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Dr Wendy Ingman

Telephone +61 8 8303 4100
Position Senior Research Officer
Email wendy.ingman@adelaide.edu.au
Fax +61 8 8303 4099
Building Medical School North
Floor/Room 6 20g
Campus North Terrace
Org Unit Obstetrics and Gynaecology (O&G)

To link to this page, please use the following URL:
http://www.adelaide.edu.au/directory/wendy.ingman

Qualifications

Doctor of Philosophy, Medicine 1998 – 2002

Thesis title: The effect of transforming growth factor beta1 null mutation on murine reproductive function.

Department of Obstetrics and Gynaecology

University of Adelaide                Adelaide, Australia

 

Bachelor of Science with Honours (first class) 1993 – 1997

Thesis title: Interactions between IGF-1 and FSH in the bovine ovary

Department of Obstetrics and Gynaecology

University of Adelaide                Adelaide, Australia

Awards & Achievements

Tall Poppy Science Award, Australian Institute of Political Science (2005)

NHMRC CJ Martin Fellowship (2003-2008)

World Academy of Arts and Science’s Emily Hartshorne Mudd Scholarship & C. Lalor Burdick Scholarship (2003)

Junior Scientist Award, 1st place, Society for Reproductive Biology (2001)

Trainee Research Award, 2nd place, Society for the Study of Reproduction (2001)

Ross Wishart Award, Australian Society for Medical Research (2001)

Research Funding

Ingman WV (2009-2011)

Project Grant, ID 565313

National Health and Medical Research Council

“Macrophages in developmental programming of reproductive health”

Ingman WV (2003-2008)

CJ Martin Fellowship, ID 250473

National Health and Medical Research Council

“Macrophages in mammary gland development and disease”

 

Publications

Ingman WV, Robertson SA. The essential role of TGFB1 in reproduction. Accepted 4/5/2009 CGFR539 Cytokine and Growth Factor Reviews

McGrath LM, Ingman WV, Robker RL, Robertson SA. Exogenous transforming growth factor beta1 replacement and fertility in male Tgfb1 null mutant mice. Reproduction, Fertility and Development 2009 21(4):561-570

Ingman WV, McGrath LM, Breed WG, Musgrave IF, Robker RL, Robertson SA. The mechanistic basis for sexual dysfunction in male transforming growth factor beta1 null mutant mice. E-published ahead of print 19/2/2009 Journal of Andrology

Ingman WV, Robertson SA. Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects. Biology of Reproduction 2008 79:711-717

Ingman WV, Jones RL. Cytokine knockouts in reproduction: The use of gene ablation to dissect the roles of cytokines in reproductive biology. Human Reproduction Update 2008 14:179-192

Ingman WV, Robertson SA. TGFbeta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Endocrinology 2007 148(8):4032-4043

Ingman WV, Robker RL, Woitiez K, Robertson SA. Null mutation in TGFB1 disrupts ovarian function causing impaired folliculogenesis, oocyte incompetence and early embryo arrest. Endocrinology 2006 147(2):835-845

Ingman WV, Wyckoff J, Gouon-Evans V, Condeelis J, Pollard JW. Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Developmental Dynamics 2006 235(12):3222-3229

Ingman WV, Robertson SA. Defining the actions of transforming growth factor beta in reproduction. BioEssays 2002 24(10):904-914

Robertson SA, Ingman WV, O'Leary S, Sharkey DJ, Tremellen KP. Transforming growth factor beta - a mediator of immune deviation in seminal plasma. Journal of Reproductive Immunology 2002 57:109-128

Ingman WV, Owens PC, Armstrong DT. Differential regulation by FSH and IGF-I of extracellular matrix IGFBP-5 in bovine granulosa cells: effect of association with the oocyte. Molecular and Cellular Endocrinology 2000 164:53-58

Professional Interests

Macrophages in developmental programming of reproductive health

Programming of reproductive health in women begins long before sexual maturity. Development during childhood, puberty and adulthood produces a fully functional reproductive system capable of conceiving, gestating and nurturing a child. We are investigating the role of immune cells known as macrophages in development of the reproductive system, and how their disruption might influence developmental programming and have lifetime consequences for the reproductive health of the individual.

Macrophages in mammary gland development and breast cancer susceptibility

This research project aims to investigate the involvement of macrophages in breast cancer susceptibility. Macrophages usually protect against cancer, by killing damaged cells, however macrophages are known to have an alternate role in the breast – in regulating breast development and remodelling across the reproductive cycle. Through understanding how macrophage functions in the breast are controlled, we have the potential to utilise the body’s immune system to reduce women’s breast cancer risk.

Entry last updated: Tuesday, 26 May 2009

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