Recent Publications

Furness, SB, Lees, MJ, Whitelaw, ML. (2007) The Dioxin (Aryl hydrocarbon) Receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581, 3616-25

Dave, KA, Hamilton, BR, Wallis, TP, Furness, SGB, Whitelaw ML, Gorman, JJ. (2007) Identification of N,Ne-dimethyl-lysine in the murine dioxin receptor using MALD-TOF/TOF and ESI-LTQ-Orbitrap-FT-MS. Int. J. Mass Spec., in press

Chapman-Smith, A. and Whitelaw, M.L. (2006) Novel DNA binding by a basic helix-loop-helix protein: The role of the dioxin receptor pas domain. J. Biol. Chem. 281, 12535-45

Cameron P. Bracken, C.P., Fedele, A.O., Linke, S., Balrak, W., Lisy, K., Whitelaw, M.L. and Peet, D.J. (2006) Cell-specific regulation of HIF-1alpha and HIF-2alpha : Stabilisation and transactivation in a graded oxygen environment. J. Biol. Chem. 281, 22575-85

Bracken, C.P., Whitelaw, M.L., Peet, D.J. (2005) Activity of hypoxia-inducible factor 2a is regulated by association with the NF- K B essential modulator. The Journal of Biological Chemistry 280: 14240-51

Kewley, R.J., Whitelaw, M.L. (2005) Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator. Biochemical and Biophysical Research Communications 338: 660-7

Chapman-Smith, A., Lutwyche, J.K., Whitelaw, M.L. (2004) Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators. The Journal of Biological Chemistry 279: 5353-62

Kewley, R.J., Whitelaw, M.L., Chapman-Smith, A. (2004) The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. The International Journal of Biochemistry and Cell Biology 36: 189-204

Linke, S., Stojkoski, c., Kewley, R.J., Booker, G.W., Whitelaw, M.L., Peet, D.J. (2004) Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry 279: 14391-7

Peet, D.J., Lando, D., Whelan, D.A., Whitelaw, M.L., Gorman, J.J. (2004) Oxygen-dependent asparagine hydroxylation. Methods in Enzymology 381: 467-87

Bracken, C.P, Whitelaw, M.L., Peet, D.J. (2003) The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cellular and Molecular Life Sciences 60: 1376-93

Lando, D., Gorman, J.J., Whitelaw, M.L., Peet, D.J. (2003) Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation. European Journal of Biochemistry 270: 781-90

Lees, M.J., Peet, D.J., Whitelaw M.L. (2003) Defining the role for XAP2 in stabilization of the dioxin receptor. The Journal of Biological Chemistry 278: 35878-88

Anderson, P., McGuire, J., Rubio, C., Gradin, K., Whitelaw, M.L., Petterson, S., Hanburg, A., Poellinger, L. (2002) A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumours. Proceedings of the National Academy of Sciences USA , 99: 9990-5

Fedele, A.O., Whitelaw, M.L., Peet, D.P. Regulation of gene expression by the hypoxia inducible factors. Molecular Interventions 2:230-43

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L*., Bruick, R. K*. (2002) FIH is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of Hypoxia Inducible Factor. Genes and Development, 16, 1466-71. (*joint senior author)

Lando, D., Peet, D.J., Pongratz, I., Whitelaw, M.L. (2002) Mammalian Two-Hybrid Assay Showing Redox Control of HIF-Like Factor. Methods in Enzymology , Vol. 353

Lando, D., Peet, D.J., Whelan, D.A., Gorman, J.J., Whitelaw, M.L. (2002) Asparagine Hydroxylation of the HIF Transactivation Domain: A hypoxic Switch. Science 295:858-61

Lees, M.J., Whitelaw, M.L. (2002) Mediation of dioxin receptor transcription by Ara9(XAP/AIP) Toxicology 181-182:143-6

Swanson, H.I., Whitelaw, M.L., Petrulis, J.R. and Perdew, G.H. (2002) Use of [1251]4'-Iodoflavone as a tool to characterize ligand dependant differences I Ah receptor behaviour. Journal of biochemical and molecular toxicology 16: 298-310

Woods, S., Whitelaw, M.L. (2002) Differential activities of murine SIM1and SIM2 on a hypoxic response element: Crosstalk between bHLH/PAS transcription factors. The Journal of Biological Chemistry 277:10236-43

McGuire, J., Okamoto, K., Whitelaw, M.L., Tanaka, H., Poellinger, L. (2001) Definition of a Dioxin Receptor Mutant that is a Constitutive Activator of Transcription. Journal of Biological Chemistry, 276, 41841-41849

Lando, D., Pongratz, I., Poellinger, L., Whitelaw, M.L. (2000) A Redox Mechanism Controls Differential DNA Binding Activities of the Hypoxia Inducible Factors HIF-1a and HIF-Like-Factor, Journal of Biological Chemistry, 275, 4618-4628