Candida glabrata

RG-2 organism.

Culture: 
Colonies (SDA) white to cream-coloured smooth, glabrous, yeast-like.

Microscopy: 
Ovoid to ellipsoidal budding blastoconidia, 3.4 x 2.0 µm in size. No pseudohyphae or chlamydospores produced.

India ink preparation: 
Negative - no capsules present.

Dalmau plate culture: 
Ovoid budding yeast cells only. No pseudohyphae produced.

Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data
Germ Tube - L-Sorbose - L-Arabinose - D-Glucitol -
Fermentation   Sucrose - D-Arabinose - 𝝰-M-D-Glucoside -
Glucose + Maltose - D-Ribose - D-Gluconate +
Galactose - Cellobiose - L-Rhamnose - DL-Lactate v
Sucrose - Trehalose v D-Glucosamime - myo-Inositol -
Maltose - Lactose - N-A-D-glucosamine - 2-K-D-Gluconate v
Lactose - Melibiose - Glycerol v D-Glucuronate -
Trehalose v Raffinose - Erythritol - Nitrate -
Assimilation   Melezitose - Ribitol - Urease -
Glucose + Soluble Starch - Galactitol - 0.1% Cycloheximide -
Galactose - D-Xylose - D-Mannitol - Growth at 40C +

Key features:
Germ tube negative yeast and sugar assimilation pattern. C. glabrata is a common yeast species found on the body surface. Approximately 10% of clinical isolates show azole cross-resistance.

Antifungal susceptibility: Candida glabrata (Australian national data); MIC µg/mL.
Antifungal No ≤0.008 0.016 0.03 0.06 0.125 0.25 0.5 1 2 4 8 16 32 ≥64
AMB 1574 1 1 8 25 279 384 551 307 16 1     1  
FLU 1576         1 4 8 24 164 221 189 381 328 256
ISAV 358 1 4 16 35 37 80 101 53 12 11 8      
VORI 1468 5 15 64 170 259 323 319 144 55 82 31 1    
POSA 1346   2 10 16 64 158 295 384 267 6 131      
ITRA 1576     6 18 115 295 410 361 118 33 7 213    
ANID 1205   92 497 405 182 7 4 6 10 1 1      
MICA 1204 242 805 119 11 4 7 2 4 3 2 5      
CAS 1316   2 90 444 444 216 61 9 4 1 10      
5FC 1574 3   308 1188 34 10 8 6 9 3 1     9

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