Institute for Molecular Pathology

• Institute Members, Collaborators and Resources
• Key Researchers
• Selected Publications
• Contact Details
• Further Information

The University of Adelaide has recently approved the formation in 2011 of the Institute of Molecular Pathology (IMP) that will be a collaborative initiative involving research groups located in the University of Adelaide Faculties of Sciences and Health Sciences, and SA Pathology (Institute of Medical and Veterinary Sciences), including groups based at the Women’s and Children’s Hospital. Headquartered in the University’s School of Molecular & Biomedical Science, the IMP will be a centre of excellence in molecular pathology research, globally recognised for its important contributions to a better understanding of the molecular basis of diseases and bacterial infections. The IMP will play a leading role in translating its research findings to reduce the burden of disease in society, and a leading role in post-graduate education.

The IMP will bring together high profile laboratories in molecular and cell biology, human genetics, biochemistry, bacteriology and chemistry in a highly collaborative and interdisciplinary manner, in order to develop novel technologies and share successful experiences to solve common problems in the pipeline from gene discovery to diagnosis, prevention and treatment of significant human diseases. The Institute will have a strong inter- and cross disciplinary emphasis, being composed of researchers who have a diversity of research backgrounds including genetics, biochemistry, chemistry, microbiology, immunology, biomedicine, proteomics, bioinformatics and cell and cancer biology.

The Institute’s activities will be grouped around interlinking translational research themes that build on established platforms and assets and are aligned with National Research Priorities. These include:

• Molecular mechanisms and pathways of pathogenesis
• Biological markers of pathogenesis and application to diagnostics
• Chemical modifiers of pathogenesis and application to therapeutics
• Bacterial infection pathogenesis, target discovery and effective vaccine interventions
• New detection, sensing and analysis platforms for molecular pathology

School of Molecular & Biomedical Science

School of Chemistry & Physics

• Small molecule synthesis, protein ligand interactions, research translation
• Chemistry, protein structure, function and interaction

SA Pathology

Centre for Cancer Biology

Cell signaling Stem cells Regulatory RNAs and microRNAs in metastasis Programmed cell death Cancer cell biology, growth factors, inflammation

Cancer therapy Transcriptional mechanisms and molecular pathogenesis in autoimmunity and haematological malignancies Familial predisposition to cancer Cancer progression and drug response

Women's and Children's Hospital

X-linked mental retardation, disease gene discovery Lysosomal storage diseases, lysosomes, research translation

Hanson Institute

Musculoskeletal pathology Neuropathology

Adelaide Proteomics

• Mass Spectrometry
• Protein Indentification
• Biomolecule mass measurement
• 2D Electrophoresis
• Edman sequencing

Adelaide Microscopy

Professor Andrew Abell Professor Chemistry Fellow Royal Australian Institute of Chemistry	Expertise: Small molecule synthesis, protein ligand interactions, research translation Affilitation: University of Adelaide Publications: 125 Citations: 1,329 h-Index 17

Professor Dave Adelson Head, School Molecular & Biomedical Sciences

Expertise: Bioinformatics, comparative genomics Affilitation: University of Adelaide Publications: 42 Citations: 461 h-Index 11

Associate Professor Michael Beard NHMRC Senior Research Fellow Head Hepatitis C Virus Research Laboratory

Expertise: Molecular virology, host response to viral infection, genomics Affilitation: University of Adelaide Publications: 35 Citations: 1,326 h-Index 14

Associate Professor Grant Booker Associate Professor Biochemistry

Expertise: Protein structure, function and interaction, drug design Affilitation: University of Adelaide Publications: 38 Citations: 1,362 h-Index 15

Professor John Carver Deputy Executive Dean, Faculty of Sciences Professor of Chemistry

Expertise: Protein structure, function and interaction, protein chemistry Affilitation: University of Adelaide Publications: 123 Citations: 3,439 h-Index 35

Professor Jozef Gecz NHMRC Principal Research Fellow

Expertise: X-linked mental retardation, disease gene discovery Affilitation: SA Pathology & WHC Publications: 137 Citations: 2,771 h-Index 29

Associate Professor Greg Goodall Head, Cytokine Research Lab Affiliate Associate Professor University of Adelaide

Expertise: Regulatory RNAs and microRNAs in metastasis Affilitation: SA Pathology Publications: 62 Citations: 2,646 h-Index 28

Dr Peter Hoffman Director, Adelaide Proteomics Centre

Expertise: Proteomics, mass spectrometry, biomarker discovery Affilitation: University of Adelaide Publications: 25 Citations: 241 h-Index 8

Professor John Hopwood Head, Lysosomal Diseases Research Unit Affiliate Professor, University of Adelaide Officer of the Order of Australia Australian Academy of Science Fellow SA Scientist of the Year

Expertise: Lysosomal storage diseases, lysosomes, neurodegeneration, research translation Affilitation: SA Pathology Publications: 383 Citations: 6,451 h-Index 39

Associate Professor Allison Jilbert Head, Hepatitis Virus Research Group Core Laboratory Leader, Australian Centre for Hepatitis Virology Inc Group Leader, Australian Centre for HIV & Hepatitis Virology Co-convener, Adelaide Liver Research Group

Expertise: Virus pathogenesis, Hepadnaviruses and liver disease, antiviral Affilitation: University of Adelaide Publications: 68 Citations: 1,411 h-Index 23

Professor James Paton NHMRC Australia Fellow Director, Research Centre for Infectious Diseases NHMRC 10 Best Minds

Expertise: Bacterial pathogenesis, virulence genes, bacterial toxins, vaccines Affilitation: University of Adelaide Publications: 250 Citations: 9,134 h-Index 53

Professor Robert Richards Head, Discipline of Genetics Fellow of the Human Genetics Society of Australasia

Expertise: Fragile X Syndrome, Huntington's Disease, fragile sites in cancer Affilitation: University of Adelaide Publications: 173 Citations: 10,073 h-Index 48

Professor Hamish Scott Head, Department of Molecular Pathology NHMRC Senior Research Fellow

Expertise: Transcriptional mechanisms and molecular pathogenesis in autoimmunity and haematological malignancies Affilitation: SA Pathology Publications: 151 Citations: 4,769 h-Index 37

Professor John Wallace Professor of Biochemistry ARI Impact Award

Expertise: Biotin proteins, insulin-like growth factors Affilitation: University of Adelaide Publications: 209 Citations: 5,253 h-Index 38

Associate Professor Murray Whitelaw Associate Professor of Biochemistry

Expertise: Hypoxia and stress response genes Affilitation: University of Adelaide Publications: 50 Citations: 3,228 h-Index 28

Our world-class researchers are making an impact in their fields and the world with consistently high quality publications.

Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR, Dewor M, Georgiev I, Schober A, Leng L, Kooistra T, Fingerle-Rowson G, Ghezzi P, Kleemann R, McColl SR, Bucala R, Hickey MJ, Weber C. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
May 2007 Nat Med. 13, No.5, 587-96

Comerford I, Nibbs RJ, Litchfield W, Bunting M, Harata-Lee Y, Haylock-Jacobs S, Forrow S, Korner H, McColl SR. The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses Jun 18 2010 Blood  [Epub ahead of print]

C Shoubridge, PS Tarpey, F Abidi, SL Ramsden, S Rujirabanjerd, JA Murphy, J Boyle, M Shaw, A Gardner, A Proos, H Puusepp, F L Raymond, CE Schwartz, RE Stevenson, G Turner, M Field, RS walikonis, RJ Harvey, A Hackett, PA Futreal, MR Stratton & J Gécz Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability 2010 Nature Genetics 42, No. 6, 486-488

Adelson, DL, Raison, JM & Edgar, RC. Characterization and distribution of retrotransposons and simple sequence repeats in the bovine genome. 2009 PNAS, 106 No. 31, 12855-12860

Robertson AL, Headey SJ, Saunders HM, Ecroyd H, Scanlon MJ, Carver JA and Bottomley SP Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation. 2010 PNAS 107, No. 23, 10424-10429

*Byres, E., *Paton, A.W., Paton, J.C., Löfling, J.C., Smith, D.F., Wilce, M.C.J., Talbot, U.M., Chong, D.C., Yu, H., Huang, S., Chen, X., Varki, N.M., Varki, A., Rossjohn, J., and Beddoe, T. Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. 2008 Nature, 456: 648-652. [* joint 1st authors]

Rotin D, Kumar S Physiological functions of the HECT family of ubiquitin ligases. 2009 Nature Rev. Mol. Cell Biol. 10: 398-409.

Alimohammadi M, Bjorklund P, Hallgren A, Pontynen N, Szinnai G, Shikama N, Keller MP, Ekwall O, Kinkel SA, Husebye ES, Gustafsson J, Rorsman F, Peltonen L, Betterle C, Perheentupa J, Akerstrom G, Westin G, Scott HS, Hollander GA, Kampe O Autoimmune polyendocrine syndrome type 1 and NALP5, parathyroid autoantigen. 2008, New England Journal of Medicine 358:1018-102

Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y, Goodall GJ. The microRNA-200 family and miR-205 regulate epithelial-mesenchymal transition by targeting the E-cadherin repressors, ZEB1 and SIP1. 2008, Nature Cell Biol. 10;593-601

Dibbens LM, Tarpey PS, Hynes K, Bayly MA, Scheffer IE, Smith R, Bomar J, Sutton E, Vandeleur L, Shoubridge C, Edkins S, Turner SJ, Stevens C, O'Meara S, Tofts C, Barthorpe S, Buck G, Cole J, Halliday K, Jones D, Lee R, Madison M, Mironenko T, Varian J, West S, Widaa S, Wray P, Teague J, Dicks E, Butler A, Menzies A, Jenkinson A, Shepherd R, Gusella JF, Afawi Z, Mazarib A, Neufeld MY, Kivity S, Lev D, Lerman-Sagie T, Korczyn AD, Derry CP, Sutherland GR, Friend K, Shaw M, Corbett M, Kim HG, Geschwind DH, Thomas P, Haan E, Ryan S, McKee S, Berkovic SF, Futreal PA, Stratton MR, Mulley JC, Gécz J. X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. 2008, Nature Genetics 40, 776-81

Benko S, Fantes JA, Amiel J, Kleinjan D, Thomas S, Ramsay J, Jamshidi N, Essafi A,Heaney S, Gordon CT, McBride D, Golzio C, Fisher M, Perry P, Abadie V, Ayuso C, Holder-Espinasse M, Kilpatrick N, M Lees MM, Picard A, Temple IK, Thomas PQ, Vazquez M, Vekemans M, Crollius HR, Hastie ND, Munnich A, Etchevers H, Pelet A, Farlie PG, FitzPatrick DR, Lyonnet S. Highly conserved non-coding elements on either side of the SOX9 gene is associated with Pierre Robin sequence. 2009, Nature Genetics 41, 359-64.

Henshall TL, Tucker B, Lumsden AL, Nornes S, Lardelli MT, Richards RI. Selective neuronal requirement for huntingtin in the developing zebrafish. 2009, Hum Mol Genet 18(24):4830-42

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Email: enquries.dvcr@adelaide.edu.au
Telephone: +61 8 8303 3278
Facsimile: +61 8 8303 4409

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