Candida nivariensis

RG-2 organism.

Culture: 
Colonies (SDA) white to cream-coloured smooth, glabrous, yeast-like.

Microscopy: 
Ellipsoidal budding blastoconidia, 3-5 x 1.8-3 µm in size. No pseudohyphae or chlamydospores produced.

India ink preparation: 
Negative - no capsules present.

Dalmau plate culture:
No pseudohyphae produced.

Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data
Germ Tube - L-Sorbose - L-Arabinose - D-Glucitol -
Fermentation   Sucrose - D-Arabinose - 𝝰-M-D-Glucoside -
Glucose + Maltose - D-Ribose - D-Gluconate +
Galactose - Cellobiose - L-Rhamnose - DL-Lactate -
Sucrose - Trehalose - D-Glucosamime - myo-Inositol -
Maltose - Lactose - N-A-D-glucosamine - 2-K-D-Gluconate -
Lactose - Melibiose - Glycerol + D-Glucuronate -
Trehalose - Raffinose - Erythritol - Nitrate -
Assimilation   Melezitose - Ribitol - Urease -
Glucose + Soluble Starch v Galactitol - 0.1% Cycloheximide -
Galactose - D-Xylose - D-Mannitol - Growth at 40C +

Key features:
C. nivariensis is closely related to C. glabrata and C. bracarensis. These three species were found to differ by DNA-DNA reassociation experiments, RAPD-typing, AFLP-typing and D1/D2 and ITS sequence divergence (Alcoba-Flórez et al. 2005, Correia et al. 2006, Wahyuningsih et al. 2008).

Antifungal susceptibility: Candida nivariensis (Australian national data); MIC µg/mL.
Antifungal No ≤0.008 0.016 0.03 0.06 0.125 0.25 0.5 1 2 4 8 16 32 ≥64
AMB 4           1 1 2            
FLU 4                   1 1 2    
ISAV 2       2                    
VORI 4       2   1 1              
POSA 4           1 1 2            
ITRA 4           4                
ANID 4     1 1 2                  
MICA 4 2 2                        
CAS 4       2     2              
5FC 4         1   2 1            

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