Selected Recent Publications

1. Paton, A.W., Morona, R., and Paton, J.C. (2000). A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nature Medicine, 6:265-270.
   
   
2. McAllister, L.J., Tseng, H., Ogunniyi, A.D., Jennings, M.P., McEwan, A.G., and Paton, J.C. (2004). Molecular analysis of the psa permease complex of Streptococcus pneumoniae. Mol. Microbiol. 53:889-901.
   
   
3. Paton, A.W., Srimanote, P., Talbot, U.M., Wang, H., and Paton, J.C. (2004). A new family of potent AB5 cytotoxins produced by Shiga toxigenic Escherichia coli. J. Exp. Med. 200:35-46.
   
   
4. Morona, J.K., Miller, D.C., Morona, R. and Paton, J.C. (2004). The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB and cpsD have on virulence of Streptococcus pneumoniae. J. Infect. Dis. 189: 1905-1913.
   
   
5. Paton, A.W., Jennings, M.P., Morona, R., Focareta, A., Roddam, L.F., and Paton, J.C. (2005). Recombinant probiotics for treatment and prevention of travellers’ diarrhea. Gastroenterology 128: 1219-1228.
   
   
6. Standish, A.J., Stroeher, U.H., and Paton, J.C. (2005). The two-component signal transduction system RR06/HK06 regulates expression of cbpA in Streptococcus pneumoniae. Proc. Natl. Acad. Sci. USA. 102:7701-7706.
   
   
7. Paton, A.W., and Paton, J.C. (2005). Multiplex PCR for direct detection of Shiga toxigenic Escherichia coli producing the novel subtilase cytotoxin. J. Clin. Microbiol. 43: 2944-2947.
   
   
8. Talbot, U.M., Paton, J.C., and Paton, A.W. (2005). Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli. Infect. Immun. 73: 4432-4436.
   
   
9. LeMessurier, K.S., Ogunniyi, A.D., and Paton, J.C. (2006). Differential expression of key pneumococcal virulence genes in vivo. Microbiology. 152:305-311.
   
   
10. Rogers, T.J., Paton, J.C., Wang, H., Talbot, U.M., and Paton, A.W. (2006). Reduced virulence of a fliC mutant of Shiga toxigenic Escherichia coli O113:H21. Infect. Immun. 74: 1962-1966.
    
    
11. Paton, A.W., Morona, R., and Paton, J.C. (2006). Designer probiotics for prevention of enteric infections. Nature Reviews Microbiology. 4: 193-200.
    
    
12. Focareta, A., Paton, J.C., Morona, R., Cook, J., and Paton, A.W. (2006). A recombinant probiotic for treatment and prevention of cholera. Gastroenterology. 130: 1688-1695.
    
    
13. Paton, A.W., Beddoe, T., Thorpe, C.M., Whisstock, J.C., Wilce, M.C.J., Rossjohn, J., Talbot, U.M. and Paton J.C. (2006). AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature. 443: 548-552.
    
    
14. Morona, J.K., Morona, R., and Paton, J.C. (2006). Attachment of capsular polysaccharide to the cell wall of Streptococcus pneumoniae type 2 is required for invasive disease. Proc. Natl. Acad. Sci. USA. 103: 8505-8510.
    
15. Graham, R.M.A., and Paton, J.C. (2006). Differential role of CbpA and PspA in modulation of in vitro CXC chemokine responses of respiratory epithelial cells to infection with Streptococcus pneumoniae. Infect. Immun. 74: 6739-6749.
    
16. Paton, J.C., and Paton, A.W. (2006). Shiga toxin “goes retro” in human primary kidney cells. Kidney Int. 70: 2049-2051. 
    
17. Ogunniyi, A.D., Grabowicz, M., Briles, D.E., Cook, J., and Paton, J.C. (2007). Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae. Infect. Immun. 75:350-357.
    
18. Ogunniyi, A.D., LeMessurier, K.S., Graham, R.M.A., Watt, J.M., Briles, D.E., Stroeher, U.H., and Paton, J.C. (2007). Contributions of pneumolysin, pneumococcal surface protein A (PspA) and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model. Infect. Immun. 75: 1843-1851.
    
19. Maus, U.A., Backi, M., Winter, C., Srivastava, M., Schwarz, M.K., Rückle, T., Paton, J.C., Briles, D.E., Mack, M., Welte, T., Maus, R., Bohle, R.M., Seeger, W., Rommel, C., Hirsch, E., Lohmeyer, J., and Preissner, K.T. (2007). Importance of phosphoinositide 3-kinase g in host defense against pneumococcal infection. Am J. Resp. Crit. Care. Med. 175:958-966. 
    
20. Winter, C., Taut, K., Srivastava, M., Länger, F., Mack, M., Briles, D.E., Paton, J.C., Maus, R., Welte, T., Gunn, M.D., and Maus, U.A. (2007). Lung-specific overexpression of CCL2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. J. Immunol. 178:5828-5838.
    
21. Tu, L.N., Jeong, H.Y., Kwon, H.Y., Ogunniyi, A.D., Paton, J.C., Pyo, S.N., and Rhee, D.K. (2007). Modulation of adherence, invasion, and TNF-a secretion during the early stages of infection by Streptococcus pneumoniae ClpL. Infect. Immun. 75:2996-3005.
    
22. Pramanik, A., Stroeher, U.H., Krejci, J., Standish, A.J., Bohn, E., Paton, J.C., Autenrieth, I.B., and Braun, V. (2007). Albomycin is an effective antibiotic, as exemplified with Yersinia enterocolitica and Streptococcus pneumoniae. Int. J. Med. Microbiol. 297:459-469.
    
23. Wang, H., Paton, J.C., and Paton, A.W. (2007). Pathologic changes in mice induced by subtilase cytotoxin, a potent new Escherichia coli AB₅ toxin that targets the endoplasmic reticulum. J. Infect. Dis. 196:1093-1101. 
    
24. Standish, A.J., Stroeher, U.H., and Paton, J.C. (2007). Pneumococcal two-component signal transduction system RR/HK06 regulates CbpA and PspA by two distinct mechanisms. J. Bacteriol. 189:5591-5600.
    
25. Takano, Y., Hiramatsu, N., Okamura, M., Hayakawa, K., Shimada, T., Kasai, A., Yokouchi, M., Shitamura, A., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2007). Suppression of cytokine responses by GATA inhibitor K-7174: Implication for unfolded protein response. Biochem. Biophys. Res. Comm. 360: 470-475. 
    
26. Winter, C., Taut, K., Länger, F., Mack, M., Briles, D.E., Paton, J.C., Maus, R., Srivastava, M., Welte, T., and Maus, U.A. (2007). FMS-like tyrosine kinase 3 ligand aggravates the lung inflammatory response to Streptococcus pneumoniae infection in mice: role of dendritic cells. J. Immunol. 179:3099-3108.
    
27. Stroeher, U.H., Kidd, S.P., Stafford, S.L., Jennings, M.P., Paton, J.C., and McEwan, A.G. (2007). A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence. J. Infect. Dis. 196: 1820-1826.
    
28. Dessing, M.C., Florquin, S., Paton, J.C., and van der Poll, T. (2008). Toll-like receptor 2 contributes to antibacterial defense against pneumolysin-deficient pneumococci. Cell. Microbiol. 10:237-246.
    
29. Taut, K., Winter, C., Briles, D.E., Paton, J.C., Christman, J.W., Maus, R., Baumann, T., Welte, T., and Maus, U.A. (2008). Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae. Am J. Resp. Cell Mol. Biol. 38:105-113.
    
30. Buchkovich, N.J., Maguire, T.G., Yu, Y., Paton, A.W., Paton, J.C., and Alwine, J.C. (2008). Human Cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly. J. Virol. 82: 31-39.
    
31. Hayakawa, K., Hiramatsu, N., Okamura, M., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2008). Blunted activation of NF-kB and NF-kB-dependent gene expression by geranylgeranylacetone: Involvement of unfolded protein response. Biochem. Biophys. Res. Comm. 365: 47-53.
    
32. Chong, D.C., Paton, J.C., Thorpe, C.M., and Paton, A.W. (2008). Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB₅ toxin that targets the endoplasmic reticulum chaperone BiP. Cell. Microbiol. 10: 795-806.
    
33. Mahdi. L.K., Ogunniyi, A.D., LeMessurier, K.S., and Paton, J.C. (2008). Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease. Infect. Immun. 76: 646-657.
    
34. Kadioglu, A., Weiser, J.N., Paton, J.C., and Andrew, P.W. (2008). The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nature Rev. Microbiol. 6: 288-301.
    
35. Wolfson, J., Thorpe, C.M., May, K.L., Paton, J.C., Jandhyala, D.M., and Paton, A.W. (2008). Subtilase cytotoxin activates PERK, ATF6 and IRE1 endoplasmic reticulum stress-signaling pathways. Cell. Microbiol. In press.