Publications

1. Lando, D., Peet, D.J., Whelan, D.A., Gorman, J.J., and Whitelaw, M.L. Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch. (2002) Science, 295, 858-861.
   
2. Lando, D., Peet, D.J., Pongratz, I., and Whitelaw, M.L. Mammalian two-hybrid assay showing redox control of HIF-like factor. (2002) Methods Enzymol. 53, 3-10.
   
3. Lando*, D., Peet*, D.J., Gorman, J.J., Whelan, D.A., Whitelaw, M. L. and Bruick, R.K.  FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of Hypoxia Inducible Factor. (2002) Genes Dev. 16, 1466-1471 (*joint first authors).
   
4. Fedele, A.O., Whitelaw, M.L. and Peet, D.J.  Regulation of gene expression by the hypoxia inducible factors. (2002) Mol. Interv. 2:229-243.
   
5. Lando, D., Gorman, J.J., Whitelaw, M.L. and Peet, D.J.  Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylases. (2003) Eur. J. Biochem., 270, 781-790.
   
6. Bracken, C.P., Whitelaw, M.L. and Peet, D.J. The Hypoxia-Inducible Factors: key transcriptional regulators of hypoxic response. (2003) Cell. Mol. Life Sci. 60:1376-1393.
   
7. Lees, M.J., Peet, D.J., and Whitelaw, M.L.  Defining the role for XAP2 in stabilisation of the dioxin receptor. (2003) J. Biol. Chem. 278: 35878-88.
   
8. Peet,D.J., Lando, D., Whelan, D.A., Whitelaw, M.L. Gorman, J.J.  Oxygen-Dependent Asparagine Hydroxylation. (2004) Methods Enzymol. 381:467-87.
   
9. Linke, S., Stojkoski, C., Kewley, R.J., Booker, G.W., Whitelaw, M.L., and Peet, D.J.  Substrate requirements of the oxygen-sensing asparaginyl hydroxylase Factor Inhibiting HIF. (2004) J. Biol. Chem. 279, 14391-14397.
   
10. Bracken, C.P., Whitelaw, M.L., and Peet, D.J.  Activity of Hypoxia-Inducible Factor 2a (HIF-2a) is regulated by association with the NF-kB essential modulator (NEMO / IKKg).(2005) J. Biol. Chem. 280:14240-14251.
    
11. Peet, D.J. and Linke, S.  Regulation of HIF:asparaginyl hydroxylation. (2006) In Signalling Pathways in Acute Oxygen Sensing, Novartis Foundation Symposium No. 272, D. J. Chadwick and J.Goode, ed. (Weinheim, Germany: Wiley-VCH Verlag GmbH)
     
12. Bracken C.P., Fedele A.O., Linke S., Balrak W., Lisy K., Whitelaw M.L., Peet D.J.  Cell-specific Regulation of Hypoxia-inducible Factor (HIF)-1{alpha} and HIF-2{alpha} Stabilization and Transactivation in a Graded Oxygen Environment. (2006) J Biol Chem. 281:22575-85.
    
13. Hampton-Smith R.J. and Peet D.J.  Hypoxia Inducible Factor. In McGraw-Hill Yearbook of Science and Technology 2007, The McGraw-Hill Editorial Staff, ed. (McGraw-Hill, USA).Bracken C.P., Fedele A.O., Linke S., Balrak W., Lisy K., Whitelaw M.L., Peet D.J. Cell-specific Regulation of Hypoxia-inducible Factor (HIF)-1{alpha} and HIF-2{alpha} Stabilization and Transactivation in a Graded Oxygen Environment. (2006) J Biol Chem. 281:22575-85.
    
14. Hampton-Smith R.J. and Peet D.J.  Hypoxia Inducible Factor. In McGraw-Hill Yearbook of Science and Technology 2007, The McGraw-Hill Editorial Staff, ed. (McGraw-Hill, USA).
    
15. Linke S., Hampton-Smith, R.J. and Peet D.J.  Characterisation of ankyrin-repeat containing proteins as substrates of the asparaginyl hydroxylase Factor Inhibiting HIF (FIH-1). (2007) Methods Enzymol. 435:61-85.
    
16. Lisy K., Peet D.J.  Turn me on: regulating HIF transcriptional activity. (2008). Cell Death Differ. 15:642-915:805.
    
17. Zheng X.*, Linke S.*, Dias J., Zheng X., Gradin K., Wallis T.P., Hamilton B.R.,Gustafsson M., Ruas J.L., Wilkins S., Bilton R.L., Brismar K., Whitelaw M.L.,Pereira T., Gorman J.J.§, Ericson J., Peet D.J., Lendahl U., and Poellinger L.  Interaction with factor-inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. (2008) Proc. Natl Acad. Sci. USA. 105:3368-73. (* joint first authors)