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Dr Luke Selth
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Dr Selth heads a group within the Dame Roma Mitchell Cancer Research Laboratories in Adelaide. His research focuses on two aspects of prostate cancer development and progression. The first involves research into the role of microRNAs in prostate carcinogenesis and metastasis and their use as potential biomarkers of disease. The second is aimed at investigating the mechanisms underlying continued androgen signalling in lethal forms of prostate cancer. These research programs utilise contemporary genomic techniques to better understand prostate cancer at the molecular level.
Dr Selth is a past Young Investigator of Prostate Cancer Foundation of Australia and a current Young Investigator of the Prostate Cancer Foundation (USA).
A range of PhD and Honours projects are available in Dr Selth's lab for motivated students - please contact him directly if you are interested.
Awards & Achievements
2001 George Fraser Scholarship (awarded to the highest ranking applicant for an Australian Postgraduate PhD Award at University of Adelaide)
2005 European Molecular Biology Organisation Post-Doctoral Fellowship
2007 Cancer Research UK Post-doctoral Fellowship
2011 Millennium Sciences Award (Lorne Genome Conference)
2011 Prostate Cancer Foundation of Australia Young Investigator award
2012 US Prostate Cancer Foundation Young Investigator award
2013 South Australian Young Tall Poppy Science Award (Australian Institute of Policy and Science)
For a full list of Dr Selth's publications, visit his Google Scholar page:
Other selected recent publications:
Selth LA and Svejstrup JQ. (2007). Vps75, a new yeast member of the NAP histone chaperone family. J Biol Chem. 282:12358-12362.
Greenwood C, Selth LA, Dirac-Svejstrup AB and Svejstrup JQ. (2009). An iron-sulfur cluster domain in elp3 important for the structural integrity of elongator. J Biol Chem. 284:141-149.
Selth LA, Gilbert C and Svejstrup JQ. (2009). RNA immunoprecipitation for determining the association of proteins with RNA in vivo. Cold Spring Harb Protoc. doi:10.1101/pdb.prot5234.
Selth LA, Lorch Y, Ocampa-Hafalla MT, Mitter R, Shales M, Krogan NJ, Kornberg RD and Svejstrup JQ. (2009). An Rtt109 independent role for Vps75 in transcription-associated nucleosome dynamics. Mol Cell Biol. 29:4220-4234.
Kainov DE*, Selth LA*, Svejstrup JQ, Egly JM and Poterzsman A. (2009). Interacting partners of the Tfb2 subunit from yeast TFIIH. DNA Repair. 9:33-39 (*equal contributations to the work).
Selth LA, Sigurdsson S and Svejstrup JQ. (2010). Transcript elongation by RNA polymerase II. Annu Rev Biochem. 79: 271-293.
Kumar R*, Selth LA*, Schulz RB, Tay BS, Neilsen PM and Callen DF. (2011). Genome-wide mapping of ZNF652 promoter binding sites in breast cancer cells. J Cell Biochem. 112:2742-2747 (*equal contributations to the work).
Selth LA, Close P and Svejstrup JQ. (2011). Studying RNA-protein interactions in vivo by RNA Immunoprecipitation (RIP). Methods Mol Biol. 791:253-264.
Selth LA, Townley S, Gillis JL, Ochnik AM, Murti K, Macfarlane RJ, Chi KN, Marshall VR, Tilley WD and Butler LM. (2011). Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease. Int J Cancer. doi: 10.1002/ijc.26405.
Thompson VC, Day TK, Bianco-Miotto T, Selth LA, Han G, Thomas M, Buchanan G, Scher HI, Nelson CC, Greenberg NM, Butler LM and Tilley WD. (2011). Int J Cancer. DOI: 10.1002/ijc.26414.
Selth LA, Tilley WD and Butler LM. (2012). Circulating microRNAs - macro-utility as markers of prostate cancer? Endocr Relat Cancer. 19:R99-R113. doi: 10.1530/ERC-12-0010.
Trotta AP, Need EF, Butler LM, Selth LA, O'Loughlin M, Coetzee G, Tilley WD, Buchanan G. (2012). Sub-domain structure of the co-chaperone SGTA and activity of its androgen receptor client. J Mol Endocrinol. doi: 10.1530/JME-11-0152.
Moore NL, Buchanan G, Harris J, Selth LA, Bianco-Miotto T, Hanson AR, Birrell S, Butler LM, Hickey T, Tilley WD. (2012). An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity. Endocr Relat Cancer. doi: 10.1530/ERC-12-0065.
Chiam K, Ryan NK, Ricciardelli C, Day TK, Buchanan G, Ochnik AM, Murti K, Selth LA, Australian Prostate Cancer BioResource, Butler LM, Tilley WD, Bianco-Miotto T. (2012). Characterization of the prostate cancer susceptibility gene KLF6 in human and mouse prostate cancers. Prostate. doi: 10.1002/pros.22554.
Need EF, Selth LA, Harris TJ, Birrell SN, Tilley WD, Buchanan G. (2012). Interplay between the genomic and transcriptional networks of androgen receptor and estrogen receptor alpha in luminal breast cancer cells. Mol Endo. doi:10.1210/me.2011-1314.
Selth LA, Townley S, Gillis JL, Tilley WD and Butler LM. (2013). Identification of prostate cancer-associated microRNAs in circulation using a mouse model of disease. Methods Mol Biol. 1024:235-46.
Trotta AP, Need EF, Selth LA, Chopra S, Pinnock CB, Leach DA, Coetzee GA, Butler LM, Tilley WD and Buchanan G. (2013). Knockdown of the co-chaperone SGTA results in the suppression of androgen and PI3K/AKT signaling and inhibition of prostate cancer cell proliferation. Int J Cancer. doi: 10.1002/ijc.28310.
Gillis JL*, Selth LA*, Centenera MM, Townley SL, Sun S, Plymate SR, Tilley WD andButler LM (2013). Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors. Oncotarget.4:691-704. *Equal contributations to the work.
Sapre N and Selth LA. (2013). Circulating microRNAs as biomarkers of prostate cancer: the state of play. Prostate Cancer. doi:10.1155/2013/539680
Selth LA, Townley SL, Bert AG, Stricker PD, Sutherland PD, Horvath LG, Goodall GJ, Butler LM and Tilley WD. (2013). Circulating microRNAs predict biochemical recurrence in prostate cancer patients. Br J Cancer. doi: 10.1038/bjc.2013.369
Li X, Roslan S, Johnstone CN, Wright JA, Bracken CP, Anderson M, Bert AG, Selth LA, Anderson RL, Goodall GJ, Gregory PA, Khew-Goodall Y. (2013). MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways. Oncogene. doi: 10.1038/onc.2013.370.
Hu DG, Hickey TE, Irvine C, Wijayakumara DD, Lu L, Tilley WD, Selth LA, Mackenzie PI. (2014). Identification of Androgen Receptor Splice Variant Transcripts in Breast Cancer Cell Lines and Human Tissues. Hormones & Cancer. doi 10.1007/s12672-014-0171-4.
Selth LA, Roberts MJ, Chow CW, Marshall VR, Doi SA, Vincent AD, Butler LM, Lavin MF, Tilley WD, Gardiner RA. (2014). Human seminal fluid as a source of prostate cancer specific microRNA biomarkers. Endocrine Related Cancer. doi: 10.1530/ERC-14-0234.
Das R, Gregory PA, Hollier BG, Tilley WD, Selth LA. (2014). Epithelial plasticity in prostate cancer: principles and clinical perspectives. Trends in Molecular Medicine. In press.
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