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Discipline of Obstetrics and Gynaecology
School of Medicine

The University of Adelaide


Women's and Children's Hospital

King William Road

North Adealide SA 5006



Phone: +61 8 8161 7619
Facsimile: +61 8 8161 7652

Ongoing trials/studies

  • The WISH Project: Working to Improve Survival and Health for babies born very preterm: The WISH Project.

Babies born early (less than 30 weeks of gestation) are at high risk of dying in the first weeks of life or later having cerebral palsy. New research evidence shows that giving mothers magnesium sulphate immediately prior to an early birth (at less than 30 weeks' gestation) significantly increases the chances of the baby surviving without cerebral palsy.

The overall aims of the WISH Project are to optimise the care of women at risk of imminent early preterm birth and so improve the chances of survival and long term good health for their babies.

The project will gather data from mothers and their babies born very early, which will allow monitoring of the use of a new therapy for the prevention of cerebral palsy, as well as assessment of the changes in mortality and morbidity resulting from uptake of the new treatment. Furthermore, it will provide clinical indicators for care that can be used for quality improvement within participating hospitals, and information regarding strategies for implementation of the new treatment in hospitals across Australia and New Zealand.

The specific aims of this project are, in Australia and New Zealand, to monitor and improve the uptake use of antenatal magnesium sulphate as a neuroprotective therapy immediately prior to imminent (birth planned or definitely expected within 24 hours), early preterm birth (less than 30 weeks' gestation) to reduce the risk of the baby dying or having cerebral palsy.

Key research staff: Ms Emily Bain, Ms Pat Ashwood, Dr Kasia Siwicki, Dr Katie Groom

Funding: The Cerebral Palsy Institute Grant 2014-2018; For The WISH Followup Project

Investigators: Professor Caroline Crowther; Ms Philippa Middleton; A/Professor Vicki Flenady; Professor Jonathan Morris, Dr Sarah McIntyre

Further information: WISH