Associate Professor Jeremy Thompson

Biography/ Background

Current Appointments

• 2008-current  Co-Director, Research Centre for Reproductive Health.
• 2005-current  NHMRC Senior Research Fellow.
• 2001-current  Research Program Leader of Early Development Group.

Early Development Group Members

 

NAME	POSITION
Jeremy Thompson	Group Leader
Dr Karen Kind	Collaborating Researcher
Dr Melanie McDowall	Post Doctorate
Cheryl Schelbach	PhD student
Laura Frank	PhD student
Kim Tam	PhD student
Ashley Gauld	Research Technician
Annie Whitty	Research Technician
David Froiland	Research Technician
Deanne Feil	Research Assistant

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Teaching Interests

Currently primary supervisor of 4 PhD students and co-supervisor of 6 PhD students.

Primary Supervisor for:

• Laura Frank:2008 – Current “Hexosamine pathway activity and O-linked glycosylation as determinants of oocyte developmental competence”.
• Kimberley Tam:2006 – Current “Role of Hypoxia inducible factors during ovarian function”.
• Cheryl Schelbach:2004 – Final preparation "The effect of glucosamine on oocyte developmental competence and fertility".
• Kelly Banwell: 2004 – Submitted Nov 2008 “Oxygen concentration and oocyte developmental competence”.

 Co-supervisor for:

• Peck Yin Chin: 2009 – Current Co-supervisor with A/Prof Sarah Robertson “Inflammatory cytokine regulation of preimplantation embryo development in mice".
• Firas Albuz: 2006 – Current Co-Supervisor with Dr. Robert Gilchrist. 
• Deirdre Zander: 2005 – Final preparation - Co-supervisor with Dr. Michelle Lane “Programming of embryos in culture”
• Deanne Feil: 2005 – Current - Co-supervisor with Dr. Michelle Lane and Dr. Darryl Russell “Viability assays in human IVF”
• Ozlem Tunc:2005 – Current Co-supervisor with Dr. Kelton Tremellen “DNA damage in sperm” .
• Christine Yeo: 2005 – Current- Co-supervisor with Dr. Michelle Lane “Assessment of developmental competence of oocytes’'.
   

Research Interests

My overall research interest lies in the relationship between micro-environmental, especially nutritional factors, surrounding the cumulus-oocyte complex and during early embryo development, in both the in vivo (follicular/oviduct/uterine) or in vitro environment, and the developmental competence of the oocyte.  This encompasses the following research:

 

Hypoxia, Hypoxia inducible factors and their role in reproduction

My laboratory has had a long standing interest in the role of oxygen concentration in regulating events within the female reproductive tract.  This is primarily because both oocytes (within follicles) and pre-implantation stage embryos (especially within the uterus) develop in what is normally considered low oxygen concentration environments.  We have focussed on the role of the transcription factor, Hypoxia Inducible Factor, in regulating a number of transitional events, such as follicle antrum formation, corpus luteum formation, early embryo development and implantation.

Glucose concentration, the hexosamine biosynthesis pathway and oocyte competence.

My laboratory has been investigating the metabolic process of cumulus expansion, which involves the less well-recognized pathway of glucose metabolism, the hexosamine biosynthesis pathway, because of the belief that increased cumulus expansion related to better oocyte competence following maturation. When expansion is artificially stimulated (by addition of glucosamine) during oocyte maturation within either mouse, pig or cattle oocytes, it causes a profound inhibitory effect on oocyte competency not related to meiotic completion and only after fertilization and early cleavage had occurred. This is surprising, as this is the same pathway that must be up-regulated to provide hyaluronic acid for matrix formation. My laboratory has subsequently found that in both mouse and cow oocytes that this inhibition involves the O-linked-β-glycosylation of serines and threonines of un-identified proteins, in much the same way as kinases phosphorylate such sites on proteins

Oocyte secreted factors and oocyte competence.

With my collaborator, Rob Gilchrist, my laboratory has been studying cumulus cell – oocyte interactions and the role of oocyte secreted factors (OSFs). This has led to the discovery that the addition of native OSFs or the addition of recombinant specific factors, growth differentiation factor-9 (GDF-9) or bone morphogenetic protein-15 (BMP-15) to in vitro maturation of cattle or mouse oocytes significantly increases subsequent embryo yield by 50% and improves quality of resultant embryos and increases implantation rates post-transfer. This discovery is now patented and licensed to Cook Australia. We are pursuing this research area further and our aim is to apply this discovery to clinical IVM.

cAMP management during oocyte maturation

As a result of ARC Linkage funding with Cook, and in a 2nd major collaboration with Rob Gilchrist, we have found that the management of cyclic adenosine monophosphate (cAMP) during IVM of either cattle or mouse oocytes, in a manner that no other laboratory has attempted, greatly increases their competence and therefore embryo yield. In cattle, the rate of blastocyst production is doubled, which is unheard of in this species. We have filed a provisional patent (filing date May 09). Our research is now directed to understand the mechanisms which cause this increase in developmental competence.

 

Research Funding

1. NHMRC Program Grant
2. NHMRC Fellowship Grant
3. NHMRC Project Grant
4. Cook Australia 'IVM Development Funding' Grant

 

Publications

Refereed Research Publications

2009

Irving-Rodgers, H.F., Morris, S., Collett, R.A., Peura, T.T., Davy, M., Thompson, J.G., Mason, H.D., Rodgers, R.J. (2009) Phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes.  Hum. Reprod.

Mitchell M, Cashman K.S., Gardner D.K., Thompson J.G., Lane M. (2009) Disruption of mitochondrial malate-aspartate shuttle activity in mouse blastocysts impairs viability and fetal growth.  Biol. Reprod. 80(2):295-301.

2008

Berg D.K., Thompson J.G., Petersen, A.J. and Asher, G.W. (2008) The temporal relationship between oocyte maturation and early fertilisation events in relation to the preovulatory LH peak and preimplantation embryo development in red deer. Anim. Reprod. Sci. 105:  332-343.

Stokes, Y.M., Clark, A.R., Thompson, J.G. (2008) Mathematical modelling of glucose supply towards successful in vitro maturation of mammalian oocytes, Tiss. Eng.: Part A: 14 (9): 1539-1547.

Bakos, H.W., Thompson, J.G., Feil, D., Lane, M. (2008) Sperm DNA damage is associated with assisted reproductive technology pregnancy.  Int. J. Androl. 31(5):518-26.

Wakefield, S.L., Lane, M., Schulz, S.J., Hebart, M.L., Thompson, J.G., Mitchell, M. (2008) Maternal supply of omega-3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse.  Am. J. Physiol. Endocr. Metab 294:E425-34.

Tunc, O., Thompson, J.G., Tremellen, K. (2008) Development of the NBT assay as a marker of sperm oxidative stress. Int. J. Androl. [Dec 2, EPUB ahead of print]

2007

Kimura, K., Iwata, H., Thompson, J.G. (2007) The effect of glucosamine concentration on the development and sex ratio of bovine embryos. Anim. Reprod. Sci. 103: (3,4): 228-238.

Dragovic, R.A., Ritter, L.J., Schulz, S.J., Amato, F., Thompson, J.G., Armstrong, D.T., Gilchrist, R.B.  (2007)  Oocyte-Secreted Factor activation of SMAD 2/3 signalling enables initiation of mouse cumulus cell expansion.  Biol. Reprod. 76: 848-857.

Harvey, A.J. Navarrete Santos, A., Kirstein, M., Kind, K.L., Fischer, B. and Thompson, J.G. (2007) Differential expression of oxygen-regulated genes in bovine blastocysts. Mol. Reprod. Dev. 74 (3): 290-299. IF=2.54 (7).

Gutnisky, C., Dalvit G.C., Pintos, L.N., Thompson, J.G., Beconi, M.T. and Cetica, P.D. (2007) Influence of hyaluronic acid synthesis and cumulus mucification on bovine oocyte in vitro maturation, fertilisation and embryo development. Reproduction, Fertility and Development 19: 488-497.

Harvey A.J., Kind, K.L. and Thompson J.G. (2007) Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine.  Biol. Reprod. 77: 93-101.

Pringle, K.G., Kind K.L., Thompson J.G., Roberts C.T. (2007) Complex interactions between hypoxia inducible factors, insulin-like growth factor-II and oxygen in early murine Trophoblasts. Placenta 28: 1147-1157.

Banwell K.M., Lane M., Russell D.L., Kind K.L., Thompson J.G., (2007) Oxygen concentration during mouse oocyte in vitro maturation affects embryo and fetal development. Hum. Reprod 22: 2768-2775.

Tonack S., Kind K., Thompson J.G., Wobus A.M., Fischer B., Santos A.N. (2007) Dioxin affects glucose transport via the arylhydrocarbon receptor signal cascade in pluripotent embryonic carcinoma cells. Endocrinology 148: 5902-5912.

Yeo, C.X., Gilchrist, R.B., Thompson, J.G., Lane, M. (2007).  Exogenous growth differentiation factor-9 in oocyte maturation media enhances subsequent embryo development and fetal viability in mice. Hum. Reprod. 23 (1) 67-73.  IF=3.54 (0).

Tremellen, K., Miari, G., Froiland, D., Thompson J.G. (2007) A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. Aust. NZ J. Obstet. Gynaec. 47: 216-221. IF=0.833 (4).

2006

Zander, D.L., Thompson, J.G. and Lane, M.  (2006) Perturbations in mouse embryo development and viability caused by ammonium are more severe after exposure at the cleavage stages.  Biol. Reprod. 74: 288-294.

Clark A.R., Stokes, Y.M., Lane, M. and Thompson, J.G.  (2006) Mathematical modelling of oxygen concentration in bovine and murine cumulus-oocyte complexes.  Reproduction 131: 999-1006.

Sutton-McDowall, M.L., Mitchell, M., Cetica, P., Dalvit, G., Pantaleon, M., Lane, M., Gilchrist, R.B. and Thompson, J.G. (2006) Glucosamine supplementation during in vitro maturation inhibits subsequent embryo development:  Possible role of the hexosamine pathway as a regulator of developmental competence.  Biol. Reprod. 74: 881 - 888.

Kelley, R.L., Kind, K.L., Lane, M., Robker, R.L., Thompson, J.G. and Edwards, L.J. (2006) Recombinant human follicle stimulating hormone (rhFSH) alters maternal ovarian hormone concentrations and the uterus, and perturbs fetal development in mice .  Am. J. Physiol. Endocr. Metab. 291: E761-770.

Thompson, J.G.  (2006) The impact of nutrition of the cumulus oocyte complex and embryo on subsequent development in ruminants.  J. Reprod. Dev. 52: 169-175.

Feil, D., Lane, M., Roberts, C.T., Kelley, R.L., Edwards, L.J., Thompson, J.G. and Kind, K.L. (2006) Effect of culturing mouse embryos under different oxygen concentrations on subsequent fetal and placental development. J. Physiol. 572: 87-96.

Hussein, T.S., Thompson, J.G. and Gilchrist, R.B. (2006) Oocyte-secreted factors enhance oocyte developmental competence. Dev. Biol. 296: 514-521.

2005

Edwards, L.J., Kind, K.L., Armstrong D.T. and Thompson, J.G. (2005) Effects of recombinant human follicle-stimulating hormone on embryo development in mice.  Am. J. Physiol Endocr. Metab. 288:E845-E851. IF=4.14 (4).

Hussein, T., Froiland, D., Amato, F., Thompson, J.G. and Gilchrist, R.B (2005).  Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins.  J. Cell Sci. 118:5257-5268. IF=6.38 (31).

Sutton-McDowall, M.L., Gilchrist, R.B. and Thompson, J.G. (2005) The effect of hexoses and gonadotrophin supplementation on bovine oocyte nuclear maturation during in vitro maturation in a synthetic follicle fluid medium.  Reprod. Fertil. Dev. 17:407-415. IF=2.81 (10).

Thompson, J.G. (2005) A mixed bag:  A perspective on the regulation of IVF in Australia.  Human Fertility.  8: 69-70.

2004

Harvey, A.J., Kind, K.L., Pantaleon M, Armstrong D.T., and Thompson, J.G. (2004) Oxygen-regulated gene expression in bovine blastocysts.  Biol. Reprod. 71: 1108-1119. IF=3.67 (39).

Harvey, A.J., Kind, K.L. and Thompson, J.G.  (2004)  Effect of oxidative phosphorylation uncoupler, 2, 4-dinitrophenol on hypoxia-inducible factor-regulated gene expression in bovine blastocysts.  Reprod. Fertil. Dev. 16:665-673.

Sutton-McDowall, M.L., Gilchrist, R.B. and Thompson, J.G. (2004) Cumulus-expansion and glucose utilization by bovine cumulus-oocyte complexes during in vitro maturation:  the influence of glucosamine and follicle stimulating hormone.  Reproduction 128:313-319.

Thomas, R.E., Thompson, J.G., Armstrong, D.T. and Gilchrist, R.B.  (2004)  Effect of specific phosphodiesterase isoenzyme inhibitors during in vitro maturation of bovine oocytes on meiotic and developmental capacity.  Biol. Reprod.  71:1142-1149.

Kind, K.L., Collett, R.A., Harvey, A.J. and Thompson, J.G.  (2004)  Oxygen-regulated expression of GLUT-1, GLUT-3 and VEGF in the mouse blastocyst.  Mol. Reprod. Dev. 70:37-44. IF=2.54 (21).

2003-2000

Sutton, M.L., Cetica, P.D., Beconi, M.T., Kind, K.L., Gilchrist, R.B. and Thompson, J.G. (2003) Influence of oocyte-secreted factors and culture duration on the metabolic activity of bovine cumulus cell complexes.  Reproduction 126:27-34.

Berg D.K., Pugh, P.A., Thompson J.G. and Asher, G.W. (2002) Development of in vitro embryo production systems for red deer (Cervus elaphus). Part 3. In vitro fertilization using sheep serum as a capacitating agent and the subsequent birth of calves.  Anim. Reprod. Sci. 70: 85-98.

Berg D.K., Thompson J.G. and Asher, G.W. (2002) Development of in vitro embryo production systems for red deer (Cervus elaphus). Part 2. The timing of in vitro nuclear oocyte maturation.  Anim. Reprod. Sci. 70: 77-84.

Berg, D.K., Thompson, J.G. and Asher, G.W. (2002) Development of in vitro embryo production systems for red deer (Cervus elaphus).  Part 1. Effect of epithelial oviductal monolayers and heparin on in vitro sperm motility and penetration of in vitro matured

deMatos, D.G, Gasparinni, B., Pasqualini, S.R. and Thompson, J.G. (2002) Effect of glutathione synthesis stimulation during in vitro maturation of ovine oocytes on embryo development and intracellular peroxide content. Theriogenology 57: 1443-1451.

Stojkovic M., Kölle S., Peinl S., Stojkovic P., Zakhartchenko V., Thompson J.G., Wenigerkind H., Reichenbach H-D., Sinowatz F. and Wolf E.  (2002) Effects of high concentration of hyaluronan in culture medium on development and survival rates of fresh and frozen/thawed in vitro produced bovine embryos. Reproduction 124: 141-153. 

Rieger, D., McGowan, L.T., Cox, S.F., Pugh, P.A. and Thompson, J.G. (2002) The effect of 2,4-dinitrophenol on the energy metabolism of cattle embryos produced by in-vitro fertilization and culture. Reprod. Fertil. Dev. 14: 339-343. 

Macháty, Z, Thompson, J.G., Abeydeera L.R, Day, B.N. and Prather, R.S. (2001) Partial inhibition of mitochondrial ATP production at the time of compaction improves development of in vitro produced porcine embryos.  Mol. Reprod. Dev.58: 39-44. 

Whiteside, E.J., Kan, M., Jackson, M.M., Thompson, J.G., McNaughton, C., Herington, A.C. and Harvey, M.B. (2001) Urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) expression and activity during early embryo development in the cow.  Anatomy and Embryology. 204: 477-483.

Thompson, J.G., McNaughton, C., Gasparrini, B., McGowan, L.T. and Tervit, H.R. (2000)  Effect of inhibitors and uncouplers of oxidative phosphorylation during compaction and blastulation of bovine embryos.  J. Reprod. Fertil. 118: 47-55.

1999-1990

McMillan, W.H., Peterson, A.J., Thompson, J.G. and Pugh, P.A. (1999) Are cattle capable of producing litters of calves? Proc. N.Z. Soc. Anim. Prod. 59: 216-218.

Thompson, J.G., Allen, N. W., McGowan, L. T., Bell, A. C. S., Lambert, G. and Tervit, H. R. (1998) The effect of delayed supplementation of fetal calf serum to culture medium on bovine embryo development and following transfer.  Theriogenology 49: 1239-1249.

Thompson, J.G., Sherman, A., Allen, N. W., McGowan, L. T. and Tervit, H. R. (1998) Total protein content and protein synthesis within pre-elongation stage bovine embryos.  Mol. Reprod. Dev. 50: 139-145.

Eckert, J, Pugh, P.A., Thompson, J.G., Niemann, H. and Tervit, H.R. (1998) Exogenous protein affects developmental competence and metabolic activity of bovine preimplantation embryos in vitro.  Reprod. Fertil. Dev. 10: 327-332.

Thompson, J.G., Partridge, R.J., Houghton, F.D., Cox, C.I. and Leese, H.J. (1996) Oxygen uptake and carbohydrate metabolism by in vitro derived bovine embryos. J. Reprod. Fertil. 106: 299-306.

Houghton, F.D., Thompson, J.G., Kennedy, C.J. and Leese, H.J. (1996)  Oxygen consumption and energy metabolism of the early mouse embryo.  Mol. Reprod. Dev. 44: 476-485. 

Naqvi, S. M. K., McGowan, L. T., Thompson, J.G., and Tervit, H. R. (1996) Effect of amino acid supplementation in culture media on development of bovine oocytes matured and fertilised in vitro.  Ind. J. Anim. Sci. 66: 457-460.

Thompson, J.G. (1996) Defining the requirements for bovine embryo culture. Theriogenology 45: 27-40.

Thompson, J.G., Partridge, R.J., Houghton, F.D., Kennedy, C.J., Pullar, D. and Leese, H.J. (1996) Oxygen consumption by Day 7 bovine blastocysts: Determination of ATP production. Anim. Reprod. Sci. 43: 241-247.

Berg, D.K., Thompson, J.G., Pugh, P.A., Tervit, H.R. and Asher G.W. (1995) Successful in vitro culture of early cleavage stage embryos recovered from superovulated red deer.  Theriogenology 44: 247-254. 

Asher, G.W., Jabbour, H.N., Thompson, J.G., Tervit, H.R., Morrow, C.J. (1995) Superovulation of farmed red deer (Cervus elaphus) and fallow deer (Dama dama): Incidence of ovulation and changes in plasma hormone concentrations during the pre-ovulatory period in relation to ova recovery and fertilisation. Anim. Reprod. Sci. 38: 137-154.

Thompson, J.G., Bell, A.C.S. and Tervit, H.R. (1995) Partitioning of glucose carbon in post-compaction ovine embryos. Anim. Reprod. Sci. 38: 119-126.

Thompson, J.G., Bell, A.C.S., McMillan, W.H., Peterson, A.J. and Tervit, H.R. (1995) Donor and recipient ewe factors affecting in vitro development and post-transfer survival of cultured sheep embryos. Anim. Reprod. Sci., 40: 269-279.

Thompson, J.G., Gardner, D.K., Pugh, P.A., McMillan, W.H. and Tervit, H.R. (1995) Lamb birth weight is affected by culture system utilized during in vitro pre-elongation development of ovine embryos. Biol. Reprod. 53: 1385-1391.

Pugh, P.A., Thompson, J.G., Logan, K. and Tervit, H.R. (1994) In vivo survival of transferred sheep embryos following puncture of the zona pellucida and in vitro culture. Anim. Reprod. Sci. 35: 81-89.

Pugh, P.A., Thompson, J.G., McGowan, L.T., McMillan, W.H. and Tervit, H.R. (1994) In vitro production of cattle embryos: Use in beef twinning programmes. Proc. N.Z. Soc. Anim. Prod. 54: 351-352.

Davis, S.R., Farr, V.C., Prosser, C.G. and Thompson, J.G. (1993) The nature of the microcirculation in the mammary gland of the lactating rat. Proc. NZ Soc. Anim. Prod. 53: 171-172.

Thompson, J.G., Bell, A.C.S., Pugh, P.A. and Tervit, H.R. (1993) Metabolism of pyruvate by pre-elongation sheep embryos and effect of pyruvate and lactate concentrations during in vitro culture. Reprod. Fertil. Dev. 5: 417-423.

Thompson, J.G., Simpson, A.C., Pugh, P.A. and Tervit, H.R. (1992) In vitro development of early sheep embryos is superior in medium supplemented with human serum compared with sheep serum or human serum albumin. Anim. Reprod. Sci. 29: 61-68.

Thompson, J.G., Simpson, A.C., Pugh, P.A. and Tervit, H.R. (1992) Requirement for glucose during in vitro culture of sheep preimplantation embryos Mol. Reprod. Dev. 31: 253-257.

Thompson, J.G., Simpson, A.C., Pugh, P.A., McGowan, L.T., James, R.W., Berg, D.K., Payne, S.R. and Tervit, H.R. (1992) Effect of glucose level in culture medium on survival of in vitro cultured sheep embryos following transfer to recipient ewes.  Proc. NZ Soc. Anim. Prod. 52: 255-256.

Thompson, J.G., Simpson, A.C., James, R.W., Tervit, H.R., Asher, G.W. and Peterson, A.J. (1992) Timing of the LH peak and ovulations in superovulated Coopworth ewes synchronised with progesterone-containing CIDR devices. Proc. NZ Soc. Anim. Prod. 52: 171-174.

Payne, S.R., Munday, R. and Thompson, J.G. (1992) Addition of superoxide dismutase and catalase does not necessarily overcome developmental retardation of one-cell mouse embryos during in vitro culture. Reprod. Fertil. Dev. 4: 167-174. 

Wells, D.G., Thompson, J.G., Tervit, H.R, James, R.W. and Udy, G.B. (1990) Experiences in the application of embryo bisection in sheep MOET programmes. Proc. N.Z. Soc. Anim. Prod. 50: 431-435.

Tervit, H.R., Thompson, J.G. and Peterson, A.J. (1990) Developments in domestic animal embryo manipulation technology which support the application of molecular biology to animal production.  Proc. N.Z. Soc. Anim. Prod. 50: 181-190.

Thompson, J.G., Simpson, A.C., Pugh, P.A., Donnelly, P.E. and Tervit, H.R. (1990) The effect of oxygen concentration on the in vitro development of preimplantation sheep and cattle embryos. J. Reprod. Fert. 89: 573-578. IF= (Is now Reproduction –

Thompson, J.G., Simpson, A.C., James, R.W. and Tervit, H.R. (1990) The application of progesterone containing CIDR devices to superovulation in the ewe. Theriogenology 33: 1297-1304.

1989-1982

Thompson, J.G.E., Peterson, A.J. and Tervit, H.R. (1989) Development of cattle with a modified genotype. Their production through gene transfer to early embryos. Proc. N.Z. Soc. Anim. Prod. 49: 65-70.

Thompson, J.G., Parton, G.A.J., Cruickshank, G.W., Smith, J.F. and Wales, R.G. (1989) Development of sheep preimplantation embryos in media supplemented with glucose and acetate. Theriogenology 32: 323-330.

Asher, G.W. and Thompson, J.G. (1989) Plasma progesterone concentrations during oestrous synchronization in female fallow deer (Dama dama). Anim Reprod. Sci. 19: 143-153.

Thompson, J.G.E. and Smith, J.F. (1988) Effect of nutrition on the ovulatory response of Coopworth ewes to varying doses of two FSH preparations.  Proc. N.Z. Soc. Anim. Prod. 48: 81-85.

Thompson, J.G.E. and Wales, R.G. (1987) Observations on the loss of the cellular vestment surrounding superovulated sheep oocytes.  Anim. Reprod. Sci. 15: 169-175. 

Thompson, J.G.E. and Cummins, J.M. (1986)  Some effects of chondroitin  on the in vitro acrosome reaction in ram spermatozoa.  Anim. Reprod. Sci. 12: 151-155. 

Thompson, J.G.E. and Cummins, J.M. (1985) The effects of washing and protein supplementation on the acrosome reaction of ram spermatozoa in vitro.  Anim. Reprod. Sci. 9: 75-86.

Thompson, J.G.E. and Cummins, J.M. (1984) Problems of ovine in vitro fertilisation.  In “Reproduction in Sheep”, Eds. Lindsay, D.R. and Pearce, D.T.  pp 310-312, Australian Academy of Science, Canberra.

Thompson, J.G.E. and Breed, W.G. (1982) The effect of social environment on vaginal perforation and oestrus in the hopping mouse Notomys alexis.  Aust. J. Zool. 30: 169-173.

Reviews

Thompson J.G. (1997) Comparison between in vivo derived and in vitro produced pre-elongation embryos from domestic ruminants.  Reprod. Fertil. Dev. 9: 341-354.

Leese, H. J., Donnay, I. and Thompson, J.G. (1998) Human assisted conception: a cautionary tale.  Lessons from Domestic Animals. Hum. Reprod. 13 (Suppl. 4) 184-202.

Thompson, J.G. (2000) In vitro culture and embryo metabolism of cattle and sheep embryos – a decade of achievement.  Anim. Reprod. Sci. 60-61: 263-275. 

 

Thompson, J.G. and Peterson, A.J. (2000) Bovine embryo culture in vitro: new developments and post-transfer consequences.  Hum Reprod. 15 Suppl. 5: 101-109.

Harvey, A.J., Kind K.L. and Thompson J.G. (2002) REDOX regulation of embryo development.  Reproduction 123: 479-486.

Thompson, J.G., Kind, K., Roberts, C.T., Robertson, S.A. and Robinson J.S.  (2002) Short and long-term consequences for the health of children conceived through ART – more reason for caution?   Hum. Reprod. 17: 2783 – 2786

Sutton, M.L., Gilchrist, R.B. and Thompson, J.G. (2003) Effects of in vivo and in vitro environments on the metabolism of the cumulus-oocyte complex and influence on oocyte developmental capacity.  Hum. Reprod. Update 9(1): 35-48.

Thompson, J.G. (2007) Culture without the Petri-dish.  Theriogenology 67: 16-20.

Thompson, J.G., Mitchell, M., Kind, K. (2007) Embryo culture and long-term consequences. Reprod. Fert. Dev. 19: 43-52.

 

Gilchrist R.B. and Thompson, J.G. (2007) Oocyte maturation: Emerging concepts and technologies to improve developmental potential in vitro.  Theriogenology 67: 6-15.

Thompson J.G., Lane M, Gilchrist RB (2007) Metabolism of the bovine cumulus-oocyte complex and influence on subsequent developmental competence. Reproduction in Domestic Ruminants VI 64: 179-190.

 

Banwell, K.M., Thompson, J.G. (2008) In vitro maturation of Mammalian oocytes: outcomes and consequences.  Sem. Reprod. Med. 26(2):162-74.

Gilchrist, R.B., Lane, M., Thompson, J.G. (2008) Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality.  Hum. Reprod. Update 14(2):159-77.

 

Pringle, K.G., Kind, K.L., Thompson, J.G. and Roberts, C.T. (2009) Oxygen and beyond: complex regulation of the establishment of pregnancy Manuscript #HRU-09-0006  Human Reproduction Update

 

Research Book / Thesis

Thompson, J.G. (1986) Studies on fertilization in sheep using in-vitro methods. Ph.D. thesis, University of Queensland.

 

Book Chapters

Leese, H.J., Alexiou, M., Comer, M. T., Lamb, V.K. and Thompson, J.G. (1995) “Assessment of the embryo nutritional requirements and role of co-culture techniques”. In “Assisted Reproduction. Progress in Research and Practice”, Vol. 7. of “Advances in Reproductive Endocrinology Series” pp. 11-23.  Ed. R.W. Shaw, Parthenon Publishing Carnforth, UK .

 

Thompson, J.G., Tervit, H. R., Peterson, A. J. and Montgomery, G. M. (1998) Future developments in Reproductive Technology for Livestock Species. In “Reproductive Management of Grazing Ruminants”.  Eds. Fielden, E. D. and Smith, J. F. Chap 13, pp 201-213.  New Zealand Society of Animal Reproduction Occasional Publication 12, Hamilton, NZ.

 

Thompson, J.G., Peterson, A.J. and McMillan, W.H. (2000) Bovine embryo production in vitro: new redevelopments and post-transfer consequences.  In “Cloned Animal and Placentation” Eds. Roberts, R.M., Yanagimachi, R., Kariya, T. and Hashizume, K. pp 18-22.  Yokendo Ltd., Tokyo, Japan.

 

Thompson, J.G., Lane, M. and Robertson, S.  (2005)  “Adaptive responses of early embryos to their microenvironment and subsequent consequences.  In “Early Life Origin of Health and Disease”, Eds. Wintour, M. and Owens, J.  Landes Bioscience Publishing, Texas, USA.

 

Non-refereed Reviews

Thompson, J.G., Pugh, P.A., Tervit, H.R. and Berg, D.K. (1992) In-vitro production of domestic animal embryos: Advances made at Ruakura, New Zealand.  Australasian Biotechnol. 2: 280-287.

 

Thompson, J.G. (1999) Bovine embryo culture in vitro:  New developments and post-transfer consequences.  Arq. Fac. Vet. UFRGS 27: 130-143 (Suppl)

 

Thompson, J.G. and Kind, K.L. (2002) Current limitations and future directions for pre-implantation embryo culture systems.  World of Obstet. Gynaec. 54: 75-80.

 

Thompson, J.G. (2006) Book review: “Implantation and Early Development” (Eds: Critchley, H., Cameron, I., Smith, S.) Hum. Fertil. 9: 197.

 

Refereed Letters

Thompson, J.G. and Lane, M. (2006) The difference in pregnancy rates between elective single embryo transfer (SET) compared to double embryo transfer is dependent on the implantation rates of embryos being transferred. Using mathematical modeling to determine when SET becomes a viable option.  Hum. Reprod. 21: 2195.

 

Commissioned Report

Thompson, J.G., Gilchrist, R.B. ‘The Use of In vitro Maturation’. Pp 22- 61 (2009) Consultation on the use of In vitro maturation in fertility treatment: Discussion document, ACART, The New Zealand Department of Health.  http://www.acart.health.govt.nz/moh.nsf/indexcm/acart-consultation-use-of-invitro-maturation-fertility-treatment-jan09.

 

Patents

•  Buffered embryo solutions

Simmons M, Sharpin R, Thompson J.G. (1998), USA

Patent No 5, 716, 847

(Awarded in USA, NZ and Australia). Developed into commercially manufactured and marketed product by ICPbio, Auckland New Zealand.

Product is “EmCare” embryo handling medium, sold world-wide.

• Methods and compositions for improving the developmental ability and quality for pre-implantation embryos.

Thompson J.G. (2000) NZ

Patent No 512361, Aust Patent No 761187

Internally utilized within AgResearch for the improved efficiency in the development of cloned embryos.

• Modulation of granulosa cell apoptosis.

Gilchrist R.B., Thompson J.G., Hussein T., Dragovic R. (2005) PCT application no: PCT/AU2006/001002. National Phase in Australian, Canada, China, Europe, India, Japan, South Korea and the United States of America.

This patent protects our discovery that oocyte secreted factors, when added to in vitro maturation medium, improves the yield and quality of embryos following oocyte maturation and fertilization.

 

 

 

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Entry last updated: Sunday, 7 Feb 2010