Dr Michelle Lane

BSc(Hons) PhD Senior Research Fellow Scientific Director, Repromed Phone: +61 8 8303 8176 Fax: +61 8 8303 8177

Background

Dr Michelle Lane heads the Gamete and Embryo Biology Research Group. Our research interest is in understanding what contributes to the healthy development of eggs, sperm and embryos and therefore a healthy pregnancy. We also have a special interest in fertility and IVF related technology. Our group is involved in basic research questions aimed at establishing fundamental knowledge into cellular physiology, metabolism and epigenetics. We also have a translational research program in collaboration with our colleagues at Repromed involved in translating our basic research findings into improved patient care. Our laboratory has a strong focus on student training since we arrived at the University of Adelaide in 2004. Many of our students spend time working with industry to broaden their focus and knowledge. Several of our students have won awards both nationally and internationally.

Dr Lane is well known in the field of basic and applied embryo research and has received numerous invitations to give seminars both locally and internationally. She has considerable experience in the commercialisation and protection of Intellectual Property and is an inventor on several patent applications. She has been involved in the commercialisation of more than 10 products that are now routinely used in clinical IVF laboratories throughout the world. She has published extensively in the areas of reproductive medicine including assisted reproductive technology, oocyte and embryo cryopreservation and embryo development and normality. She was awarded the "Tall Poppy Award" for outstanding achievement in the field of biomedical and clinical science. She is currently the Scientific Director of the IVF clinic, Repromed.

Research Group

• Dr. Megan Mitchell (Research leader in area of diet and oocyte physiology)
• Kara Cashman
• Alicia Stump

PhD students

• Deirdre Zander
• Deanne Feil
• Christine Yeo
• Hassan Bakos
• Kathryn Gebhardt
• Sarah Wakefield

Honours Students

• Cathryn Tully
• Elise Goddard

Feil D, Henshaw RC, Lane M. Day 4 embryo selection is equal to Day 5 using a new embryo scoring system validated in single embryo transfers. Hum Reprod. 2008 Feb 21;

Wakefield SL, Lane M, Schulz SJ, Hebart ML, Thompson JG, Mitchell M. Maternal supply of omega-3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse. Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E425-34.

Yeo CX, Gilchrist RB, Thompson JG, Lane M.Exogenous growth differentiation factor 9 in oocyte maturation media enhances subsequent embryo development and fetal viability in mice. Hum Reprod. 2008 Jan;23(1):67-73.

Lane M, Mitchell M, Cashman KS , Feil D, Wakefield S, Zander-Fox DL. To QC or not to QC: the key to a consistent laboratory? Reprod Fertil Dev. 2008;20(1):23-32.

Bakos HW, Thompson JG, Feil D, Lane M. Sperm DNA damage is associated with assisted reproductive technology pregnancy. Int J Androl. 2007 Sep 5;

Gilchrist RB, Lane M, Thompson JG. Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality. Hum Reprod Update. 2008 Mar-Apr;14(2):159-77.

Lekamge DN, Barry M, Kolo M, Lane M, Gilchrist RB, Tremellen KP. Anti-Müllerian hormone as a predictor of IVF outcome. Reprod Biomed Online. 2007 May;14(5):602-10.