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North Terrace Campus
Level 1, Molecular Life Sciences
The University of Adelaide
SA 5005
AUSTRALIA
Michael Lardelli

Telephone: +61 8 8303 3212
Facsimile: +61 8 8303 4362

Publications (since 2000)

  1. Newman, M., Nornes, S., Martins, R. and Lardelli, M. (2012) Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience Letters 519: 14-19.
  2. Moussavi Nik, S. H., Wilson, L., Newman, M., Croft, K., Mori, T., Musgrave, I. and Lardelli, M. (2012) The BACE1-PSEN-AbetaPP regulatory axis has an ancient role in response to low oxygen/oxidative stress. Journal of Alzheimer's Disease 28: 515-30.
  3. Sugano, Y. and Lardelli, M. (2011) Identification and expression analysis of the zebrafish orthologue of Klotho. Development, Genes and Evolution. 221:179-86.
  4. Wells, S., Nornes, S. and Lardelli, M. (2011) Transgenic zebrafish recapitulating tbx16 gene early developmental expression. PLoS One 6(6):e21559.
  5. Moussavi Nik, S., Newman, M. and Lardelli, M. (2011) The response of HMGA1 to changes in oxygen availability is evolutionarily conserved. Experimental Cell Research 317:1503-12.
  6. Newman, M., Verdile, G., Martins, R. N. and Lardelli, M. (2011) Zebrafish as a tool in Alzheimer's disease research. Biochim Biophys Acta. - Molecular Basis of Disease 1812: 346-352.
  7. Newman, M. and Lardelli, M. (2011) A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos. BMC Research Notes 3:282 doi:10.1186/1756-0500-3-282
  8. Wells, S., Conran, J.G., Tamme, R., Gaudin, A., Webb, J. and Lardelli, M. (2011) Cryptic organisation within an apparently irregular rostrocaudal distribution of interneurons in the embryonic zebrafish. Experimental Cell Research 316: 3292-3303.
  9. Newman, M., Wilson, L., Camp, E., Verdile, G., Martins, R. and Lardelli, M. (2010) A zebrafish melanophore model of amyloidbeta toxicity. Zebrafish 7: 155-159.
  10. Nornes, S., Tucker, B. and Lardelli, M. (2009) Zebrafish aplnra functions in epiboly.
    BMC Research Notes 2:231 doi:10.1186/1756-0500-2-231
  11. Henshall. T. L., Tucker, B., Lumsden, A. L., Nornes, S., Lardelli, M. and Robert I. Richards (2009) Selective neuronal requirement for Huntingtin in the developing zebrafish. Human Molecular Genetics 18: 4830-42.
  12. Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R. N. and Lardelli, M. (2009) Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental Cell Research 315: 2791-2801.
  13. Chen, M., Martins, R. N. and Lardelli, M. (2009) Complex splicing and neural expression of duplicated tau genes in zebrafish embryos. Journal of Alzheimer's Disease 18: 305-317.
  14. Newman, M., Tucker, B., Nornes, S., Ward, A. and Lardelli, M. (2009) Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's Disease pathogenesis. Journal of Alzheimer's Disease 16: 133-147.
  15. Lardelli, M. (2008) Using zebrafish in human disease research: some advantages, disadvantages and ethical considerations. Pp. 23-28 in: Proceedings of 2008 ANZCCART Conference, Auckland, New Zealand. (http://www.royalsociety.org.nz/includes/download.aspx?ID=101782)
  16. Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C., Tucker, B., Frederich-Sleptsova, I., Martins, R., Lardelli, M. (2008) Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human Molecular Genetics 17: 402-412. Advance access published 2 November 2007.
  17. Wyatt, L., Wadham, C., Crocker, L.A., Lardelli, M. and Khew-Goodall, Y. (2007)
    The protein tyrosine phosphatise Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development. The Journal of Cell Biology 178: 1223-35.
  18. Lumsden, A.L., Henshall, T.L., Dayan, S., Lardelli, M.T. and Richards R.I. (2007)
    Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.
    Human Molecular Genetics 16: 1905-20.
  19. Newman, M., Musgrave, I. and Lardelli, M. (2007) Alzheimer Disease: Amyloidogenesis, The Presenilins and Animal Models. Biochim Biophys Acta. - Molecular Basis of Disease 1772: 285-97.
  20. Tucker, B. and Lardelli, M. (2007) A Rapid Apoptosis Assay Measuring Relative Acridine Orange Fluorescence in Zebrafish Embryos. Zebrafish 4: 113-116.
  21. Khut, P-Y., Tucker, B., Lardelli, M. and  Wood, S.A. (2007) Evolutionary and Expression Analysis of the Zebrafish Deubiquitylating Enzyme, Usp9. Zebrafish 4: 95-101.
  22. Tucker, B., Hepperle, C., Kortschak, D., Rainbird, B., Wells, S., Oates, A.C. and Lardelli, M. (2007) Zebrafish Angiotensin II Receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia. Gene Expr. Patterns 7:258-265.
  23. Tucker, B., Richards, R. and Lardelli, M. (2006) Contribution of mGluR and Fmr1 Functional Pathways to Neurite Morphogenesis, Craniofacial Development and Fragile X Syndrome. Human Molecular Genetics 15: 3446-3458.
  24. Tucker, B., Richards, R. and Lardelli, M. (2004) Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships. Dev. Genes Evol. 214: 567-574.
  25. Steffen Scholpp, S., Casper Groth, C., Claudia Lohs, C., Lardelli, M. and Brand, M. (2004) Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Dev. Genes Evol. 214:285-295.
  26. Lardelli, M. (2003) The evolutionary relationships of zebrafish genes tbx6, tbx16/spadetail and mga. Dev. Genes Evol. 213: 519-522.
  27. Nornes, S., Groth, C., Camp, E., Ey, P. and Lardelli, M. (2003) Developmental control of Presenilin1 expression, endoproteolysis and interaction in zebrafish embryos. Exp. Cell Res. 289:124-132.
  28. Camp, E., Badhwar, P., Mann, G. and Lardelli, M. (2003) Expression analysis of a tyrosinase promoter sequence in zebrafish. Pigment Cell Res. 16: 117–126.
  29. Camp, E., Hope, R., Korschak, R.D., Cox, T. and Lardelli, M. (2003) Expression of three spalt homologues in zebrafish embryos. Dev. Genes Evol. 213: 35–43.
  30. Lardelli, M. (2003) Something fishy in 21st century genomics. Today’s Life Science 15: 20-23.
  31. Groth, C., Nornes, S., McCarty, R., Tamme, R. and Lardelli, M. (2002) Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer’s disease gene presenilin2. Dev. Genes Evol. 212: 486-90.
  32. Groth, C. and Lardelli, M. (2002) The structure and function of vertebrate fibroblast growth factor receptor 1. Int. J. Dev. Biol. 46: 393-400.
  33. Tamme, R., Wells, S., Conran, J.G. and Lardelli, M. (2002) The identity and distribution of neural cells expressing the mesodermal determinant spadetail. BMC Developmental Biology 2: 9
  34. Lardelli, M. (2002) Nonspecific, nested suppression PCR method for isolation of unknown flanking DNA (“Cold-start method”). in Methods in Molecular Biology, Vol. 192: PCR Cloning Protocols, 2nd. Ed., pages 285-99, Edited by B.-Y. Chen and H. W. Janes, Humana Press Inc., Totowa, N.J., U.S.A.
  35. Lardelli, M. (2002) Generation and PCR-screening of bacteriophage lambda sublibraries enriched for rare clones (the "sublibrary method"). in Methods in Molecular Biology, Vol. 192: PCR Cloning Protocols, 2nd. Ed., pages 391-9, Edited by B.-Y. Chen and H. W. Janes, Humana Press Inc., Totowa, N.J., U.S.A.
  36. Jönsson, J.-I., Xiang, Z., Pettersson, M., Lardelli, M. and Nilsson, G. (2001) Distinct and regulated expression of Notch receptors in hematopoietic lineages and during myeloid differentiation. Eur J Immunol. 31: 3240-7.
  37. Tamme, R., Mills, K, Rainbird, B., Nornes, S. and Lardelli, M. (2001) Simple, directional cDNA cloning for in situ transcript hybridisation screens. BioTechniques 31: 938-946.
  38. Kortschak, R. D., Tamme, R. and Lardelli, M. (2001) Evolutionary analysis of vertebrate Notch genes. Dev. Genes Evol. 211: 350-354.
  39. Camp, E. and Lardelli, M. (2001) Tyrosinase gene expression in zebrafish embryos. Dev. Genes Evol. 211: 150-153.
  40. Holland, L.Z., Abi Rached, Tamme, R., L., Holland, N.D., Kortschak, R.D., Inoko, H., Shiina, T., Burgtorf, C. and Lardelli, M. (2001) Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): Evolutionary conservation of multiple expression domains in amphioxus and vertebrates. Dev. Biol. 232:493-507.
  41. Tamme, R., Camp, E., Kortschak, R.D. and Lardelli, M. (2000) Non-specific, nested suppression PCR method for isolation of unknown flanking DNA. BioTechniques 28: 895-902.