Research Activities of the Centre for Molecular Pathology
The CMP's research activities will focus on three main themes - cancer, development and infectious diseases.
These themes will be underpinned through a cross-disciplinary approach to exploiting enabling technology platforms and in particular building on the University's emerging strengths and opportunities in structural biology, chemical biology, bioinformatics, systems biology, proteomics, genomics and novel detection technologies. Research projects that address disease susceptibility and pathogenesis through molecular pathology and systems biology approaches will have priority.
The Centre's research theme activities provide a critical mass based on the founding member's research interests, track records and grants. The themes are based on grouping the following strengths that have been previously recognised - genetics and development, neurogenetics (intellectual disability, epilepsy), biochemistry, cancer biology, bacterial and viral infection, and chemokine pathobiology. Each research theme will be strongly supported by three enabling technology platforms that have significant potential at the University of Adelaide - a) bioinformatics and systems biology, b) chemistry, chemical biology and structure and c) detection, proteomics and genomics. The overall structure of the Centre is therefore based on a matrix of cross-disciplinary activities linking research themes with enabling technology platforms (see Figure 1).
Figure 1: The Centre's matrix portfolio
Each research theme will have a strong genesis in major molecular pathology questions using a common approach:
- Molecular mechanisms and pathways of pathogenesis
- Biological markers of pathogenesis and application to diagnostics
- Chemical or biological modifiers of pathogenesis and application as research tools and therapeutics
- New detection, sensing and analysis platforms for molecular pathology