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Carbonic anhydrases as drug targets
Date/Time: Wednesday, 2 November 2016, 12:00 pm to 1:00 pm
Location: G04 lecture theatre, Napier building, North Terrace campus
Cost: Free
More information: Visit website
Executive Dean's Public Lecture Series presents 'Carbonic Anhydrases as Drug Targets'.
Presented by Claudiu Supuran, Professor of Medicinal Chemistry at the Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, University of Florence, Italy.
Carbonic anhydrases (CAs) are proteins present in all organisms living on earth. They interact with carbon dioxide, the gas responsible for the hot house effects, which is generated by many organisms and used by plant for photosynthesis.
The CAs rapidly convert carbon dioxide into bicarbonate, a weak base, and an acid, interfering with the acid-base balance in many tissues, in both plant, animals and microorganisms. There are many types of such proteins in all investigated life forms. Interference with the activity of these proteins has pharmacological applications. Compounds that diminish their activity, i.e., CA inhibitors, have clinical applications as drugs.
One such compound is currently in clinical trials in the USA and Canada as an anticancer/antimetastatic agent. The group at university of Florence is involved in research in all these fields: antitumor, antoconvulsants, antiobesity and antiinfective agents based on CA inhibitors.
Contact: Faculty of Health and Medical Sciences, Email: fhs.events@adelaide.edu.au
