Recent Publications

On Pyruvate Carboxylase:
Reviews 

Jitrapakdee, S., St.Maurice, M., Rayment, I., Cleland, W.W., Wallace, J.C. & Attwood, P.V. (2008) Structure, Mechanism and Regulation of Pyruvate Carboxylase. Biochem J., 413, 369-387.

Jitrapakdee, S., Vidal-Puig, A. & Wallace, J.C. (2006) Anaplerotic Roles of Pyruvate Carboxylase in Mammalian Tissues.  Cell and Molecular Life Sciences, 63, 843-854.

Wallace, J.C. & Barritt, G.J. (2005) Gluconeogenesis (version 2.0) Encyclopedia of Life Sciences, http://www.els.net/els/els/viewArticle...rtid=A3930.

Jitrapakdee, S. & Wallace, J.C. (2004) Pyruvate Carboxylation, Transamination and Gluconeogenesis. Encyclopedia of Biological Chemistry  3, 606-610. [Ed. Lennarz W. & Lane, M.D.] [ISBN 0124437109].

Jitrapakdee, S. & Wallace, J.C. (2003) The Biotin Enzyme Family: Conserved Structural Motifs and Domain Rearrangements.  Current Protein and Peptide Science, 4(2) 217-229.

Attwood, P.V. & Wallace, J.C. (2002) Chemical and Catalytic Mechanisms of Carboxyl Transfer Reactions in Biotin-dependent Enzymes.  Accounts of Chemical Research [American Chemical Society, Los Angeles] 35, 113-120.

Original Research Publications: 

Zeczycki, T.N., St.Maurice, M., Jitrapakdee, S., Wallace, J.C., Attwood, P.V. & Cleland, W.W. (2009) Insight into the carboxyl transferase domain mechanism of pyruvate carboxylase from Rhizobium etli. Biochemistry 48, 4305–4313.

Hasan NM, Longacre MJ, Stoker SW, Boonsaen T, Jitrapakdee S, Kendrick MA,

Wallace JC, MacDonald MJ. (2008)  Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.

J Biol Chem. 283(42):28048-59.

Adina-Zada A, Jitrapakdee S, Surinya KH, McIldowie MJ, Piggott MJ, Cleland WW, Wallace JC, Attwood PV. (2008) Insights into the mechanism and regulation of pyruvate carboxylase by characterisation of a biotin-deficient mutant of the Bacillus thermodenitrificans enzyme. 

Int J Biochem Cell Biol. 40(9):1743-52.

Jitrapakdee, S., Surinya, K.H., Adina-Zada, A., Polyak, S.W.,  Cvetan Stojkoski, C., Smyth, R., Booker, G.W.,  Cleland, W.W., Attwood^, P.V. & Wallace, J.C. (2007) Conserved Glu40 and Glu433 of the Biotin Carboxylase Domain of Yeast Pyruvate Carboxylase I Isoenzyme Are Essential for the Association of Tetramers. Int. J. Biochem. & Cell Biol. 39, 2120-2134.

St.Maurice, M., Reinhardt, L., Surinya, K.H., Attwood, P.V., Wallace, J.C., Cleland, W.W. & Rayment, I. (2007) Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional protein. Science 317, 1076-1079.

Boonsaen, T., Rojvirat, P., Surinya, K.H., Wallace, J.C. & Jitrapakdee, S. (2007) Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3b/Foxa2 and upstream stimulatory factors in insulinoma cells. Biochem. J. 405, 359-367.

Jitrapakdee, S., Adina-Zada, A., Besant, P.G., Surinya, K.H., Cleland, W.W., Wallace, J.C. & Attwood, P.V. (2007) Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl-CoA. Int. J. Biochem. & Cell Biol. 39, 1211-1223.

Jitrapakdee, S., Slawik, M., Medina-Gomez, G., Campbell, M., Wallace, J.C., Sethi, J.K., O'Rahilly, S. and Vidal-Puig, A.J. (2005) The peroxisome proliferator-activated receptor gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro. J. Biol. Chem. 280, 27466-76.

Sunyakumthorn, P., Boonsaen, T., Boonsaeng, V., Wallace, J.C. & Jitrapakdee, S. (2005) Involvement of Specific Proteins (Sp1/Sp3) and Nuclear Factor Y (NF-Y) in basal transcription of the distal promoter of the rat pyruvate carboxylase gene in beta-cells. Biochem. Biophys. Res. Commun. 329, 188-196.

Petchampai, N., Boonsaeng, V., Wallace, J.C. & Jitrapakdee, S. (2004) Expression of human pyruvate carboxylase in insect cells using the baculovirus system. Biochem. Biophys. Res. Commun. 316, 177-181.

Branson JP, Nezic M, Jitrapakdee S, Wallace JC, Attwood PV. (2004) Kinetic Characterization of Yeast Pyruvate Carboxylase Isozyme Pyc1 and the Pyc1 Mutant, C249A.

Biochemistry, 43, 1075-1081.

On Biotin Protein Ligase
Reviews

Pendini, N.R., Bailey, L.M., Booker, G.W., Wilce, M.C., Wallace, J.C. & Polyak, S.W. (2008)  Microbial Biotin Protein Ligases aid in understanding holocarboxylase synthetase deficiency. BBA Proteins and Proteomics, 1784, 973-982

Original Publications

Pendini NR, Bailey LM, Booker GW, Wilce MC, Wallace JC, Polyak SW. (2008)

Biotin protein ligase from Candida albicans: expression, purification and development of a novel assay.

Arch Biochem Biophys. 479(2):163-9.

Pendini NR, Polyak SW, Booker GW, Wallace JC, Wilce MC. (2008)

Purification, crystallization and preliminary crystallographic analysis of biotin protein ligase from Staphylococcus aureus.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 64(6):520-3.

Pendini NR, Bailey LM, Booker GW, Wilce MC, Wallace JC, Polyak SW. (2008)

Microbial biotin protein ligases aid in understanding holocarboxylase synthetase deficiency.

Biochim Biophys Acta 1784(7-8):973-82.  Review.

Bailey LM, Ivanov RA, Jitrapakdee S, Wilson CJ, Wallace JC, Polyak SW. (2008)

Reduced half-life of holocarboxylase synthetase from patients with severe multiple carboxylase deficiency. Hum Mutat. 29(6):E47-57.

Ng B, Polyak SW, Bird D, Bailey L, Wallace JC, Booker GW. (2008)

Escherichia coli biotin protein ligase: characterization and development of a high-throughput

assay. Anal Biochem. 376(1):131-6.

Bailey, L.M. Ivanov, R.A., Wallace, J.C. & Polyak, S.W. (2008) Artifactual detection of biotin on histones by streptavidin.  Anal. Biochem.  373, 71-77.

On Insulin-like Growth Factors, their Receptors and Binding Proteins
Reviews:

Denley, A., Wallace J.C., Cosgrove L.J., & Forbes B.E. (2003) The Insulin Receptor Isoform Exon 11- (IR-A) in Cancer and Other Diseases: A Review. Horm Metab Res. 35, 778-85.  

Denley, A., Cosgrove, L.J., Booker, G.W., Wallace, J.C. & Forbes, B.E. (2005) Molecular Interactions of the IGF system.  Cytokines & Growth Factor Reviews, 16,  421-439.   

Original Research Publications:

Alvino CL, McNeil KA, Ong SC, Delaine C, Booker GW, Wallace JC, Whittaker J,
Forbes BE.(2009) A novel approach to identify two distinct receptor binding surfaces of
insulin-like growth factor II. J Biol Chem. 284, 7656-7664.

Gauguin L, Delaine C, Alvino CL, McNeil KA, Wallace JC, Forbes BE, De Meyts P. (2008)
Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I.
J Biol Chem. 283(30):20821-9.

Surinya KH, Forbes BE, Occhiodoro F, Booker GW, Francis GL, Siddle K, Wallace
JC, Cosgrove LJ. (2008) An investigation of the ligand binding properties and negative cooperativity of soluble insulin-like growth factor receptors.
J Biol Chem. 283(9):5355-63.

Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY. (2008) Structure and functional analysis of the IGF-II/IGF2R interaction. EMBO J. 27(1):265-76 (2008).

Delaine, C.,Alvino, C.L., McNeil, K.A., Mulhern, T.D., Gauguin, L., De Meyts, P.D., Jones, E.Y., Brown, J., Wallace, J.C., & Forbes, B.E. (2007) A novel binding site for the human IGF-II/mannose 6-phospate receptor (IGF2R) on IGF-II. J. Biol. Chem. 282, 18886-1894. 

Denley, A.,Carroll, J.M, Brierley, G.V., Cosgrove,L., Wallace, J., Forbes, B., & Roberts, C.T. Jr., (2007) Differential Activation of Insulin Receptor Substrates-1 And 2 by IGF-Activated Insulin Receptors. Mol. Cell. Biol. 27, 3569-3577. 

Chandrashekaran, I.R., Yao, S., Wang,C.C., Bansal, P.S., Alewood, P.F., Forbes, B.E., Wallace, J.C., Bach,L.A., & Norton, R.S. (2007) The N-terminal sub-domain of insulin-like growth factor (IGF) binding protein-6. Structure and interaction with IGFs. Biochemistry 46, 3065-74.   

Keyhanfar, M., Booker, G.W., Whittaker, J.,Wallace, J.C., & Forbes, B.E. (2007) Precise mapping of an IGF-I binding site on the IGF-1R. Biochem. J. 401, 269-277.

Kuang Z., Yao S., Keizer D.W., Wang C.C., Bach L.A., Forbes B.E., Wallace J.C. and Norton R.S. (2006) Structure, Dynamics and Heparin Binding of the C-terminal Domain of Insulin-like Growth Factor Binding Protein-2 (IGFBP-2). J. Mol. Biol. 364, 690-704.

Keyhanfar M., Forbes B.E., Cosgrove L.J., Booker G.W. and Wallace J.C. (2006) Production and characterisation of monoclonal antibodies against insulin-like growth factor type 1 receptor (IGF-1R).  Hybridoma 25, 230-7.

Roche P., Brown J., Denley A., Forbes B.E., Wallace J.C., Jones E.Y. and Esnouf R. M. (2006).  A computational model for the IGF-II/IGF2R complex that is predictive of mutational and surface plasmon resonance data.  Proteins: Structure, Function and bioinformatics 64, 758-768.

Denley, A., Briefley, G.V., Carroll, J.M., Lindenberg, A., Booker, G.W., Cosgrove, L.J.,Wallace, J.C., Forbes, B.E. and roberts, Jr. C.T. (2006) Differential activation of insulin receptor isoforms by i9nsulin-like growth factors is determined by the C domain.  Endocrinol. 147, 1029-36.

Akekawatchai C, Holland J.D., Kochetkova M., Wallace J.C., McColl S.R. (2005) Transactivation of CXCR4 by IGF-1R in human MDA-MB-231 breast cancer epithelial cells. J Biol Chem.  280, 39701-8.

Carrick, F.E., Hinds, M.G., McNeil, K.A., Wallace, J.C., Forbes, B.E. and Norton, R.S. (2005) Interaction of insulin-like growth factors I and II with IGF binding protein 2: mapping the binding surfaces by NMR. J. Mol. Endocrinol. 34, 685–698.

Denley, A., Wang, C.C., McNeil, K.A., Walenkamp, M.J., van Duyvenvoorde, H., Wit, J.M., Wallace, J.C., Norton, R.S., Karperien, M. & Forbes, B.E. (2005)  Structural and functional characteristics of the Val44Met IGF-I missense mutation: correlation with effects on growth and development.  Mol Endocrinol. 19, 711-721. 

Headey, S.J., Keizer, D.W., Yao, S., Wallace, J.C., Bach, L.A. &  Norton, R.S. (2004) Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions, FEBS Letters 568, 19-22. 

Denley, A., Bonython,E.R., Booker, G.W., Cosgrove, L.J., Forbes, B.E., Ward, C.W. & Wallace, J.C. (2004) Structural determinants for high affinity binding of IGF-II to IR-A, the exon 11 minus isoform of the insulin receptor. Mol. Endocrinol. 18, 2502-12.