Cyberlindnera fabianii

Synonymy: 
Candida fabianii.

Cyberlindnera fabianii is a rare cause of candidaemia.

RG-1 organism. 

Culture: 
Colonies (SDA) white to cream-coloured smooth, glabrous, yeast-like.

Microscopy: 
Spheroidal to ellipsoidal budding blastoconidia, 3.0-6.5 x 2-5.5 µm in size. No pseudohyphae are produced. Asci when present, are spherical, containing one to four spherical, finely roughened ascospores.

India ink preparation: 
Negative - no capsules present.

Dalmau plate culture: 
Spherical to ovoid budding yeast cells and occasional pseudohyphae produced.

Molecular identification: 
ITS sequencing recommended.

MALDI-TOF MS: 
Able to accurately identify this species.

Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data
Germ Tube - L-Sorbose - L-Arabinose - D-Glucitol +
Fermentation   Sucrose + D-Arabinose - 𝝰-M-D-Glucoside +
Glucose + Maltose + D-Ribose - D-Gluconate +
Galactose - Cellobiose + L-Rhamnose - DL-Lactate -
Sucrose + Trehalose + D-Glucosamime - myo-Inositol -
Maltose +,s Lactose - N-A-D-glucosamine - 2-K-D-Gluconate -
Lactose - Melibiose - Glycerol + D-Glucuronate nd
Trehalose - Raffinose + Erythritol - Nitrate +
Assimilation   Melezitose + Ribitol - Urease -
Glucose + Soluble Starch + Galactitol - 0.1% Cycloheximide nd
Galactose - D-Xylose + D-Mannitol + Growth at 37C +

Key features: 
Germ tube negative yeast and sugar assimilation pattern. Molecular identification may be required.

Antifungal susceptibility: Cyberlindnera fabianii (Pfaller et al. 2015, Australian national data); MIC µg/mL.
Antifungal No ≤0.03 0.06 0.125 0.25 0.5 1 2 4 8 16 32 ≥64
AMB 1     1                  
FLU 1                 1      
VORI 5 4   1                  
POSA 5       3 2              
ITRA 1         1              
ANID 1         1              
MICA 4 2 1 1                  
CAS 1         1              
5FC 1 1                      

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