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MAILES
Royal Adelaide Hospital
Level 6, Room EH6-45
Eleanor Harrald Building
THE UNIVERSITY OF ADELAIDE
SA 5005 AUSTRALIA
Email

Telephone: +61 8 8222 4705
Facsimile: +61 8 8223 3870

 

The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study

 

Overview l Aims l Chief Investigators l Publications l Funding / Partnerships l Research Areas l Collaborate l Contact Us

 

Overview

The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study was conceived in 2009 to investigate the effect of sex steroids, inflammation, environmental and bio psychosocial factors on cardio-metabolic disease risk in men.

The study was the union of two existing cohort studies: all participants of the Florey Adelaide Male Ageing Study (FAMAS) and male participants of the North West Adelaide Health Study (NWAHS). Both the FAMAS and NWAHS are representative longitudinal adult cohort studies.

The MAILES study comprises:

  • all FAMAS participants - FAMAS commenced in 2002 and at baseline, recruited 1195 men aged between 35 and 80 years with a response rate of 45.1% (FAMAS publications);
  • and a sub-set of NWAHS men who were aged 35 to 80 years of age at baseline and randomly selected from the population of the northern and western suburbs of Adelaide - NWAHS commenced in 1999 and recruited 4056 adults aged 18 years and over, with a baseline response rate of 49.4%; of these, 1389 men aged 35-80 at baseline have been included in the MAILES study (NWAHS publications).

The MAILES study is based on three matched stages so far:

  • Part 1 (MAILES1) is data collected by FAMAS at participants' baseline biomedical examination (Phase A 2002-03 and Phase B 2004-05) and NWAHS at the first follow-up biomedical examination (Stage 2 2004-06);
  • Part 2 (MAILES2) is follow-up biomedical examination data (FAMAS Phase A 2007-08 & Phase B 2009-10; and NWAHS Stage 3 2008-10); and
  • Part 3 (MAILES3) is data collected from a Computer Assisted Telephone Interviewing (CATI) survey in August 2010.

Aims

The study aims to assess the:

  • Relationships between obesity, inflammation and sex-steroids, and those of
  • Obesity, sex steroids and inflammation with cardiovascular disease and type 2 diabetes mellitus cross-sectionally and over time,
  • Effect of the modifying factors shown in Fig 1, on the independent variables (obesity, sex steroids, and inflammation) and their relationship with cardiovascular disease and type 2 diabetes mellitus,
  • Direct effect of the modifying variables on cardiovascular disease and/or type 2 diabetes mellitus
  • Clustering of variables in determining cardiovascular disease and type 2 diabetes mellitus,
  • Pathways of different variables in determining cardiovascular disease.

Figure 1: Working research model depicting the major relationships to be examined 

1. The relationship between sex steroids & markers of inflammation and cardiovascular (CV) events and type 2 diabetes mellitus (T2DM). 2. To what extent is 1. mediated by both traditional (above the line in each box) and promising novel (below the line in each box) effect modifiers. 3. Using prospective data, examine the direction, relative influence and temporal sequence of 2. in predicting 1.


News and Events 

An article based on a paper presented at Endo 2012 was recently published in the August 2012 edition on Endocrine News titled 'Low Testosterone Is Not a Natural Result of Aging'.