Professor Claire Roberts
A number of pathologies of pregnancy, including up to 50% of miscarriages, preeclampsia (hypertension and proteinuria in pregnancy), intrauterine growth restriction (IUGR), preterm labour, unexplained stillbirth and placental abruption are characterised by impaired cytotrophoblast invasion and inadequate response of the uterine spiral arteries to undergo physiological transformation. Together these conditions affect more than one quarter of pregnant women in developed societies. Our laboratory takes a "bench to bedside" approach to discovery and solving clinical problems in pregnancy that have their origins in placental development and maternal adaptation to pregnancy. We undertake basic cellular and molecular experiments to elucidate mechanisms that govern normal and abnormal placental development. We also have a strong focus on identifying genetic, nutritional, lifestyle and clinical factors that associate with pregnancy outcome in the SCOPE and PAPO pregnancy cohorts. Current projects include single nucleotide polymorphisms in mother, father, baby trios in prediction of pregnancy complications, the role of vitamin D in placentation (in human and knockout mice), the role of hypoxia in early placental differentiation, and sex differences in the human placental transcriptome.
1. Diagnosing risk for pregnancy complications and applying results of basic research to clinical problems
We were funded by Government of South Australia to develop predictive tests for couples' risks for complications of late pregnancy, specifically preeclampsia, IUGR and pre-term birth. This is the Adelaide arm of the SCOPE (SCreening fOr Pregnancy Endpoints) project. SCOPE is an international consortium of clinicians and scientists who at end 2011 have recruited nearly 6,000 women pregnant for the first time. Recruiting has ceased in Auckland and Adelaide but is ongoing in London, Manchester and Leeds in the UK and in Cork in Ireland. We have assembled a biobank of samples from women pregnant for the first time, their partners and babies. In Adelaide we are undertaking a targeted gene approach and aim to identify genes that determine a couple's risk prior to the development of symptoms. These genes have already been shown to be important in the control of placental development. We have a particular interest in how the father imparts risk for pregnancy complications in the mother and baby. Furthermore, we are determining whether there are differences in circulating microRNAs (miRs) in the mother in early gestation that are associated with later development of preeclampsia.
We have a new cohort Predicting Adverse Pregnancy Outcomes (PAPO) in whom women suffer recurrent pregnancy complications but primarily recurrent spontaneous miscarriage (RSM). It appears that RSM is in the continuum of pregnancy complications associated with poor placentation. We aim to elucidate molecular mediators in RSM and identify potential therapeutic targets for subsequent development and testing.
2. The role of Vitamin D in the placenta and pregnancy success
Recently, vitamin D has emerged as a micronutrient critical to optimal pregnancy outcome. In women, vitamin D deficiency has been associated with complications of pregnancy including preeclampsia, intrauterine growth restriction, gestational diabetes, preterm birth and a greater need for caesarean section. Although our understanding of the specific functions of vitamin D in pregnancy is scant, it seems likely that vitamin D deficiency may play a role in complicated pregnancies because robust regulation of vitamin D activation and degradation occurs in the placenta. The placenta contains enzymes responsible for localized vitamin D activation and degradation, as well as the vitamin D receptor, which is responsible for mediating vitamin D-dependent gene expression. In addition, vitamin D is known to interact with the IGFs and with members of the renin angiotensin system that are also important in pregnancy success (see below).
Perhaps the best known function of vitamin D is in the maintenance of calcium balance. Indeed, calcium supplementation in women with low dietary calcium has been shown to prevent preeclampsia. However, little is known of the mechanisms by which vitamin D and calcium act in the placenta and in maternal adaptation to pregnancy. Vitamin D is likely to interact with a number of other systems in a calcium-dependent and -independent manner, thus providing a potential mechanism for complications of pregnancy resulting from vitamin D deficiency. We will elucidate the molecular mechanisms by which vitamin D deficiency affects placentation and pregnancy outcome to provide the breakthrough in vitamin D and pregnancy research that has been elusive to date.
3. Epigenetic programming of placental and fetal development
IGF2 and its specific membrane receptor, IGF2R, are imprinted genes which means that only one copy of the gene is expressed, the other having been silenced by DNA methylation. IGF2 is expressed from the paternal allele, while IGF2R is expressed only from the maternal allele in most species. We have recently shown that both genes are important in controlling placental invasion. A number of factors can alter the methylation status of imprinted genes including maternal nutrition, ex vivo embryo culture and cloning. Previously, we examined the effect of cloning, ex vivo embryo culture and periconceptional undernutrition on placental development and methylation of imprinted genes in the sheep. Currently we are determining whether imprinting may play a role in human pregnancy complications and particularly in placental development. We have recently quantified allele specific expression of IGF2, IGF2R and H19 across gestation in human placenta. Of most intrerest is our finding that H19 imprinting in placenta is plastic across first trimester. Biallelic expression of H19 has previously been shown in term placenta from preeclamptic pregnancies and was associated with hypertensive crisis. Could it be that aberrant H19 imprinting in first trimester is an important epigenetic link to preeclampsia?
4. Placental invasion and the blood supply to the placenta
Our group's major current focus in basic research is on the development of the placenta and the vessels which supply it. A number of pathologies of pregnancy, including up to 50% of miscarriages, preeclampsia, intrauterine growth restriction (IUGR), preterm labour, unexplained stillbirth and placental abruption are characterised by an impaired cytotrophoblast invasion and inadequate response of the uterine spiral arteries to undergo physiological transformation. Together these conditions affect more than one quarter of pregnant women in developed societies. We aim to understand the factors that impair placental invasion and function and apply this understanding to determining which couples are at risk of developing serious pregnancy complications.
We are investigating the cellular and molecular mechanisms underlying the formation of vascular connections between the mother and fetus. The uterine arterioles which supply the placenta are invaded by placental cytotrophoblast cells and are dramatically remodelled to produce dilated compliant vessels which allow the 12 fold increase in blood flow to the uterus which is essential for normal placental, and hence fetal, growth. However, the mechanisms by which physiological transformation of these vessels occurs are poorly understood. We are currently delineating the cellular and molecular interactions between maternal decidua and fetal trophoblast during the normal transformation of the arterioles which supply the placenta. Our work focuses on the role of insulin-like growth factor II (IGF-II) in placental invasion and how oxygen interacts with IGF-II in early pregnancy.
5. The role of IGFs in placental function and fetal growth
Our laboratory has previously shown that maternal administration of either IGF-I or IGF-II to guinea pigs for two weeks in early to mid pregnancy improves placental differentiation and function and fetal growth in late gestation. These data suggest that IGFs, and IGF-II in particular, could be administered to pregnant women at risk of fetal growth restriction to ameliorate the condition. We are currently undertaking in vitro experiments to elucidate the mechanisms by which IGFs improve placental differentiation and function. In addition, we are determining the role of these growth factors, and polymorphisms in the genes that encode them, in healthy and complicated human pregnancies.
6. The role of the renin angiotensin system in the placenta and pregnancy outcome
The renin angiotensin system is best known for its actions in regulating blood pressure and water/salt homeostasis. During pregnancy this system is an important mediator of the dramatic changes in plasma volume and peripheral resistance. Pregnant women are less sensitive to the pressor effects of angiotensin II than non-pregnant women and are able to maintain blood pressure at normal levels in this highly haemodynamic state. However, the placenta also has its own local RAS which appears to be important for local angiogenesis and affects trophoblast invasion. We are identifying associations of this system with pregnancy complications and are undertaking in vitro studies to determine functional effects and interactions.
Staff and students
Prof Claire Roberts, Research Leader
Prof Gus Dekker,
Dr Tina Bianco-Miotto, Lecturer School of Agriculture Food and Wine
Dr Amanda Highet, NHMRC Biomedical Training Fellow
Dr Sean O'Leary, Research Fellow
Dr Prabha Andraweera, Postdoctoral Fellow
Dylan McCullough, Research Assistant
Dr Dee McCormack, Postgraduate student
Jessica Laurence, Postgraduate student
Shalem Leemaqz, Postgraduate student
Sam Buckberry, Postgraduate student
Sultana Mahabbat-e Khoda, Masters student
Ben Mayne, Honours student
Zimin Zhuang, Honours student
- Sykes S, Pringle KG, Zhou A, Dekker GA, Roberts CT, Lumbers ER The balance between human maternal plasma angiotensin II and angiotensin 1-7 levels in early gestation pregnancy is influenced by fetal sex Journal Of The Renin-Angiotensin-Aldosterone System Available online 25 February 2013
- Sykes S, Pringle KG, Zhou Z, Dekker GA, Roberts CT, Lumbers ER Fetal sex and the circulating renin-angiotensin system in early gestation in women who later develop preeclampsia or gestational hypertension Journal of Human Hypertension 28(2):133-9.
- Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann D, Walker SK, Roberts CT, McMillen IC Periconceptional Undernutrition Programs Changes in Insulin Signaling Molecules and MicroRNAs in Skeletal Muscle in Singleton and Twin Fetal Sheep Biology of Reproduction 90(1):5-15.
- Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann D, Walker SK, Roberts CT, McMillen IC Impact of embryo number and maternal undernutrition in the periconceptional or preimplantation period on insulin signalling molecules, gluconeogenic factors and microRNAs in the liver in the fetal sheep American Journal of Physiology: Endocrinology and Metabolism 306(9):E1013-24.
- Buckberry S, Bent SJ, Bianco-Miotto T, Roberts CT massiR: a method for predicting the sex of samples in gene expression microarray datasets Bioinformatics Available online 16 April 2014.
- Buckberry S, Bent SJ, Bianco-Miotto T, Dekker GA, Roberts CT Integrative transcriptome meta-analysis reveals widespread sex-biased gene expression at the human fetal-maternal interface. Molecular Human Reproduction Available online 27 May 2014.
- Andraweera PH, Dekker GA, Thompson SD, Jayasekara RW, Dissanayake VHW, Roberts CT Hypoxia-inducible factor-1α gene polymorphisms in early and late onset preeclampsia in Sinhalese women. Placenta 35(7):491-495.
- Kenny LC, Black M,Poston L, Taylor R, Myers J, Baker PN, McCowan LME, Simpson N, Dekker GA, Roberts CT, Rodems K, Noland B, Raymundo M, Walker JJ, North RA Early pregnancy prediction of preeclampsia in nulliparous women, combining clinical risk and biomarkers; the SCOPE international cohort study. Hypertension Accepted 17 May 2014.
- Myers JE, Thomas G, Tuytten R, Van Herrewege Y, Djiokep RO, Roberts CT, Kenny LC, Simpson NAB, North RA, Baker PN Mid trimester maternal ADAM12 levels differ according to fetal sex in pregnancies complicated by preeclampsia. Reproductive Sciences Available Online 4 June 2014.
- Williams-Wyss O, Zhang S, MacLaughlin SM, Kleemann DO, Walker SK, Suter CM, Cropley JE, Morrison JL, Roberts CT, McMillen IC Embryo number and periconceptional undernutrition in the sheep have differential effects on adrenal epigenotype, growth and development. American Journal of Physiology: Endocrinology and Metabolism Available online 27 May 2014.
- Zhou A, Dekker GA, Lumbers ER, Lee SY, Thompson SD, McCowan LME, Roberts CT The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI Placenta 34(1): 75-81.
- Andraweera PH, Dekker GA, Dissanayake V, Bianco-Miotto T, Jayasekara R, Roberts CT Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka. Journal of Maternal-Fetal & Neonatal Medicine 26(5): 532-536.
- Xiang R, Johns WH, Eindorf T, Rutley DL, Kruk ZA, Fitzsimmons CJ, Thomsen DA, Roberts CT, Burns BM, Anderson GI, Greenwood PL, Hiendleder S Maternal and Paternal Genetics Differentially Affect Myofibre Characteristics and Muscle Weights of Bovine Fetuses at Midgestation PLoS One 8(1):e53402.
- Myers J, Tuytten R, Thomas G, Laroy W, Kas K, Vanpoucke G, Roberts CT, Kenny LC, Simpson NAB, Baker PN, North RA Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia Hypertension 61(6):1281-8.
- Zhou A, Dekker GA, Lumbers ER, Leemaqz SY, Thompson SD, Heinemann GA, McCowan LME, Roberts CT The association of maternal ACE A11860G with small for gestational age pregnancies is modulated by the environment and fetal sex: a multicentre prospective case-control study Molecular Human Reproduction 19:618-627.
- McCowan LME, Thompson J, Taylor RS, North RA, Poston L, Baker PN, Myers J, Roberts CT, Dekker GA, Simpson NB, Walker JJ, Kenny LC Clinical prediction of infants small for gestational age by customised birthweight centiles in a healthy nulliparous cohort. PLoS One 8(8):e70917.
- van der Graaf AM, Zeeman G, Groen H, Roberts CT, Dekker GA Non-invasive assessment of maternal hemodynamics in early pregnancy. Pregnancy Hypertension 3(4):261-269.
- McCarthy FP, O'Keeffe LM, Khashan AS, North RA, Poston L, McCowan LME, Baker PN, Dekker GA, Roberts CT, Walker JJ, Kenny LC The impact of maternal alcohol consumption in early pregnancy on pregnancy outcome Obstetrics and Gynaecology 122(4):830-837.
- Lie S, Sim SM, McMillen IC, William-Wyss O, MacLaughlin SM, Kleeman DO, Walker SK, Roberts CT, Morrison JL Maternal undernutrition around the time of conception and embryo number each impact on the abundance of key regulators of cardiac growth and metabolism in the fetal sheep heart J DOHAD 4(5):377-390.
- Zhang S, Williams-Wyss O, Maclaughlin SM, Walker SK, Kleeman DO, Suter CM, Morrison JL, Molloy L, Cropley JE, Roberts CT, McMillen IC Maternal undernutrition during the first week after conception results in decreased expression of glucocorticoid receptor mRNA in the absence of GR exon 17 hypermethylation in the fetal pituitary in late gestation J DOHAD 4(5):391-401.
- Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann D, Walker SK, Roberts CT, McMillen IC Impact of embryo number and periconceptional undernutrition on factors regulating adipogenesis, lipogenesis and metabolism in adipose tissue in the sheep fetus American Journal of Physiology: Endocrinology and Metabolism Accepted 30 July 2013
- Unwin RD, Blankley RT, Fisher C, Westwood M, North RA, Baker PN, Walker MJ, Williamson A, Whetton AD, Lin W, McCowan LME, Roberts CT, Cooper G, Myers J A label-free SRM workflow identifies a subset of pregnancy specific glycoproteins as novel predictive markers of early-onset pre-eclampsia Molecular and Cellular Proteomics Accepted 17 July 2013
Dekker GA, Lee SY, North RA, McCowan LM, Simpson N, Roberts CT Risk factors for preterm birth in an international prospective cohort of nulliparous women PLoS One 7(7):e39154.
Furness DLF, Fenech M, Dekker GA, Khong TY, Roberts CT, Hague WM Folate, vitamin B12, vitamin B6 and homocysteine: impact on pregnancy outcome. Maternal and Child Nutrition 25(8):1423-7.
Gatford KL, Smits RJ, Collins CL, De Blasio MJ, Roberts CT, Nottle MB, van Wettere WHEJ, Kind KL, Owens JA Maternal low-dose porcine somatotropin treatment in late gestation increases progeny weight at birth and weaning in sows but not in gilts. Journal of Animal Science 90(5):1428-35.
Andraweera PH, Dekker GA, Thompson SD, North RA, McCowan LME, Roberts CT A functional variant in ANGPT1 and the risk of pregnancies with hypertensive disorders and small-for-gestational-age infants Molecular Human Reproduction 18(6):325-332.
Soo PS, Hiscock J, Botting KJ, Roberts CT, Davey AK, Morrison JL Maternal undernutrition reduces P-glycoprotein in guinea pig placenta and developing brain in late gestation Reproductive Toxicology 33:374-381.
Andraweera PH, Dekker GA, Thompson SD, Roberts CT Single nucleotide polymorphisms in the KDR gene in pregnancies complicated by gestational hypertensive disorders and small for gestational age infants Reproductive Sciences 19(5):547-54.
Andraweera PH, Dekker GA, Laurence J, Roberts CT Placental expression of VEGF family mRNA in adverse pregnancy outcomes Placenta 33: 467-472.
Andraweera PH, Dekker GA, Thompson SD, McCowan LME, North RA, Roberts CT Interaction between maternal BMI and angiogenic gene polymorphisms associates with the risk of spontaneous preterm birth Molecular Human Reproduction 18(9):459-465.
Highet AR, Zhang VJ, Heinemann GK, Roberts CT Use of Matrigel in culture affects cell phenotype and gene expression in the first trimester trophoblast cell line HTR8/SVneo Placenta 33(7):586-588.
Lee SY, Lee SX, Dekker GA, Roberts CT Multivariate Visual Clustering of Single Nucleotide Polymorphisms and Clinical Predictors using Chernoﬀ Faces Proceedings of the 5th Annual Applied Statistics Education and Research Collaboration (ASEARC) Conference 2012:56-59.
Tung E, Roberts CT, Heinemann GA, DeBlasio MJ, Kind KL, van Wettere WHEJ, Owens JA, Gatford KL Increased placental nutrient transporter expression after maternal growth hormone treatment in pigs: A placental mechanism for increased fetal growth Biology of Reproduction 87(5):126, 1-8.
- Buckberry S, Bianco-Miotto T, Hiendleder S, Roberts CT Quantitative Allele-Specific Expression Analysis of H19, IGF2 and IGF2R in the Human Placenta Across Gestation PLoS One 7(12): e51210.
- Leemaqz SY, Dekker GA, Roberts CT Tiered Prediction System for Preeclampsia: an integrative application of multiple models. Proceedings of MODSIM2013, 20th International Congress on Modelling and Simulation. Modelling and Simulation Society of Australia and New Zealand, December 2013
O'Connell BA, Moritz K, Roberts CT, Walker DW, Dickinson H The placental response to excess maternal glucocorticoid exposure differs between the male and female conceptus. Biology of Reproduction 85(5):1040-1047.
Horgan RP, Broadhurst DI, Walsh SK, Dunn WB, Brown M, Roberts CT, North RA, McCowan L, Kell DB, Baker PN, Kenny LC Metabolic profiling uncovers an early phenotypic signature of Small for Gestational Age in early pregnancy. Journal of Proteome Research 10(8):3660-3683.
Carty DM, Siwy J, Brennand JE, Zurbig P, Mullen W, Franke J, McCulloch JW, Roberts CT, North RA, Chappell LC, Mischak H, Poston L, Dominiczak AF, Delles C Urinary Proteomics for Prediction of Preeclampsia. Hypertension 57:561-569.
McCowan LME, Kho EM, Black MA, Chan E, Dekker GA, Poston L, Taylor RS, North RA, Roberts CT Paternal contribution to small for gestational age babies: a multicentre prospective study. Obesity 19(5):1035-1039.
Andraweera PH, Dekker GA, Thompson SD, Nowak RC, Zhang VJ, McCowan LME, North RA, Roberts CT Association of vascular endothelial growth factor +936 C/T single nucleotide polymorphism with pregnancies complicated by small for gestational age babies Archives of Pediatrics & Adolescent Medicine 165(12):1123-1130.
Andraweera PH, Dekker GA, Thompson SD, North RA, McCowan LME, Roberts CT A functional variant in the thrombospondin-1 gene and the risk of small for gestational age infants. Journal of Thrombosis and Haemostasis 9(11):2221-2228.
Novakovic B, Wong N, Sibson M, Ng H-K, Morley R, Manuelpillai U, Down T, Rakyan V, Beck S, Hiendleder S, Roberts CT, Craig JM, Saffery R DNA methylation-mediated down regulation of DNMT1, is co-incident with, but not essential for, global hypomethylation in extraembryonic tissues. Journal of Biological Chemistry 285(13):9583-9593.
Ng HK, Novakovic B, Hiendleder S, Craig J, Roberts CT, Saffery R Distinct patterns of gene specific methylation in mammalian placentae: implications for placental evolution and function. Placenta 31(4):259-268.
McCowan LME, Roberts CT, Dekker GA, Taylor R, Chan E, Kenny L, Baker P, Ross-Morris R, Chappell L, North RA Risk factors for infants small for gestational age by customised birthweight centiles : data from an international prospective cohort study BJOG 117(13):1599-1607.
McArdle AM, Roberts CT, Maduwegedera D, Flower RL, Denton KM Chronic maternal hypertension reduces late gestation placental blood flow in rabbits. American Journal of Physiology: Regulatory Integrative Comparative Physiology 298:R1043-R1049.
Kenny LC, Broadhurst DI, Dunn W, Brown M, North RA, McCowan L, Roberts CT, Cooper GJS, Kell DB, Baker PN Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension 56(4):741-9.
Gatford KL, Smits RJ, Collins CL, Argent C, De Blasio MJ, Roberts CT, Nottle MB, Kind KL, Owens JA Maternal responses to daily maternal porcine somatotropin injections during early-mid or early-late pregnancy in sows and gilts. Journal of Animal Science 88(4):1365-1378.
- McArdle AM, Maduwegedera D, Moritz K, Flower RL, Wintour EM, Denton KM, Roberts CT Chronic maternal hypertension affects placental gene expression and differentiation in rabbits. Journal of Hypertension 28(5):959-968.
Sferruzzi-Perri AN, MacPherson AM, Roberts CT, Robertson SA Csf2 Null Mutation Alters Placental Gene Expression and Trophoblast Glycogen Cell and Giant Cell Abundance in Mice. Biology of Reproduction 81:207-221.
Kho EM, McCowan LME, Roberts CT, Chan E, Black MA, Taylor RS, North RA, Dekker GA Duration of Sexual Relationship and Its Effect on Preeclampsia and Small for Gestational Age: a Multicentre Prospective Study. Journal of Reproductive Immunology 82(1):66-73.
Gatford KL, de Blasio M, Roberts CT, Nottle MB, Kind KL, van Wettere WH, Smits RJ, Owens JA Responses to maternal growth hormone injections or ractopamine during early-mid pregnancy are similar in primiparous and multiparous pregnant pigs. Journal of Endocrinology 203(1):143-154.
- McArdle AM, Denton KM, Maduwegedera D, Moritz K, Flower RL, Roberts CT Ontogeny of placental structural development and expression of renin angiotensin system and 11β-HSD2 genes in the rabbit. Placenta 30:590-598.
- Buckberry S, Bianco-Miotto T, Roberts CT Imprinted and X-linked non-coding RNAs as potential regulators of human placental function. Epigenetics 9(1):81-89.
- Ahmed MS,,Aleksunes LM, Boeuf P, Chung MK, Daoud G, Desoye G, Diaz P, Golos TG, Illsley NP, Kikuchi K, Komatsu R, Lao T, Morales-Prieto DM, Nanovskaya T, Nobuzane T, Roberts CT, Saffery R, Tamura L, Tamura K, Than NG, Tomi M, Umbers A, Wang B, Weedon-Fekjaer S, Yanmada S, Yamazaki K, Yoshie M, Lash GE IFPA Meeting 2012 Workshop Report II: Epigenetics and imprinting in the placenta, growth factors and villous trophoblast differentiation, role of the placenta in regulating fetal exposure to xenobiotics during pregnancy, infection and the placenta Placenta 34 SUPPL:S6-S10.
- Andraweera PH, Dekker GA, Roberts CT The Vascular endothelial growth factor family and adverse pregnancy outcome Human Reproduction Update 18(4):436-57. INVITED REVIEW.
Dekker GA, Robillard PY, Roberts CT The etiology of preeclampsia; the role of the father. Journal of Reproductive Immunology INVITED REVIEW 89(2):126-132.
Sferruzzi-Perri AN, Owens JA, Pringle KG, Roberts CT The neglected role of maternal endocrine insulin-like growth factors in regulating fetal growth. Journal of Physiology-London 589(1):7-20. INVITED REVIEW.
Furness DLF, Dekker GA, Roberts CT DNA damage and health in pregnancy. Journal of Reproductive Immunology INVITED REVIEW 89(2):153-162.
Roberts CT IFPA Award Lecture: Complicated interactions between genes and the environment in placentation, pregnancy outcome and long term health. Placenta 31: Suppl. A Trophoblast Research 24:S47-S53 INVITED REVIEW.
Pringle KG, Kind KL, Thompson JG, Roberts CT Oxygen and beyond: complex regulation of the establishment of pregnancy. Human Reproduction Update 16(4):415-431 INVITED REVIEW.
- Lash GE, Burton GJ, Chamley LW, Clifton VL, Constancia M, Crocker IP, Dantzer V, Desoye G, Drewlo S, Hemmings DG, Hiendleder S, Kalionis B, Keelan JA, Kudo Y, Lewis RM, Manuelpillai U, Murthi P, Natale D, Pfarrer C, Robertson SA, Saffery R, Saito S, Sferruzzi-Perri A, Sobrevia L, Waddell BJ, Roberts CT IFPA Meeting 2009 Workshops Report. Placenta 31:Suppl. Trophoblast Research 24:S2-S20.
Roberts CT and Owens PC (2002) Regulation of cytotrophoblast cell differentiation and cell migration. Patent Cooperation Treaty Application # PCT/AU02/01226 filed 30 August 2002, International Publication Date 28 February 2004, WO2003/018781, Claiming priority #PR7331 from 30 August 2001. Licensed by Medicult A/S, Denmark. Currently being examined in Australia, Canada and Europe. Granted in USA. Granted in New Zealand.
Roberts CT (2005) Compositions and methods for improving implantation, development and pregnancy outcomes. PCT # 2005903997 Filed 27 July 2006 Claiming priority from 27 July 2005 International Publication Date 1 February 2007 #WO2007/012117 A1 Licensed by Medicult A/S, Denmark. Filed in Australia, USA, Europe and China (Chinese application #200680032241.8).
Roberts CT and Thompson SD (2008). IGF2 polymorphisms associated with pregnancy complications. Provisional patent application #2008902646 filed 27.5.2008 (Priority Date).
Roberts CT (2008) Insulin gene polymorphisms associated with pregnancy complications. Provisional patent application #2008902733 filed 30.5.2008 (Priority Date)
Roberts CT (2008) UPA polymorphisms associated with pregnancy complications.Provisional patent application # 2008902753 filed 2.6.2008 (Priority Date)
Roberts CT (2008) Polymorphisms in genes of the renin angiotensin system associated with pregnancy complications. Provisional patent application #2008903044 Filed 16.6.2008 (Priority Date)
Roberts CT, Thompson SD, Zhou A, Andraweera P. Polymorphisms associated with pregnancy complications. #PCT/AU2009/000668 filed 27.5.2009 Claiming priority from 27.5.2008 incorporating Provisional patent applications #2008902646, #2008902646, # 2008902753 and #2008903044.
Roberts CT, Furness DL, Andraweera P, Nowak R. Maternal, paternal and neonatal polymorphisms associated with pregnancy complications. Provisional patent application #2009903976 Filed 21.8.2009 (Priority Date)
Roberts CT, Furness DL, Andraweera P, Nowak R, Thompson SD, Zhou A. Polymorphisms associated with pregnancy complications. Provisional patent application #2009904774 Filed 1.10.2009 (Priority Date)
International Patents Granted:
Roberts CT and Owens PC (2007) Regulation of cytotrophoblast cell differentiation and cell migration. US Patent 7,244,707. Issued July 2007.
Roberts CT and Owens PC (2008) Regulation of cytotrophoblast cell differentiation and cell migration. New Zealand Patent 531362 Issued 12 June 2008.
Expertise for Media Contact
|Categories||Medicine & Medical Research, Fertility & Reproduction|
|Expertise||Pregnancy complications; placenta; pre-term birth; preeclampsia; intrauterine growth restriction; fetus|
|Notes||Head, Placental Development Laboratory|
|Mobile||0406 381 575|
Entry last updated: Sunday, 27 Jul 2014
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