“ I believe in innovation and that the way you get innovation is you fund research and you learn the basic facts. ” Bill Gates.
TV News Stories About PARC Clinical Research Studies
The PARC clinical unit at Royal Adelaide Hospital in Australia has initiated a clinical study to test a new pain medication for a Dermatitis study. This study is being run by Dr Richard Walsh and Professor Guy Ludbrook. - Currently recruiting
The PARC Clinical Research unit at Royal Adelaide Hospital in Australia in association with the University of Adelaide and Hampstead Hospital are currently running a study in Spinal Cord Injury.- Currently recruiting
The PARC clinical unit at Royal Adelaide Hospital in Australia has initiated a clinical study to test a new pain medication for Rheumatoid arthritis and Gout study \. This study is being run by Dr Richard Walsh and Professor Guy Ludbrook. - No longer recruiting
The PARC clinical unit at Royal Adelaide Hospital in Australia has initiated a clinical study to test a new pain medication called CMX-020. This study was run by Professor Guy Ludbrook. - No longer recruiting
The prestigious London Business School has named our Director Professor Guy Ludbrook, one of their trailblazing alumni.
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The Royal Adelaide Hospital has adopted an initiative that was developed at PARC Clinical Research and spearheaded by our Director Professor Guy Ludbrook. The initiative entitled "Preoperative assessment and management for adult elective surgery in South Australia". The project will focus on the development of a State-wide Model of Care for preoperative assessment and management for adult elective surgery in South Australia and a Clinical Governance Framework to deliver the Model of Care within each LHN.
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Most recent Journal Articles from our Investigators
G. L. Ludbrook1,2,* and A. G. Goldsman3
1Department of Anaesthesia, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, 2Discipline of
Acute Care Medicine, University of Adelaide, North Terrace, Adelaide, South Australia 5005 and 3Kings College NHS
Foundation Trust, Denmark Hill, London UK
Links Associated with PARC Clinical Trials
Publications of Studies Performed at the PARC Clinic (Including Journal, Magazine and Theses)
“ All I’m armed with is research. ” Mike Wallace.
Kwok, Y.H., Swift, J.E., Gazerani, P., Rolan, P.E. (2016). A double-blind, randomized, placebo-controlled pilot trial to determine the efficacy and safety of ibudilast, a potential glial attenuator, in chronic migraine, J Pain Res, 9: 899-907
Swift, J., Johnson J., Rolan, P. (2015, March). New Ways to Split a Headache, Australasian Science, 36(2), 14-17.
Johnson, J.L. (2015). Codeine, heightened pain sensitivity and medication overuse headache: a neuroimmune hypothesis and novel treatment strategy (Doctoral Thesis, University of Adelaide, Adelaide, Australia). Retrieved from
Johnson, J. L., Y. H. Kwok, N. M. Sumracki, J. E. Swift, M. R. Hutchinson, K. Johnson, D. B. Williams, J. Tuke and P. E. Rolan (2015). "Glial Attenuation With Ibudilast in the Treatment of Medication Overuse Headache: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Efficacy and Safety." Headache 55(9): 1192-1208.
Sumracki, N.M. (2015). The thermal grill as a tool to investigate analgesic clinical pharmacology (Doctoral Thesis, University of Adelaide, Adelaide, Australia). Retrieved from
Kwok, Y.H. (2014). Potential peripheral biomarkers for chronic pain (Doctoral Thesis, University of Adelaide, Adelaide, Australia). Retrieved from
Johnson, J. L., P. E. Rolan, M. E. Johnson, L. Bobrovskaya, D. B. Williams, K. Johnson, J. Tuke and M. R. Hutchinson (2014). "Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation." Transl Psychiatry 4: e482.
Solomon, C. A. (2014). It’s numbers and that’s it: An exploration of children’s beliefs about mathematics through their drawings and words (Doctoral thesis, University of Canterbury, Christchurch, New Zealand). Retrieved from
Sumracki, N. M., F. T. Buisman-Pijlman, M. R. Hutchinson, M. Gentgall and P. Rolan (2014). "Reduced response to the thermal grill illusion in chronic pain patients." Pain Med 15(4): 647-660.
Ahmad, M.I. (2014). A pilot study assessing fentanyl dose requirements in opioid-maintained individuals (Thesis, University of Adelaide, Adelaide, Australia). Retrieved from
Kwok, Y. H., J. Tuke, L. L. Nicotra, P. M. Grace, P. E. Rolan and M. R. Hutchinson (2013). "TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers." PLoS One 8(10): e77799.
Hutchinson, M. R., M. Buijs, J. Tuke, Y. H. Kwok, M. Gentgall, D. Williams and P. Rolan (2013). "Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection." Brain Behav Immun 30: 3-11.
Maddison, J., A. A. Somogyi, B. P. Jensen, H. M. James, M. Gentgall and P. E. Rolan (2013). "The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship to VKORC1 genotype." Br J Clin Pharmacol 75(1): 208-216.
Vallence, A. M., A. Smith, A. Tabor, P. E. Rolan and M. C. Ridding (2013). "Chronic tension-type headache is associated with impaired motor learning." Cephalalgia 33(12): 1048-1054.
Haylock, C.L. (2013). Neuro-endocrine function in older men with chronic pain: effects of chronic opioid usage (Thesis, University of Adelaide, Adelaide, Australia). Retrieved from https://digital.library.adelaide.edu.au/dspace/handle/2440/87365
Kwok, Y. H., M. R. Hutchinson, M. G. Gentgall and P. E. Rolan (2012). "Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients." PLoS One 7(8): e44232.
Sumracki, N. M., M. R. Hutchinson, M. Gentgall, N. Briggs, D. B. Williams and P. Rolan (2012). "The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica." PLoS One 7(6): e38525.
Aykanat, V., M. Gentgall, N. Briggs, D. Williams, S. Yap and P. Rolan (2012). "Intradermal capsaicin as a neuropathic pain model in patients with unilateral sciatica." Br J Clin Pharmacol 73(1): 37-45.
Grace, P.M. (2011). Two methods of biomarker discovery: applications in neuropathic pain and pharmacology (Doctoral Thesis, University of Adelaide, Adelaide, Australia). Retrieved from
Grace, P. M., T. Stanford, M. Gentgall and P. E. Rolan (2010). "Utility of saccadic eye movement analysis as an objective biomarker to detect the sedative interaction between opioids and sleep deprivation in opioid-naive and opioid-tolerant populations." J Psychopharmacol 24(11): 1631-1640.
Gustafsson, H., J. Akesson, C. L. Lau, D. Williams, L. Miller, S. Yap and P. Rolan (2009). "A comparison of two formulations of intradermal capsaicin as models of neuropathic pain in healthy volunteers." Br J Clin Pharmacol 68(4): 511-517.
The Following is a Collection of Archived Media and Interviews.
A clinical pharmacologist’s journey in pain research and treatment
Paul Rolan speaks to Roshaine Gunawardana, Commissioning Editor: Paul Rolan graduated in Medicine (MBBS) from the University of Adelaide, Australia, in 1979 and trained in internal medicine and clinical pharmacology. In 1987 he went to the UK to work at the Wellcome Research Laboratories where he was responsible for the exploratory development of a range of compounds, some of which became marketed (atovaquone, zolmitriptan). He was awarded an MD degree from the University of Adelaide in 1995 for novel conceptual work on the use of biomarkers in exploratory development for work performed while at Wellcome.
What to do about opioids for chronic noncancer pain? A perspective from Australia.Many countries in the developed world are awash with opioid overuse, misuse and opioid - related deaths, which have paralleled the increasing medical use of opioids for chronic noncancer pain. This is despite growing concern over the efficacy of these drugs in long-term management. To attempt to reduce the harm associated with opioids but to ensure the continued availability for patient benefit, multiple attempts to develop guidelines, improve regulation and training have recently been attempted or are in progress.
Comparison of pain models to detect opioid-induced hyperalgesiaObjective: Chronic opioid therapy may be associated with hyperalgesia. Our objective was to determine if opioid-induced hyperalgesia detection sensitivity is dependent on the stimulus used to detect it.
Methods: This open design study compared the detection of hyperalgesia in opioid-dependent subjects (n = 16) and healthy control subjects (n = 16) using the following pain stimuli: cold pain, electrical stimulation, mechanical pressure, and ischemic pain. The opioid-dependent subjects were maintained on either methadone (n = 8) or buprenorphine (n = 8) for at least 3 months. None of the controls was dependent on opioids or other drugs of abuse.