|Robert Gibson||Ge Liu||Yichao Huang|
The Lipidomics unit aims to:
- build fundamental understanding of lipid biochemistry with particular emphasis on long chain polyunsaturated fatty acids
- better understand how different classes of lipids and lipid derivatives influence physiological processes
- develop and optimise novel methods for monitoring lipid interventions in clinical trial interventions.
The health benefits of the omega-3 fatty acids are of particular interest and investigating these fatty acids is a focus of our research in in vitro systems and animal models as well as clinical research. Our current research areas include building new methods for the measurement of fatty acids and their metabolites in human tissues and plasma; characterising the function of desaturase and elongase genes isolated from food animals.
A range of analytical tools are routinely used in our research, including capillary gas chromatography (GC) and high-performance liquid chromatography (HPLC). We have recently adopted a metabolomics approach, using liquid chromatography, tandem mass spectrometry (LC-MSMS) systems, as it allows for simultaneous measurement of a large number of metabolites from very small quantities of material (less than one drop of blood). FOODplus is currently collaborating with researchers around Australia to validate this method for measuring omega-3 fatty acids and their derivatives in dried blood spots.