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Dr Carlos Rodriguez Lopez

Telephone +61 8 8313 0779
Position PDRA
Email carlos.rodriguezlopez@adelaide.edu.au
Building Plant Research Centre
Floor/Room 1 83
Campus Waite
Org Unit School of Agriculture, Food and Wine

To link to this page, please use the following URL:
http://www.adelaide.edu.au/directory/carlos.rodriguezlopez

Research Interests

I am interested on three main areas. My first research interest is functional epigenetics, or the effect of epigenetic processes on gene regulation. The second thread is the generation and use of epigenotyping tools to 1. study the importance of epigenetics on the expression of phenotypes; 2. identify stresses, describe the source material (tissue/organ/cell type) or to establish its physiological, developmental state or sex. This line of research has an applied side since epigenetic markers can be used in variety of fields such as medicine (nutrigenomics), forensics, agriculture, food quality and security. On a more fundamental side epigenetic markers are an effective forward genetic tool to identify genes regulated by epigenetic processes. The final thread that binds the two previous together is to study the importance of epigenetic effects on evolutionary biology both by facilitating adaptation to changing environments and by accelerating the ratio of base substitution.

Research Funding


    1. Epigenetics Research Platform (Waite Research Institute Research Capacity Development Funding 2015). 
    2. Epigenetic markers for cancer diagnosis (2015).   
    3. Obesity and prostate cancer risk (Waite Research Institute Research Capacity Development Funding 2015). 
    4. Ecogenomics of Terroir (Australian Genome Research Facility ltd Pilot program in Genomics application; The University of Adelaide Interdisciplinary Research Fund. Australia's icons benefit from genomics research
    5. Breeding drought and heat tolerant grapevines using epigenetic tools (Grape and Wine Research and Development Corporation (GWRDC) Incubator Project call 2014). 
    6. Epigenetic control of wine quality in response to grapevine age (Waite Research Institute grant 2013/14).
    7. Demonstrating the potential of mobile RNAs for grafted epibreeding- a paradigm shift for plant and animal breeding(University of Adelaide Interdisciplinary Research Fund (IRF) 2013/14 grant). 
    8. Diagnosing the response of Calendula officinalis to saline water irrigation (Jurlique Limited funded grant 2013/14). 

Publications

SUBMITTED

GRIGG D, METHVEN D, DE BEI R, RODRIGUEZ, LOPEZ CM, DRY P, COLLINS C. Vine age effects on vine performance in the Barossa Valley, Australia. (Australian Journal of Grape and Wine Research)

BREEN J, MUR L, SIVAKUMARAN A, AKINYEMI A, WILKINSON M, RODRIGUEZ LOPEZ, C‡DNA methylation plays a role on in vitro culture induced loss of virulence in Botrytis cinerea. Archived on the pre-print repository BioRxiv doi: 10.1101/059477.

 

REFEREED JOURNAL ARTICLES

(26) CONSUEGRA S, RODRIGUEZ LOPEZ C. Epigenetic-induced alterations in sex-ratios in response to climate change: an epigenetic trap? Bioessays. (accepted 8 July 2016). DOI: 10.1002/bies.20160005810

(25) ADU-GYAMFI R, WETTEN A, RODRIGUEZ LOPEZ, C. Effect of cryopreservation and post-cryopreservation somatic embryogenesis on the epigenetic fidelity of cocoa (Theobroma cacao L.). PLOS ONE (accepted 23 June 2016). DOI: 10.1371/ journal.pone.0158857

(24) BIANCO-MIOTT0 T, MAYNE BT, BUCKBERRY S, BREEN J, RODRIGUEZ, LOPEZ CM, ROBERTS CTRecent progress towards understanding the role of DNA methylation in human placental development. Reproduction (2016)http://www.reproduction-online.org/content/152/1/R23.abstract?etoc

(23ELLISON, A., RODRIGUEZ, LOPEZ C.M., MORAN, P., BREEN, J., SWAIN, M., MEGIAS, M., HEGARTY, M., WILKINSON, M., PAWLUK, R., CONSUEGRA, S. Epigenetic regulation of sex-ratios may explain natural variation in self-fertilisation rates. Proceedings of the Royal Society B (2015). 

(22) GUZMÁN, B., RODRIGUEZ, LOPEZ C.M., FORREST A., CANO, E., VARGAS, P. Protected areas of Spain preserve the genetic diversity of Quercus ilex L. irrespective of glacial refugia. Tree Genetics & Genomes (2015).

(21) BIANCO-MIOTTO T, RODRÍGUEZ LÓPEZ, C.M., LEEMAQZ SY, ZHUANG Z, MCCULLOUGH D, DEKKER G, WILKINSON M, ROBERTS CT. DNA Methylation Biomarkers for Predicting Pregnancy Complications. Placenta (2015).

(20) KITIMU, S.R., TAYLOR, J., MARCH, T., TAIRO, F., WILKINSON, M.J., RODRÍGUEZ LÓPEZ, C.M. Meristem micropropagation of cassava (Manihot esculenta) evokes genome-wide changes in DNA methylation. Frontiers in Plant Sciences (2015). http://journal.frontiersin.org/article/10.3389/fpls.2015.00590/abstract

(19) RODRÍGUEZ LÓPEZ, C.M.*, WILKINSON, MJ. Epi-fingerprinting and epi-interventions for improved crop production and food quality. Frontiers in Plant Sciences (2015). http://journal.frontiersin.org/article/10.3389/fpls.2015.00397/abstract#

(18) ROIS, A.S.*, RODRÍGUEZ LÓPEZ, C.M.*, CORTINHAS, A., ERBEN, M., ESPIRITO SANTO, D, WILKINSON, M.J., CAPERTA, A.D. Epigenetic rather than genetic factors may explain phenotypic divergence between coastal populations of diploid and tetraploid (Limonium sp.; Plumbaginaceae) in Portugal. BMC Plant biology (2013). *Equal contributors

(17) TRICKER P., RODRÍGUEZ LÓPEZ, C.M., HADLEY P., Wagstaff, C., WILKINSON, M.J. Pre-conditioning the epigenetic response to high vapour pressure deficit increases the drought tolerance in Arabidopsis thaliana. Plant Signaling & Behavior(2013). https://www.landesbioscience.com/journals/psb/article/25974/

(16) TRICKER P., RODRÍGUEZ LÓPEZ, C.M.GIBBINGS G., HADLEY P., WILKINSON, M.J. Transgenerational, dynamic methylation of stomata genes in response to low relative humidity. International Journal of Molecular Sciences (2013) http://www.mdpi.com/1422-0067/14/4/6674                    

(15) AMOAH S., KURUP S., RODRÍGUEZ LÓPEZ C.M., WELHAM S.J., POWERS S.J., HOPKINS C.J., WILKINSON M.J, KING G.J. A Hypomethylated Population of Brassica rapa for Forward and Reverse Epi-Genetics. BMC Plant biology (2012) http://www.biomedcentral.com/1471-2229/12/193

(14) RODRÍGUEZ LÓPEZ C.M.
, LLOYD A.J., LEONARD K., WILKINSON M.J. Diferential Effect of Three Base Modifications on DNA Thermostability Revealed by High Resolution Melting.Analytical Chemistry (2012) http://dx.doi.org/10.1021/ac301459x.

(13) TRICKER P., GIBBINGS G., RODRÍGUEZ LÓPEZ, C.M.,HADLEY P., WILKINSON, M.J. Low relative humidity triggers RNA-directed de novo DNA methylation and suppression of genes controlling stomatal development. Journal of Experimental Botany (2012)

(12) RODRÍGUEZ LÓPEZ, C.M., BECKHAM, M., CONSUEGRA, S.,LAGO, F., ESPIÑEIRA, M., MORÁN P. Detection and Quantification of Tissue of Origin in Salmon and Veal Products using Methylation Sensitive AFLPs. Food Chemistry (2012).

(11) GEYER, K.K., RODRÍGUEZ LÓPEZ, C.M., HEALD, J., WILKINSON, M.J. AND HOFFMANN K.F. DNA methylation regulates egg production in the pathogenic blood flukeSchistosoma mansoni.Nature Communications (2011). Rated Must Read on Faculty 1000

(10) RODRÍGUEZ LÓPEZ, C.M., GUZMÁN ASENJO B., LLOYD A.J., WILKINSON M.J. Direct Detection and Quantification of Methylation in Nucleic Acid Sequences using High Resolution Melting analysis. Analytical Chemistry(2010).

(9) RODRÍGUEZ LÓPEZ, C.M., WETTEN, A.C., WILKINSON, M.J. Progressive erosion of genetic and epigenetic variation in callus-derived cocoa (Theobroma cacao) plants. New Phytologist(2010).

(8) RODRÍGUEZ LÓPEZ, C.M., SICILIA BRAVO, H., WETTEN, A.C., WILKINSON, M.J. An algorithm for the detection of Single Nucleotide Polymorphisms (SNPs) using Cleaved Amplified Polymorphic Sequence (CAPs). Molecular Breeding (2010).

(7) JONG-YI FANG, ANDY WETTEN, RAPHAEL ADU-GYAMFI, MIKE WILKINSON AND RODRIGUEZ-LOPEZ, C.M. Use of secondary somatic embryos promotes genetic fidelity in cryopreservation of cocoa (Theobroma cacao L.). Agricultural & Food Science (2009).

(6) WETTEN, A. ADU-GYAMFI, R. FANG, J.Y. RODRÍGUEZ LÓPEZ C. Cryopreservation of cocoa (theobroma cacao l.) somatic embryos - is somaclonal variation an issue? Cryoletters (2009). 

(5) RODRÍGUEZ LÓPEZ, C.M.
, CROXFORD A.E., WILKINSON M.J. High-resolution melt analysis for SNP discovery, linkage mapping and analysis of DNA methylation. Comparative biochemistry and physiology A (2008). doi:10.1016/j.cbpa.2008.04.035

(4) FANG, J.Y. RODRÍGUEZ LÓPEZ C. WETTEN, A. Screening for genetic fidelity of cocoa (theobroma cacao l.) somatic embryos following cryopreservation. Cryobiology (2007). 

(3) RODRÍGUEZ LÓPEZ, C.M., WETTEN, A.C., WILKINSON, M.J. Detection and quantification of in vitro-culture induced chimerism using Simple Sequence Repeat (SSR) analysis in Theobroma cacao (L.). Theoretical and Applied Genetics (2004).

(2) RODRÍGUEZ LÓPEZ, C.M., SICILIA, H., WETTEN, A.C., WILKINSON, M.J. Assessment of somaclonal variation in somatic embryo-derived cocoa (Theobroma cacao). In vitro cellular and developmental biology animal (2002).


(1) ALBANI, M., TAYLOR, S., RODRÍGUEZ LÓPEZ C., CEKIC, C., AL-SHEIKH, M., GREENLAND, A., WETTEN, A., WILKINSON, M., BATTEY, N. Fragaria vesca.... One way to understand flowering in perennials. Flowering Newsletters. In: Journal of Experimental Botany (2001).

 

BOOK CHAPTERS

(2) SCAMILLA, J.-M., BÄUERL, C., RODRÍGUEZ LÓPEZ, C.M.,PEKKALA, S.P., NAVARRO S., BARETTINO, D. Retinoic-Acid-induced downregulation of the expression of the 67 KDa Laminin Receptor correlates with reduced biological aggressiveness of human neuroblastoma cells. In:Neuroblastoma - Present and Future (2012). (Ed. Hiroyuki Shimada). Intech. ISBN 978-953-307-016-2. http://www.intechopen.com/books/neuroblastoma-present-and-future. 

(1) RODRÍGUEZ LÓPEZ, C.M. (translation). Organismos Geneticamente Modificados (Chapter 7). In: Proteina de Soja y Formulas para Productos Carnicos (2008). By W. Hoogenkamp. Ed. Acribia S.A. Spain.

 

PATENTS

(3) TRICKER P., RODRÍGUEZ LÓPEZ, C., WILKINSON, MJ., HADLEY P. (WO2011157995) "Method for producing a stress tolerant plant or precursor thereof" (2011)

(2) 
MEADE ANDREW PAUL, WILKINSON MICHAEL JAMES, RODRÍGUEZ LÓPEZ C.M. WO2011141711 (A1) - "Methods for Selecting Methylation Markers" (2011)WO2011GB00733 20110512.

(1) RODRÍGUEZ LÓPEZ, C., WILKINSON, MJ. "US2010291565 (A1) - Detection of Methylation in Nucleic Acid Sequences" (2008).


SCIENTIFIC SOFTWARES

(1) RODRÍGUEZ LÓPEZ, C.M., SICILIA BRAVO, H.
ArtBio: 
Artbio surveys known sequences for existing restriction enzyme recognition sites but also identifies all single nucleotide polymorphism (SNP) deviations from such motifs. ArtBio is free to download fromwww.artbio.net.

Entry last updated: Friday, 26 Aug 2016

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