Dr Claire Jessup

Qualifications

BBiotech(Hons); PhD

Awards & Achievements

1995     Letter of Commendation – Head of School of Biological Sciences, Flinders University

1995     Chancellor’s Letter of Commendation, Flinders University

1996     Letter of Commendation – Biotechnology Programme Committee, Flinders University

1996     Member of the Golden Key National Honour Society (Flinders University Chapter)

1997     Letter of Commendation – Chairperson Examinations Board (Flinders University)

1998     Chancellor’s Letter of Commendation, Flinders University

2001     MF & MH Joyner Postgraduate Scholarship in Medicine, South Australia

2001     Peter Meffin Memorial Postgraduate Research Prize, Flinders University

2002     Communication Award, Flinders Medical Research Institute Postgraduate Research Day

2003     Communication Award, Flinders Medical Research Institute Postgraduate Research Day

2003     Biorad Best Poster Award, ASMR (SA) Scientific conference

2004     Young Investigator Award, Transplantation Society for Australia and New Zealand conference

2004     International Society for Eye Research Travel Fellowship

2004     Australian Society of Immunology, Student Travel Bursary

2009     Overseas Conference Scheme, University of Adelaide

2010     Faculty International Conference Award, Faculty of Health Sciences, University of Adelaide

2010     Young Investigator Award, Transplantation Society for Australia and New Zealand conference

Teaching Interests

CBL Tutor - Bachelor of Medicine, MLTU, University of Adelaide

Supervisor - Ms Amy Hughes (PhD) and Ms Daniella Penko (Honours)

Research Interests

As an Adjunct Senior Lecturer with the University of Adelaide, I work collaboratively with the Islet Transplantation and Dendritic Cell Biology Laboratory run by Assoc Prof Toby Coates (http://www.adelaide.edu.au/directory/patrick.coates).

From 2012 I will be based at Flinders University in the Department of Human Physiology (School of Medicine). My contact details are here http://www.flinders.edu.au/people/claire.jessup.

My primary research interests focus on the vasculature of the pancreatic islet. The dense network of capillaries is crucial for the sensitive detection of blood glucose and release of insulin. Many islets die when they are disconnected from their blood supply for transplantation purposes - limiting the success of islet transplantation. In collaboration with Dr Claudine Bonder in the Centre for Cancer Biology (http://www.centreforcancerbiology.org.au/Bonder.htm) we are investigating the use of endothelial progenitor cells (see Figure below) to swiftly reconnect blood supply to transplanted islets and improve their function and survival.

 

Research Funding

2011	Project Grant - Medvet Laboratories CI: CF Jessup; AI: PTH Coates, CS Bonder	$276,000
2010	Project Grant - Centre for Stem Cell Research, Robinson Institute CI: PTH Coates, CS Bonder, CF Jessup	$75,000
2010	Research Grant - Robinson Institute Collaborative Research Funding Scheme CI: CF Jessup, CS Bonder, PTH Coates	$12,000
2010	Australian Federation of University Women Postdoctoral Grant CF Jessup	$5,000
2010	Research Grant – TSANZ/Amgen S Kireta, HS Eng, M Stephenson, CF Jessup, G Bennett, G Russ, PTH Coates	$50,000
2009	Young Scientist Research Travel Grant - Juvenile Diabetes Research Foundation CF Jessup	$2,500
2005	Overseas Postdoctoral Training Fellowship (Biomedical CJ Martin) – NHMRC CF Jessup	$304,118

Publications

REFEREED JOURNALS

 

Penko D, Mohanasundaram D, Sen S, Drogemuller C, Mee C, Bonder CS, Coates PT, Jessup CF (corresponding author). Incorporation of endothelial progenitor cells into mosaic pseudoislets. Islets. 2011 May 1;3(3): 73-9.

 

Jessup CF, Bonder CS, Pitson SM, Coates PTH. (2011) The sphingolipid rheostat: a potential target for improving pancreatic islet survival and function. Endocrine, Metabolic & Immune Disorders – Drug Targets, invited review accepted May 2011

 

Hughes A, Jessup C, Drogemuller C, Mohanasundaram D, Milner C, Rojas D, Russ GR and Coates PTH. (2010) Gene therapy to improve pancreatic islet transplantation for Type I Diabetes Mellitus. Current Diabetes Reviews 6(5):274-84. ERA Ranking C

 

Coster DJ, Jessup CF, Williams KA. (2009) Mechanisms of corneal allograft rejection and regional immunosuppression. Eye (23)10: 1894-7 ERA Ranking B

 

Parker DG, Kaufmann C, Brereton HM, Anson DS, Francis-Staite L, Jessup CF, Marshall K, Tan C, Koldej R, Coster DJ, Williams KA. (2007) Lentivirus-mediated gene transfer to the rat, ovine and human cornea. Gene Therapy 14(9):760-7 ERA Ranking A

 

Jessup, CF, Brereton HM, Sykes PJ, Thiel MA, Coster DJ and Williams KA. (2005) Local gene transfer to modulate rat corneal allograft rejection. Investigative Ophthalmology and Visual Science 46(5):1675-81  ERA Ranking A*

 

Jessup CF, Brereton HM, Coster DJ and Williams KA. (2005) In vitro adenovirus-mediated gene transfer to the human cornea. British Journal of Ophthalmology 89(6):658-61 ERA Ranking B

 

*Coster DJ, Jessup CF and Williams KA (2005) Mechanisms of corneal allograft rejection. The Ocular Surface 3(4): S165-S168 ERA Ranking B

 

Williams KA, Jessup C and Coster DJ (2004) Gene therapy approaches to prolonging corneal allograft survival. Expert Opinion on Biological Therapy 4(7):1059-71 ERA Ranking B

 

Kodituwkku AP, Jessup C, Zola H and Roberton DM (2003) Isolation of antigen-specific B cells. Immunology and Cell Biology 81: 163-170 ERA Ranking A

 

Macardle, PJ, Mardell C, Bailey S, Wheatland L, Ho A, Jessup C, Roberton D and Zola H. (2002) FcgRIIb expression on human germinal center B lymphocytes. European Journal of Immunology 32: 3736-44 ERA Ranking A

 

Jessup CF, Ridings J, Ho A, Nobbs S, Roberton DM, Macardle P and Zola H. (2001) The Fc receptors for IgG (FcgRII; CD32) on human neonatal B lymphocytes. Human Immunology 62: 679-85 ERA Ranking B

 

Jessup CF, Baxendale H, Goldblatt D. and Zola H. (2000) Preparation of human-mouse heterohybridomas against an immunising antigen. Journal of Immunological Methods 246: 187-202 ERA Ranking B

 

Zola H, Jessup C, Nicholson IC and Macardle, PJ. (2000) CD32 (Fc gammaRII). Journal of Biological Regulators and Homeostatic Agents 14: 311-316 ERA Ranking C

 

PATENTS

 

JESSUP, Claire, F., BRERETON, Helen, M., COSTER, Douglas, J., WILLIAMS, Keryn, A. (2004) Ocular tissue modification. Patent ID 2004290461. International application number PCT/AU2004/001606

 

OTHER ARTICLES

 

(book section) Coster DJ, Jessup CF, Williams KA. (2010) Mechanisms of Corneal Allograft Rejection and the Development of New Therapies. In Reinhard T and Larkin F, Essentials in Ophthalmology: Cornea and External Eye Disease. Corneal Allotransplantation, Allergic Disease and Trachoma. Springer, Berlin

 

(published report) JDRF: Australian Type I Diabetes Research Agenda. Partnering science, government and the community.  (Scientific contributor: JESSUP CF) Sydney, 2010

 

(book section) Zola H, Jessup C and Jackson D (2000) CD44 Workshop Panel Report: Analysis of CD44 isoform-specific and pan-CD44 antibodies. Leucocyte Typing VII: 14-17

 

PUBLISHED ABSTRACTS

 

Jessup CF, Bonder CS, Mohanasundaram D, Mee C, Sun WY, Sen S, Drogemuller C, Russ G, Coates PTH: (Abstract) Characterisation of rat endothelial progenitor cells (EPC) as a novel cellular therapy to enhance the engraftment of pancreatic islets. Immunol Cell Biol 87:A29-30, 2009

 

Drogemuller CJ, Mohanasundaram D, Mee C, Murgia C, Zalewski P, Milner C, Jessup CF, Hawthorne W, Loudavaris T, Russ G, Coates PTH: (Abstract) Variability of zinc transporter gene expression in isolated human islets: in particular ZIP14 and the B-cell specific ZnT8. Immunol Cell Biol 87:A29-30, 2009

 

Hughes A, Kupke AJ, Drogemuller C, Mohanasundaram D, Jessup CF, Mee C, Milner CR, Coates PTH (Abstract) Adenovirus-mediated transduction of pancreatic islets using insulin-like growth factor-II (IGF-II) to prevent apoptosis. Immunol Cell Biol 2009, 87:A29-A30.

 

Jessup CF, Mohanasundaram D, Mee C, Sun WY, Drogemuller C, Milner C, Sen S, Bonders CS, Coates PTH (Abstract) Co-transplantation of rat endothelial progenitor cells to enhance the engraftment of pancreatic islets. Xenotransplantation 2009, 16(5):412.

 

Hughes A, Kupke AJ, Drogemuller C, Mohanasundaram D, Jessup CF, Milner CR, Mee C, Coates PTH: (Abstract) Transgenic expression of insulin-like growth factor-II (IGF-II) in pancreatic islets to prevent apoptosis. Xenotransplantation 2009, 16(5):413.

 

Jessup C, Brereton H, Sykes P, Thiel M, Coster D and Williams K. (2004) Expression of anti-rat CD4 and CD28 antibody fragments by donor corneas. Immunology and Cell biology 82(2): A11

 

Jessup CF, Brereton HM, Sykes P, Thiel MA, Coster D, Williams KA. (2004) Expression of anti-rat CD4 and CD28 antibody fragments by donor corneas during corneal transplantation. Clinical and Investigative Medicine. 27(4): 209A

 

Jessup C, Brereton H, Sykes P, Thiel M, Coster D and Williams K. (2003) Ex vivo gene transfer to donor rat corneas. Immunology and Cell Biology 81(2): A8

 

Williams KA, Klebe S, Coster DJ, Sykes P, Swinburne S, Scheerlinck J-P, Krishnan R, Francis-Staite L, Anson DS, Thiel MA, Jessup CF and Brereton HM. (2003) Gene therapy approaches to prolonging corneal allograft survival. 33^rd Annual Scientific Meeting, Australasian Society for Immunology (Perth, Australia)

 

Thiel MA, Jessup CF, Zola H, Coster DJ and Williams KA. (1999) Engineered antibody fragments for experimental corneal transplantation. Immunology and Cell Biology 77(Suppl): A6

 

 

 

 

Professional Associations

The Transplantation Society of Australia and New Zealand (TSANZ)

Australasian Society for Immunology (ASI)

Australian Society for Medical Research (ASMR)

Australasian Gene Therapy Society

Australian Diabetes Society

Women Leaders in Transplantation member (The Transplantation Society)

Community Engagement

2000-2004     Postgraduate Research in the School of Medicine (PRISM), Flinders University

                    Deputy Convenor, Executive committee member

2001-2004     Gus Fraenkel Medical Library Committee, Flinders University

                    Postgraduate student representative,

2003             ASMR Medical Research Week, Public display and information booth, Adelaide, SA

2004             Biotechnology 10 year reunion committee, Flinders University

2006-2007     Females in Engineering Science and Technology (FEST), Oxford University, UK

                    Member

2009             Early Career Researchers Group, Basil Hetzel Institute, Adelaide, SA

                    Founder

2009             BHI Research Day committee,

2000-2009     Adelaide Wildcats Netball Club (Vice president, committee member, player)

2009             BHI Strategic Research Directions Working Group, TQEH, SA (Member)

2009-2011     Australian Society for Immunology, Annual Meeting Organising Committee 2011

Files

• ASI flyer - flyer.tif [4.1MB] (image/tiff)
• Endothelial Progenitor Cell colony - RATepc.jpg [58.7K] (image/jpeg)

Entry last updated: Friday, 27 Jul 2012