Men Androgen Inflammation Lifestyle Environment and Stress

The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study was conceived in 2009 to investigate the effect of sex steroids, inflammation, environmental and bio psychosocial factors on cardio-metabolic disease risk in men. 

The study was the union of two existing cohort studies: all participants of the Florey Adelaide Male Ageing Study (FAMAS) and male participants of the North West Adelaide Health Study (NWAHS). Both the Florey Adelaide Male Ageing Study and the North West Adelaide Health Study are representative longitudinal adult cohort studies.

The study comprises:

  • all Florey Adelaide Male Ageing Study participants, which commenced in 2002 and at baseline, recruited 1195 men aged between 35 and 80 years with a response rate of 45.1%;
  • and a sub-set of North West Adelaide Health Study men who were aged 35 to 80 years of age at baseline and randomly selected from the population of the northern and western suburbs of Adelaide, which commenced in 1999 and recruited 4056 adults aged 18 years and over, with a baseline response rate of 49.4%; of these, 1389 men aged 35-80 at baseline have been included in the MAILES study

The study is based on three matched stages so far:

  • Part 1 (MAILES1) is data collected by FAMAS at participants' baseline biomedical examination (Phase A 2002-03 and Phase B 2004-05) and NWAHS at the first follow-up biomedical examination (Stage 2 2004-06);
  • Part 2 (MAILES2) is follow-up biomedical examination data (FAMAS Phase A 2007-08 & Phase B 2009-10; and NWAHS Stage 3 2008-10); and
  • Part 3 (MAILES3) is data collected from a Computer Assisted Telephone Interviewing (CATI) survey in August 2010.

Contact(s): Dr Sean Martin, and Professor Gary Wittert

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  • Aims

    The study aims to assess the:

    • Relationships between obesity, inflammation and sex-steroids, and those of
    • Obesity, sex steroids and inflammation with cardiovascular disease and type 2 diabetes mellitus cross-sectionally and over time,
    • Effect of the modifying factors shown in Fig 1, on the independent variables (obesity, sex steroids, and inflammation) and their relationship with cardiovascular disease and type 2 diabetes mellitus,
    • Direct effect of the modifying variables on cardiovascular disease and/or type 2 diabetes mellitus
    • Clustering of variables in determining cardiovascular disease and type 2 diabetes mellitus,
    • Pathways of different variables in determining cardiovascular disease.
  • Research areas

    Psychosocial
    • Stress & Socio-economic status (SES)
    • Subjective (MacArthur scales) vs objective SES markers
    • Status inconsistency & health outcomes
    • Social dominance
    • Financial & social support
    Sleep
    • In-home polysomnography testing (WatchPAT, Embletta)
    • Obstructive sleep apnea prevalence & disease
    • Shiftwork
    • Sympathetic nervous system (SNS) paper
    • Sleep & obesity
    • Obstructive sleep apena predictive measure
    • Posture & Sleep disordered breathing (SDB)
    • Instrument and scale comparison studies
    Sex Steroids
    • Secular decline in sex steroids (testosterone (T), dihydrotestosterone (DHT), estradiol (E2), sex hormone binding globulin (SHBG), luteinising hormone (LH), follicle-stimulating hormone (FSH))
    • Comparison of various testosterone (T) measures (total testosterone (radioimmunoassay, mass spectrometry), free T, bioavailable T)
    • Sex steroids & endocrine disruptors (Bisphenol-A (BPA), phthalates)
    • T, sex hormone binding globulin (SHBG) and relation to incident diabetes
    • Geospatial changes & T
    Sexual health / Lower Urinary Tract Symptoms (LUTS)
    • Lower urinary tract symptoms (LUTS) & erectile dysfunction (ED) - mechanisms
    • LUTS / ED and inflammation
    • LUTS / ED and endocrine disruptors
    • LUTS / ED and medication patterns
    Diabetes
    • Prevalence (incl undiagnosed) and predictors
    • Sex hormone-binding globulin (SHBG), testosterone (T) & incident type 2 diabetes
    • Insulin resistance & changes to body composition
    Health Service Usage
    • Pharmaco-epidemiology in men
    • Health service utilisation in men
    • Men's preferences for health services
    Mental health
    • Depression and modifiable factors
    • Anxiety (PHQ)-prevalence and predictors
    • Quality of life determinants
    • Depression & cytokine exposure
    Other
    • Environmental exposures
    • Health literacy
    • Fractures and body composition
    • Life events and health outcomes
    • Nutritional intake / alcohol & health
    • Health-related quality of life and disability
    • Behavioural (lifestyle) risk factors
  • Chief investigators

  • Data access and collaboration

    Data may be made available to collaborating researchers where there is a formal request to make use of the material. Permission to use the data must be obtained from the MAILES Executive and Investigator Committee, following the completion and submission of a MAILES data request form and a manuscript proposal form.

    The MAILES study is focused on a range of harmonised self-reported and biomedically measured information from the baseline clinic, regular self-reported telephone and questionnaire-based information and follow-up clinic data. Data collected includes chronic medical conditions, risk factors, prior surgery, overall health status, quality of life, medication use, anthropometry, body composition, demographic, psycho-social and economic factors, as well as plasma and urine samples (summary of data collection items from the MAILES Study)

    Initial approaches regarding the study data can be made to either the Principal Investigator Gary Wittert or the Project Coordinator Sean Martin.

  • Funding acknowledgement

    MAILES acknowledge the following organisations for their financial support:

    • The Florey Foundation
    • SA Health
    • Bellberry Limited
    • National Health and Medical Research Foundation
    • Freemasons Foundation Centre for Men's Health