Dr Tina Bianco-Miotto

Telephone	+61 8 8222 3057
Position	W Bruce Hall Cancer Research Fellow
Email	tina.bianco@adelaide.edu.au
Fax	+61 8 8222 3217
Building	Hanson Institute
Floor/Room	4 16
Campus	Institute of Medical & Veterinary Science
Org Unit	Medicine

To link to this page, please use the following URL:
http://www.adelaide.edu.au/directory/tina.bianco

Biography/ Background

EDUCATION
1993-1996 Bachelor of Science, University of Adelaide, SA, Australia

1997 Bachelor of Health Sciences (Honours), University of Adelaide, SA, Australia

1998-2002 Doctor of Philosophy, University of Adelaide, SA, Australia

PAST APPOINTMENTS
2002-2003 Research Officer & Visiting Research Fellow, Department of Surgery, Royal Adelaide Hospital & University of Adelaide

2003-2004 Postdoctoral Fellow, Discipline of Medicine, University of Adelaide

2005-2009 NHMRC Peter Doherty Fellow, Discipline of Medicine, University of Adelaide

PRESENT APPOINTMENT

2009- W Bruce Hall Cancer Research Fellow, Cancer Council SA, Discipline of Medicine, University of Adelaide

Publications

Peters AA, Buchanan G, Ricciardelli C, Bianco-Miotto T, Centenera MM, Harris JM, Jindal S, Segara D, Jia L, Moore NL, Henshall SM, Coetzee GA, Sutherland RL, Butler LM, Tilley WD. Androgen receptor inhibits genomic activity of estrogen receptor-alpha and is prognostic for breast cancer outcome. Cancer Res. 2009. 69:6131-40.
Bianco-Miotto T, Hussey DJ, Day TK, O-Keefe DS, Dobrovic A. DNA methylation of the ABO promoter underlies loss of ABO allelic expression in a significant proportion of leukemic patients. PLoS One. 2009. 4(3):e4788.
Chiam K, Tilley WD, Butler LM, Bianco-Miotto T. The dynamic and static modification of the epigenome by hormones: a role in the developmental origin of hormone related cancers. Biochim Biophys Acta - Reviews on Cancer. 2009. 1795: 104-109.
Cops EJ, Bianco-Miotto T, Moore NL, Clarke CL, Birrell SN, Butler LM, Tilley WD. Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors. J Steroid Biochem Mol Biol. 2008. 110:236-43.
Marrocco DL, Tilley WD, Bianco-Miotto T, Evdokiou A, Scher HI, Rifkind RA, Marks PA, Richon VM, Butler LM. Suberoylanilide hydroxamic acid (SAHA; vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation. Mol Cancer Ther. 2007. 6:51-60.
Buchanan G, Birrell SN, Peters AA, Bianco-Miotto T, Ramsay K, Cops EJ, Yang M, Harris JM, Simila HA, Moore NL, Bentel JM, Ricciardelli C, Horsfall DJ, Butler LM, Tilley WD. Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate. Cancer Res. 2005. 65:8487-96.
Smith E*, Bianco-Miotto T*, Drew P, Watson D. Method for optimizing methylation-specific PCR. BioTechniques. 2003. 35:32-33. (*Joint first authors).
Dobrovic A, Bianco T, Tan LW, Sanders T, Hussey D. Screening for and analysis of methylation differences using methylation-sensitive single-strand conformation analysis. Methods. 2002. 27:134-8.
Tan LW, Bianco T, Dobrovic A. Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer. Carcinogenesis. 2002. 23:231-6.
Bianco T, Farmer BJ, Sage RE, Dobrovic A. Loss of red cell A, B, and H antigens is frequent in myeloid malignancies. Blood. 2001. 97:3633-39.
Bianco T, Chenevix-Trench G, Walsh DC, Cooper JE, Dobrovic A. Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer. Carcinogenesis. 2000. 21:147-51.
Butler LM, Dobrovic A, Bianco T, Cowled PA. Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma. Br J Cancer. 2000. 82:131-5.
Bianco T, Hussey D, Dobrovic A. Methylation-sensitive, single-strand conformation analysis (MS-SSCA): A rapid method to screen for and analyze methylation. Hum Mutat. 1999. 14:289-93.

Entry last updated: Tuesday, 3 Nov 2009

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