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Dr Ian Musgrave

Telephone +61 8 8313 3905
Position Senior Lecturer
Email ian.musgrave@adelaide.edu.au
Fax +61 8 8313 8059
Building Medical School South
Floor/Room 5 15a
Campus North Terrace
Org Unit Clinical and Experimental Pharmacology

To link to this page, please use the following URL:
http://www.adelaide.edu.au/directory/ian.musgrave

Biography/ Background

Dr Musgrave is a molecular pharmacologist/toxicologist who works at the University of Adelaide, Australia. He has a broad interest in the understanding of how surface receptors can modulate neuronal function and survival, as well as interests in natural product pharmacology and drug design. As well he is interested in evolutionary biology, science communication (committee member of SA Science Communicators) and an avid amateur astronomer.

He did postdoctoral work in the Institute of Pharmacology at the Free University of Berlin in 1991-1994, returning to Australia in 1994. He has collaborated with Professor John Carver, Dr. Scot Smid and Professor Colin Barrow on using natural products to attack the neurodegeneration process in Alzheimer’s Disease. He was recently elected as convenor of the Toxicology Special Interest Group of the Australasian Society for Pharmacology and Toxicology. He is collaborating with Professor Roger Byard on the forensic implications of herbal medicines. He has held ARC funding and currently holds NH&MRC funding.

 

Research Interests

Neuroprotection, neurotoxicology, natural product pharmacology, natural products as drugs, anti-amyoid drugs, anti-amyloid drugs and HIV, herbal medicine safety. See more on my research homepage.

Publications

For a full list and download links, see my publications profile on Google Scholar: Ian Musgrave
Selected Publications:

1: Byard RW, Musgrave I, Hoban C, Bunce M. DNA sequencing and metabolomics: new approaches to the forensic assessment of herbal therapeutic agents. Forensic Sci Med Pathol. 2014 Feb 11. [Epub ahead of print] PubMed PMID: 24515579.

2: Lloyd H, Hinton T, Bullock S, Babey AM, Davis E, Fernandes L, Hart J, Musgrave I, Ziogas J. An evaluation of pharmacology curricula in Australian science and health-related degree programs. BMC Med Educ. 2013 Nov 19;13:153. doi: 10.1186/1472-6920-13-153. PubMed PMID: 24252183; PubMed Central PMCID: PMC3842843.

3: Wong DY, Musgrave IF, Harvey BS, Smid SD. Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro. Neurosci Lett. 2013 Nov 27;556:221-6. doi: 10.1016/j.neulet.2013.10.027. Epub 2013 Oct 22. PubMed PMID: 24161892.

4: Liu Y, Pukala TL, Musgrave IF, Williams DM, Dehle FC, Carver JA. Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6336-40. doi: 10.1016/j.bmcl.2013.09.071. Epub 2013 Oct 1. PubMed PMID: 24157371.

5: Rahman SZ, Basilakis J, Rahmadi A, Lujic S, Musgrave I, Jorm L, Hay P, Münch G. Use of serotonergic antidepressants and St John's wort in older Australians: a population-based cohort study. Australas Psychiatry. 2013 Jun;21(3):262-6. doi: 10.1177/1039856213475681. Epub 2013 Feb 25. PubMed PMID: 23439542.

6: Calabrese AN, Markulic K, Musgrave IF, Guo H, Zhang L, Bowie JH. Structural and activity changes in three bioactive anuran peptides when Asp is replaced by isoAsp. Peptides. 2012 Dec;38(2):427-36. doi: 10.1016/j.peptides.2012.10.001. Epub 2012 Oct 13. PubMed PMID: 23069634.

7: Smid SD, Maag JL, Musgrave IF. Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical. Food Funct. 2012 Dec;3(12):1242-50. doi: 10.1039/c2fo30075c. Review. PubMed PMID: 22929970.

8: Koudelka T, Dehle FC, Musgrave IF, Hoffmann P, Carver JA. Methionine oxidation
enhances κ-casein amyloid fibril formation. J Agric Food Chem. 2012 Apr
25;60(16):4144-55. Epub 2012 Apr 11. PubMed PMID: 22443319.

9: Weekley CM, Aitken JB, Musgrave IF, Harris HH. Methylselenocysteine treatment leads to diselenide formation in human cancer cells: evidence from X-ray absorption spectroscopy studies. Biochemistry. 2012 Jan 24;51(3):736-8. Epub 2012 Jan 17. PubMed PMID: 22242710.

10: Harvey BS, Ohlsson KS, Mååg JL, Musgrave IF, Smid SD. Contrasting protective
effects of cannabinoids against oxidative stress and amyloid-β evoked
neurotoxicity in vitro. Neurotoxicology. 2012 Jan;33(1):138-46. Epub 2012 Jan 3. 
PubMed PMID: 22233683. (2 citations)

11: Moussavi Nik SH, Wilson L, Newman M, Croft K, Mori TA, Musgrave I, Lardelli M. The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress. J Alzheimers Dis. 2012;28(3):515-30. PubMed PMID: 22045484.

12: Wilkins JS, Stanyon C, Musgrave I. Selection without replicators: the origin of genes, and the replicator/interactor distinction in etiobiology Biol Philos 2012 27:215–239

13: Vega IF, Rittschof D, Dickinson GH, Musgrave I. Evolutionary Proteomics:
Empowering Tandem Mass Spectrometry and Bioinformatics Tools for the Study of Evolution.
In: Tandem Mass Spectrometry – Applications and Principles. 2012 Pp. 57-86.

 

Publications via Google Scholar

http://scholar.google.com/citations?user=eU_PyAEAAAAJ

Community Engagement

A comittee member of the Australian Science Communicators (South Australia), Dr. Musgrave has given several community talks and radio interviews on various aspects of science. He has been interviewed for the TV program Today Tonight three times.  

Dr. Musgrave writes a regular column for The Conversation on issues relating to Pharmacology and Toxicology. His Conversation article ‘Doctors' orders: debunking homeopathy once and for all’, is included in The Best Australian Science Writing 2012 anthology

Expertise for Media Contact

CategoriesMedicine & Medical Research, Science & Technology
ExpertiseAlzheimer's disease, Alzheimers Disease, neurodegeneration, neuropharmacology, amyloid, antioxidants, natural products as drugs, toxicology, toxicology of natural products, molecular toxicology, molecular pharmacology, receptor structure and function, herbal medicine toxicology, Pharmacology Teaching
NotesMember, Australasian Society of Clinical and Experimental Pharmacology and Toxicology (Chair, Toxicology Special Interest Group, Member, Teaching and Drugs Discovery special interest groups). Member, Australian Neuroscience Society Member, Australian Science Communicators. Co-convenor, Adelaide Healthy Ageing Research Cluster (HARC) (2007-2010) AWARD: 1995 ASCEPT Young Investigator

Entry last updated: Sunday, 24 Aug 2014

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