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Discipline of Obstetrics and Gynaecology
School of Medicine

The University of Adelaide


Women's and Children's Hospital

King William Road

North Adealide SA 5006



Phone: +61 8 8161 7619
Facsimile: +61 8 8161 7652

PROGRESS: PROGesterone after previous preterm birth for prevention of neonatal RESpiratory distress Syndrome.

ISRCTN20269066; NHMRC207744; NCT00097110

This trial has completed recruitment and 2 year followup is currently being undertaken. Primary publication expected end 2014.

Neonatal respiratory disease, due to immature lung development, is a significant consequence of preterm birth and the major cause of early neonatal mortality and morbidity. The incidence of preterm birth (birth less than 37 weeks gestation) is approximately 7.0%, with 2.6% of all births occurring before 34 weeks gestation. The exact mechanism of the onset of labour in humans is complex. Progesterone is essential for maintaining pregnancy, having an important role in uterine relaxation. Although recent reports of progesterone supplementation for women at risk of preterm birth show promise, there is currently insufficient data to recommend the use of progesterone to prevent preterm birth.

This trial will involve women who have a history of spontaneous preterm birth at less than 34 weeks in the preceding pregnancy and will evaluate whether antenatal vaginal progesterone is effective in reducing the risk of subsequent preterm birth and its associated risk of adverse infant health outcomes.

Funding: NHMRC Project Grants 2006-2009 and 2010-2012
Chief Investigators: Professor Caroline Crowther, Professor Jodie Dodd, Dr Andrew McPhee, Ms Vicki Flenady, E/Professor Jeffrey Robinson
Clinical Trial Coordinator: Ms Pat Ashwood
61 8 8161 7767
61 8 8161 7652
Address: Contact Us

Collaborating Centres:










SA - Gawler Hospital
Lyell McEwin Hospital
Women's & Children's Hospital
Flinders Medical Centre
VIC - Mercy Hospital for Women
Monash Medical Centre
Royal Women's Hospital
TAS - Launceston General Hospital
Royal Hobart Hospital
NSW - St George Hospital
Nepean Hospital
Royal North Shore Hospital
Liverpool Hospital
Westmead Hospital
Royal Hospital for Women
QLD - Ipswich Hospital
Logan Hospital
Mater Mothers' Hospital
Redcliffe Hospital
Caboolture Hospital
The Townsville Hospital
Mater Hospital Mackay
ACT - The Canberra Hospital

New Zealand


Christchurch Women’s Hospital
Dunedin Hospital
National Women’s Hospital
Palmerston North Hospital
Wellington Women’s Hospital


Mt Sinai Hospital, Toronto
British Columbia Women's Hospital


  • Dodd JM, Flenady V, Cincotta R, Crowther CA. Prenatal administration of progesterone for preventing preterm birth ibn women considered to be at risk of preterm birth. Cochrane Database of Systematic Reviews. 2013;Issue 7. (Review)
  • Dodd JM, Crowther CA, McPhee AJ, Flenady V, Robinson JS. Progesterone after previous preterm birth for prevention of neonatal respiratory distress syndrome (PROGRESS): a randomised controlled trial. BMC Preg Childbirth 2009, 9:6. (Protocol)