BIOCHEM 3520 - Cancer, Stem Cells and Development (Theory) III
North Terrace Campus - Semester 2 - 2020
General Course Information
Course Code BIOCHEM 3520 Course Cancer, Stem Cells and Development (Theory) III Coordinating Unit School of Biological Sciences Term Semester 2 Level Undergraduate Location/s North Terrace Campus Units 3 Contact Up to 4 hours per week Available for Study Abroad and Exchange Y Prerequisites BIOCHEM 2500 & BIOCHEM 2501 Corequisites SCIENCE 3100 Incompatible BIOCHEM 3001, BIOCHEM 3235 Restrictions Available to BSc (Advanced) students only Course Description This course covers major conceptual and technical advances in this field, focussing on two principle themes:
1. Molecular Basis of Cancer: topics include the molecular mechanisms of cell-cell communication, signal transduction pathways, genetic mutations, oncogenes and tumour suppressor genes, clonal selection, the hallmarks of cancer and metastasis, dysregulation of cell cycle checkpoints, DNA damage, replicative senescence, telomere shortening and genomic instability, control of cell proliferation and apoptosis, cancer-specific metabolism and oncometabolites. Specific examples are included of current of diagnostic and therapeutic approaches for cancer.
2. Stem Cells and Development: topics include the embryonic and adult stem cells, cellular reprogramming and induced pluripotent stem cells (iPS), generation of transgenic/knock-out mice using CRISPR/Cas9 and other techniques, with medical and other applications. Finally, the topics of cell differentiation, neurogenesis and exploring neural circuits will be covered.
Course Coordinator: Associate Professor Dan Peet
The full timetable of all activities for this course can be accessed from Course Planner.
Course Learning Outcomes
1 Understand key theoretical aspects of the regulation of cellular signalling, proliferation and differentiation in the context of embryonic development, stem cells and diseases such as cancer. 2 Understand and apply advanced experimental techniques required to solve specific biochemical problems, and understand of the ethical implications of this research. 3 Find, interpret and critically analyse relevant scientific literature and apply it to specific problems in biochemical research.
University Graduate Attributes
This course will provide students with an opportunity to develop the Graduate Attribute(s) specified below:
University Graduate Attribute Course Learning Outcome(s) Deep discipline knowledge
- informed and infused by cutting edge research, scaffolded throughout their program of studies
- acquired from personal interaction with research active educators, from year 1
- accredited or validated against national or international standards (for relevant programs)
1, 2, 3 Critical thinking and problem solving
- steeped in research methods and rigor
- based on empirical evidence and the scientific approach to knowledge development
- demonstrated through appropriate and relevant assessment
4 Teamwork and communication skills
- developed from, with, and via the SGDE
- honed through assessment and practice throughout the program of studies
- encouraged and valued in all aspects of learning
4 Career and leadership readiness
- technology savvy
- professional and, where relevant, fully accredited
- forward thinking and well informed
- tested and validated by work based experiences
na Intercultural and ethical competency
- adept at operating in other cultures
- comfortable with different nationalities and social contexts
- Able to determine and contribute to desirable social outcomes
- demonstrated by study abroad or with an understanding of indigenous knowledges
na Self-awareness and emotional intelligence
- a capacity for self-reflection and a willingness to engage in self-appraisal
- open to objective and constructive feedback from supervisors and peers
- able to negotiate difficult social situations, defuse conflict and engage positively in purposeful debate
Recommended ResourcesText book: Molecular Biology of the Cell (5th Edn) by Alberts et al., 2008, Published by Garland Science
Online LearningResource material such as lecture, tutorial and past exams will be available on Myuni. Online assessment will be conducted via Myuni.
Learning & Teaching Activities
Learning & Teaching ModesThis course will be delivered by the following means:
3 Lectures of 1 hour each per week. The stacked / same time teaching components are the lectures timetabled with the existing course, Cancer, Stem Cells and Development III (BIOCHEM 3001).
1 Tutorial of 1 hour per week developing material covered in lectures. The lecturer takes the tutorial classes for their section.
3 online multiple choice tests of 1 hour duration per semester (weeks 4, 8 and 12, with immediate feedback provided).
During Covid -1 9
Lectures will all be delivered online, with a combination of prerecorded and live-streamed (Zoom) lectures.It is anticipated that tutorials will be a combination of face-to-face and live-streamed (Zoom) tutorials, with one each week recorded.
The information below is provided as a guide to assist students in engaging appropriately with the course requirements.A student enrolled in a 6 unit course, such as this, should expect to spend, on average 24 hours per week on the studies required. This includes both the formal contact time required to the course (e.g., lectures and practicals), as well as non-contact time (e.g., reading and revision).
Learning Activities Summary
Schedule Week 1 Mechanisms of Epigenetic Cellular Memory Lecture Week 2 Cell Signalling Pathways Lecture Week 3 Signalling Domains: Structure and Function Lecture Week 4 Signalling Domains: Structure and Function Lecture Week 5 Cancer and metabolism Lecture Week 6 Cancer molecular biology Lecture Week 7 Cancer molecular biology Lecture Week 8 mTOR signalling in cancer Lecture Week 9 Cancer, the immune system and immunotherapy Lecture Week 10 Stem cells/CRISPR technology Lecture Week 11 Cell Differentiation/Neurogenesis Lecture Week 12 In vitro production of neurons and exploring neuronal circuits Lecture
The University's policy on Assessment for Coursework Programs is based on the following four principles:
- Assessment must encourage and reinforce learning.
- Assessment must enable robust and fair judgements about student performance.
- Assessment practices must be fair and equitable to students and give them the opportunity to demonstrate what they have learned.
- Assessment must maintain academic standards.
Assessment Task Task Type Due Weighting Learning Outcome Written test on lecture material Summative
30% 1, 2, 3 Online assessment Formative and Summative Weeks 6, 10 and 12 10% 1, 2 Written exam on lecture material Summative
60% 1, 2, 3
Assessment DetailEnd of semester written Exam (80% of total course grade) – 3 hour examination covering the lecture material. It is made up of a mixture of short and long answer type questions.
Online exercises: Three multiple choice tests in weeks 4, 8 and 12 (20% of total course grade). Encourages revision of the material soon after the relevant lectures, and immediate feedback provided to students.
SubmissionIf an extension is not applied for, or not granted,then a penalty for late submission
will apply. A penalty of 10% of the value of the assignment for each calendar day that the assignment is late (i.e. weekends count as 2 days), up to a maximum of 50% of the available marks will be applied. This means that an assignment that is 5 days late or more without an approved extension can only receive a maximum of 50% of the marks available for that assignment.
Grades for your performance in this course will be awarded in accordance with the following scheme:
M10 (Coursework Mark Scheme) Grade Mark Description FNS Fail No Submission F 1-49 Fail P 50-64 Pass C 65-74 Credit D 75-84 Distinction HD 85-100 High Distinction CN Continuing NFE No Formal Examination RP Result Pending
Further details of the grades/results can be obtained from Examinations.
Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. More information at Assessment for Coursework Programs.
Final results for this course will be made available through Access Adelaide.
The University places a high priority on approaches to learning and teaching that enhance the student experience. Feedback is sought from students in a variety of ways including on-going engagement with staff, the use of online discussion boards and the use of Student Experience of Learning and Teaching (SELT) surveys as well as GOS surveys and Program reviews.
SELTs are an important source of information to inform individual teaching practice, decisions about teaching duties, and course and program curriculum design. They enable the University to assess how effectively its learning environments and teaching practices facilitate student engagement and learning outcomes. Under the current SELT Policy (http://www.adelaide.edu.au/policies/101/) course SELTs are mandated and must be conducted at the conclusion of each term/semester/trimester for every course offering. Feedback on issues raised through course SELT surveys is made available to enrolled students through various resources (e.g. MyUni). In addition aggregated course SELT data is available.
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- Reasonable Adjustments to Teaching & Assessment for Students with a Disability Policy
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- Assessment for Coursework Programs
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- Modified Arrangements for Coursework Assessment
- Student Experience of Learning and Teaching Policy
- Student Grievance Resolution Process
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