, Adam B, Liebregts T, Cooper N.J, Holtmann G, Liedtke W & L.A Blackshaw (2008). A selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology. Jun;134(7):2059-69. [Epub ahead of print] Jan 31. (Impact factor: 13.1).
20). Sipe W, Brierley SM, Martin CM, Phillis BD, Spreadbury I, Grady E.F, Liedtke W, Vanner S, Blackshaw L.A, & NW Bunnett. (2008). Transient Receptor Potential Vanilloid 4 Mediates Protease Activated Receptor 2-Induced Sensitization of Colonic Afferent Nerves and Mechanical Hyperalgesia. American Journal of Physiology, GI and Liver Physiology. May;294(5): G1288-98. Epub 2008 Mar 6. (Impact factor: 3.681).
21). Lindström E, Brusberg M, Hughes P.A, Martin C.M Brierley S.M, Phillis B.D, Martinsson R, Abrahamsson C, Larsson H, Martinez V & L.A Blackshaw. (2007). Involvement of metabotropic glutamate 5 receptor in visceral pain. Pain. Jul 15;137(2):295-305. Epub 2007 Oct 15. (Impact factor: 4.309).
22). Page A.J, Slattery J.A, Brierley S.M, Jacoby A.S & L.A Blackshaw (2007). Involvement of Galanin receptors 1 and 2 in the modulation of mouse vagal afferent mechanosensitivity. The Journal of Physiology,. 583: 675-684 (Impact factor: 4.4).
23). Page AJ, *Brierley SM, Martin CM, Hughes PA, & L.A Blackshaw (2007). Acid sensing ion channels required for inhibition of afferent mechanosensitivity by benzamil. Pain. Dec 15;133(1-3):150-60. Epub 2007 Apr 27. (Impact factor 4.309).
24). Page A.J, Slattery J.A, Milte C, Laker R, O’Donnell T, Dorian C.L, Brierley S.M, & L.A Blackshaw (2007). Ghrelin selectively reduces mechanosensitivity of upper gastrointestinal vagal afferents. GI and Liver Physiology. 292(5):G1376-84. (Impact factor: 3.47).
25). *Hughes P.A, *Brierley S.M, Young, R.L & L.A Blackshaw (2007). Localization and comparative analysis of acid sensing ion channel (ASIC1, 2 and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. , 500, 863-875. (* Equal first authorship). (Impact factor 3.7).
26). Slattery J.A, Page A.J, Dorian C.L, Brierley S.M, & L.A Blackshaw (2006). Potentiation of vagal afferent mechanosensitivity by ionotropic and metabotropic glutamate receptors. The Journal of Physiology,, 577(1):295-306. (Impact factor: 4.4).
27). Brierley S.M, Jones III R.C.W, Xu L, Gebhart G.F & L.A Blackshaw (2005). Activation of splanchnic and pelvic colonic afferents by bradykinin in mice. Neurogastroenterology & Motility, 17(6) 854-862. (Impact factor: 3.0).
28). Brierley S.M, Jones III R.C.W, Xu L, Robinson D.R, Hicks G.A, Gebhart G.F & L.A Blackshaw (2005). Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice. The Journal of Physiology, 567(1) 267-281. (Impact factor: 4.4).
29). *Page A.J, *Brierley S.M, Martin C.M, Price M.P, Wemmie J.A, Symonds E, Butler R, & L.A Blackshaw (2005). Different contributions of ASIC channels 1a, 2 and 3 in gastrointestinal mechanosensory function. Gut, 54(10) 1408-1415 (* Equal first authorship). (Impact factor: 10.09).
30). *Page A.J, *Brierley S.M, Martin C.M, Martinez-Salgado C, Wemmie J.A, Brennan T.J, Symonds E, Omari T, Lewin G.R, Welsh M.J & L.A Blackshaw (2004). The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology, 127, 1739–1747. (* Equal first authorship)(Impact factor: 13.1).
31). Brierley S.M, Jones III R.C.W, Gebhart G.F & L.A Blackshaw (2004). Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice. Gastroenterology, 127(1), 166-178. (Impact factor: 13.1).
32). Brierley S.M, Nichols K, Grasby D.J and S.A. Waterman. (2001). Neural mechanisms underlying migrating motor complex formation in mouse isolated colon. British Journal of Pharmacology, 132, 507-517. (Impact factor: 3.889). e**- Of Outstanding Interest (Evaluations come from Current Opinion Journals.
2) Invited Reviews (Peer Reviewed):
33). Brierley S.M and D.R Linden (2014). Neuroplasticity and dysfunction after gastrointestinal inflammation. Nature Reviews Gastroenterology and Hepatology. 2014 Jul 8. doi: 10.1038/nrgastro. 2014.103. [Epub ahead of print]. (Impact factor: 10.25).
34). Blackshaw LA and Brierley S.M (2013). Emerging receptor target in the pharmacotherapy of irritable bowel syndrome with constipation. Expert Review of Gastroenterology & Hepatology, July 2013, Vol. 7, No. 5s1, Pages 15-19.
35). Brierley S.M (2012). Guanylate cyclase-C receptor activation: unexpected biology. Current Opinion in Pharmacology. Special edition. 2012 Dec;12(6):632-40. (Impact factor: 7.15).
36). Brierley S.M, Kelber O. (2011). Use of natural products in gastrointestinal therapies. Current Opinion in Pharmacology. Special edition. 2011 Dec;11(6):604-11. Epub 2011 Oct 11. (Impact factor: 7.15).
37). Brierley S.M, Hughes P.A, Harrington A.M, Rychkov G.R and L.A Blackshaw (2010). Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals, Special Edition, 3, 2768-2798.
38). Brierley S.M. (2010). Molecular basis of mechanosensitivity. Autonomic Neuroscience; Basic and Clinical, Special Edition, Volume 153, Issues 1-2, 16 February 2010, Pages 58-68.
39). Blackshaw LA, Brierley S.M & Hughes PA. (2010). TRP channels: new targets for visceral pain. Gut. Jan;59(1):126-35.
40). Hughes PA, Brierley S.M & Blackshaw LA. (2009). Post-inflammatory modification of colonic afferent mechano-sensitivity. Clinical and Experimental Pharmacology and Physiology. Oct;36(10):1034-40. Epub 2009 Jun 29.
3) Invited Editorials (Peer Reviewed):
41). Blackshaw LA, Brierley S.M, Hughes PA, Harrington A.M. (2011). “The hot mustard receptor’s role in gut motor function”. Gastroenterology. 2011 Aug;141(2):423-7. Epub 2011 Jun 22. (Impact factor: 12.81).
42). Brierley S.M (2010). “Visualising vagal afferent neurons and their terminals whilst silencing TRPV1”. Perspectives article. Journal of Physiology. Nov 1;588(Pt 21):4069-70.
43). Brierley S.M (2010). “All ahead stop! How intestinal motility adapts to cope with inflammation induced ulceration”. Perspectives article. The Journal of Physiology. Mar 1;588(Pt 5):753-4. Journal of Physiology: A*.
44). L.A. Blackshaw & Brierley S.M (2010). “Highlights in Autonomic Neuroscience”. Autonomic Neuroscience: Basic and Clinical. Jan 15;152(1-2):1-3. Epub 2009 Dec 4.
4) Book Chapters:
45). Andrews, JM, Brierley S.M and L.A Blackshaw (2013). “Small Intestinal Motor and Sensory Function and Dysfunction”. Sleisenger and Fordtran's Gastrointestinal and Liver Disease”.
46). Blackshaw L.A, Brierley S.M, Harrington A.M, and Hughes PA (2013). ‘TRP channels in visceral pain’. The Open Pain Journal. 6, (Suppl 1: M4) 23-30.
47). Hughes P.A, Brierley S.M, Castro J, Harrington AM and Blackshaw LA (2012). “Experimental Models of Colitis”. Arpad Szallasi and Tamás Bíró (eds.), TRP Channels in Drug Discovery: Volume II, Methods in Pharmacology and Toxicology, DOI 10.1007/978-1-62703-095-3_23
48). Brierley S.M, Hughes P.A & Harrington A.M, Blackshaw L.A. “Innervation of the Gastrointestinal Tract by Spinal and Vagal Afferent Nerves” . In: LR Johnson (Editor-In-Chief) Physiology of the Gastrointestinal Tract. 5th edition. Elsevier Academic press. 2012. pp. 703-732.
49). Brierley S.M & Blackshaw L.A, (2006). In: Pasricha J, Willis W, and Gebhart G (eds.) Chronic Abdominal and Visceral Pain: Theory And Practice. The Neurobiology of Visceral Nociceptors. Section II, Chapter 3. Taylor & Francis, New York
50). Brierley S.M, Coldwell J.R, Cooper N.J, Howarth G.S and Blackshaw L.A. (2003). Colonic spinal primary afferents: anatomical, histochemical, mechanosensory and chemosensory subtypes and effects of inflammation. In G. Holtmann, N. Talley (Eds.) Gastrointestinal inflammation and disturbed gut function. Kluwer, Dordrecht, 2003;120-125.
1). Channel 7 News, Adelaide. April 19th 2011.
1). ABC 891 Adelaide. “Afternoons with Carole Whitelock”. April 19th 2011. 1.45PM, Duration: 4.15 mins.
2). ABC 891 Adelaide. “Main news of the day with State News Editor Mr Rick Keegan 19/04/2011 5:06 PM, Duration: 0.43 mins.
3). ABC 891 Adelaide. “Main news of the day with State News Editor Mr Rick Keegan 19/04/2011 6:07 PM, Duration: 0.32 mins.
4). Radio Adelaide. “Breakfast with Jess Wingard”. April 27th 2011. 7:42 AM, Duration: 6.18 mins.
5). ABC Newcastle. “Mornings with Helen Clare”. April 27th 2011. 9.12AM, Duration: 9.45 mins.
6) 3AW Melbourne. “Mornings with Neil Mitchell”. February 24th 2012. 1045am, duration 5 mins.
1). The Advertiser, Adelaide, Australia “Gutsy pair hailed for their finds”, August 26, 2011.
2). The Advertiser, Adelaide, Australia. “Hanson Institute Award Winners”. 2006.
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