Research Interests
Publications
Professional Associations

Dr Stephen Gregory

Telephone	+61 8 8303 7536
Position	Genetics and CMGD Research Officer
Email	stephen.gregory@adelaide.edu.au
Fax	+61 8 8303 4362
Building	Molecular Life Sciences
Floor/Room	1 32
Campus	North Terrace
Org Unit	Molecular and Biomedical Science, School of

To link to this page, please use the following URL:
http://www.adelaide.edu.au/directory/stephen.gregory

Research Interests

The aim of our research is to understand the genetic control of cell division, using the most powerful model system available, Drosophila melanogaster. Drosophila has the great advantages of a completely sequenced and annotated genome, an existing detailed description of its development at the cellular level and the availability of mutants for most genes. In addition, it is a convenient system for sophisticated molecular, genetic and cell biological techniques, allowing us to probe cellular and developmental processes. Drosophila therefore provides the most exciting intellectual challenges in studying developmental biology, because so many experimental approaches are possible. Experience has shown that discoveries made in Drosophila often lead the way by explaining mechanisms or providing tools that help the analysis of cell and developmental biology in other organisms.

Our work has identified key genes that control cell division and allowed us to see what they are doing in their normal setting: a live, developing animal. We are currently working towards being able to visualise the cellular machinery that divides cells in two at the end of mitosis, and to find the genes that regulate this process. This work is critical for an understanding of how normal growth works, but also to give us potential therapeutics that will allow us to block the uncontrolled cell division seen in cancer.

Publications

S. L. Gregory, S. Ebrahimi, J. Milverton, W. H. Jones, A. Bejsovec and R. Saint (2008). Cell division requires a direct interaction between microtubule-associated RacGAP and the contractile ring component Anillin.

Current Biology 18:25-29. Impact 11.0

S. L. Gregory, T. Shandala, L. O’Keefe, L. Jones, M. J. Murray and R. Saint (2007). A Drosophila overexpression screen for modifiers of Rho signaling in cytokinesis.

Fly 1:13-22

S. L. Gregory, T. Shandala, H. Dalton and R. Saint (2005). Rho signalling in cytokinesis.

Mechanisms of Development 122:S143. Impact: 3.3

S. L. Gregory, T. Shandala and R. Saint (2005). Regulation of Rho small GTPase signaling during cell division. In “Signal Transduction of Cell Division”, T Miki, ed. Research Signpost Press. pp285-305.

T. Shandala, S. L. Gregory, H. E. Dalton, M. Smallhorn and R. Saint (2004). Citron kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster.

Development 131:5053-5063. Impact: 7.6, Citations: 10

N. H. Brown, S. L. Gregory, W. L. Rickoll, L. I. Fessler, M. Prout, R. A. H. White and J. W. Fristrom (2002). Talin is essential for integrin function in Drosophila.

Developmental Cell 3:569-579. Impact: 14.8, Citations: 67

K. Roeper, S. L. Gregory and N. H. Brown (2002). The 'Spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families.

Journal of Cell Science 115:4215-4225. Impact: 7.2, Citations: 41

N. H. Brown, S. L. Gregory and M. D. Martin-Bermudo (2000). Integrins as mediators of morphogenesis in Drosophila.

Developmental Biology 223:1-16. Impact: 5.3, Citations: 51

S. L. Gregory (2000). Fly methods for the new millennium.

Nature Cell Biology 2:E211 Impact: 20.2

C. G. Zervas, S. L.Gregory and N. H. Brown (2000). Drosophila Integrin Linked Kinase is required at sites of Integrin adhesion to link the cytoskeleton to the plasma membrane.

Journal of Cell Biology 152:1007-1018. Impact: 12.2 Citations: 113

T. Shandala, R. D. Kortschak, S. L. Gregory and R. Saint (1999). The Drosophila dead ringer gene is required for normal embryonic patterning through regulation of argos and buttonhead.

Development 126:4341-4349. Impact: 7.6 Citations: 23

S. L. Gregory and N. H. Brown (1998). Kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to Plectin and Dystrophin.

Journal of Cell Biology 143:1271-1282. Impact: 12.2 Citations: 81

S. L. Gregory, R. D. Kortschak, B. K. Kalionis and R. Saint (1996). Characterisation of the dead ringer gene identifies a novel, highly conserved family of sequence specific DNA-binding proteins.

Molecular and Cellular Biology 16:792-799. Impact: 8.1 Citations: 89

J. A. Dibbens, S. L. Gregory and J. B. Egan (1992). Control of gene expression in the temperate coliphage 186. The cI repressor directly represses transcription of the late control gene.

Molecular Microbiology 6:2643-2650. Impact: 5.5 Citations: 9

Professional Associations

Australian and New Zealand Society for Cell and Developmental Biology

Genetics Society of Australia

Genetics Society of America

Entry last updated: Tuesday, 26 May 2009

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