You are here: 
text zoom : S | M | L
Printer Friendly Version
Login
Further Enquiries
North Terrace Campus
Level 5, Molecular Life Sciences
The University of Adelaide
SA 5005
AUSTRALIA
Lindsay Dent

Telephone: +61 8 8303 4155
Facsimile: +61 8 8303 4362

Representative Publications

Dent, L.A. and Finlay-Jones, J.J. (1985) In vivo detection and partial characterization of effector and suppressor cell populations in spleens of mice with large metastatic fibrosarcomas. Br. J. Cancer, 51, 533.

Dent, L.A., Spencer, L.K., Attridge, S. and Finlay-Jones, J.J. (1989)  Differences in the phenotypes of cells mediating anti-tumour immunity at various stages of tumour progression in mice. Immunol. Cell Biol., 67, 403.

Dent, L.A., Strath, M., Mellor, A. and Sanderson, C.J. (1990) Eosinophilia in transgenic mice expressing interleukin 5. J. Exp Med., 172, 1425-1431.

Dent, L.A., Munro, G.H., Piper, K.P., Sanderson, C.J., Finlay, D.A., *Dempster, R.K., Bignold, L.P., Harkin, D.G. and Hagan, P., (1997a) Eosinophilic interleukin 5 (IL-5) transgenic mice: eosinophil activity and impaired clearance of Schistosoma mansoni. Parasite Immunology, 19:291-300.

Dent, L.A, *Daly, C., *Geddes, A., *Cormie, J., Finlay, D.A., Bignold, L., Hagan, P., Parkhouse, R.M.E., Garate, T., Parsons, J. and Mayrhofer, G. (1997b) Immune responses of IL-5 transgenic mice to parasites and aeroallergens. Memorias do Instituto Oswaldo Cruz, 92 (Suppl.II); 45-54.

Dent, L.A., *Daly, C., Mayrhofer, G., Zimmerman, T., Hallett, A., Bignold, L. and Parsons, J. (1999) Interleukin-5 transgenic mice show enhanced resistance to Nippostrongylus brasiliensis  but not to Toxocara canis, Infection and Immunity, 67:989-993.

*Daly, C.M., Mayrhofer, G. and Dent, L.A., (1999) Trapping and immobilization of Nippostrongylus brasiliensis larvae at the site of inoculation in primary infections in interleukin-5 transgenic mice. Infection and Immunity, 67:5315-5323.

MacKenzie, J.R. Mattes, J., Dent, L.A. and Foster, P.S. (2001) Eosinophils promote allergic disease of the lung by regulating CD4+ T-helper 2 lymphocyte function. J. Immunology, 167:3146-3155.

Dent, L.A. (2002) For Better or Worse: Common Determinants in immunity and inflammatory diseases, homeostasis and reproduction. J. Reproductive Immunology, 57: 255-272.

Mattes, J., Yang, M., Mahalingham, S., Kuehr, J., Webb, D.C., Simson, L., Hogan, S.P., Koskinen, A., McKenzie, A.N.J., Dent, L.A., Rothenberg, M.E., Matthaei, K.I., Young, I.G. and Foster, P.S. (2002), Intrinsic defect in T cell production of interleukin-(IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J. Exp. Med. 195:1433-1444.

Recent Publications

*Sferruzzi-Perri, A.N. Robertson, S.A. and Dent, L.A. (2003) Interleukin-5 transgene expression and eosinophilia are associated with retarded mammary gland development in mice. Biology of Reproduction, 69: 224-233.

Clark, K., Simson, L., Newcombe, N., Koskinen, A.M.L., Mattes, J., Lee, N.A., Lee, J.J., Dent, L.A., Matthaei, K.I., Foster, P.S., (2004), Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen. J. Leukocyte Biology, 75:1001-1009.

*Giacomin, P.R., Wang, H., Gordon, D.L. and Dent, L.A., (2004) Quantitation of complement and leukocyte binding to a parasitic helminth species. J. Immunological Methods, 289: 201-210.

*Giacomin, P.R., Wang, H., Gordon, D.L. Botto, M. and Dent, L.A., (2005) Loss of complement activation and leukocyte adherence as Nippostrongylus brasiliensis develops within the murine host. Infection and Immunity, 73:7442-7449.

Forbes, E., Hulett, M.,  Ahrens, R., Wagner, N., Smart, V., Matthaei, K.I., Brandt, E.B., Dent, L.A., Rothenberg, M.E., Tang, M., Foster, P.S. and Hogan, S.P. (2006) ICAM-1 dependent pathways regulate colonic eosinophilic inflammation. Journal of Leukocyte Biology, 80:330-341.

Gwinn, W.M., Damsker, J.M. Falahati, R., Okwumabua, I., Kelly-Welch, A., Keegan, A.D., Vanpouille, C., Lee, J.J., Dent, L.A., Leitenberg, D., Bukrinsky, M.I. and Constant, S.L. (2006) Novel approach to inhibit asthma-mediated lung inflammation using anti-CD147 intervention. Journal of Immunology, 177:4870-4879.

Simson, L., Ellyard, J.I., Dent, L.A., Matthaei, K.I., Rothenberg, M.E., Foster, P.S., Smythe, M.J. and Parish, C.R., (2007) Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. Journal of Immunology, 178:42222-4229.

*Tumes, D.J., *Cormie, J., *Calvert, M.G., *Stewart, K., Webb, D., Nassenstein, C, Braun, A., Foster, P.S. and Dent, L.A. (2007) Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophils. J. Leukocyte Biology. 81:1362-1373.

*Knott, M.L., Matthaei, K.I., *Giacomin, P.R., Wang, H., Foster, P.S. and Dent, L.A. (2007) Eosinophils mediate early resistance during secondary Nippostrongylus brasiliensis infections in mice. International Journal for Parasitology, 37:1367-1378.

*Giacomin, P.R., Gordon, D.R., Botto, M., Daha, M.R., Sanderson, S.D., Taylor, S.M. and Dent, L.A., (2008) The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis. Molecular Immunology 45: 446-455.

*Giacomin, P.R., *Cava, M., *Tumes, D.J., *Gauld, A.D., Iddawela, D.R., McColl, S.R., Parsons, J.C., Gordon, D.L. and Dent, L.A. (2008) Toxocara canis larval excretory/secretory proteins impair eosinophil-dependent resistance of mice to Nippostrongylus brasiliensis. Parasite Immunology, 30:435-445. 

*Tumes, D.J., Wong, A.C.H., Sewell, W.A., McColl, S.R., Connolly, A. and Dent, L.A. (2008) Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice. Molecular Immunology, 45:3609-3617.

*Leitch, V.D., Strudwick, X.L., Matthaei, K.I., Dent, L.A. and Cowin, A.J., (2009) Eosinophilia alters wound healing via mechanisms involving prolonged inflammation in IL-5 overexpressing mice. Immunology and Cell Biology, 87:131-140.

*Knott, M.L., Hogan, S.P., Wang, H., Matthaei, K.I. and Dent, L.A. (2009) FVB/N mice are highly resistant to primary infection with Nippostrongylus brasiliensis. Parasitology, 136:93-106.

*Tumes, D.J., Connolly, A. and Dent, L.A., (2009) Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma. International Immunology, in press, doi: 10.1093/intiimm/dxp032, electronic publication 23 April 2009.

* students in the Eosinophil Biology Laboratory