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North Terrace Campus
Level 4, Molecular Life Sciences
The University of Adelaide
SA 5005
AUSTRALIA
Renato Morona

Telephone: +61 8 8303 4151
Facsimile: +61 8 8303 7532

Referred publications since 1997.

  1. Ogunniyi, A.D., Kotlarski, I., Morona, R., and Manning, P.A.  (1997) “Role of the SefA subunit protein of SEF14 fimbriae in the pathogenesis of Salmonella enterica serovar Enteriditis”. Infect. Immun. 65: 708-717.

  2. Morona, J.K., Morona, R., and Paton, J.C. (1997) “Analysis of the genes encoding biosynthesis of type 19F capsule from Streptococcus pneumoniae”. Mol. Microbiol. 23: 751-763.

  3. Baker, S.J, Daniels, C., and Morona, R.  (1997) “Identification of PhoP/Q regulated genes in Salmonella typhi: identification of melittin sensitive mutants”. Microb. Pathogen. 22: 165-179.

  4. Van Den Bosch, L., Manning, P.A., and Morona, R. (1997) “Regulation of O-antigen chain length is required for Shigella flexneri virulence”. Mol. Microbiol. 23: 765-775

  5. Paton, J.C., Morona, J.K., and Morona, R. (1997) “Characterisation of the capsular polysaccharide biosynthesis locus of Streptococcus pneumoniae type 19F”. Microbial Drug Resistance 3: 89-99.

  6. Morona, J.K., Morona, R., and Paton, J.C. (1997) “Molecular and genetic characterisation of the capsular biosynthesis genes Streptococcus pneumoniae type 19B capsule”. J. Bacteriol. 179: 4953-4958.

  7. Mavris, M., Manning, P.A., and Morona, R. (1997) “Mechanism of bacteriophage SfII mediated serotype conversion in Shigella flexneri”. Mol. Microbiol. 26: 939-950.

  8. Coffey, T.J., Enright, M.C., Daniels, M., Morona, J.K., Morona, R., Hryniewicz, V., Paton, J.C., and Spratt, B.G. (1998) “Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae”. Mol. Microbiol. 27: 73-84.

  9. Daniels, C., Vindurampulle, C., and Morona, R. (1998) “Overexpression and topology of the Shigella flexneri O-antigen polymerase (Rfc/Wzy)”. Mol. Microbiol. 28: 1211-1222

  10. Baker, S.J., Gunn, J.S. and Morona, R. (1999) “The Salmonella typhi melittin resistance gene pqaB affects intracellular growth in PMA-differentiated U937 cells, polymyxin B resistance, and lipopolysaccharide.” Microbiol. 145: 367-378

  11. Morona, J.K., Miller, D.C., Coffey, T.J., Vinurampulee, C.J., Spratt, B.G., Morona, R., and Paton, J.C. (1999) “Molecular and genetic characterisation of the capsule biosynthesis locus of Streptococcus pneumoniae type 23F.” Microbiol. 145: 781-789

  12. Morona, J.K., Morona, R. and Paton, J.C. (1999) “Analysis of the 5’ portion of the type 19A capsule locus identifies two classes of cpsC, cpsD and cpsE genes in Streptococcus pneumoniae.” J. Bacteriol. 181: 3599-3605

  13. Chua, J. E.H., Manning, P.A., and Morona, R. (1999) “The Shigella flexneri bacteriophage Sf6 tailspike protein (TSP)/endorhamnosidase is related to the bacteriophage P22 TSP and has a motif common to exo- and endoglycanases, and C-5 epimerases.” Microbiol. 145: 1649-1659.

  14. Morona, J.K, Morona, R., and Paton, J.C. (1999) “Comparative genetics of capsular polysaccharide biosynthesis in Streptococcus pneumoniae types belonging to serogroup 19” J. Bacteriol. 181: 5355-5364.

  15. Daniels, C., and Morona, R. (1999) “Analysis of Shigella flexneri Wzz (Rol) function by mutagenesis and cross-linking: Wzz is able to oligomerise.” Mol. Microbiol. 34: 181-194.

  16. Morona, R., Van Den Bosch, L., and Daniels, C. (2000) “Evaluation of Wzz/MPA1/MPA2 proteins based on the presence of coiled-coil regions.” Microbiol. 146: 1-4.

  17. Morona, J.K., Paton, J., Miller, D., and Morona, R. (2000) “Tyrosine phosphorylation of CpsD negatively regulates capsule polysaccharide production in Streptococcus pneumoniae. ” Mol. Microbiol. 35: 1431-1442

  18. Paton, A. W., Morona, R., and Paton, J.C. (2000). “Recombinant bacteria expressing a Shiga toxin receptor analogue: a novel biological agent for treatment of Shiga toxigenic Escherichia coli infections in humans. Proceedings of the European Union Concerted Action (CT98-3935) Conference on "Pathogenicity and Virulence of Verocytotoxigenic E. coli." G. Duffy, P. Garvey, D.A. McDowell, Y. Wasteson and J. Coia. (2000).( Eds.) Universite de Liège, Belgium, 8-10th November 1999. ISBN 1 84170 103 3

  19. Paton, A., Morona, R., and Paton, J.C. (2000) “A novel biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans.” Nature Medicine 6: 265-270

  20. Paton, J.C., Rodgers, T.J., Morona, R., and Paton, A.W. (2001) “Oral administration of formaldehyde-killed recombinant bacteria expressing a mimic of the shiga toxin receptor protects mice from fatal challenge with Shiga-toxigenic Escherichia coli.” Infect. Immun. 69: 1389-1393.

  21. Paton, A.W., Morona, R., and Paton, J.C. (2001) “Neutralisation of Shiga toxins Stx1, Stx2c and Stx2e by recombinant bacteria expressing mimics of globotriose and globotetraose.” Infect. Immun. 69: 1967-1970.

  22. Morona, J.K. Morona, R., Miller, D.C., and Paton, J.C. (2002) “The Streptococcus pneumoniae capsule biosynthesis protein CpsB is a novel manganese-dependent phosphotyrosine-protein phosphatase.” J. Bacteriol. 184: 577-583.

  23. Ogunniyi, A., Kotlarski, I., Morona, R., and Manning, P. (2002) “Epitope analysis of the FanC subunit protein of the K99 (F5) fimbriae of enterotoxigenic Escherichia coli using a recombinant fusion technique.” FEMS Immunol. Med. Microbiol. 34: 23-31.

  24. Freiberg, A., Morona, R., Van Den Bosch, L., Jung, C., Behlke, J., Carlin, N, Seckler, R., and Baxa, U. (2003) “The tailspike protein of Shigella phage Sf6: A structural homolog of Salmonella phage P22 tailspike without sequence similarity in the b-helix domain.” J. Biol. Chem. 278: 1542-1548

  25. Murray, G.L., Attridge, S.R., and Morona, R. (2003) “Regulation of Salmonella typhimurium lipopolysaccharide O antigen chain length is required for virulence; identification of FepE as a second Wzz.” Mol. Microbiol. 47: 1395-1406.

  26. Morona, R., Daniels, C., and Van Den Bosch, L. (2003) “Genetic modulation of Shigella flexneri 2a lipopolysaccharide O antigen modal chain length reveals that it has been optimised for virulence.” Microbiology, 49: 925-939

  27. Morona, J.K., Morona, R., Miller, D.C., and Paton, J.C. (2003) "Mutational analysis of the carboxy-terminal [YGX]4 repeat domain of CpsD, an autophosphorylating tyrosine kinase required for capsule biosynthesis in Streptococcus pneumoniae." J. Bacteriol. 185: 3009-3019.

  28. Morona, R., and Van Den Bosch, L. (2003) "Lipopolysaccharide O antigen chains mask IcsA(VirG) in Shigella flexneri" FEMS Microbiol. Lett. 221: 173-180.

  29. Morona, R., and Van Den Bosch, L. (2003) "Multi-copy icsA is able to suppress the virulence defect caused by the wzzSF mutation in Shigella flexneri." FEMS Microbiol. Lett. 221: 213-219.

  30. Van Den Bosch, L. and Morona, R. (2003) "The actin-based motility defect of Shigella flexneri rmlD rough LPS mutant is not due to loss of IcsA polarity." Microb. Pathogen. 35: 11-18.

  31. Morona, J.K., Miller, D.C., Morona, R., and James C. Paton, J.C. (2004) "The effect of mutations in the conserved genes cps2A, cps2B and cps2D on virulence in Streptococcus pneumoniae." J. Infect. Dis. 189:1905-1913.

  32. Pinyon, R., Paton, J.C., Paton, A.W., Botten, J.A., and Morona, R. (2004) "Refinement of a therapeutic Shiga toxin-binding probiotic for human trials." J. Infect. Dis. 189: 1547-1555.

  33. Casjeans, S., Winn-Stapley, D.A., Gilcrease, E., Morona, R., Kühlewein, C., Chua, J.E.H., Manning., P.A., Inwood., W., and Clark., A.J. (2004) "The chromosome of Shigella flexneri bacteriophage Sf6: complete nucleotide sequence, genetic mosaicism, and DNA packaging." J. Mol. Biol. 339: 379-394.

  34. Korres, H., Mavris, M., Morona, R., Manning, P.A., and Verma, N. (2005) "Topological analysis of GtrA and GtrB proteins encoded by the serotype-converting cassette of Shigella flexneri." Biochem. Biophys. Res. Comm. 328: 1252-1260

  35. Paton, A.W., Jennings, M.P., Morona, R., Wang, H., Focareta, A., Roddam, L.F., and Paton, J.C. (2005) " Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea." Gastroenterology 128: 1219-1228.

  36. Murray, G.L., Attridge, S.R., and Morona, R. (2005) "Inducible serum resistance in Salmonella typhimurium is dependent on wzzfepE-regulated very long O antigen chains". Microbes Infect. 7: 1296-1304

  37. Murray, G.L., Attridge, S.R., and Morona, R. (2006) "Altering the length of Salmonella typhimurium lipopolysaccharide O antigen has an impact on interaction with macrophages and complement". J. Bacteriol. 188: 2735-2739.

  38. Paton, A.W, Morona, R., and Paton, J.C. (2006) "Designer probiotics for prevention of enteric infections". Nat. Rev. Microbiol. 4:193-200.

  39. Focareta, A., Paton, J.C., Morona, R., Cook, J., and Paton, A.W. (2006) “A recombinant probiotic for treatment and prevention of cholera”. Gastroenterology 130: 1688-1695.

  40. Diaz, P.I. Sladeski, N., Reynolds, E.C., Morona, R., Rogers, A.H., and Kolenbrander, P.E. (2006) “Role of oxyR in the oral anaerobe Porphyromonas gingivalis.” J. Bacteriol 188: 2454-2462.

  41. Morona, J.K., Morona, R., Paton, J.C. (2006) Attachment of capsular polysaccharide to the cell wall of Streptococcus pneumoniae type 2 is required for invasive disease. Proc Natl Acad Sci U. S. A. 103: 8505-8510.