Dr Irmeli Penttila
Biography/ Background
A/Prof Imme Penttila is Head of the Nutrition and Mucosal Immunology Laboratory
at the Women’s and Children’s Health Research Institute. Her research focus is to
understand the early mechanisms underlying the development of food allergy in
infancy, as well as the development of nutritional therapeutic interventions for child
heath. Over the last 16 years she has focused on the analysis of the role of maternal
milk bioactives in infant immune development working closely with industry (both
national and international). In recognition of her involvement in milk bioactive
research with industry she was awarded an NHMRC Industry Fellowship 2005-09.
Qualifications
| Year |
Appointment/study |
Institution |
1975-1979
|
Bachelor of Science |
University of Adelaide |
| 1980 |
Bachelor of Science (Hon) |
University of Adelaide |
| 1985 |
PhD Conferred |
University of Adelaide |
Research Interests
- Maternal milk
- Infant immune development
- Food Allergy
- Bioactives (dairy and grains)
Publications
Key publications
- Marmion B.P., Shannon M., Maddocks S., Storm P. & Penttila I.A. Protracteddebility and fatigue after acute Q fever. Lancet 347, No 9006, 977-978 (1996).
- Penttila I.A., Harris R., Storm D., Haynes D., & Marmion B.P. Cytokinedys regulation in the post Q fever debility and fatigue syndrome. Q. J. Med. 91, 549-560 (1998).
- Penttila I.A., Van Spriel A., Xian C., Steeb C., Cummins A., Zhang M., Read C. & Zola H. TGF-beta expression in maternal rat milk and in post-natal and weaning rat intestine. Pediatr. Res. 44(4), 524-531 (1998).
- Steeb C B., Lamb J., Shoubridge C., Tivey D., Penttila I.A. & Read L.C. Systemically but not orogastrically delivered IGF-I and LR3IGF-I stimulates intestinal disaccharidase activity in two age groups of suckling rats. Pediatr. Res. 44(5), 663-672 (1998).
- Zhang M.F., Zola H., Read L.C. & Penttila I.A. Localization of Transforming Growth Factor- receptor types I, II and III in the postnatal rat small intestine. Ped Res. 46(6), 657-665 (1999).
- Zhang M.F., Zola H., Read L.C. & Penttila I.A. Identification of soluble Transforming Growth Factor -ß receptor III (sTGF-betaRIII) in rat milk. Immunol Cell Biol 79,291-297 (2001).
- Penttila I.A., Zhang M.F., Bates E., Regester G., Read L.C. & Zola H. Immune modulation in suckling rat pups by a growth factor extract derived from milk whey. J Dairy Res. 68, 587-599 (2001).
- Zhang M.F., Zola H., Read L.C. & Penttila I.A. Immunoregulatory function of milk and development of the infant intestinal mucosal immune response. J. Nutri. Immunol. 5(3), 1-15
- Penttila I.A., Flesch I.E.A., MCCue A.L., Powell L B.C., Zhou F.H., Read L.C. & Zola H. Maternal milk regulation of cell infiltration and interleukin-18 in the intestine of suckling rat pups. Gut 52. 1579-1586 (2003).
- Sergi B.P & Penttila I.A. Interleukin-18 receptor. J Biological Regulators and Homeostatic Agents. 18: 67-73 (2004).
- Karlis J., Penttila I.A.,Tran T., Jones B., Nobbs S., Zola H and Flesch I. Characterization of colonic and mesenteric lymph node dendritic cell subpopulations in a murine adoptive transfer model of IBD. IBD 10, No 6, 834-847. (2004)
- Penttila I.A. Maternal milk Cytokines and infant immune development 2005. Aust. J. Dairy Technol. 60,71-73
- Marmion B, Harris R, Storm P, Helbig K, Penttila I & Semendric L & Q Fever Research Group Adelaide. Q fever prophylaxis, markers of persistent infection & variations in immune function genes in subjects with chronic Q fever" exit summary 1981 – 2004. 2005. Ann.N.Y.Acad Sci 1063, 181-186
- Penttila I.A Effects of transforming growth factor-beta and formula feeding on systemic immune responses to dietary beta-lactoglobulin in allergy prone rats. 2006. Ped. Res. 59: 650-655.
- Tooley KL, Howarth GS, Butler RN, Lymn KA and Penttila IA. The effects of formula feeding on physiological and immunological parameters in the gut of neonatal rats. 2009 Dig Dis Sci. 154 (7) 1432
- Penttila I A. Milk derived Transforming Growth Factor Beta (TGF-) and the infant immune response. J of Ped. 156, (2) s21 - s25
Entry last updated: Thursday, 17 Mar 2011
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